LOCUS       NM_031571               2265 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Rattus norvegicus activin A receptor type 2A (Acvr2a), mRNA.
ACCESSION   NM_031571 XM_342431
VERSION     NM_031571.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2265)
  AUTHORS   Szabo,Z., Vainio,L., Lin,R., Swan,J., Hulmi,J.J., Rahtu-Korpela,L.,
            Serpi,R., Laitinen,M., Pasternack,A., Ritvos,O., Kerkela,R. and
            Magga,J.
  TITLE     Systemic blockade of ACVR2B ligands attenuates muscle wasting in
            ischemic heart failure without compromising cardiac function
  JOURNAL   FASEB J 34 (8), 9911-9924 (2020)
   PUBMED   32427381
REFERENCE   2  (bases 1 to 2265)
  AUTHORS   Zhuo,C., Hu,D., Li,J., Yu,H., Lin,X., Chen,Y., Zhuang,Y., Li,Q.,
            Zheng,X. and Yang,C.
  TITLE     Downregulation of Activin A Receptor Type 2A Is Associated with
            Metastatic Potential and Poor Prognosis of Colon Cancer
  JOURNAL   J Cancer 9 (19), 3626-3633 (2018)
   PUBMED   30310521
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2265)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   4  (bases 1 to 2265)
  AUTHORS   Xue,L.X., Xu,Z.H., Wang,J.Q., Cui,Y., Liu,H.Y., Liang,W.Z.,
            Ji,Q.Y., He,J.T., Shao,Y.K., Mang,J. and Xu,Z.X.
  TITLE     Activin A/Smads signaling pathway negatively regulates Oxygen
            Glucose Deprivation-induced autophagy via suppression of JNK and
            p38 MAPK pathways in neuronal PC12 cells
  JOURNAL   Biochem Biophys Res Commun 480 (3), 355-361 (2016)
   PUBMED   27769861
REFERENCE   5  (bases 1 to 2265)
  AUTHORS   Indjeian,V.B., Kingman,G.A., Jones,F.C., Guenther,C.A.,
            Grimwood,J., Schmutz,J., Myers,R.M. and Kingsley,D.M.
  TITLE     Evolving New Skeletal Traits by cis-Regulatory Changes in Bone
            Morphogenetic Proteins
  JOURNAL   Cell 164 (1-2), 45-56 (2016)
   PUBMED   26774823
REFERENCE   6  (bases 1 to 2265)
  AUTHORS   Matzuk,M.M., Kumar,T.R. and Bradley,A.
  TITLE     Different phenotypes for mice deficient in either activins or
            activin receptor type II
  JOURNAL   Nature 374 (6520), 356-360 (1995)
   PUBMED   7885474
REFERENCE   7  (bases 1 to 2265)
  AUTHORS   Xu,J., McKeehan,K., Matsuzaki,K. and McKeehan,W.L.
  TITLE     Inhibin antagonizes inhibition of liver cell growth by activin by a
            dominant-negative mechanism
  JOURNAL   J Biol Chem 270 (11), 6308-6313 (1995)
   PUBMED   7890768
REFERENCE   8  (bases 1 to 2265)
  AUTHORS   Feng,Z.M., Madigan,M.B. and Chen,C.L.
  TITLE     Expression of type II activin receptor genes in the male and female
            reproductive tissues of the rat
  JOURNAL   Endocrinology 132 (6), 2593-2600 (1993)
   PUBMED   7916681
REFERENCE   9  (bases 1 to 2265)
  AUTHORS   Shinozaki,H., Ito,I., Hasegawa,Y., Nakamura,K., Igarashi,S.,
            Nakamura,M., Miyamoto,K., Eto,Y., Ibuki,Y. and Minegishi,T.
  TITLE     Cloning and sequencing of a rat type II activin receptor
  JOURNAL   FEBS Lett 312 (1), 53-56 (1992)
   PUBMED   1385212
REFERENCE   10 (bases 1 to 2265)
  AUTHORS   Mathews,L.S. and Vale,W.W.
