LOCUS       NM_199230               2276 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus activin A receptor type 1B (Acvr1b), mRNA.
ACCESSION   NM_199230 XM_235673
VERSION     NM_199230.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2276)
  AUTHORS   Jin,W., Lei,Z., Xu,S., Fachen,Z., Yixiang,Z., Shilei,Z., Tao,G.,
            Zhe,S., Fengzhou,L., Su,W.H. and Chundong,G.
  TITLE     Genetic Mutation Analysis in Small Cell Lung Cancer by a Novel
            NGS-Based Targeted Resequencing Gene Panel and Relation with
            Clinical Features
  JOURNAL   Biomed Res Int 2021, 3609028 (2021)
   PUBMED   33880365
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2276)
  AUTHORS   Liu,K., Wang,B.J., Han,W., Chi,C.H., Gu,C., Wang,Y., Fu,X.,
            Huang,W., Liu,Z. and Song,X.
  TITLE     CFIm25-regulated lncRNA acv3UTR promotes gastric tumorigenesis via
            miR-590-5p/YAP1 axis
  JOURNAL   Oncogene 39 (15), 3075-3088 (2020)
   PUBMED   32066878
REFERENCE   3  (bases 1 to 2276)
  AUTHORS   Ohno,Y., Shingyoku,S., Miyake,S., Tanaka,A., Fudesaka,S.,
            Shimizu,Y., Yoshifuji,A., Yamawaki,Y., Yoshida,S., Tanaka,S.,
            Sakura,K. and Tanaka,T.
  TITLE     Differential regulation of the sphere formation and maintenance of
            cancer-initiating cells of malignant mesothelioma via CD44 and ALK4
            signaling pathways
  JOURNAL   Oncogene 37 (49), 6357-6367 (2018)
   PUBMED   30061637
REFERENCE   4  (bases 1 to 2276)
  AUTHORS   Hu,J., Wang,X., Wei,S.M., Tang,Y.H., Zhou,Q. and Huang,C.X.
  TITLE     Activin A stimulates the proliferation and differentiation of
            cardiac fibroblasts via the ERK1/2 and p38-MAPK pathways
  JOURNAL   Eur J Pharmacol 789, 319-327 (2016)
   PUBMED   27477354
REFERENCE   5  (bases 1 to 2276)
  AUTHORS   Colas,A.R., McKeithan,W.L., Cunningham,T.J., Bushway,P.J.,
            Garmire,L.X., Duester,G., Subramaniam,S. and Mercola,M.
  TITLE     Whole-genome microRNA screening identifies let-7 and mir-18 as
            regulators of germ layer formation during early embryogenesis
  JOURNAL   Genes Dev 26 (23), 2567-2579 (2012)
   PUBMED   23152446
REFERENCE   6  (bases 1 to 2276)
  AUTHORS   Attisano,L., Wrana,J.L., Montalvo,E. and Massague,J.
  TITLE     Activation of signalling by the activin receptor complex
  JOURNAL   Mol Cell Biol 16 (3), 1066-1073 (1996)
   PUBMED   8622651
REFERENCE   7  (bases 1 to 2276)
  AUTHORS   Verschueren,K., Dewulf,N., Goumans,M.J., Lonnoy,O., Feijen,A.,
            Grimsby,S., Vandi Spiegle,K., ten Dijke,P., Moren,A.,
            Vanscheeuwijck,P., Heldin,C.H., Miyazono,K., Mummery,C., Van Den
            Eijnden-Van Raaij,J. and Huylebroeck,D.
  TITLE     Expression of type I and type IB receptors for activin in
            midgestation mouse embryos suggests distinct functions in
            organogenesis
  JOURNAL   Mech Dev 52 (1), 109-123 (1995)
   PUBMED   7577669
REFERENCE   8  (bases 1 to 2276)
  AUTHORS   Xu,J., McKeehan,K., Matsuzaki,K. and McKeehan,W.L.
