LOCUS       NM_031675               3885 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus actinin alpha 4 (Actn4), mRNA.
ACCESSION   NM_031675 XM_346541
VERSION     NM_031675.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3885)
  AUTHORS   Ge,H., Yu,A., Chen,J., Yuan,J., Yin,Y., Duanmu,W., Tan,L., Yang,Y.,
            Lan,C., Chen,W., Feng,H. and Hu,R.
  TITLE     Poly-L-ornithine enhances migration of neural stem/progenitor cells
            via promoting alpha-Actinin 4 binding to actin filaments
  JOURNAL   Sci Rep 6, 37681 (2016)
   PUBMED   27874083
  REMARK    GeneRIF: Polyornithine activates alpha-Actinins 4 (ACTN4), which is
            firstly certified to be expessed in neural stem/progenitor cells,
            to promote filopodia formation and therefore enhances NSPCs
            migration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3885)
  AUTHORS   Sun,Y., Jaldin-Fincati,J., Liu,Z., Bilan,P.J. and Klip,A.
  TITLE     A complex of Rab13 with MICAL-L2 and alpha-actinin-4 is essential
            for insulin-dependent GLUT4 exocytosis
  JOURNAL   Mol Biol Cell 27 (1), 75-89 (2016)
   PUBMED   26538022
  REMARK    GeneRIF: Findings suggest that MICAL-L2 is an effector of
            insulin-activated Rab13, which links to GLUT4 through ACTN4,
            localizing GLUT4 vesicles at the muscle cell periphery to enable
            their fusion with the membrane.
REFERENCE   3  (bases 1 to 3885)
  AUTHORS   Kalinowska,M., Chavez,A.E., Lutzu,S., Castillo,P.E., Bukauskas,F.F.
            and Francesconi,A.
  TITLE     Actinin-4 Governs Dendritic Spine Dynamics and Promotes Their
            Remodeling by Metabotropic Glutamate Receptors
  JOURNAL   J Biol Chem 290 (26), 15909-15920 (2015)
   PUBMED   25944910
REFERENCE   4  (bases 1 to 3885)
  AUTHORS   Ehrlicher,A.J., Krishnan,R., Guo,M., Bidan,C.M., Weitz,D.A. and
            Pollak,M.R.
  TITLE     Alpha-actinin binding kinetics modulate cellular dynamics and force
            generation
  JOURNAL   Proc Natl Acad Sci U S A 112 (21), 6619-6624 (2015)
   PUBMED   25918384
REFERENCE   5  (bases 1 to 3885)
  AUTHORS   Zhao,X., Hsu,K.S., Lim,J.H., Bruggeman,L.A. and Kao,H.Y.
  TITLE     alpha-Actinin 4 potentiates nuclear factor
            kappa-light-chain-enhancer of activated B-cell (NF-kappaB) activity
            in podocytes independent of its cytoplasmic actin binding function
  JOURNAL   J Biol Chem 290 (1), 338-349 (2015)
   PUBMED   25411248
REFERENCE   6  (bases 1 to 3885)
  AUTHORS   Honda,K., Yamada,T., Endo,R., Ino,Y., Gotoh,M., Tsuda,H.,
            Yamada,Y., Chiba,H. and Hirohashi,S.
  TITLE     Actinin-4, a novel actin-bundling protein associated with cell
            motility and cancer invasion
  JOURNAL   J Cell Biol 140 (6), 1383-1393 (1998)
   PUBMED   9508771
  REMARK    Erratum:[J Cell Biol 1998 Oct 5;143(1):following 276]
REFERENCE   7  (bases 1 to 3885)
  AUTHORS   Geisert,E.E. Jr., Yang,L. and Irwin,M.H.
  TITLE     Astrocyte growth, reactivity, and the target of the
            antiproliferative antibody, TAPA
  JOURNAL   J Neurosci 16 (17), 5478-5487 (1996)
   PUBMED   8757260
REFERENCE   8  (bases 1 to 3885)
  AUTHORS   Irwin,M.H. and Geisert,E.E. Jr.
  TITLE     The upregulation of a glial cell surface antigen at the astrocytic
            scar in the rat
  JOURNAL   Neurosci Lett 154 (1-2), 57-60 (1993)
   PUBMED   8361649
REFERENCE   9  (bases 1 to 3885)
  AUTHORS   Geisert,E.E. Jr., Murphy,T.P., Irwin,M.H. and Larjava,H.
  TITLE     A novel cell adhesion molecule, G-CAM, found on cultured rat glia
  JOURNAL   Neurosci Lett 133 (2), 262-266 (1991)
   PUBMED   1816505
REFERENCE   10 (bases 1 to 3885)
  AUTHORS   Poliakov,L.E., Malinskii,D.M. and Kubakin,V.I.