  TITLE     Expression cloning of an activin receptor, a predicted
            transmembrane serine kinase
  JOURNAL   Cell 65 (6), 973-982 (1991)
   PUBMED   1646080
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_031571.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L10639.1, SRR26643298.15701.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                JAXUCZ010000003.1  53614786-53614854
            70-277              JAXUCZ010000003.1  53670176-53670383
            278-387             JAXUCZ010000003.1  53672925-53673034
            388-542             JAXUCZ010000003.1  53673221-53673375
            543-686             JAXUCZ010000003.1  53688032-53688175
            687-830             JAXUCZ010000003.1  53689848-53689991
            831-976             JAXUCZ010000003.1  53691225-53691370
            977-1091            JAXUCZ010000003.1  53692821-53692935
            1092-1230           JAXUCZ010000003.1  53694976-53695114
            1231-1361           JAXUCZ010000003.1  53697223-53697353
            1362-2265           JAXUCZ010000003.1  53698325-53699228
FEATURES             Location/Qualifiers
     source          1..2265
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q12"
     gene            1..2265
                     /gene="Acvr2a"
                     /gene_synonym="Acvr2; rActR-II"
                     /note="activin A receptor type 2A"
                     /db_xref="GeneID:29263"
                     /db_xref="RGD:70911"
     exon            1..69
                     /gene="Acvr2a"
                     /gene_synonym="Acvr2; rActR-II"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1556
                     /gene="Acvr2a"
                     /gene_synonym="Acvr2; rActR-II"
                     /EC_number="2.7.11.30"
                     /note="activin receptor type-2A; type II activin receptor;
                     ACTR-IIA; activin receptor type IIA; activin receptor IIA;
                     activin A receptor, type IIA"
                     /codon_start=1
                     /product="activin receptor type-2A precursor"
                     /protein_id="NP_113759.2"
                     /db_xref="GeneID:29263"
                     /db_xref="RGD:70911"
                     /translation="MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWERDRTNQ
                     TGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCIEKKDSPEVYF
                     CCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWV
                     YRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAV
                     KIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLS
                     DFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNL
                     TACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGL
                     VLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAG
                     MAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPP
                     KESSL"
     exon            70..277
                     /gene="Acvr2a"
                     /gene_synonym="Acvr2; rActR-II"
                     /inference="alignment:Splign:2.1.0"
     exon            278..387
                     /gene="Acvr2a"
                     /gene_synonym="Acvr2; rActR-II"
                     /inference="alignment:Splign:2.1.0"
     exon            388..542
                     /gene="Acvr2a"
                     /gene_synonym="Acvr2; rActR-II"
                     /inference="alignment:Splign:2.1.0"
     exon            543..686
                     /gene="Acvr2a"
                     /gene_synonym="Acvr2; rActR-II"
                     /inference="alignment:Splign:2.1.0"
     exon            687..830
