LOCUS       NM_031554               1843 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus activin A receptor type 2B (Acvr2b), mRNA.
ACCESSION   NM_031554 XM_217297
VERSION     NM_031554.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1843)
  AUTHORS   Feng,B., Meng,L., Luan,L., Fang,Z., Zhao,P. and Zhao,G.
  TITLE     Upregulation of Extracellular Vesicles-Encapsulated miR-132
            Released From Mesenchymal Stem Cells Attenuates Ischemic Neuronal
            Injury by Inhibiting Smad2/c-jun Pathway via Acvr2b Suppression
  JOURNAL   Front Cell Dev Biol 8, 568304 (2021)
   PUBMED   33763412
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1843)
  AUTHORS   Szabo,Z., Vainio,L., Lin,R., Swan,J., Hulmi,J.J., Rahtu-Korpela,L.,
            Serpi,R., Laitinen,M., Pasternack,A., Ritvos,O., Kerkela,R. and
            Magga,J.
  TITLE     Systemic blockade of ACVR2B ligands attenuates muscle wasting in
            ischemic heart failure without compromising cardiac function
  JOURNAL   FASEB J 34 (8), 9911-9924 (2020)
   PUBMED   32427381
REFERENCE   3  (bases 1 to 1843)
  AUTHORS   Tauer,J.T. and Rauch,F.
  TITLE     Novel ActRIIB ligand trap increases muscle mass and improves bone
            geometry in a mouse model of severe osteogenesis imperfecta
  JOURNAL   Bone 128, 115036 (2019)
   PUBMED   31419601
REFERENCE   4  (bases 1 to 1843)
  AUTHORS   Goebel,E.J., Corpina,R.A., Hinck,C.S., Czepnik,M., Castonguay,R.,
            Grenha,R., Boisvert,A., Miklossy,G., Fullerton,P.T., Matzuk,M.M.,
            Idone,V.J., Economides,A.N., Kumar,R., Hinck,A.P. and Thompson,T.B.
  TITLE     Structural characterization of an activin class ternary receptor
            complex reveals a third paradigm for receptor specificity
  JOURNAL   Proc Natl Acad Sci U S A 116 (31), 15505-15513 (2019)
   PUBMED   31315975
  REMARK    GeneRIF: the structure of an activin class member, GDF11, in
            complex with the type II receptor ActRIIB and the type I receptor
            Alk5, is reported.
REFERENCE   5  (bases 1 to 1843)
  AUTHORS   Magga,J., Vainio,L., Kilpio,T., Hulmi,J.J., Taponen,S., Lin,R.,
            Rasanen,M., Szabo,Z., Gao,E., Rahtu-Korpela,L., Alakoski,T.,
            Ulvila,J., Laitinen,M., Pasternack,A., Koch,W.J., Alitalo,K.,
            Kivela,R., Ritvos,O. and Kerkela,R.
  TITLE     Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute
            Ischemia-Reperfusion Injury
  JOURNAL   Mol Ther 27 (3), 600-610 (2019)
   PUBMED   30765322
REFERENCE   6  (bases 1 to 1843)
  AUTHORS   Feng,Z.M., Madigan,M.B. and Chen,C.L.
  TITLE     Expression of type II activin receptor genes in the male and female
            reproductive tissues of the rat
  JOURNAL   Endocrinology 132 (6), 2593-2600 (1993)
   PUBMED   7916681
REFERENCE   7  (bases 1 to 1843)
  AUTHORS   Nakamura,T., Sugino,K., Kurosawa,N., Sawai,M., Takio,K., Eto,Y.,
            Iwashita,S., Muramatsu,M., Titani,K. and Sugino,H.
  TITLE     Isolation and characterization of activin receptor from mouse
            embryonal carcinoma cells. Identification of its
            serine/threonine/tyrosine protein kinase activity
  JOURNAL   J Biol Chem 267 (26), 18924-18928 (1992)
   PUBMED   1326537
REFERENCE   8  (bases 1 to 1843)
  AUTHORS   Legerski,R., Zhou,X., Dresback,J., Eberspaecher,H., McKinney,S.,
            Segarini,P. and de Crombrugghe,B.
  TITLE     Molecular cloning and characterization of a novel rat activin
            receptor
  JOURNAL   Biochem Biophys Res Commun 183 (2), 672-679 (1992)
   PUBMED   1312838
REFERENCE   9  (bases 1 to 1843)
  AUTHORS   Attisano,L., Wrana,J.L., Cheifetz,S. and Massague,J.
  TITLE     Novel activin receptors: distinct genes and alternative mRNA
            splicing generate a repertoire of serine/threonine kinase receptors
  JOURNAL   Cell 68 (1), 97-108 (1992)
   PUBMED   1310075
REFERENCE   10 (bases 1 to 1843)
  AUTHORS   Pukach,L.P.
  TITLE     [Value of electrocardiography in the selection of persons for work
            under high altitude conditions]
  JOURNAL   Voen Med Zh (11), 49-51 (1978)
   PUBMED   734934
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097358.1.