  TITLE     [Complex evaluation of the health status indicators of military
            personnel]
  JOURNAL   Voen Med Zh (11), 15-20 (1978)
   PUBMED   734924
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB805703.1, BC061788.1, BQ206143.1 and AI070095.1.
            
            On Oct 12, 2005 this sequence version replaced NM_031675.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061788.1, AY724534.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 CB805703.1         4-12
            10-3486             BC061788.1         1-3477
            3487-3503           BQ206143.1         143-159
            3504-3885           AI070095.1         13-394              c
FEATURES             Location/Qualifiers
     source          1..3885
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3885
                     /gene="Actn4"
                     /note="actinin alpha 4"
                     /db_xref="GeneID:63836"
                     /db_xref="RGD:61816"
     exon            1..270
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..2844
                     /gene="Actn4"
                     /note="non-muscle alpha-actinin 4; F-actin cross-linking
                     protein"
                     /codon_start=1
                     /product="alpha-actinin-4"
                     /protein_id="NP_113863.2"
                     /db_xref="GeneID:63836"
                     /db_xref="RGD:61816"
                     /translation="MVDYHAANQAYQYGPSSGGNGTGGGGGMGDYMAQEDDWDRDLLL
                     DPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERG
                     KMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISV
                     EETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKD
                     DPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAET
                     AANRICKVLAVNQENEHLMEDYERLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLED
                     FRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNGWQHLEQ
                     AEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIK
                     ALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDNLGSL
                     THSRREALEKTEKQLETIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGL
                     ISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTSVTPQIINSKWE
                     KVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANMVGPWIQTKMEEIGRISIEMNGT
                     LEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHLRVGWEQLL
                     TTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLG
                     YDVENDRQGDAEFNRIMSVVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLA
                     GDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAAPGALDYKSFSTALYGESDL"
     exon            271..385
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            386..505
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            506..592
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            593..680
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            681..759
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            760..841
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            842..927
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1020
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1251
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1399
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1550
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1659
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1800
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1983
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2118
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2298
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2445
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2526
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..2685
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..3878
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttgggcgggc tgaaagcagc tgaagcggcg gccgagtcgt aggctccgac ataggggcgg
       61 gagctgagcg gtagcggacc ggctggcggg ctagcgaaag gcggcgggat ggtggactat
      121 cacgcggcga accaggcgta ccagtacggc ccaagcagcg gcggcaatgg cacgggcggc
      181 ggcggaggca tgggcgacta catggcccag gaggatgact gggaccggga cctgctgttg
      241 gacccggcct gggagaagca gcagcgcaag accttcacag cctggtgcaa ctcccatctg
