LOCUS       NM_031068               2114 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus actin related protein 3 (Actr3), mRNA.
ACCESSION   NM_031068 XM_341112
VERSION     NM_031068.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2114)
  AUTHORS   Su,L., Wang,Z., Xie,S., Hu,D., Cheng,Y.C., Mruk,D.D. and Guan,Y.
  TITLE     Testin regulates the blood-testis barrier via disturbing
            occludin/ZO-1 association and actin organization
  JOURNAL   J Cell Physiol 235 (9), 6127-6138 (2020)
   PUBMED   31975378
  REMARK    GeneRIF: Testin regulates the blood-testis barrier via disturbing
            occludin/ZO-1 association and actin organization.
REFERENCE   2  (bases 1 to 2114)
  AUTHORS   Rao,J., Ashraf,S., Tan,W., van der Ven,A.T., Gee,H.Y., Braun,D.A.,
            Feher,K., George,S.P., Esmaeilniakooshkghazi,A., Choi,W.I.,
            Jobst-Schwan,T., Schneider,R., Schmidt,J.M., Widmeier,E.,
            Warejko,J.K., Hermle,T., Schapiro,D., Lovric,S., Shril,S., Daga,A.,
            Nayir,A., Shenoy,M., Tse,Y., Bald,M., Helmchen,U., Mir,S.,
            Berdeli,A., Kari,J.A., El Desoky,S., Soliman,N.A., Bagga,A.,
            Mane,S., Jairajpuri,M.A., Lifton,R.P., Khurana,S., Martins,J.C. and
            Hildebrandt,F.
  TITLE     Advillin acts upstream of phospholipase C 1 in steroid-resistant
            nephrotic syndrome
  JOURNAL   J Clin Invest 127 (12), 4257-4269 (2017)
   PUBMED   29058690
REFERENCE   3  (bases 1 to 2114)
  AUTHORS   Detsika,M.G., Lygirou,V., Frantzis,V., Zoidakis,J., Atsaves,V.,
            Poulaki,E., Gakiopoulou,H., Vlahou,A. and Lianos,E.A.
  TITLE     Effect of Heme Oxygenase-1 Deficiency on Glomerular Proteomics
  JOURNAL   Am J Nephrol 43 (6), 441-450 (2016)
   PUBMED   27251563
REFERENCE   4  (bases 1 to 2114)
  AUTHORS   Rucksaken,R., Haonon,O., Pinlaor,P., Pairojkul,C., Roytrakul,S.,
            Yongvanit,P., Selmi,C. and Pinlaor,S.
  TITLE     Plasma IgG autoantibody against actin-related protein 3 in liver
            fluke Opisthorchis viverrini infection
  JOURNAL   Parasite Immunol 37 (7), 340-348 (2015)
   PUBMED   25809205
REFERENCE   5  (bases 1 to 2114)
  AUTHORS   Lee,H.K., Finniss,S., Cazacu,S., Xiang,C., Poisson,L.M.,
            Blumberg,P.M. and Brodie,C.
  TITLE     RasGRP3 regulates the migration of glioma cells via interaction
            with Arp3
  JOURNAL   Oncotarget 6 (3), 1850-1864 (2015)
   PUBMED   25682201
REFERENCE   6  (bases 1 to 2114)
  AUTHORS   Gavard,J., Lambert,M., Grosheva,I., Marthiens,V., Irinopoulou,T.,
            Riou,J.F., Bershadsky,A. and Mege,R.M.
  TITLE     Lamellipodium extension and cadherin adhesion: two cell responses
            to cadherin activation relying on distinct signalling pathways
  JOURNAL   J Cell Sci 117 (Pt 2), 257-270 (2004)
   PUBMED   14657280
REFERENCE   7  (bases 1 to 2114)
  AUTHORS   Rombouts,K., Knittel,T., Machesky,L., Braet,F., Wielant,A.,
            Hellemans,K., De Bleser,P., Gelman,I., Ramadori,G. and Geerts,A.
