LOCUS       NM_001005383            1598 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus aminoacylase 1 (Acy1), transcript variant 1,
            mRNA.
ACCESSION   NM_001005383 XM_006243715 XM_217258
VERSION     NM_001005383.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1598)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1598)
  AUTHORS   Wei,X., Das,J., Fragoza,R., Liang,J., Bastos de Oliveira,F.M.,
            Lee,H.R., Wang,X., Mort,M., Stenson,P.D., Cooper,D.N., Lipkin,S.M.,
            Smolka,M.B. and Yu,H.
  TITLE     A massively parallel pipeline to clone DNA variants and examine
            molecular phenotypes of human disease mutations
  JOURNAL   PLoS Genet 10 (12), e1004819 (2014)
   PUBMED   25502805
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1598)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   4  (bases 1 to 1598)
  AUTHORS   Zhang,Y., Li,Y., Qiu,F. and Qiu,Z.
  TITLE     Comprehensive analysis of low-abundance proteins in human urinary
            exosomes using peptide ligand library technology, peptide OFFGEL
            fractionation and nanoHPLC-chip-MS/MS
  JOURNAL   Electrophoresis 31 (23-24), 3797-3807 (2010)
   PUBMED   21082674
REFERENCE   5  (bases 1 to 1598)
  AUTHORS   Cigna,N., Nicoletti,C., Durand,A., Chaix,J.C., Giardina,T. and
            Perrier,J.
  TITLE     Acylase 1 expression in rat intestinal crypt--villus axis
  JOURNAL   Cell Biol Int 31 (9), 966-973 (2007)
   PUBMED   17478110
  REMARK    GeneRIF: These findings proposed ACY 1 as a new marker transcript
            for absorbing cells of intestinal crypt, which can be used to
            monitor the process of intestinal N-alpha-acetylated protein
            metabolism.[ACY 1]
REFERENCE   6  (bases 1 to 1598)
  AUTHORS   Perrier,J., Durand,A., Giardina,T. and Puigserver,A.
  TITLE     The rat kidney acylase 1. Evidence for a new cDNA form and
            comparisons with the porcine intestinal enzyme
  JOURNAL   Comp Biochem Physiol B Biochem Mol Biol 138 (3), 277-283 (2004)
   PUBMED   15253876
REFERENCE   7  (bases 1 to 1598)
  AUTHORS   Durand,A., Giardina,T., Villard,C., Roussel,A., Puigserver,A. and
            Perrier,J.
  TITLE     Rat kidney acylase I: further characterisation and mutation studies
            on the involvement of Glu 147 in the catalytic process
  JOURNAL   Biochimie 85 (10), 953-962 (2003)
   PUBMED   14644550
  REMARK    GeneRIF: active site characterization
REFERENCE   8  (bases 1 to 1598)
  AUTHORS   Giardina,T., Perrier,J. and Puigserver,A.
  TITLE     The rat kidney acylase I, characterization and molecular cloning.
            Differences with other acylases I
  JOURNAL   Eur J Biochem 267 (20), 6249-6255 (2000)
   PUBMED   11012679
REFERENCE   9  (bases 1 to 1598)
  AUTHORS   Mao,M., Fu,G., Wu,J.S., Zhang,Q.H., Zhou,J., Kan,L.X., Huang,Q.H.,
            He,K.L., Gu,B.W., Han,Z.G., Shen,Y., Gu,J., Yu,Y.P., Xu,S.H.,
            Wang,Y.X., Chen,S.J. and Chen,Z.
