LOCUS       NM_001009268            1326 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus actin related protein 2 (Actr2), mRNA.
ACCESSION   NM_001009268 XM_214109
VERSION     NM_001009268.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1326)
  AUTHORS   Zhao,H., Wang,L., Yan,Y., Zhao,Q.H., He,J., Jiang,R., Luo,C.J.,
            Qiu,H.L., Miao,Y.Q., Gong,S.G., Yuan,P. and Wu,W.H.
  TITLE     Identification of the shared gene signatures between pulmonary
            fibrosis and pulmonary hypertension using bioinformatics analysis
  JOURNAL   Front Immunol 14, 1197752 (2023)
   PUBMED   37731513
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1326)
  AUTHORS   Schrank,B.R., Aparicio,T., Li,Y., Chang,W., Chait,B.T.,
            Gundersen,G.G., Gottesman,M.E. and Gautier,J.
  TITLE     Nuclear ARP2/3 drives DNA break clustering for homology-directed
            repair
  JOURNAL   Nature 559 (7712), 61-66 (2018)
   PUBMED   29925947
REFERENCE   3  (bases 1 to 1326)
  AUTHORS   Rao,J., Ashraf,S., Tan,W., van der Ven,A.T., Gee,H.Y., Braun,D.A.,
            Feher,K., George,S.P., Esmaeilniakooshkghazi,A., Choi,W.I.,
            Jobst-Schwan,T., Schneider,R., Schmidt,J.M., Widmeier,E.,
            Warejko,J.K., Hermle,T., Schapiro,D., Lovric,S., Shril,S., Daga,A.,
            Nayir,A., Shenoy,M., Tse,Y., Bald,M., Helmchen,U., Mir,S.,
            Berdeli,A., Kari,J.A., El Desoky,S., Soliman,N.A., Bagga,A.,
            Mane,S., Jairajpuri,M.A., Lifton,R.P., Khurana,S., Martins,J.C. and
            Hildebrandt,F.
  TITLE     Advillin acts upstream of phospholipase C 1 in steroid-resistant
            nephrotic syndrome
  JOURNAL   J Clin Invest 127 (12), 4257-4269 (2017)
   PUBMED   29058690
REFERENCE   4  (bases 1 to 1326)
  AUTHORS   Singer,B.F., Bubula,N., Przybycien-Szymanska,M.M., Li,D. and
            Vezina,P.
  TITLE     Stimuli associated with the presence or absence of amphetamine
            regulate cytoskeletal signaling and behavior
  JOURNAL   Eur Neuropsychopharmacol 26 (11), 1836-1842 (2016)
   PUBMED   27720500
REFERENCE   5  (bases 1 to 1326)
  AUTHORS   Jilek,J.L., Sant,K.E., Cho,K.H., Reed,M.S., Pohl,J., Hansen,J.M.
            and Harris,C.
  TITLE     Ethanol Attenuates Histiotrophic Nutrition Pathways and Alters the
            Intracellular Redox Environment and Thiol Proteome during Rat
            Organogenesis
  JOURNAL   Toxicol Sci 147 (2), 475-489 (2015)
   PUBMED   26185205
REFERENCE   6  (bases 1 to 1326)
  AUTHORS   Cai,L., Holoweckyj,N., Schaller,M.D. and Bear,J.E.
  TITLE     Phosphorylation of coronin 1B by protein kinase C regulates
            interaction with Arp2/3 and cell motility
  JOURNAL   J Biol Chem 280 (36), 31913-31923 (2005)
   PUBMED   16027158
REFERENCE   7  (bases 1 to 1326)
  AUTHORS   Peng,J., Kim,M.J., Cheng,D., Duong,D.M., Gygi,S.P. and Sheng,M.
  TITLE     Semiquantitative proteomic analysis of rat forebrain postsynaptic
            density fractions by mass spectrometry
  JOURNAL   J Biol Chem 279 (20), 21003-21011 (2004)
   PUBMED   15020595
REFERENCE   8  (bases 1 to 1326)
  AUTHORS   Otsubo,T., Iwaya,K., Mukai,Y., Mizokami,Y., Serizawa,H.,
            Matsuoka,T. and Mukai,K.
  TITLE     Involvement of Arp2/3 complex in the process of colorectal
            carcinogenesis
  JOURNAL   Mod Pathol 17 (4), 461-467 (2004)
   PUBMED   14990971
REFERENCE   9  (bases 1 to 1326)
  AUTHORS   Rombouts,K., Knittel,T., Machesky,L., Braet,F., Wielant,A.,
            Hellemans,K., De Bleser,P., Gelman,I., Ramadori,G. and Geerts,A.