      301 cggaaggctg gcactcagat cgagaacatc gatgaggatt tccgggatgg gctcaaactt
      361 atgcttctgc tggaggtcat ttcaggggag cggttgccta agccagagcg ggggaagatg
      421 cgagtgcaca agatcaacaa tgtaaacaaa gccctggact tcatcgccag caagggagtc
      481 aagctggtgt ccattggggc agaagagatc gtggatggca atgcaaagat gaccctggga
      541 atgatctgga ccatcatcct caggttcgcc atccaagaca tctctgtgga agagacctct
      601 gccaaggaag gactcctcct ctggtgccag agaaagacag ccccgtataa aaacgtcaac
      661 gtccagaact tccatatcag ctggaaggat ggtctggcct tcaacgcgct catccaccgg
      721 cacagacctg agctgattga gtatgacaaa ctgaggaagg atgatccagt caccaaccta
      781 aacaatgcat ttgaagtggc tgagaaatac cttgatatcc ccaagatgtt ggatgctgag
      841 gacatcgtga acacagcccg gcccgacgag aaggccataa tgacatatgt gtccagcttc
      901 taccatgcct tttcaggagc gcagaaggct gagactgctg ccaaccggat ctgcaaggtg
      961 ctggctgtga accaggaaaa tgagcacctg atggaagatt acgagcgcct ggccagtgat
     1021 cttctagagt ggatccggcg caccatcccc tggctggaag accgtgtgcc tcagaagacc
     1081 atccaggaga tgcagcagaa gctggaggac ttccgagact ataggcgtgt gcacaagccc
     1141 cccaaggtac aggagaagtg tcagctggag atcaacttca acaccctgca gaccaagctg
     1201 cggctgagca accggcctgc cttcatgccc tccgagggca ggatggtctc ggacatcaac
     1261 aatgggtggc aacatctgga gcaggctgag aagggctatg aagaatggct cttgaatgaa
     1321 atccgtaggc tggaacgact tgatcacctg gcagagaaat tccggcagaa ggcttccatc
     1381 catgaggcct ggaccgatgg gaaggaggcc atgctgaagc accgggacta tgagacagcc
     1441 accctgtcag acatcaaagc tctgatccga aagcatgagg cctttgagag tgacctggcg
     1501 gcgcaccagg accgcgtgga gcagatcgcg gctattgccc aggagctcaa cgaactggac
     1561 tactatgact cccacaacgt caacacacgg tgccagaaga tctgtgacca gtgggataac
     1621 ctgggctctc tgacccacag tcgcagggaa gccttggaga aaacagagaa acagctggag
     1681 accatcgacc agctacactt ggagtatgct aagcgggccg cgcccttcaa caactggatg
     1741 gagagtgcca tggaggacct gcaggacatg ttcatcgtcc acaccatcga ggagattgag
     1801 ggcctgatct cagcccacga ccagttcaag tccaccctgc cagatgccga cagggagcgt
     1861 gaggccatcc tggccatcca caaagaggcc caaaggatcg ctgagagcaa tcacatcaag
     1921 ctgtcgggca gcaaccccta caccagcgtt acaccccaga tcatcaactc caaatgggag
     1981 aaggtgcagc agctggtgcc gaagcgggac cacgcactcc tggaagagca gagcaagcag
     2041 caatccaatg agcaccttcg ccgacagttt gccagccaag ccaatatggt ggggccctgg
     2101 atccagacca agatggagga gattgggcgc atctccatcg agatgaacgg gactctggaa
     2161 gaccagctga gtcacttgaa gcagtacgag cgcagcattg tggactacaa gcccaacctg
     2221 gacttgctgg agcagcagca ccagctcatc caggaggccc tcatcttcga caacaagcac
     2281 accaactaca caatggagca cctccgtgtg ggctgggagc agctgctcac caccattgcc
     2341 cgcaccatca acgaggtaga gaatcagatc ctcacccgag atgccaaggg catcagccag
     2401 gagcaaatgc aggagttccg agcctccttc aaccactttg acaaggacca tggcggggca
     2461 ctggggcctg aggaattcaa ggcctgcctc atcagcctgg gctacgacgt ggagaatgac
     2521 cggcagggtg atgctgagtt caaccggatc atgagtgtgg tcgaccccaa ccatagtggc
     2581 ctcgtgacct tccaagcctt cattgacttc atgtcaaggg agaccacaga cacagacacc
     2641 gccgatcagg tcatcgcctc cttcaaggtc ctggccgggg acaagaactt catcactgct
     2701 gaggaacttc ggagagagct gccccctgac caggctgagt actgcatcgc ccgcatggcg
     2761 ccctaccagg gccctgatgc tgctccaggc gcccttgact acaagtcctt ctctacagcc
     2821 ctctatgggg agagcgacct gtgaggccct cagccaccct gaacagactc ccttggcctc
     2881 ccggaggggc tgaggagccc tgccccaccc tgactcagta tctatgcaaa gagctctttg
     2941 tggtccttct agggggtcag gcagggaggg gctaggcagg cctcttttct cagtctggta
     3001 ggggagatgg aggcttgtcg atcagcgctt ctggtctgct aaatatatat gttgtattgt
     3061 gggttcttag cctatatgaa aggaacaacg gacacctgag cccctctggg ccccagagac
     3121 atctttctaa acccaggtcc cctctgcccc tgaggccagc cccttcaaag cctctcacat
     3181 ccaggccaaa gccccatgtg ccttgtccag gaaccgcctg ccctaagaag tccagcagag
     3241 ggcacccagc tcccctggac cagattctag tggctcctcc cacctccctg ccctgtgtca
     3301 caccaggagc agaggacctg ccataacccc tctctgcctc cacagtggct gctggggcaa
     3361 tcgcccccgc ccacctggcc ttgtttcacc tgggctctga gtctcagatt ttctaaggac
     3421 caaaaccaac aaaacacaaa gaatggaaca gaaacaaaca aacaaaaaaa tcattaaaaa
     3481 aaaaaagaag aaagaaaaaa aaaagcttaa aaaaaatcct ataaaaaatt aaaaccttcc
     3541 agagaattac tatttacttt attaacttac ggatttatta tataaatata tatccatcta
     3601 gctgcatatc tctgccacct ctctcactct cataatgaag acatagctga ttcgctgccc
     3661 tcccagcccc ctcctgattt tccccttatg gcggtgggca ggggtctacg gggacctcct
     3721 gaggtggagg tgggcgctgg cctgcctgcc tggtcgttaa tgggtttctc tccacccacc
     3781 cccttgagtt tattctgatt gatttttatt ttcttggttt ctggataaac caccctctgg
     3841 ggatgggaga ataaaacaag taatattttt aagaaggaaa aaaaa
//
