LOCUS       NM_001009603            1336 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus aminoacylase 3 (Acy3), mRNA.
ACCESSION   NM_001009603 XM_215159
VERSION     NM_001009603.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1336)
  AUTHORS   Tsirulnikov,K., Abuladze,N., Vahi,R., Hasnain,H., Phillips,M.,
            Ryan,C.M., Atanasov,I., Faull,K.F., Kurtz,I. and Pushkin,A.
  TITLE     Aminoacylase 3 binds to and cleaves the N-terminus of the hepatitis
            C virus core protein
  JOURNAL   FEBS Lett 586 (21), 3799-3804 (2012)
   PUBMED   23010594
REFERENCE   2  (bases 1 to 1336)
  AUTHORS   Tsirulnikov,K., Abuladze,N., Bragin,A., Faull,K., Cascio,D.,
            Damoiseaux,R., Schibler,M.J. and Pushkin,A.
  TITLE     Inhibition of aminoacylase 3 protects rat brain cortex neuronal
            cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and
            4-hydroxy-2-nonenal
  JOURNAL   Toxicol Appl Pharmacol 263 (3), 303-314 (2012)
   PUBMED   22819785
  REMARK    GeneRIF: we report a new potential mechanism for neuronal damage in
            Alzheimer disease that involves AA3; This previously unrecognized
            mechanism may also function in Parkinson disease
REFERENCE   3  (bases 1 to 1336)
  AUTHORS   Hsieh,J.M., Tsirulnikov,K., Sawaya,M.R., Magilnick,N., Abuladze,N.,
            Kurtz,I., Abramson,J. and Pushkin,A.
  TITLE     Structures of aminoacylase 3 in complex with acetylated substrates
  JOURNAL   Proc Natl Acad Sci U S A 107 (42), 17962-17967 (2010)
   PUBMED   20921362
REFERENCE   4  (bases 1 to 1336)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1336)
  AUTHORS   Ryazantsev,S., Abuladze,N., Newman,D., Bondar,G., Kurtz,I. and
            Pushkin,A.
  TITLE     Structural characterization of dimeric murine aminoacylase III
  JOURNAL   FEBS Lett 581 (9), 1898-1902 (2007)
   PUBMED   17434493
REFERENCE   6  (bases 1 to 1336)
  AUTHORS   Pushkin,A., Carpenito,G., Abuladze,N., Newman,D., Tsuprun,V.,
            Ryazantsev,S., Motemoturu,S., Sassani,P., Solovieva,N.,
            Dukkipati,R. and Kurtz,I.
  TITLE     Structural characterization, tissue distribution, and functional
            expression of murine aminoacylase III
  JOURNAL   Am J Physiol Cell Physiol 286 (4), C848-C856 (2004)
   PUBMED   14656720
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088190.1.