  TITLE     Actin filament formation, reorganization and migration are impaired
            in hepatic stellate cells under influence of trichostatin A, a
            histone deacetylase inhibitor
  JOURNAL   J Hepatol 37 (6), 788-796 (2002)
   PUBMED   12445420
REFERENCE   10 (bases 1 to 1326)
  AUTHORS   Gournier,H., Goley,E.D., Niederstrasser,H., Trinh,T. and Welch,M.D.
  TITLE     Reconstitution of human Arp2/3 complex reveals critical roles of
            individual subunits in complex structure and activity
  JOURNAL   Mol Cell 8 (5), 1041-1052 (2001)
   PUBMED   11741539
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088442.1.
            
            On Jan 7, 2005 this sequence version replaced XM_214109.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088442.1, FQ233785.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1326
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..1326
                     /gene="Actr2"
                     /note="actin related protein 2"
                     /db_xref="GeneID:289820"
                     /db_xref="RGD:1310826"
     exon            1..112
                     /gene="Actr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1249
                     /gene="Actr2"
                     /note="actin-like protein 2; ARP2 actin related protein 2
                     homolog"
                     /codon_start=1
                     /product="actin-related protein 2"
                     /protein_id="NP_001009268.1"
                     /db_xref="GeneID:289820"
                     /db_xref="RGD:1310826"
                     /translation="MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRST
                     TKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDT
                     RSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSG
                     DGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKE
                     KLCYVGYNIEQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGV
                     GVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDV
                     EKLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDNFWMTRQEYQEKGVRVLEKLGVT
                     VR"
     exon            113..223
                     /gene="Actr2"
                     /inference="alignment:Splign:2.1.0"
     exon            224..439
                     /gene="Actr2"
                     /inference="alignment:Splign:2.1.0"
     exon            440..512
                     /gene="Actr2"
                     /inference="alignment:Splign:2.1.0"
     exon            513..649
                     /gene="Actr2"
                     /inference="alignment:Splign:2.1.0"
     exon            650..799
                     /gene="Actr2"
                     /inference="alignment:Splign:2.1.0"
     exon            800..945
                     /gene="Actr2"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1078
                     /gene="Actr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1320
                     /gene="Actr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgagggcggg gccgtgtgga ggaggaagcg ggccaggccg ggcggcggct caccagggcg
       61 aaccatggac agccagggca ggaaggtggt ggtgtgcgac aacggcactg ggtttgtgaa
      121 gtgtggatat gcaggctcta actttccaga acacatcttc ccagctttgg ttggaagacc
      181 tattatcaga tcaaccacca aagtgggaaa cattgaaatc aaggatctca tggttggcga
      241 tgaggcaagt gagctgcgct ccatgttgga ggtgaactac ccgatggaga acggcatcgt
      301 gcgcaactgg gacgacatga agcacctgtg ggactacaca ttcgggccag agaagctcaa
      361 tatagacacc aggagctgca agatcttact tacagaaccc ccaatgaatc caaccaagaa
      421 cagagagaag attgtcgagg taatgtttga aacttaccag ttttctggtg tgtatgtagc
      481 catccaagca gttctgactt tgtatgctca aggtttactg actggtgtgg tagtggactc
      541 tggagatggt gtcactcaca tttgcccagt atatgaaggc ttttccctcc ctcaccttac
      601 aaggaggctg gatattgctg ggagggatat taccaggtat cttatcaagc tgctgctgtt
      661 gcgaggatat gccttcaacc attctgctga ctttgagaca gttcgcatga ttaaagaaaa
      721 actttgttat gtgggttaca atattgagca agagcagaag ctggccttag agaccacagt
      781 gctagttgag tcatacactc ttccagatgg acgtattatt aaggttggag gagaaagatt
      841 tgaagcacca gaagctttat ttcagcctca tttgatcaat gttgaggggg ttggtgttgc
      901 tgaattgctt tttaacacaa tccaggcagc cgacattgat accagatctg aattttataa
      961 gcacattgtg ctttctggag gttctaccat gtatcctggc ctgccatcga ggttggaacg
     1021 agagcttaaa cagctttacc tagaacgagt tctgaaagga gatgtggaga aactttcgaa
     1081 atttaagatc cgcattgaag acccgcctcg caggaagcac atggtgttct tgggtggcgc
     1141 agtcctagca gacatcatga aagacaaaga caacttctgg atgaccagac aagagtacca
     1201 agaaaagggt gtccgtgtgc tggagaaact cggtgtgact gttcgataaa atagcaggct
     1261 tgtccccatc acgcctctaa tgctttttct ttttcccttt taaaaaaaaa aaaaaaaaaa
     1321 aaaaaa
//