            
            On Jun 13, 2005 this sequence version replaced XM_217297.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097358.1, M87067.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132301, SAMEA5756307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1843
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1843
                     /gene="Acvr2b"
                     /note="activin A receptor type 2B"
                     /db_xref="GeneID:25366"
                     /db_xref="RGD:2028"
     exon            1..266
                     /gene="Acvr2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1753
                     /gene="Acvr2b"
                     /EC_number="2.7.11.30"
                     /note="activin receptor type-2B; ACTR-IIB; activin
                     receptor type IIB; Activine receptor 2b (transmembrane
                     serine kinase); ActRIIB type II activin receptor B;
                     activin receptor IIB; activin A receptor, type IIB"
                     /codon_start=1
                     /product="activin receptor type-2B precursor"
                     /protein_id="NP_113742.1"
                     /db_xref="GeneID:25366"
                     /db_xref="RGD:2028"
                     /translation="MTAPWAALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQS
                     GLERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFC
                     CCEGNFCNERFTHLPEPGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMY
                     RHRKPPYGHVDIHEDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKI
                     FPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDY
                     LKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLT
                     AVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLV
                     LWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGL
                     AQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNSSTSDCLVSLVTSVTNVDLLPK
                     ESSI"
     exon            267..474
                     /gene="Acvr2b"
                     /inference="alignment:Splign:2.1.0"
     exon            475..584
                     /gene="Acvr2b"
                     /inference="alignment:Splign:2.1.0"
     exon            585..736
                     /gene="Acvr2b"
                     /inference="alignment:Splign:2.1.0"
     exon            737..880
                     /gene="Acvr2b"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1024
                     /gene="Acvr2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1173
                     /gene="Acvr2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1288
                     /gene="Acvr2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1427
                     /gene="Acvr2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1558
                     /gene="Acvr2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1809
                     /gene="Acvr2b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgggccgc actgtgcgcc gcccgcagcg gccctgagcc cttatccccg cacgctgcct
       61 gggaaccgaa gcgcagaagc gcgcgcgtct ggaagcgaga cccagagaag gagcgggaag
      121 cagagcgcag ccgccgccgg gccctgcgcg ccccgggagc gcagcgcggc cctgcccgcg
      181 ggctccgggt gtccgcgggg cggcgccgcg gaacatgacg gcgccctggg cggccctcgc
      241 ccttctctgg ggatcgctgt gcgccggttc cgggcgaggg gaagctgaga ctcgggagtg
      301 catctactac aacgccaact gggagctgga gcgcaccaac cagagcggcc tggagcgctg
      361 cgagggggaa caggacaagc ggctgcactg ctatgcctcg tggcgcaaca gctcgggcac
      421 catcgagctg gtgaagaagg gctgctggct agatgacttc aattgctacg acaggcagga
      481 gtgtgtggcc actgaggaga acccccaggt gtatttctgc tgctgtgaag gcaatttctg
      541 caacgagcgc ttcacccatt tgccggagcc tgggggccca gaagtcacgt acgagccacc
      601 cccgacagcc cccaccctgc tcacggtgct ggcctattcg ctgctgccca ttggaggcct
      661 ctctctcatc gtcctgctgg ccttctggat gtaccgacat cgaaagcctc cctacggcca
      721 cgtggacatc catgaggacc ctgggcctcc tcccccatcg cctctggtgg gcctgaagcc
      781 gctacagttg ctggagatca aggctcgagg tcgctttggc tgcgtctgga aggctcagct
      841 catgaacgac tttgtggctg tgaagatctt cccacttcag gacaagcagt cgtggcagag
      901 tgagcgggag atcttcagca caccgggcat gaagcacgaa aacctcctgc agttcattgc
      961 tgcagagaaa cgaggctcca acctggaggt ggagctgtgg ctcatcacag ccttccacga
     1021 caagggctcc ctcacggatt acctcaaggg gaacatcatc acgtggaacg agctgtgtca
     1081 tgtggcagag acgatgtcac gaggcctctc gtacctgcat gaggatgtgc cgtggtgtcg
     1141 tggcgagggc cacaagcctt ctattgccca cagggacttc aaaagcaaga atgttctgct
     1201 gaagagcgac ctcaccgcgg tgctggctga ctttggcctg gctgttcggt ttgagccggg
     1261 gaagcctcca ggggataccc atgggcaggt tggcaccaga cggtacatgg cccccgaggt
     1321 gctggagggg gccatcaact tccagagaga cgccttcctg cgtatcgaca tgtacgccat
     1381 gggcctggtg ctgtgggagc tcgtttctcg ttgcaaggcc gcagatgggc ctgtcgatga
     1441 gtacatgctg cctttcgagg aagagattgg ccaacaccct tcactggagg agcttcagga
     1501 ggtggttgtc cacaagaaga tgaggcccac cattaaggat cactggctga aacatccggg
     1561 cctggcccag ctctgcgtga ccatcgagga gtgctgggac catgatgcag aggctcgtct
     1621 gtctgcaggc tgtgtggaag agcgggtatc cctgatcagg aggtcggtca acagctctac
     1681 ctcggactgt ctcgtctctc tggtgacctc cgtcaccaat gtggacctgc tccctaaaga
     1741 gtccagcatc taagcccagg acactagcgt ttctccagac tcagtggatc tgaagaagaa
     1801 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
