LOCUS       NM_130399               1417 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus adenosine deaminase (Ada), mRNA.
ACCESSION   NM_130399
VERSION     NM_130399.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1417)
  AUTHORS   Zanini,D., Manfredi,L.H., Pelinson,L.P., Pimentel,V.C.,
            Cardoso,A.M., Carmo Araujo Goncalves,V.D., Santos,C.B.D.,
            Gutierres,J.M., Morsch,V.M., Leal,D.B.R. and Schetinger,M.R.C.
  TITLE     ADA activity is decreased in lymphocytes from patients with
            advanced stage of lung cancer
  JOURNAL   Med Oncol 36 (9), 78 (2019)
   PUBMED   31375946
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1417)
  AUTHORS   Manzoni,A.G., Passos,D.F., da Silva,J.L.G., Bernardes,V.M.,
            Bremm,J.M., Jantsch,M.H., de Oliveira,J.S., Mann,T.R., de
            Andrade,C.M. and Leal,D.B.R.
  TITLE     Rutin and curcumin reduce inflammation, triglyceride levels and ADA
            activity in serum and immune cells in a model of hyperlipidemia
  JOURNAL   Blood Cells Mol Dis 76, 13-21 (2019)
   PUBMED   30679022
REFERENCE   3  (bases 1 to 1417)
  AUTHORS   Omolekulo,T.E., Michael,O.S. and Olatunji,L.A.
  TITLE     Sodium acetate improves disrupted glucoregulation and hepatic
            triglyceride content in insulin-resistant female rats: involvement
            of adenosine deaminase and dipeptidyl peptidase-4 activities
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 392 (1), 103-116 (2019)
   PUBMED   30280312
REFERENCE   4  (bases 1 to 1417)
  AUTHORS   Bin,A., Caputi,V., Bistoletti,M., Montopoli,M., Colucci,R.,
            Antonioli,L., De Martin,S., Castagliuolo,I., Orso,G., Giaroni,C.,
            Debetto,P. and Giron,M.C.
  TITLE     The ecto-enzymes CD73 and adenosine deaminase modulate
            5'-AMP-derived adenosine in myofibroblasts of the rat small
            intestine
  JOURNAL   Purinergic Signal 14 (4), 409-421 (2018)
   PUBMED   30269308
REFERENCE   5  (bases 1 to 1417)
  AUTHORS   Baldissarelli,J., Santi,A., Schmatz,R., Zanini,D., Cardoso,A.M.,
            Abadalla,F.H., Thome,G.R., Murussi,C., Polachini,C.R.N.,
            Delenogare,D.P., Loro,V.L., Morsch,V.M. and Schetinger,M.R.C.
  TITLE     Quercetin changes purinergic enzyme activities and oxidative
            profile in platelets of rats with hypothyroidism
  JOURNAL   Biomed Pharmacother 84, 1849-1857 (2016)
   PUBMED   27832996
  REMARK    GeneRIF: Quercetin decreases NTPDase, 5'-nucleotidase and adenosine
            deaminase activities in blood platelets of hypothyroid rats, and
            improves the oxidative profile to reduce platelet aggregation.
REFERENCE   6  (bases 1 to 1417)
  AUTHORS   Winston,J.H., Hanten,G.R., Overbeek,P.A. and Kellems,R.E.
  TITLE     5' flanking sequences of the murine adenosine deaminase gene direct
            expression of a reporter gene to specific prenatal and postnatal
            tissues in transgenic mice
  JOURNAL   J Biol Chem 267 (19), 13472-13479 (1992)
   PUBMED   1618849
REFERENCE   7  (bases 1 to 1417)
  AUTHORS   Bansal,S.K., Singh,R.P., Narang,R.K., Joshi,L.D., Bansal,A. and
            Agrawal,A.K.
  TITLE     Serum adenosine deaminase in pulmonary tuberculosis, malignancy and
            non-tubercular respiratory diseases
  JOURNAL   Indian J Chest Dis Allied Sci 33 (4), 189-193 (1991)
   PUBMED   1818842
REFERENCE   8  (bases 1 to 1417)
  AUTHORS   Yasue,M., Serikawa,T. and Yamada,J.
  TITLE     Chromosomal assignments of 23 biochemical loci of the rat by using
            rat x mouse somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 142-148 (1991)
   PUBMED   1914521
REFERENCE   9  (bases 1 to 1417)
  AUTHORS   Baganha,M.F., Pego,A., Lima,M.A., Gaspar,E.V. and Cordeiro,A.R.
  TITLE     Serum and pleural adenosine deaminase. Correlation with lymphocytic
            populations
  JOURNAL   Chest 97 (3), 605-610 (1990)
   PUBMED   1689629
REFERENCE   10 (bases 1 to 1417)
  AUTHORS   Barton,R., Martiniuk,F., Hirschhorn,R. and Goldschneider,I.
  TITLE     The distribution of adenosine deaminase among lymphocyte
            populations in the rat
  JOURNAL   J Immunol 122 (1), 216-220 (1979)
   PUBMED   310828
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088116.1.