  TITLE     Actin filament formation, reorganization and migration are impaired
            in hepatic stellate cells under influence of trichostatin A, a
            histone deacetylase inhibitor
  JOURNAL   J Hepatol 37 (6), 788-796 (2002)
   PUBMED   12445420
REFERENCE   8  (bases 1 to 2114)
  AUTHORS   Gournier,H., Goley,E.D., Niederstrasser,H., Trinh,T. and Welch,M.D.
  TITLE     Reconstitution of human Arp2/3 complex reveals critical roles of
            individual subunits in complex structure and activity
  JOURNAL   Mol Cell 8 (5), 1041-1052 (2001)
   PUBMED   11741539
REFERENCE   9  (bases 1 to 2114)
  AUTHORS   Bailly,M., Macaluso,F., Cammer,M., Chan,A., Segall,J.E. and
            Condeelis,J.S.
  TITLE     Relationship between Arp2/3 complex and the barbed ends of actin
            filaments at the leading edge of carcinoma cells after epidermal
            growth factor stimulation
  JOURNAL   J Cell Biol 145 (2), 331-345 (1999)
   PUBMED   10209028
REFERENCE   10 (bases 1 to 2114)
  AUTHORS   Welch,M.D., DePace,A.H., Verma,S., Iwamatsu,A. and Mitchison,T.J.
  TITLE     The human Arp2/3 complex is composed of evolutionarily conserved
            subunits and is localized to cellular regions of dynamic actin
            filament assembly
  JOURNAL   J Cell Biol 138 (2), 375-384 (1997)
   PUBMED   9230079
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098014.1.
            
            On Jul 18, 2005 this sequence version replaced XM_341112.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098014.1, FQ212256.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676806, SAMN16676807
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2114
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q12"
     gene            1..2114
                     /gene="Actr3"
                     /gene_synonym="Arp3"
                     /note="actin related protein 3"
                     /db_xref="GeneID:81732"
                     /db_xref="RGD:71024"
     exon            1..129
                     /gene="Actr3"
                     /gene_synonym="Arp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1342
                     /gene="Actr3"
                     /gene_synonym="Arp3"
                     /note="actin-like protein 3; actin-related protein 3
                     homolog (yest); ARP3 actin related protein 3 homolog"
                     /codon_start=1
                     /product="actin-related protein 3"
                     /protein_id="NP_112330.1"
                     /db_xref="GeneID:81732"
                     /db_xref="RGD:71024"
                     /translation="MAGRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKESAKVG
                     DQAQRRVMKGVDDLDFFIGDEAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLR
                     AEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGE
                     RTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPE
                     QSLETAKAVKERYSYVCPDLVKEFNKYDTDGSKWIKQYTGVNAISKKEFSIDVGYERF
                     LGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRR
                     LQRDLKRTVDARLKLSEELSGGRLKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQ
                     VCHTKKDYEEIGPSICRHNPVFGVMS"
     exon            130..185
                     /gene="Actr3"
                     /gene_synonym="Arp3"
                     /inference="alignment:Splign:2.1.0"
     exon            186..310
                     /gene="Actr3"
                     /gene_synonym="Arp3"
                     /inference="alignment:Splign:2.1.0"
     exon            311..421
                     /gene="Actr3"
                     /gene_synonym="Arp3"
                     /inference="alignment:Splign:2.1.0"
     exon            422..517
                     /gene="Actr3"