  TITLE     Inhibin antagonizes inhibition of liver cell growth by activin by a
            dominant-negative mechanism
  JOURNAL   J Biol Chem 270 (11), 6308-6313 (1995)
   PUBMED   7890768
REFERENCE   9  (bases 1 to 2276)
  AUTHORS   Takumi,T., Moustakas,A., Lin,H.Y. and Lodish,H.F.
  TITLE     Molecular characterization of a type I serine-threonine kinase
            receptor for TGF-beta and activin in the rat pituitary tumor cell
            line GH3
  JOURNAL   Exp Cell Res 216 (1), 208-214 (1995)
   PUBMED   7813622
REFERENCE   10 (bases 1 to 2276)
  AUTHORS   He,W.W., Gustafson,M.L., Hirobe,S. and Donahoe,P.K.
  TITLE     Developmental expression of four novel serine/threonine kinase
            receptors homologous to the activin/transforming growth factor-beta
            type II receptor family
  JOURNAL   Dev Dyn 196 (2), 133-142 (1993)
   PUBMED   8395914
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_199230.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.21010.1,
                                           SRR26643292.32019.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               JAXUCZ010000007.1  134165001-134165104
            105-344             JAXUCZ010000007.1  134186907-134187146
            345-593             JAXUCZ010000007.1  134187761-134188009
            594-824             JAXUCZ010000007.1  134192225-134192455
            825-992             JAXUCZ010000007.1  134195479-134195646
            993-1149            JAXUCZ010000007.1  134196393-134196549
            1150-1274           JAXUCZ010000007.1  134197679-134197803
            1275-1405           JAXUCZ010000007.1  134202659-134202789
            1406-2133           JAXUCZ010000007.1  134205306-134206033
            2134-2276           JAXUCZ010000007.1  134206050-134206192
FEATURES             Location/Qualifiers
     source          1..2276
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2276
                     /gene="Acvr1b"
                     /gene_synonym="Skr2"
                     /note="activin A receptor type 1B"
                     /db_xref="GeneID:29381"
                     /db_xref="RGD:735207"
     exon            1..104
                     /gene="Acvr1b"
                     /gene_synonym="Skr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1531
                     /gene="Acvr1b"
                     /gene_synonym="Skr2"
                     /EC_number="2.7.11.30"
                     /note="Serine/threonine-protein kinase receptor R2;
                     activin receptor type-1B; ALK-4; activin A receptor, type
                     IB; ACTR-IB; activin receptor-like kinase 4; activin
                     receptor type IB"
                     /codon_start=1
                     /product="activin receptor type-1B precursor"
                     /protein_id="NP_954700.1"
                     /db_xref="GeneID:29381"
                     /db_xref="RGD:735207"
                     /translation="MAESAGASSFFPLVVLLLAGSGGSGPRGIQALLCACTSCLQTNY
                     TCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYIDFCN
                     KIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQ
                     RLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRF
                     GEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWT
                     QLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHR
                     DLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINM
                     KHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQ
                     KLRPNVPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI"
     exon            105..344
                     /gene="Acvr1b"
                     /gene_synonym="Skr2"
                     /inference="alignment:Splign:2.1.0"
     exon            345..593
