LOCUS       NM_133424               2904 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus actinin alpha 3 (Actn3), mRNA.
ACCESSION   NM_133424
VERSION     NM_133424.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2904)
  AUTHORS   Head SI, Chan S, Houweling PJ, Quinlan KG, Murphy R, Wagner S,
            Friedrich O and North KN.
  TITLE     Altered Ca2+ kinetics associated with alpha-actinin-3 deficiency
            may explain positive selection for ACTN3 null allele in human
            evolution
  JOURNAL   PLoS Genet 11 (2), e1004862 (2015)
   PUBMED   25590636
  REMARK    Erratum:[PLoS Genet. 2015 Jun;11(6):e1005312. PMID: 26125182]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2904)
  AUTHORS   Yuan B, Wan P, Chu D, Nie J, Cao Y, Luo W, Lu S, Chen J and Yang Z.
  TITLE     A cardiomyocyte-specific Wdr1 knockout demonstrates essential
            functional roles for actin disassembly during myocardial growth and
            maintenance in mice
  JOURNAL   Am J Pathol 184 (7), 1967-1980 (2014)
   PUBMED   24840128
REFERENCE   3  (bases 1 to 2904)
  AUTHORS   Garton FC, Seto JT, Quinlan KG, Yang N, Houweling PJ and North KN.
  TITLE     alpha-Actinin-3 deficiency alters muscle adaptation in response to
            denervation and immobilization
  JOURNAL   Hum Mol Genet 23 (7), 1879-1893 (2014)
   PUBMED   24234654
REFERENCE   4  (bases 1 to 2904)
  AUTHORS   Revenu C, Ubelmann F, Hurbain I, El-Marjou F, Dingli F, Loew D,
            Delacour D, Gilet J, Brot-Laroche E, Rivero F, Louvard D and Robine
            S.
  TITLE     A new role for the architecture of microvillar actin bundles in
            apical retention of membrane proteins
  JOURNAL   Mol Biol Cell 23 (2), 324-336 (2012)
   PUBMED   22114352
REFERENCE   5  (bases 1 to 2904)
  AUTHORS   Yang N, Schindeler A, McDonald MM, Seto JT, Houweling PJ, Lek M,
            Hogarth M, Morse AR, Raftery JM, Balasuriya D, MacArthur DG, Berman
            Y, Quinlan KG, Eisman JA, Nguyen TV, Center JR, Prince RL, Wilson
            SG, Zhu K, Little DG and North KN.
  TITLE     alpha-Actinin-3 deficiency is associated with reduced bone mass in
            human and mouse
  JOURNAL   Bone 49 (4), 790-798 (2011)
   PUBMED   21784188
REFERENCE   6  (bases 1 to 2904)
  AUTHORS   Triplett JW and Pavalko FM.
  TITLE     Disruption of alpha-actinin-integrin interactions at focal
            adhesions renders osteoblasts susceptible to apoptosis
  JOURNAL   Am J Physiol Cell Physiol 291 (5), C909-C921 (2006)
   PUBMED   16807302
REFERENCE   7  (bases 1 to 2904)
  AUTHORS   Itoh S, Ding B, Shishido T, Lerner-Marmarosh N, Wang N, Maekawa N,
            Berk BC, Takeishi Y, Yan C, Blaxall BC and Abe J.
  TITLE     Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme
            in ischemic and diabetic myocardium
  JOURNAL   Circulation 113 (14), 1787-1798 (2006)
   PUBMED   16585392
REFERENCE   8  (bases 1 to 2904)
  AUTHORS   Keicher C, Gambaryan S, Schulze E, Marcus K, Meyer HE and Butt E.
  TITLE     Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and
            cGMP-dependent protein kinase
  JOURNAL   Biochem Biophys Res Commun 324 (1), 308-316 (2004)
   PUBMED   15465019
REFERENCE   9  (bases 1 to 2904)
  AUTHORS   Dixson JD, Forstner MJ and Garcia DM.
  TITLE     The alpha-actinin gene family: a revised classification
  JOURNAL   J Mol Evol 56 (1), 1-10 (2003)
   PUBMED   12569417
REFERENCE   10 (bases 1 to 2904)
  AUTHORS   Schiaffino S and Reggiani C.