                     /gene="Acvr2a"
                     /gene_synonym="Acvr2; rActR-II"
                     /inference="alignment:Splign:2.1.0"
     exon            831..976
                     /gene="Acvr2a"
                     /gene_synonym="Acvr2; rActR-II"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1091
                     /gene="Acvr2a"
                     /gene_synonym="Acvr2; rActR-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1230
                     /gene="Acvr2a"
                     /gene_synonym="Acvr2; rActR-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1361
                     /gene="Acvr2a"
                     /gene_synonym="Acvr2; rActR-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..2265
                     /gene="Acvr2a"
                     /gene_synonym="Acvr2; rActR-II"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcctcgg gaaaatggga gctgctgcaa agttggcgtt cgccgtcttt cttatctctt
       61 gctcttcagg tgctatactt ggcagatcgg aaactcagga gtgtcttttc tttaatgcta
      121 attgggaaag agacagaacc aatcagactg gtgttgagcc ttgctatggt gataaagaca
      181 aacgacgaca ttgttttgct acctggaaga atatttctgg ttccattgaa atagtaaagc
      241 aaggttgttg gctggatgat atcaactgct atgacaggac tgattgtata gaaaaaaaag
      301 acagccctga agtgtacttt tgttgctgtg agggcaatat gtgtaatgaa aagttctctt
      361 attttccgga gatggaagtc acacagccca catcaaatcc tgttaccccg aaaccaccct
      421 actacaacat cctgctgtat tccttggtac cacttatgtt aattgcgggg attgtcattt
      481 gtgcgttttg ggtgtacaga catcacaaga tggcctaccc tcctgtactt gttcctactc
      541 aggaccctgg accacctcca ccttccccat tactagggtt gaagccattg cagctattgg
      601 aagtgaaagc aaggggaaga tttggttgtg tctggaaagc ccagttgctc aatgagtatg
      661 tggctgtcaa aatatttccg atacaggaca aacagtcctg gcagaatgaa tatgaagtct
      721 atagtttacc tggtatgaag catgaaaaca tactacagtt cattggtgca gagaaaagag
      781 gcaccagtgt tgatgtggac ctgtggctaa tcacggcttt tcatgaaaag ggctcactgt
      841 cagactttct taaggctaat gtggtctctt ggaatgaact ttgtcatatt gcagaaacca
      901 tggctagagg attggcatat ttacatgagg atatacctgg cttaaaagat ggccacaagc
      961 ctgcaatatc tcacagggac ataaaaagta aaaatgtgct gttgaaaaac aatctgacag
     1021 cttgcattgc tgactttggg ttggccttaa agtttgaggc tggcaagtct gcaggtgaca
     1081 cccatggcca ggttggtacc cggaggtata tggctccaga ggtgttagag ggtgctataa
     1141 acttccaaag ggacgcattt ctgaggatag atatgtacgc catgggatta gtcctgtggg
     1201 aactggcttc tcgttgtact gctgcagatg gacctgtaga tgagtacatg ttgccatttg
     1261 aggaggaaat tggccagcat ccatctcttg aagatatgca ggaagttgtt gtgcataaaa
     1321 aaaagaggcc cgttttaaga gattattggc agaaacacgc aggaatggca atgctctgtg
     1381 aaacgataga agaatgctgg gatcatgatg cagaagccag gttatcagct ggatgtgtag
     1441 gtgaaagaat tactcagatg caaagactaa caaatataat tactacagag gacattgtaa
     1501 cagtggtcac aatggtgaca aatgttgact ttcctcccaa agaatctagt ctatgatggt
     1561 tgcaccatct gtccacactg agaatcggga ctctgaactg gagctgctaa gctaaggaaa
     1621 ctgcttagtt tattttctgt gtgaaatgag tagggtgcct ccgggacacg tatgcaagca
     1681 gccccttgtg gaaagcatgg attgggagac ttcctgcagc gtctgcaaca cggatatgaa
     1741 gggggtctaa ggggaaactg cgaactgtaa agaacttctg aaaacttaca cgaagaatgt
     1801 ggccctctcc aaatcaagga tcttttggac ctggctaatc aagtatttga aaactgacat
     1861 cagatttctt aatgtctgtc agaagacact aattccttaa atgaactact gctatttttt
     1921 ttaaatcaaa aacttttcat ttcagatttt aaaaagggta actttttatt gcatttgctg
     1981 ttgtttctat aaatgactat tgtaatgcca acatgacaca gcttgtgaat gtgtagtgtg
     2041 ctgctgttct gtgtacatag tcatcaaagt ggggtacagt aaagaggctt ccaagcatta
     2101 ctttaacctc cctcaacaag gtatacctca gttccacggt tgctaaatta taaaattgaa
     2161 aacactaaca gaatttgaat aaatcagtcc atgttttata acaaggtatt acaaactcac
     2221 tgtgttattt aagaaaaaat ggtaagctat gcttagtgcc aatag
//