  TITLE     Identification of genes expressed in human CD34(+) hematopoietic
            stem/progenitor cells by expressed sequence tags and efficient
            full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 95 (14), 8175-8180 (1998)
   PUBMED   9653160
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Mar 18, 2021 this sequence version replaced
            XM_006243715.4, NM_001005383.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ232544.1, SRR22582419.886749.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760494,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               JAXUCZ010000008.1  115956149-115956405 c
            258-362             JAXUCZ010000008.1  115955662-115955766 c
            363-427             JAXUCZ010000008.1  115954972-115955036 c
            428-532             JAXUCZ010000008.1  115954779-115954883 c
            533-627             JAXUCZ010000008.1  115954316-115954410 c
            628-704             JAXUCZ010000008.1  115953973-115954049 c
            705-794             JAXUCZ010000008.1  115953790-115953879 c
            795-851             JAXUCZ010000008.1  115953643-115953699 c
            852-925             JAXUCZ010000008.1  115953182-115953255 c
            926-975             JAXUCZ010000008.1  115953045-115953094 c
            976-1120            JAXUCZ010000008.1  115952760-115952904 c
            1121-1189           JAXUCZ010000008.1  115952609-115952677 c
            1190-1269           JAXUCZ010000008.1  115951624-115951703 c
            1270-1330           JAXUCZ010000008.1  115951422-115951482 c
            1331-1598           JAXUCZ010000008.1  115951068-115951335 c
FEATURES             Location/Qualifiers
     source          1..1598
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1598
                     /gene="Acy1"
                     /gene_synonym="Acy1a; Acy1b"
                     /note="aminoacylase 1"
                     /db_xref="GeneID:300981"
                     /db_xref="RGD:2030"
     exon            1..257
                     /gene="Acy1"
                     /gene_synonym="Acy1a; Acy1b"
                     /inference="alignment:Splign:2.1.0"
     exon            258..362
                     /gene="Acy1"
                     /gene_synonym="Acy1a; Acy1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..1495
                     /gene="Acy1"
                     /gene_synonym="Acy1a; Acy1b"
                     /EC_number="3.5.1.14"
                     /note="aminoacylase-1B; ACY IA; ACY IB; ACY-1A; ACY-1B;
                     N-acyl-L-amino-acid amidohydrolase"
                     /codon_start=1
                     /product="aminoacylase-1A"
                     /protein_id="NP_001005383.2"
                     /db_xref="GeneID:300981"
                     /db_xref="RGD:2030"
                     /translation="MTTKGPESEHPSVTLFRQYLRICTVQPNPDYGSAVTFLEERARQ
                     LGLSCQKIEVAPGYVITVLTWPGTNPLLHSILLNSHTDVVPVFKEHWHHDPFEAFKDS
                     EGYIYARGAQDMKSVSIQYLEAVRRLKSEGHRFPRTIHMTFVPDEEVGGHKGMELFVK
                     RPEFQALRAGFALDEGLANPTDAFTVFYSERSPWWIRVTSTGKPGHASRFIEDTAAEK
                     LHKVVNSILAFREKERQRLQANPHLKEGAVTSVNLTKLEGGVAYNVVPATMSACFDFR
                     VAPDVDMKAFEKQLQSWCQEAGEGVTFEFAQKFTEPRMTPTDDTDPWWAAFSGACKEM
                     NLTLEPEIFPAATDSRYIRAVGIPALGFSPMNRTPVLLHDHNERLHEAVFLRGVDIYT
                     RLVAALASVPALPGES"
     exon            363..427
                     /gene="Acy1"
                     /gene_synonym="Acy1a; Acy1b"
                     /inference="alignment:Splign:2.1.0"
     exon            428..532
                     /gene="Acy1"
                     /gene_synonym="Acy1a; Acy1b"
                     /inference="alignment:Splign:2.1.0"
