LOCUS       NM_024486               1780 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus activin A receptor type 1 (Acvr1), mRNA.
ACCESSION   NM_024486
VERSION     NM_024486.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1780)
  AUTHORS   Zheng,J., Zhang,T., Han,S., Liu,C., Liu,M., Li,S. and Li,J.
  TITLE     Activin A improves the neurological outcome after ischemic stroke
            in mice by promoting oligodendroglial ACVR1B-mediated white matter
            remyelination
  JOURNAL   Exp Neurol 337, 113574 (2021)
   PUBMED   33345977
REFERENCE   2  (bases 1 to 1780)
  AUTHORS   Kondkar,A.A., Azad,T.A., Sultan,T., Osman,E.A., Almobarak,F.A. and
            Al-Obeidan,S.A.
  TITLE     Association of rs12997 variant in the ACVR1 gene: a member of bone
            morphogenic protein signaling pathway with primary open-angle
            glaucoma in a Saudi cohort
  JOURNAL   J Investig Med 69 (2), 402-407 (2021)
   PUBMED   33443061
REFERENCE   3  (bases 1 to 1780)
  AUTHORS   Kou,S., De Cunto,C., Baujat,G., Wentworth,K.L., Grogan,D.R.,
            Brown,M.A., Di Rocco,M., Keen,R., Al Mukaddam,M., le Quan
            Sang,K.H., Masharani,U., Kaplan,F.S., Pignolo,R.J. and Hsiao,E.C.
  TITLE     Patients with ACVR1R206H mutations have an increased prevalence of
            cardiac conduction abnormalities on electrocardiogram in a natural
            history study of Fibrodysplasia Ossificans Progressiva
  JOURNAL   Orphanet J Rare Dis 15 (1), 193 (2020)
   PUBMED   32727600
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1780)
  AUTHORS   Kondkar,A.A., Sultan,T., Azad,T.A., Osman,E.A., Almobarak,F.A. and
            Al-Obeidan,S.A.
  TITLE     Association analysis of polymorphisms rs12997 in ACVR1 and
            rs1043784 in BMP6 genes involved in bone morphogenic protein
            signaling pathway in primary angle-closure and pseudoexfoliation
            glaucoma patients of Saudi origin
  JOURNAL   BMC Med Genet 21 (1), 145 (2020)
   PUBMED   32641001
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1780)
  AUTHORS   Shahid,M., Spagnolli,E., Ernande,L., Thoonen,R., Kolodziej,S.A.,
            Leyton,P.A., Cheng,J., Tainsh,R.E., Mayeur,C., Rhee,D.K., Wu,M.X.,
            Scherrer-Crosbie,M., Buys,E.S., Zapol,W.M., Bloch,K.D. and
            Bloch,D.B.
  TITLE     BMP type I receptor ALK2 is required for angiotensin II-induced
            cardiac hypertrophy
  JOURNAL   Am J Physiol Heart Circ Physiol 310 (8), H984-H994 (2016)
   PUBMED   26873969
  REMARK    GeneRIF: Suggest that BMP signaling upregulates the
            calcineurin/nuclear factor of activated T cell pathway via BMP type
            I receptor ALK2, contributing to cardiac hypertrophy and fibrosis.
REFERENCE   6  (bases 1 to 1780)
  AUTHORS   Verschueren,K., Dewulf,N., Goumans,M.J., Lonnoy,O., Feijen,A.,
            Grimsby,S., Vandi Spiegle,K., ten Dijke,P., Moren,A.,
            Vanscheeuwijck,P., Heldin,C.H., Miyazono,K., Mummery,C., Van Den
            Eijnden-Van Raaij,J. and Huylebroeck,D.
  TITLE     Expression of type I and type IB receptors for activin in
            midgestation mouse embryos suggests distinct functions in
            organogenesis
  JOURNAL   Mech Dev 52 (1), 109-123 (1995)
   PUBMED   7577669
REFERENCE   7  (bases 1 to 1780)
  AUTHORS   Tsuchida,K., Mathews,L.S. and Vale,W.W.
  TITLE     Cloning and characterization of a transmembrane serine kinase that
            acts as an activin type I receptor
  JOURNAL   Proc Natl Acad Sci U S A 90 (23), 11242-11246 (1993)
   PUBMED   8248234
REFERENCE   8  (bases 1 to 1780)
  AUTHORS   Attisano,L., Carcamo,J., Ventura,F., Weis,F.M., Massague,J. and
            Wrana,J.L.
  TITLE     Identification of human activin and TGF beta type I receptors that
            form heteromeric kinase complexes with type II receptors
  JOURNAL   Cell 75 (4), 671-680 (1993)
   PUBMED   8242742
REFERENCE   9  (bases 1 to 1780)
  AUTHORS   Ebner,R., Chen,R.H., Shum,L., Lawler,S., Zioncheck,T.F., Lee,A.,
            Lopez,A.R. and Derynck,R.
  TITLE     Cloning of a type I TGF-beta receptor and its effect on TGF-beta
            binding to the type II receptor
  JOURNAL   Science 260 (5112), 1344-1348 (1993)
   PUBMED   8388127
REFERENCE   10 (bases 1 to 1780)
  AUTHORS   Mathews,L.S. and Vale,W.W.
  TITLE     Expression cloning of an activin receptor, a predicted
            transmembrane serine kinase
  JOURNAL   Cell 65 (6), 973-982 (1991)
   PUBMED   1646080
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L19341.1.
