LOCUS       NM_139090               1899 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus activin A receptor type 1C (Acvr1c), mRNA.
ACCESSION   NM_139090
VERSION     NM_139090.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1899)
  AUTHORS   Liu,L., Zhou,X., Zhang,Q., Li,L., Shang,Y., Wang,Z., Zhong,M.,
            Chen,Y., Zhang,W. and Tang,M.
  TITLE     Activin receptor-like kinase 7 silencing alleviates cardiomyocyte
            apoptosis, cardiac fibrosis, and dysfunction in diabetic rats
  JOURNAL   Exp Biol Med (Maywood) 247 (16), 1397-1409 (2022)
   PUBMED   35666032
  REMARK    GeneRIF: Activin receptor-like kinase 7 silencing alleviates
            cardiomyocyte apoptosis, cardiac fibrosis, and dysfunction in
            diabetic rats.
REFERENCE   2  (bases 1 to 1899)
  AUTHORS   Ono,A., Hirooka,K., Nakano,Y., Nitta,E., Nishiyama,A. and
            Tsujikawa,A.
  TITLE     Gene expression changes in the retina after systemic administration
            of aldosterone
  JOURNAL   Jpn J Ophthalmol 62 (4), 499-507 (2018)
   PUBMED   29713904
REFERENCE   3  (bases 1 to 1899)
  AUTHORS   Li,W.B., Zhao,J., Liu,L., Wang,Z.H., Han,L., Zhong,M., Zhang,Y.,
            Zhang,W. and Tang,M.X.
  TITLE     Silencing of activin receptor-like kinase 7 alleviates aortic
            stiffness in type 2 diabetic rats
  JOURNAL   Acta Diabetol 52 (4), 717-726 (2015)
   PUBMED   25577243
  REMARK    GeneRIF: ALK7 gene silencing has a protective effect on
            diabetes-induced aortic stiffness, insulin resistance and
            hyperlipidemia, thus implicating a new potential therapeutic
            approach to diabetic macrovascular stiffness.
REFERENCE   4  (bases 1 to 1899)
  AUTHORS   Zhao,F., Huang,F., Tang,M., Li,X., Zhang,N., Amfilochiadis,A.,
            Li,Y., Hu,R., Jin,T., Peng,C. and Wang,Q.
  TITLE     Nodal induces apoptosis through activation of the ALK7 signaling
            pathway in pancreatic INS-1 beta-cells
  JOURNAL   Am J Physiol Endocrinol Metab 303 (1), E132-E143 (2012)
   PUBMED   22550067
  REMARK    GeneRIF: Data suggest that up-regulation of Nodal expression
            increases apoptosis of beta cells and is associated with increased
            Alk7 expression, activation of Smad3 signaling, and down-regulation
            of apoptosis regulatory proteins.
REFERENCE   5  (bases 1 to 1899)
  AUTHORS   Li,Q., Liu,X., Wu,Y., An,J., Hexige,S., Ling,Y., Zhang,M., Yang,X.
            and Yu,L.
  TITLE     The conditioned medium from a stable human GDF3-expressing CHO cell
            line, induces the differentiation of PC12 cells
  JOURNAL   Mol Cell Biochem 359 (1-2), 115-123 (2012)
   PUBMED   21805089
REFERENCE   6  (bases 1 to 1899)
  AUTHORS   Jornvall,H., Blokzijl,A., ten Dijke,P. and Ibanez,C.F.
  TITLE     The orphan receptor serine/threonine kinase ALK7 signals arrest of
            proliferation and morphological differentiation in a neuronal cell
            line
  JOURNAL   J Biol Chem 276 (7), 5140-5146 (2001)
   PUBMED   11084022
REFERENCE   7  (bases 1 to 1899)
  AUTHORS   Watanabe,R., Yamada,Y., Ihara,Y., Someya,Y., Kubota,A.,
            Kagimoto,S., Kuroe,A., Iwakura,T., Shen,Z.P., Inada,A., Adachi,T.,
            Ban,N., Miyawaki,K., Sunaga,Y., Tsuda,K. and Seino,Y.
