LOCUS       NM_022441               3540 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Rattus norvegicus activin A receptor like type 1 (Acvrl1), mRNA.
ACCESSION   NM_022441
VERSION     NM_022441.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3540)
  AUTHORS   Li,Q., Zhou,X. and Zhou,X.
  TITLE     Downregulation of miR-98 contributes to hypoxic pulmonary
            hypertension by targeting ALK1
  JOURNAL   Mol Med Rep 20 (3), 2167-2176 (2019)
   PUBMED   31322216
  REMARK    GeneRIF: These results provided clear evidence that miR98 was a
            direct regulator of ALK1, and that the downregulation of miR98
            contributed to the pathogenesis of hypoxic pulmonary hypertension.
REFERENCE   2  (bases 1 to 3540)
  AUTHORS   Abdullahi,W., Brzica,H., Hirsch,N.A., Reilly,B.G. and
            Ronaldson,P.T.
  TITLE     Functional Expression of Organic Anion Transporting Polypeptide 1a4
            Is Regulated by Transforming Growth Factor-beta/Activin
            Receptor-like Kinase 1 Signaling at the Blood-Brain Barrier
  JOURNAL   Mol Pharmacol 94 (6), 1321-1333 (2018)
   PUBMED   30262595
  REMARK    GeneRIF: Oatp1a4 transport activity at the BBB is directly
            regulated by TGF-beta/ALK1 signaling.
REFERENCE   3  (bases 1 to 3540)
  AUTHORS   Hofmann,A.D., Zimmer,J., Takahashi,T., Gosemann,J.H. and Puri,P.
  TITLE     The Role of Activin Receptor-Like Kinase 1 Signaling in the
            Pulmonary Vasculature of Experimental Diaphragmatic Hernia
  JOURNAL   Eur J Pediatr Surg 26 (1), 106-111 (2016)
   PUBMED   26540443
  REMARK    GeneRIF: Increased expression of ALK-1 in the pulmonary vasculature
            of congenital diaphragmatic hernia (CDH) suggest that ALK-1 may
            play a crucial role in the molecular pathogenesis of vascular
            remodeling in CDH.
REFERENCE   4  (bases 1 to 3540)
  AUTHORS   Alaa El Din,F., Patri,S., Thoreau,V., Rodriguez-Ballesteros,M.,
            Hamade,E., Bailly,S., Gilbert-Dussardier,B., Abou Merhi,R. and
            Kitzis,A.
  TITLE     Functional and splicing defect analysis of 23 ACVRL1 mutations in a
            cohort of patients affected by Hereditary Hemorrhagic
            Telangiectasia
  JOURNAL   PLoS One 10 (7), e0132111 (2015)
   PUBMED   26176610
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3540)
  AUTHORS   Sanz-Ramos,P., Dotor,J. and Izal-Azcarate,I.
  TITLE     The role of Alk-1 and Alk-5 in the mechanosensing of chondrocytes
  JOURNAL   Cell Mol Biol Lett 19 (4), 659-674 (2014)
   PUBMED   25424912
  REMARK    GeneRIF: Overexpression of Alk-5 and silencing of Alk-1 led to a
            loss of the chondrocyte phenotype, proving that they are key
            regulators of chondrocyte mechanosensing.
REFERENCE   6  (bases 1 to 3540)
  AUTHORS   Pangas,S.A. and Woodruff,T.K.
  TITLE     Activin signal transduction pathways
  JOURNAL   Trends Endocrinol Metab 11 (8), 309-314 (2000)
   PUBMED   10996525
  REMARK    Review article
REFERENCE   7  (bases 1 to 3540)
  AUTHORS   Oh,S.P., Seki,T., Goss,K.A., Imamura,T., Yi,Y., Donahoe,P.K.,
            Li,L., Miyazono,K., ten Dijke,P., Kim,S. and Li,E.
  TITLE     Activin receptor-like kinase 1 modulates transforming growth
            factor-beta 1 signaling in the regulation of angiogenesis
  JOURNAL   Proc Natl Acad Sci U S A 97 (6), 2626-2631 (2000)
   PUBMED   10716993
REFERENCE   8  (bases 1 to 3540)
  AUTHORS   Panchenko,M.P., Williams,M.C., Brody,J.S. and Yu,Q.
  TITLE     Type I receptor serine-threonine kinase preferentially expressed in
            pulmonary blood vessels
  JOURNAL   Am J Physiol 270 (4 Pt 1), L547-L558 (1996)
   PUBMED   8928814
REFERENCE   9  (bases 1 to 3540)
  AUTHORS   Attisano,L., Carcamo,J., Ventura,F., Weis,F.M., Massague,J. and
            Wrana,J.L.
  TITLE     Identification of human activin and TGF beta type I receptors that
            form heteromeric kinase complexes with type II receptors
  JOURNAL   Cell 75 (4), 671-680 (1993)
   PUBMED   8242742
REFERENCE   10 (bases 1 to 3540)
  AUTHORS   He,W.W., Gustafson,M.L., Hirobe,S. and Donahoe,P.K.