            
            [WARNING] On Jul 16, 2024 this sequence was replaced by
            NM_024486.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L19341.1, BC167754.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1780
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..1780
                     /gene="Acvr1"
                     /note="activin A receptor type 1"
                     /db_xref="GeneID:79558"
                     /db_xref="RGD:620200"
     exon            1..140
                     /gene="Acvr1"
                     /inference="alignment:Splign:2.1.0"
     exon            141..214
                     /gene="Acvr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1677
                     /gene="Acvr1"
                     /EC_number="2.7.11.30"
                     /note="activin receptor type-1; activin A receptor, type
                     I; SKR1; TSR-I; ACTR-I; activin receptor type I; TGF-B
                     superfamily receptor type I; serine/threonine-protein
                     kinase receptor R1; activin type I receptor; ALK2-B"
                     /codon_start=1
                     /product="activin receptor type-1 precursor"
                     /protein_id="NP_077812.1"
                     /db_xref="GeneID:79558"
                     /db_xref="RGD:620200"
                     /translation="MVDGAMILSVLMMMALPSPSMEDEEPKVNPKLYMCVCEGLSCGN
                     EDHCEGQQCFSSLSVNDGFRVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRN
                     VTARLPTKGKSFPGSQNFHLEVGLIILSVVFAVCLFACILGVALRKFKRRNQERLNPR
                     DVEYGTIEGLITTNVGDSTLAELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGR
                     YGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSS
                     TQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAH
                     RDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQ
                     VDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCV
                     DQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTD
                     C"
     exon            215..478
                     /gene="Acvr1"
                     /inference="alignment:Splign:2.1.0"
     exon            479..690
                     /gene="Acvr1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..790
                     /gene="Acvr1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..937
                     /gene="Acvr1"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1213
                     /gene="Acvr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1411
                     /gene="Acvr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1542
                     /gene="Acvr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1780
                     /gene="Acvr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtgctgggt gtgccccaga gctggctttg actgtacgct gtcaggctct ccctggacct
       61 cacggaacag cattgccagc cacacggctt ccaacaaatc acctcttttc atgctgtttg
      121 gcacagatcg aatctacagg ttatacaatg gtcgatggag caatgatcct ttctgtgcta
      181 atgatgatgg ctctcccttc cccgagtatg gaagatgagg agcccaaggt caacccgaag
      241 ctttacatgt gtgtgtgtga gggcctctcc tgcgggaacg aggaccactg tgagggccag
      301 cagtgttttt cctccctgag cgtcaatgat ggcttccgcg tctaccagaa gggctgcttt
      361 caggtctatg agcaggggaa gatgacgtgt aagaccccgc cgtcgcctgg ccaggctgtg
      421 gagtgctgcc aaggggactg gtgcaacagg aacgtcacgg cccggctgcc cactaaaggg
      481 aaatccttcc ctggatcgca gaacttccac ctggaagttg gccttatcat cctctccgtg
      541 gtgtttgcgg tatgcctttt cgcttgcatc cttggcgttg ctctcaggaa gtttaaaagg
      601 cgcaatcaag agcgcctgaa ccccagagac gtggagtacg gtactatcga agggctcatc
      661 accaccaacg tcggagatag cactctagcg gaattactag atcactcatg tacatcagga
      721 agtggctccg gtcttccttt tctggtacag agaactgtgg ctcgacagat aaccctgttg
      781 gagtgtgtcg ggaagggccg gtatggagaa gtgtggaggg gcagctggca aggcgaaaat
      841 gttgctgtga agatcttctc ctcccgtgat gagaagtcgt ggttcaggga gacagaattg
      901 tacaacacgg ttatgctgag gcatgagaat atcttaggtt tcattgcttc agacatgacc
      961 tctagacact ccagtaccca gctgtggctc attacacatt accacgaaat gggatcgttg
     1021 tatgactacc ttcagctcac cactctggac acggttagct gccttcggat cgtgttgtcc
     1081 atagccagcg gccttgcaca cttgcacata gagatatttg ggacccaggg gaagtctgcc
     1141 atcgcccacc gagatctaaa gagcaaaaac atcctcgtga agaagaacgg acagtgctgc
     1201 atagcagatt tgggcctggc agtcatgcat tcccagagca cgaatcagct tgatgtggga
     1261 aacaaccccc gtgtggggac caagcgctac atggcccctg aagtgcttga tgaaaccatc
     1321 caagtggatt gctttgattc ttataagagg gtcgatattt gggcctttgg cctcgttctg
     1381 tgggaagtgg ccaggaggat ggtgagcaat ggtatagtgg aagattacaa gccaccattc
     1441 tatgatgttg ttcccaatga cccaagtttt gaagatatga ggaaagttgt ctgtgtggat
     1501 caacagaggc caaacatacc taacagatgg ttctcagacc cgacattaac ttctctggcg
     1561 aagctgatga aagaatgctg gtaccagaac ccatccgcca gactcacagc tctacgtatc
     1621 aaaaagactt tgaccaaaat tgataactcc ctagacaaat taaaaactga ctgttgacat
     1681 tgtcaccggt gtcaagaagg agagtcaatg ctgtcattgt ccagctggga cctaatgctg
     1741 gcctgactgg ttgtcagaac agaatccatc tgtccccctc
//