  TITLE     The MH1 domains of smad2 and smad3 are involved in the regulation
            of the ALK7 signals
  JOURNAL   Biochem Biophys Res Commun 254 (3), 707-712 (1999)
   PUBMED   9920806
REFERENCE   8  (bases 1 to 1899)
  AUTHORS   Lorentzon,M., Hoffer,B., Ebendal,T., Olson,L. and Tomac,A.
  TITLE     Habrec1, a novel serine/threonine kinase TGF-beta type I-like
            receptor, has a specific cellular expression suggesting function in
            the developing organism and adult brain
  JOURNAL   Exp Neurol 142 (2), 351-360 (1996)
   PUBMED   8934566
REFERENCE   9  (bases 1 to 1899)
  AUTHORS   Ryden,M., Imamura,T., Jornvall,H., Belluardo,N., Neveu,I.,
            Trupp,M., Okadome,T., ten Dijke,P. and Ibanez,C.F.
  TITLE     A novel type I receptor serine-threonine kinase predominantly
            expressed in the adult central nervous system
  JOURNAL   J Biol Chem 271 (48), 30603-30609 (1996)
   PUBMED   8940033
REFERENCE   10 (bases 1 to 1899)
  AUTHORS   Tsuchida,K., Sawchenko,P.E., Nishikawa,S. and Vale,W.W.
  TITLE     Molecular cloning of a novel type I receptor serine/threonine
            kinase for the TGF beta superfamily from rat brain
  JOURNAL   Mol Cell Neurosci 7 (6), 467-478 (1996)
   PUBMED   8875430
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_139090.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U69702.1, U35025.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               JAXUCZ010000003.1  63300934-63301154   c
            222-452             JAXUCZ010000003.1  63269852-63270082   c
            453-692             JAXUCZ010000003.1  63249695-63249934   c
            693-923             JAXUCZ010000003.1  63243526-63243756   c
            924-1091            JAXUCZ010000003.1  63240711-63240878   c
            1092-1248           JAXUCZ010000003.1  63239247-63239403   c
            1249-1373           JAXUCZ010000003.1  63237445-63237569   c
            1374-1504           JAXUCZ010000003.1  63235976-63236106   c
            1505-1899           JAXUCZ010000003.1  63231442-63231836   c
FEATURES             Location/Qualifiers
     source          1..1899
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..1899
                     /gene="Acvr1c"
                     /gene_synonym="Alk-7; Alk7; habrec1"
                     /note="activin A receptor type 1C"
                     /db_xref="GeneID:245921"
                     /db_xref="RGD:621789"
     exon            1..221
                     /gene="Acvr1c"
                     /gene_synonym="Alk-7; Alk7; habrec1"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1630
                     /gene="Acvr1c"
                     /gene_synonym="Alk-7; Alk7; habrec1"
                     /EC_number="2.7.11.30"
                     /note="activin receptor type-1C; TGF-beta type 1 receptor;
                     ACTR-IC; activin receptor type IC; activin receptor-like
                     kinase 7; activin A receptor, type IC"
                     /codon_start=1
                     /product="activin receptor type-1C precursor"
                     /protein_id="NP_620790.2"
                     /db_xref="GeneID:245921"
                     /db_xref="RGD:621789"
                     /translation="MTPARRSALSLALLLVALASDLAAGLKCVCLLCDSSNFTCQTEG
                     ACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTA
                     SPDAPRLGPTELTVVITVPVCLLSIAAMLTIWACQDRQCTYRKTKRHNVEEPLAEYSL
                     VNAGKTLKDLIYDATASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGED
                     VAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQG
                     SLYDYLNRNIVTVAGMVKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKC
                     DTCAIADLGLAVKHDSIMNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIY
                     SVGLVYWEIARRCSVGGLVEEYQLPYYDMVPSDPSIEEMRKVVCDQKLRPNLPNQWQS
                     CEALRVMGRIMRECWYANGAARLTALRVKKTISQLCVKEDCKA"
     exon            222..452
                     /gene="Acvr1c"
                     /gene_synonym="Alk-7; Alk7; habrec1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..692
                     /gene="Acvr1c"
                     /gene_synonym="Alk-7; Alk7; habrec1"
                     /inference="alignment:Splign:2.1.0"
     exon            693..923
                     /gene="Acvr1c"
                     /gene_synonym="Alk-7; Alk7; habrec1"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1091
                     /gene="Acvr1c"
                     /gene_synonym="Alk-7; Alk7; habrec1"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1248
                     /gene="Acvr1c"
                     /gene_synonym="Alk-7; Alk7; habrec1"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1373
                     /gene="Acvr1c"
                     /gene_synonym="Alk-7; Alk7; habrec1"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1504
                     /gene="Acvr1c"
                     /gene_synonym="Alk-7; Alk7; habrec1"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1899
                     /gene="Acvr1c"
                     /gene_synonym="Alk-7; Alk7; habrec1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagcgccc gctgccacta gagccaaccg cgcacttccg aagggtgtcg cggctgcgct
       61 cccctcccgc gccccgggaa cttcaaagcg gcccgcgctg cgggctgcgc tctgggaccc
      121 cgaagccttg caccgccgcg gggtggccat gaccccagcg cgccgctccg cactgagcct
      181 ggccctcctg ctggtggcac tggcctccga ccttgcggca ggactgaagt gtgtgtgtct
      241 tttgtgtgat tcctcaaact ttacctgcca aaccgaagga gcatgctggg cctctgtcat
      301 gctaaccaac gggaaagaac aggtgatcaa atcgtgcgtg tccctcccgg aactaaatgc
      361 tcaggtcttc tgtcacagtt ccaacaacgt gaccaagacc gaatgttgct tcacagactt
      421 ctgcaacaac atcactctgc accttcccac agcatctcca gatgccccta gacttggccc
      481 cacagagctg acggttgtta tcactgtacc tgtttgcctc ctgtccatcg cagccatgct
      541 aacgatatgg gcctgccagg accgccagtg cacatacagg aagaccaaga gacacaatgt
      601 ggaggaacca ctggcagagt acagccttgt caatgctgga aaaaccctca aagatctgat
      661 ttatgatgcc actgcctcgg gctcaggatc tggcctgcct cttttggttc aaagaaccat
      721 cgcaaggaca attgtacttc aagaaatcgt aggaaaaggt cggtttgggg aagtgtggca
      781 cggaagatgg tgtggagaag atgtggctgt gaaaatattc tcctccagag atgagagatc
      841 ttggttccgt gaggcagaaa tttatcagac ggtaatgctg agacatgaga atattctcgg
      901 tttcatcgcg gccgacaaca aagataatgg aacctggact cagctttggc ttgtgtcaga
      961 gtatcacgag cagggctcct tatatgacta tttgaataga aacatagtga ccgtggctgg
     1021 aatggtcaag ttggcgcttt caatagcgag tggtctggct cacctacaca tggagatcgt
     1081 gggcactcaa ggtaagcctg ctattgctca ccgagatata aagtcaaaga atatcttagt
     1141 caaaaagtgt gacacttgtg ccatagctga cttagggctg gctgtgaaac atgattctat
     1201 catgaacact atagatatac cccagaatcc taaagtggga accaagaggt atatggctcc
     1261 cgaaatgctt gatgatacaa tgaacgtcaa catctttgag tccttcaagc gagctgacat
     1321 ctattcggtg gggctggttt actgggaaat agctcgaagg tgttcagttg gaggacttgt
     1381 tgaagagtac cagttgcctt attatgacat ggtgccttca gatccttcca tagaggaaat
     1441 gaggaaggtc gtttgtgatc agaaactccg accaaatctc ccaaaccagt ggcaaagctg
     1501 tgaggcgctc cgggtcatgg gaagaataat gcgtgagtgc tggtatgcca acggggcagc
     1561 tcgcctgacc gccctgcgcg tgaagaagac catttctcag ctgtgtgtca aggaagactg
     1621 taaggcctaa ggccgcatac aggcgacggg aaagccctca ccactctctt tcatgtctcc
     1681 tgctttgtgt aaatgttttc gtttcttttc tgctgtgttt tgttttagtt ctacctcaaa
     1741 gatgattcac tacagtgttg aagtgtccca aaggcagcat gaaaagataa ctctaagcat
     1801 gggcaggtct tgactttccc agtttccatg ttgtccgtac ttttattttt aaaggtgaca
     1861 ctattcattt ttctttttat ttaaggagga agatgttat
//