                     /gene="Acvr1b"
                     /gene_synonym="Skr2"
                     /inference="alignment:Splign:2.1.0"
     exon            594..824
                     /gene="Acvr1b"
                     /gene_synonym="Skr2"
                     /inference="alignment:Splign:2.1.0"
     exon            825..992
                     /gene="Acvr1b"
                     /gene_synonym="Skr2"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1149
                     /gene="Acvr1b"
                     /gene_synonym="Skr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1274
                     /gene="Acvr1b"
                     /gene_synonym="Skr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1405
                     /gene="Acvr1b"
                     /gene_synonym="Skr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..2276
                     /gene="Acvr1b"
                     /gene_synonym="Skr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggcggtt actatggcgg agtcggccgg agcctcctcc ttcttccccc ttgttgtcct
       61 cctgctcgcc ggcagtggcg ggtccgggcc ccgggggatc caggctctgc tgtgtgcatg
      121 caccagctgc ctacagacca actacacctg cgaaacagat ggggcctgca tggtctccat
      181 ctttaacctg gatggcatgg agcaccacgt acgcacctgc atccccaagg tggagcttgt
      241 gcctgctggg aagcccttct actgcctgag ttcagaggac ctgcgcaaca cgcactgctg
      301 ctatattgac ttctgcaaca agattgacct gagggtgccc agtggacacc tcaaggagcc
      361 tgagcacccc tccatgtggg gccctgtgga gctggtcggc atcattgccg gtcctgtctt
      421 cctcctcttc ctcatcatca tcatcgtctt cctggtcatc aactatcatc agcgtgtcta
      481 ccacaaccgc caaagactgg acatggagga cccctcatgt gagatgtgtc tctccaaaga
      541 caagacgctc caggatctcg tctacgatct ctccacttca ggatcgggct cagggttacc
      601 cctttttgtc cagcgcacag tggcccgaac cattgtttta caagagatta tcggcaaggg
      661 ccggtttggg gaagtatggc gtggccgctg gaggggtggt gatgtggctg tgaaaatctt
      721 ctcttcccgt gaagagcggt cgtggttccg ggaggcagag atctaccaga ctgtcatgct
      781 gcgccatgaa aacatccttg ggtttattgc tgctgacaat aaagacaatg gcacctggac
      841 ccagctgtgg cttgtctctg actatcacga gcacggctca ctgttcgatt atctgaaccg
      901 ctacacagtg accattgagg ggatgattaa actggccctg tctgcagcca gtggtttggc
      961 acacctgcat atggagattg tgggcactca ggggaagcct ggaattgctc atcgagactt
     1021 gaagtcaaag aacattctgg tgaagaagaa tggcatgtgt gccattgcag acctgggcct
     1081 agctgtccgt cacgatgctg tcactgacac catagacatt gctccaaatc agagggtggg
     1141 aaccaaacga tacatggctc ctgaagtact tgacgagacc atcaacatga agcactttga
     1201 ctccttcaag tgtgccgata tctacgccct cgggcttgtc tattgggaga ttgctcggag
     1261 gtgcaattct ggaggagtcc atgaagagta tcaactgcca tattatgatt tagtgccctc
     1321 tgacccttcc attgaggaaa tgcgaaaggt cgtctgtgac cagaagctac ggcccaatgt
     1381 ccccaactgg tggcagagtt atgaggcctt gcgagtgatg gggaagatga tgcgggagtg
     1441 ctggtacgcc aatggtgctg cccgcctgac agcgctgcgc atcaagaaga ctttgtccca
     1501 gctaagcgtg caggaagacg tgaagattta agctgttcct ctgcctacgc aaagaacctg
     1561 ggcagtgagg atgcctgcag ccaccgtgca agcgtggagg cctacctctt gtttctgccc
     1621 agccctctgg ccagagccct ggtctgcaag agggacagag cctgggagac gcacactccc
     1681 tactgggttt gagacagaca ctttttatat ttacctcctg atggcatgga gactctgaga
     1741 gcaaatcatg tagatgactc gatgccacaa ctcgcactgc gtgcagtggg aaggacagaa
     1801 agcccagtgc atctggcatg ttgccaggag tggtgatggg tgctgggctc gcctgggagc
     1861 agcccccata ccgtgttgtc cactggactg caggtttcct ccagggacca gtcaactggc
     1921 agatactgag aggaaccgga agtgtcctcc cttttacctg tgggcagtcc tgagccacgc
     1981 catccccttc tcatctggag ggactgcccc tagagacaca acctgctgcc tgtctgtcca
     2041 gccaagtgcg catgtgccga ggtgtgtctc acattgtgcc tggtccgtgc ctcgcccgtg
     2101 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtaggtgtg tgtgagtgtg tgtgttagtg
     2161 taggtgtgtg agagtgtgtg tgtaggtgtg tgagtgtggg tgtgtgagag tgtgtgtagg
     2221 tgtatgtgag tgtgtaagtg tgtgtaggtg tgtgagtgtg taggtgtgtg agtgtg
//