  TITLE     Developmental expression of four novel serine/threonine kinase
            receptors homologous to the activin/transforming growth factor-beta
            type II receptor family
  JOURNAL   Dev Dyn 196 (2), 133-142 (1993)
   PUBMED   8395914
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083173.1.
            
            On Jun 10, 2007 this sequence version replaced NM_022441.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083173.1, L36088.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3540
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..3540
                     /gene="Acvrl1"
                     /gene_synonym="Alk1; R-3; R3; SETHKIR"
                     /note="activin A receptor like type 1"
                     /db_xref="GeneID:25237"
                     /db_xref="RGD:2029"
     exon            1..65
                     /gene="Acvrl1"
                     /gene_synonym="Alk1; R-3; R3; SETHKIR"
                     /inference="alignment:Splign:2.1.0"
     exon            66..205
                     /gene="Acvrl1"
                     /gene_synonym="Alk1; R-3; R3; SETHKIR"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1656
                     /gene="Acvrl1"
                     /gene_synonym="Alk1; R-3; R3; SETHKIR"
                     /EC_number="2.7.11.30"
                     /note="serine/threonine-protein kinase receptor R3; SKR3;
                     TSR-I; TGF-B superfamily receptor type I; Activin receptor
                     like kinase 1; activin A receptor type II-like 1; activin
                     A receptor type IL; activin receptor type-1-like"
                     /codon_start=1
                     /product="activin receptor type-1-like precursor"
                     /protein_id="NP_071886.1"
                     /db_xref="GeneID:25237"
                     /db_xref="RGD:2029"
                     /translation="MTLGIFRRVFLMLSVALGLTKGDLVKPSRGQLVNCTCENPHCKR
                     PICQGAWCTVVLVREQGRHPQVYRGCGSLNQELCLGRPTEFVNHHCCYRSFCNHNVSL
                     MLEATQTPSEEPEVDAHLPLILGPVLALLVLVALGTLGLWRVRRRQEKQRGLHSDLGE
                     SSLILKASEQGDSMLGDFLVSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVW
                     RGSWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWL
                     ITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDLKS
                     RNVLVKSNLQCCIADLGLAVMHSQSSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFE
                     SYKWTDIWAFGLVLWEIARRTIINGIVEDYRPPFYDMVPNDPSFEDMKKVVCVDQQTP
                     TIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKLSQNPEKPKVIH"
     exon            206..457
                     /gene="Acvrl1"
                     /gene_synonym="Alk1; R-3; R3; SETHKIR"
                     /inference="alignment:Splign:2.1.0"
     exon            458..669
                     /gene="Acvrl1"
                     /gene_synonym="Alk1; R-3; R3; SETHKIR"
                     /inference="alignment:Splign:2.1.0"
     exon            670..769
                     /gene="Acvrl1"
                     /gene_synonym="Alk1; R-3; R3; SETHKIR"
                     /inference="alignment:Splign:2.1.0"
     exon            770..916
                     /gene="Acvrl1"
                     /gene_synonym="Alk1; R-3; R3; SETHKIR"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1192
                     /gene="Acvrl1"
                     /gene_synonym="Alk1; R-3; R3; SETHKIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1390
                     /gene="Acvrl1"
                     /gene_synonym="Alk1; R-3; R3; SETHKIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1521
                     /gene="Acvrl1"
                     /gene_synonym="Alk1; R-3; R3; SETHKIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..3504
                     /gene="Acvrl1"
                     /gene_synonym="Alk1; R-3; R3; SETHKIR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagacttca atctaaacaa tcttgattcc tgtagccggc ctggcgggac cctgaatggc
       61 aggaagagga gaccttggtc accacagcta tcacagtttg cagatctcgt cacatctctt
      121 ctcctcctat ctccaaggac catgaccctg gggattttcc gaagggtctt tttgatgctg