                     /gene_synonym="Arp3"
                     /inference="alignment:Splign:2.1.0"
     exon            518..625
                     /gene="Actr3"
                     /gene_synonym="Arp3"
                     /inference="alignment:Splign:2.1.0"
     exon            626..769
                     /gene="Actr3"
                     /gene_synonym="Arp3"
                     /inference="alignment:Splign:2.1.0"
     exon            770..943
                     /gene="Actr3"
                     /gene_synonym="Arp3"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1036
                     /gene="Actr3"
                     /gene_synonym="Arp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1162
                     /gene="Actr3"
                     /gene_synonym="Arp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1246
                     /gene="Actr3"
                     /gene_synonym="Arp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..2090
                     /gene="Actr3"
                     /gene_synonym="Arp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccagtgcat ggtcagctag ctcacatctc tatccccggc ctcttagcag cacggaacgg
       61 acggcagcgg cgggcgagga ggaagatggc gggacggctg ccggcctgtg tggtggactg
      121 tggcacggga tatacaaaac taggatatgc tggaaataca gaaccacagt ttatcatccc
      181 atcatgtatt gccattaaag agtctgcaaa agtgggtgat caagcccaga ggagggtgat
      241 gaaaggcgtg gatgacctag acttcttcat tggtgatgaa gcaatagaaa agcccacata
      301 tgcaacaaag tggccaatcc gccatggtat agttgaagac tgggacttaa tggaaaggtt
      361 tatggagcaa gtgattttta aatatttaag ggcagaacct gaagatcatt actttctttt
      421 gactgaacct ccactgaata ctccagaaaa cagggaatat actgctgaga taatgtttga
      481 gtccttcaat gttccaggcc tgtacattgc tgtgcaggct gttcttgcct tagctgcatc
      541 ctggacctca agacaagtag gagagcggac actgacgggt acagtaatag acagtggaga
      601 cggagtcact catgtcattc ctgtggctga aggatatgtt atcggcagct gtattaaaca
      661 cattccaatc gctggaagag atataacata ttttattcag caactgctga gagaccgaga
      721 agtaggaatc cctcctgaac agtccttgga aactgcaaaa gcagtgaagg agcgctacag
      781 ttatgtctgc ccagatttag taaaagaatt taacaagtat gacactgatg ggtcaaagtg
      841 gatcaaacag tacaccggag tcaacgccat ctcaaagaag gaattctcca ttgatgttgg
      901 ctacgagcga tttctgggac cggagatctt tttccatcca gagtttgcta atccagattt
      961 tacacaacct atctcagaag ttgtagatga agtcattcag aattgcccca ttgatgtccg
     1021 gcgtcctctc tacaagaaca ttgtcctctc tggtggttca accatgttca gggactttgg
     1081 acgtcgtttg caaagagatc tgaagagaac tgtagatgcc aggctgaagt tgagtgagga
     1141 gctgagcggt ggcagattga agcccaagcc tattgatgta caagttatta cacaccacat
     1201 gcagcggtat gcagtctggt ttggaggatc aatgctggct tccacgcctg agttctacca
     1261 agtatgccac accaaaaagg attatgaaga aatcggacct agcatttgtc gtcacaatcc
     1321 agtgtttgga gtcatgtcct aaagttgact tcttgttcat tgaggttagg gagatggaaa
     1381 caagataatc tttctgatga cctgtttttg tctgagtgga tggttctgag gtttttaacc
     1441 aaacatgatc atacaggaat atttaatgat gagtgtgtca acatgcagat gtagaagaga
     1501 gccaagacga tcttttcctt taggttgaat atttgaatct tatgtgtatc aaaaaagaaa
     1561 tgggttttag ttctttctgt gccctgatat tttgtatact cctgacttcc ccagtgtgct
     1621 ggctctgagg gcgtgtggag agctctgtaa tgcctggttg ggcactgctg aggggcctgc
     1681 cgagcttgtt tctatttcat actttttata ctttgtggaa aaagtcaacg gaaaactata
     1741 gtattggagg gaaccagtgt gaccaaggaa aagatgattt caacaagcag cctcatggga
     1801 cttggcgtgc actctgggtt ccagttatct cgagctgctc cacccctccc cagcccaacg
     1861 gttctctctg caaacgcttg gatctaagaa gctagtctcc tgggttagct gatgcctgcc
     1921 ctgctttctg gttacttaca ttctgtttct tgctttaaaa gaaagacaag actgttggac
     1981 cagtattgca attctgtaga gtcgtttctt attaaaacaa taatgtgatt accaaaattg
     2041 gcatatttaa ggcctaatgc cattctaata aaggcaaaaa tttcttttta aaaaaaaaaa
     2101 aaaaaaaaaa aaaa
//