     exon            533..627
                     /gene="Acy1"
                     /gene_synonym="Acy1a; Acy1b"
                     /inference="alignment:Splign:2.1.0"
     exon            628..704
                     /gene="Acy1"
                     /gene_synonym="Acy1a; Acy1b"
                     /inference="alignment:Splign:2.1.0"
     exon            705..794
                     /gene="Acy1"
                     /gene_synonym="Acy1a; Acy1b"
                     /inference="alignment:Splign:2.1.0"
     exon            795..851
                     /gene="Acy1"
                     /gene_synonym="Acy1a; Acy1b"
                     /inference="alignment:Splign:2.1.0"
     exon            852..925
                     /gene="Acy1"
                     /gene_synonym="Acy1a; Acy1b"
                     /inference="alignment:Splign:2.1.0"
     exon            926..975
                     /gene="Acy1"
                     /gene_synonym="Acy1a; Acy1b"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1120
                     /gene="Acy1"
                     /gene_synonym="Acy1a; Acy1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1189
                     /gene="Acy1"
                     /gene_synonym="Acy1a; Acy1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1269
                     /gene="Acy1"
                     /gene_synonym="Acy1a; Acy1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1330
                     /gene="Acy1"
                     /gene_synonym="Acy1a; Acy1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1598
                     /gene="Acy1"
                     /gene_synonym="Acy1a; Acy1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccagcgcag gccccacgca gagcctggca gggacaacgg cgccggctcc gccacgggaa
       61 ctgggacagc ccatatagtc ttcggtctcc gcccctccac tccgcccagg ccacgtggtg
      121 ggtggccccg ggcggttttg agattgtgac ctcggtggac cctgagttcc ggccacagtc
      181 tcaagagggc cctgagagag gagagcactg gactgagacc tgaggagagc actggactga
      241 gacctggaga gagcaagcac gccgcgtcat gaccaccaag ggtcctgagt ctgagcaccc
      301 ctccgtgacg ctcttccgcc agtacctgcg catctgcact gtgcaaccca atcctgacta
      361 tgggagtgcg gtcaccttcc ttgaggagag agcccgccag ctgggtctga gctgtcagaa
      421 aatagaggtg gcgcctggct atgtgatcac tgtgctgact tggccaggca ccaacccgtt
      481 gcttcattcc atcttgctaa actcccacac agatgtggta cctgtcttca aggagcattg
      541 gcatcacgac ccctttgaag ccttcaagga ttccgagggc tacatctatg ctaggggcgc
      601 ccaggacatg aagagtgtca gcatccagta cctggaggcc gtgagaaggc tgaagagcga
      661 gggccaccgg ttccccagaa ccatccacat gacatttgtg cctgacgagg aggtcggagg
      721 tcacaagggg atggagttgt ttgtgaagag gcctgagttc caggctctgc gggcaggctt
      781 tgctctggat gagggcctgg ccaaccccac tgatgccttc accgtttttt atagtgaacg
      841 gagtccttgg tggatacggg ttaccagcac tgggaagcca ggccatgcct cacgcttcat
      901 tgaagataca gcagctgaga agttgcataa ggttgtaaac tccatcttgg cattccggga
      961 gaaggagagg cagaggctgc aggcgaaccc tcacctgaag gaaggggccg tgacttcggt
     1021 gaatctgact aagctcgaag gtggtgtggc ctataatgtg gtacctgcta ccatgagtgc
     1081 ctgttttgac ttccgagtgg cgccagatgt agacatgaag gccttcgaga agcagctgca
     1141 gagctggtgc caggaagcgg gagagggggt cacctttgag tttgctcaga agtttacaga
     1201 gcctcgaatg acacccactg atgatacgga cccctggtgg gcagctttca gcggggcctg
     1261 caaggaaatg aacctcactc tggagccgga gatctttcct gctgccactg acagccgtta
     1321 tatccgagcg gtggggatcc cagctctggg cttctcgccc atgaaccgca cacccgtgtt
     1381 actacatgac cataacgaac gactgcacga ggctgtgttt ctacgtggag ttgacatata
     1441 tacacgccta gttgctgcac ttgctagtgt gcccgctctg cctggtgaaa gctgagcccc
     1501 aggccttcca accctcatag ctttcagccc aaccactgcc aaggatctgt tgcccccgcc
     1561 cagtaataaa gccagtgttg aatgggatgt tctttata
//