      181 tcggtggcct tgggcctaac taagggagac ttggtgaagc cctccagggg tcagctggta
      241 aactgcactt gtgagaaccc acactgcaag aggccaatct gccagggggc atggtgcaca
      301 gtggtgctag ttcgagagca gggcaggcac ccccaggtct atcggggctg cgggagcctg
      361 aaccaggagc tctgcctggg acgtcccacg gagtttgtga accatcactg ctgctataga
      421 tccttctgca accacaatgt gtccctgatg ctggaggcca cccaaactcc ttcggaggag
      481 ccagaagtag atgcccatct gcctctgatc ctgggtcccg tgctggcctt gctggtcctg
      541 gtggccctgg gcactctggg cttgtggcgt gtccggagaa ggcaggagaa gcagcggggt
      601 ctgcacagtg acctgggcga gtccagtctc atcctgaagg catcggaaca gggagacagc
      661 atgttggggg acttcctggt cagcgactgt accacaggca gcggctcagg gctacccttc
      721 ttggtgcaga ggacagtagc gcgacaggtt gcactggtgg agtgtgtggg aaagggccga
      781 tatggcgagg tgtggcgcgg ttcgtggcat ggcgagagtg tggcggtcaa gattttctcc
      841 tcacgagatg agcagtcctg gttccgggag acagagatct acaacacagt tctgcttaga
      901 cacgacaaca tcctaggctt catcgcctcc gacatgacct cgcggaactc cagcacgcag
      961 ctgtggctta tcacccacta ccacgagcat ggctccctct atgactttct gcagaggcag
     1021 acgctggagc cccagttggc cctgaggctg gctgtgtccg cggcctgcgg cctggcgcac
     1081 ctgcatgtag agatctttgg cactcaaggc aaaccagcca tcgcccatcg tgacctcaag
     1141 agccgcaacg tgctggtcaa gagcaacttg cagtgttgca ttgcagacct gggattggct
     1201 gtgatgcact cgcaaagcag cgattacctg gacattggta acaacccccg agtgggtacc
     1261 aagagataca tggcacccga ggtgctggat gagcagatcc gcacagactg ttttgagtcg
     1321 tacaagtgga cagacatctg ggccttcggc ttagtgctat gggagattgc ccggcggacc
     1381 atcatcaatg gcattgtgga ggactacagg ccacccttct atgacatggt acccaatgac
     1441 cccagttttg aggacatgaa aaaggtggtg tgtgttgacc agcagacccc caccatccct
     1501 aaccgactgg cagcagatcc ggtcctctcc gggctggccc agatgatgcg agagtgctgg
     1561 taccccaacc cctccgctcg cctcaccgca ctgcgcataa agaagacatt acagaagctc
     1621 agccagaatc cagagaaacc caaagtgatt cactagccca gcatcaccag actttctctg
     1681 cctaaagtat gtgctgggcc agaagacata gcccgtctgg gtagaggtag ctcgagtgtg
     1741 cagggtgccc tgcgtgtgcc tgctcagctt ggcccccagc ccattcagcc aaaaatacag
     1801 ctgggctgaa attcgatccg cctccgtctg gcctgctcaa agtggccggc tctctgacgc
     1861 ctggctggat tccctgtccc caaggccagc agagcacacc ccctaccact cccagggcag
     1921 ggtggccaag ccagggaatc ccgggcccgg atcctgggct ttcactcccc acccttggtc
     1981 aaccttgctg ccccgtcaga gctgccagga tggcacaggg ccctgtccag attcagcaga
     2041 cattccacct gctggggctc agccagagag atactcagca gcctcagtgt ctctctgtgg
     2101 gtgtttattg ctcctatgat gcctttccgt tgtcctgact agaccccctg gctagcgaat
     2161 gctagtctct tgggagaggt ggtacctgac ccttccaccc accgtcccct taccacctca
     2221 gctgactcat taaggcatca aaacccaagg gtcctctgag gagaaggtca agcatggtag
     2281 aagggaccca gcattgctcc ctctgatagg agaggacttc actgtcttag gatcttttgt
     2341 cccaatgtcc tttgaggtgt ctcagaacct gattttcctt gaagctcagg ctgtgtgaaa
     2401 gctaggtctt gtctactaca ccccgttcct atcacttgag tcaagctgtg gtttgtaaat
     2461 agccaccaca gtccaggatg gcccaacgtg ccccctgggc taatctccag gcccctgttc
     2521 ttgccttgag ctttgcaagt ggccaccctg ggacctgggc agcacaggaa tttctgactc
     2581 cctctgtggc ttggtcttct gcccagggct ccgggagggg gtggtggtgg tgacttcctt
     2641 tggggtcttc caagactaaa aggaaattcg gcccctgtca agaagcctcc agcaaccagg
     2701 gttctacacc tcctggctgt gactctctgg ccaaagccca cactctgggc caggtcccag
     2761 aaagtgcacc ttgggagaac ttggcctaca gaaacaccaa gagtcccagc atttagaaat
     2821 gtgaagggta caccccatcc cgaagcctga gttgatggac tggagagaag cgggctgtag
     2881 gcaaggctta tggagggcaa agtagggctc gggcaagaga caagatcagc atccatcttg
     2941 ggaagacctg gcctagaaac ccttggcctt tgaagggtga aacaacggag acagttcatc
     3001 ctgctctgca cacgtgccga cccgccgacg gcgccgaccg cttgagttcc tccggtgtgt
     3061 gctcccagct ctccataatg tcactcaaga ctacctttca gcagtgtgca aggaccaagg
     3121 agaaccagga agtgaaacga gatggaaaac agaaagtaaa cgggactttt tcagaccagt
     3181 ggggcaaagt ctgaaggttc tctggtcact ggagccaggg aatcgctttc tgacctgaag
     3241 gatttttatt tctactggac ttgggaacaa attcatcctc agattccaca gccagaaacg
     3301 gaagacagta gctcctccag gccaggaaat cctaagtgcg gagaggggtg cgggtgttga
     3361 acgactggag atgtggcaag gaaggtggca ttctccaaat gcttcctaac gcaggtgtgc
     3421 aagtggaacc acacagttta tggaagcact tagcccgtga caggcacata gtaggtcctc
     3481 aataaaccat gtttgacccc ctgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