            
            On Jan 2, 2005 this sequence version replaced NM_130399.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088116.1, FQ221792.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1417
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1417
                     /gene="Ada"
                     /note="adenosine deaminase"
                     /db_xref="GeneID:24165"
                     /db_xref="RGD:2031"
     exon            1..109
                     /gene="Ada"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1135
                     /gene="Ada"
                     /EC_number="3.5.4.4"
                     /note="adenosine aminohydrolase"
                     /codon_start=1
                     /product="adenosine deaminase"
                     /protein_id="NP_569083.1"
                     /db_xref="GeneID:24165"
                     /db_xref="RGD:2031"
                     /translation="MAQTPAFNKPKVELHVHLDGAIKPETILYYGKKRGIDLPADTVE
                     GLRNIIGMDKPLSLPDFLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRY
                     SPHLLANSKVDPIPWNQAEGDLTPDEVVDLVNQGLQEGEQAFGIKVRSILCCMRHQPS
                     WSPEVLELCKKYHQKTVVAMDLAGDETIEGSSLFPGHVEAYEGAVKDGIHRTVHAGEV
                     GSAEVVREAVDILKTERVGHGYHTIEDEALYNRLLKENMHFEVCPWSSYLTGAWNPKT
                     THAVVRFKDDQANYSLNSDDPLIFKSTVDTDYQMVKKDMGFTEEEFKRLNINAAKSSF
                     LPEDEKKELLERLYKEYQ"
     exon            110..171
                     /gene="Ada"
                     /inference="alignment:Splign:2.1.0"
     exon            172..294
                     /gene="Ada"
                     /inference="alignment:Splign:2.1.0"
     exon            295..438
                     /gene="Ada"
                     /inference="alignment:Splign:2.1.0"
     exon            439..554
                     /gene="Ada"
                     /inference="alignment:Splign:2.1.0"
     exon            555..682
                     /gene="Ada"
                     /inference="alignment:Splign:2.1.0"
     exon            683..754
                     /gene="Ada"
                     /inference="alignment:Splign:2.1.0"
     exon            755..856
                     /gene="Ada"
                     /inference="alignment:Splign:2.1.0"
     exon            857..921
                     /gene="Ada"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1051
                     /gene="Ada"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1151
                     /gene="Ada"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1395
                     /gene="Ada"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagtgacc ctgccaccga gccaacgcgg acccagagag cttcagcgga gggagtcgga
       61 gcgcacgctc agcaccatgg cccagacgcc cgcattcaac aagcccaaag tagagctgca
      121 cgtccacctg gatggagcca tcaagccaga aaccatcttg tactatggca agaagagagg
      181 aatcgacctc ccggcagata cagtggaggg actacgcaac attatcggca tggacaagcc
      241 tctctcgctc ccagacttcc tggccaagtt cgattactac atgcctgcca tcgcgggctg
      301 cagggaggcc atcaagagaa tcgcctatga atttgtggag atgaaggcaa aggaaggcgt
      361 ggtgtacgtg gaagttcgct acagcccaca cctgctggcc aactccaaag tggacccaat
      421 cccctggaac caggccgaag gagacctcac ccctgatgag gttgtggatc ttgtaaacca
      481 gggcctgcag gagggagagc aagcattcgg catcaaggtc cggtccatct tgtgctgcat
      541 gcgccaccag cccagctggt cccctgaggt gttggagctg tgtaagaagt accatcagaa
      601 gaccgtggtg gctatggact tggctgggga tgagaccatt gaaggaagca gccttttccc
      661 gggccacgtg gaagcctacg agggtgcagt gaaggatggc attcaccgga ctgtccatgc
      721 tggagaggtg ggctctgctg aggtggtgcg agaggctgtg gacatactca agacagagag
      781 agtggggcac ggctaccaca caatagagga tgaagccctc tacaacaggc tactgaaaga
      841 aaacatgcac tttgaggtct gcccctggtc cagctacctc actggcgcct ggaatcccaa
      901 aacgacgcat gcagttgttc gcttcaaaga tgatcaggcc aactactccc tcaactcgga
      961 cgaccccctc atcttcaagt ccaccgtgga cactgactac cagatggtga aaaaagacat
     1021 gggcttcact gaagaggagt tcaagagact gaacatcaat gcggcgaagt caagcttcct
     1081 cccagaggac gagaagaagg aacttctgga acggctctac aaggaatacc aatagccacc
     1141 acaggctgat gggcaggccc cctgaagatg gcaaggccgc ttctccgagc ctcatcctgt
     1201 gaatggagtc tttacaactc tgacatactg accttccttc cttccttcct tcaagacctt
     1261 gaagtggcca ggtctgtcct ctgattggat gtcttggcta ggcccaggga ccttgacaat
     1321 catgggcatg aatgtgaaac cttcctttct aaagctaaaa atacggtgtt caataaagca
     1381 gctggtgact gggaaaaaaa aaaaaaaaaa aaaaaaa
//