            
            On Jan 13, 2005 this sequence version replaced XM_215159.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088190.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1336
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1336
                     /gene="Acy3"
                     /gene_synonym="RGD1305394"
                     /note="aminoacylase 3"
                     /db_xref="GeneID:293653"
                     /db_xref="RGD:1305394"
     exon            1..50
                     /gene="Acy3"
                     /gene_synonym="RGD1305394"
                     /inference="alignment:Splign:2.1.0"
     exon            51..430
                     /gene="Acy3"
                     /gene_synonym="RGD1305394"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1154
                     /gene="Acy3"
                     /gene_synonym="RGD1305394"
                     /EC_number="3.5.1.114"
                     /note="aspartoacylase 3; aspartoacylase-2; ACY-3;
                     aspartoacylase (aminoacylase) 3; aspartoacylase
                     (aminocyclase) 3"
                     /codon_start=1
                     /product="N-acyl-aromatic-L-amino acid amidohydrolase
                     (carboxylate-forming)"
                     /protein_id="NP_001009603.1"
                     /db_xref="GeneID:293653"
                     /db_xref="RGD:1305394"
                     /translation="MCSLPGSRKPLLRVAVTGGTHGNEMCGVYLARYWLQNPGELQRP
                     SFSAMPVLANPAATAACRRYIDRDLNRTFTLTFLGSTATPDDPYEVKRAQELNQLLGP
                     KGTCQAFDFILDLHNTTANTGACLISEVSQNPFNLHLCHYLQLQNPGLPCRLFQFEPP
                     GTESYSMDSVSKNGISLELGPQPQGVLRAELFSQMRAMVASILDFIELFNQGMEFPAF
                     EMEVYKNLGSVDFPRTTDGHLTGTVHSRLQDHDFEPLRPGEPIFKLFSGEDVLYEGDS
                     VVYPLFVNEAAYYEKRVAFLKSEKIRISVPALPGLTPSSTQTP"
     exon            431..626
                     /gene="Acy3"
                     /gene_synonym="RGD1305394"
                     /inference="alignment:Splign:2.1.0"
     exon            627..720
                     /gene="Acy3"
                     /gene_synonym="RGD1305394"
                     /inference="alignment:Splign:2.1.0"
     exon            721..828
                     /gene="Acy3"
                     /gene_synonym="RGD1305394"
                     /inference="alignment:Splign:2.1.0"
     exon            829..938
                     /gene="Acy3"
                     /gene_synonym="RGD1305394"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1310
                     /gene="Acy3"
                     /gene_synonym="RGD1305394"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggatgcat tgggcctgtg gcctagggca gcccaggctc aagccagcag gtgggtcata
       61 actgacatca ctaaccagct accttcacga gcagcctcct gcctcagact cttcagggcc
      121 tgagaagctc acctactgtc caagcttctg gatactaggc tccacgtctc ttgtgtactc
      181 cttcccacac tgagatgtgc tccctgcctg ggtcccggaa gcccctgctc cgtgtggctg
      241 tgactggggg cacccatggg aatgagatgt gtggtgtcta cctggcccgg tactggttac
      301 agaacccagg ggagctgcag agacccagct tctcagccat gccagttctg gccaacccag
      361 cagccacagc tgcctgtcgc cgttacatag accgtgatct caaccgcacc ttcacactca
      421 ccttccttgg ttccaccgct acccccgatg acccatatga agtgaaaaga gcccaagagt
      481 tgaaccagct actgggtccc aaaggcacat gtcaggcttt cgactttata ctagacctgc
      541 acaacaccac agcgaacact ggggcctgtc tcatttctga agtctcccag aaccccttca
      601 acttgcacct gtgccactac ctacagctgc agaacccggg gctgccctgc cgccttttcc
      661 agtttgagcc acctgggaca gagtcctaca gtatggattc tgtgtcgaaa aatggaatct
      721 ctctggagct gggcccccag cctcagggcg tgctgcgggc tgaactgttc tcccagatga
      781 gagcgatggt ggcctccatt ctggacttca tcgaactctt caaccaaggc atggaattcc
      841 ccgcctttga gatggaggtc tacaagaact tgggcagcgt ggacttccca cgcaccacag
      901 atggtcacct gactggcact gtgcactcta ggctgcagga ccacgacttt gagccgctga
      961 ggcctggtga acctatcttt aagctgttca gtggagagga tgtactgtat gagggggact
     1021 ctgttgtata ccctctgttt gttaatgagg ccgcctacta cgagaagcgt gtggcttttc
     1081 tgaagtctga gaagatccgg atctcggtgc ctgccctgcc agggctgacc cccagctcca
     1141 cccagactcc ataatccaag tcatatgcct acctaacctc agtctcccta tctgagcaat
     1201 gggtctcaag acacagttcc aagtccgggg tctcctgtct cactctggac accatgtcct
     1261 tttccagaca actgatctca tgatataaaa tagactgtgc ccctcaaaaa aaaaaaaaaa
     1321 aaaaaaaaaa aaaaaa
//