  TITLE     Molecular diversity of myofibrillar proteins: gene regulation and
            functional significance
  JOURNAL   Physiol Rev 76 (2), 371-423 (1996)
   PUBMED   8618961
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF450248.1.
            
            On Aug 31, 2012 this sequence version replaced NM_133424.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF450248.1, BC166600.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2904              AF450248.1         2-2905
FEATURES             Location/Qualifiers
     source          1..2904
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2904
                     /gene="Actn3"
                     /note="actinin alpha 3"
                     /db_xref="GeneID:171009"
                     /db_xref="RGD:621792"
     exon            1..182
                     /gene="Actn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..2741
                     /gene="Actn3"
                     /codon_start=1
                     /product="alpha-actinin-3"
                     /protein_id="NP_596915.1"
                     /db_xref="GeneID:171009"
                     /db_xref="RGD:621792"
                     /translation="MMMVMQPEGLGAGEGPFSGGGGGEYMEQEEDWDRDLLLDPAWEK
                     QQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHK
                     IANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAK
                     EGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNL
                     NTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRIC
                     KVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRR
                     LHKPPRVQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYE
                     DWLLSEIRRLQRLQHLAEKFQQKASLHEAWTRGKEEMLNQHDYESASLQEVRALLRRH
                     EAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRD
                     ALERMEKLLETIDQLQLEFARRAAPFNNWLDGAIEDLQDVWLVHSVEETQSLLTAHEQ
                     FKATLPEADRERGAILGIQGEIQKICQTYGLRPKSGNPYITLSSQDINNKWDTVRKLV
                     PSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQGKVEEVGRLAAGLAGSLEEQMA
                     GLRQQEQNIINYKSNIDRLEGDHQLLQEGLVFDNKHTVYSMEHIRVGWEQLLTSIART
                     INEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKRNGMMEPDDFRACLISMGYDLGEV
                     EFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTAEQVVASFKILAGDKNYITPEEL
                     RRELPAEQAEYCIRRMAPYKGSGAPSGALDYVAFSSALYGESDL"
     exon            183..297
                     /gene="Actn3"
                     /inference="alignment:Splign:2.1.0"
     exon            298..417
                     /gene="Actn3"
                     /inference="alignment:Splign:2.1.0"
     exon            418..504
                     /gene="Actn3"
                     /inference="alignment:Splign:2.1.0"
     exon            505..592
                     /gene="Actn3"
                     /inference="alignment:Splign:2.1.0"
     exon            593..671
                     /gene="Actn3"
                     /inference="alignment:Splign:2.1.0"
     exon            672..753
                     /gene="Actn3"
                     /inference="alignment:Splign:2.1.0"
     exon            754..839
                     /gene="Actn3"
                     /inference="alignment:Splign:2.1.0"
     exon            840..932
                     /gene="Actn3"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1163
                     /gene="Actn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1311
                     /gene="Actn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1462
                     /gene="Actn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1571
                     /gene="Actn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1712
                     /gene="Actn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1895
                     /gene="Actn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2030
                     /gene="Actn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2210
                     /gene="Actn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2357
                     /gene="Actn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2423
                     /gene="Actn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2582
                     /gene="Actn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2868
                     /gene="Actn3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccagtgga gcagagccga gccaagagcc tgagcaagat gatgatggtt atgcagcccg
       61 agggtctggg ggccggggag gggcccttct ctggtggcgg gggcggtgag tacatggaac
      121 aggaggaaga ctgggaccgc gacttgctgt tggatcctgc ctgggagaaa cagcagcgga
      181 aaaccttcac tgcatggtgc aactcccatc tgcgcaaggc aggcacacag atcgagaaca
      241 ttgaagagga cttccgcaat ggcctgaagc tcatgctgct cctggaggtc atttctggag
      301 agaggctgcc caggccagac aaaggcaaga tgcgcttcca caaaatcgcc aatgtcaaca
      361 aagccctgga cttcattgcc agcaaaggag ttaagctagt gtccatcggt gctgaagaaa
      421 ttgttgacgg gaacctgaag atgaccctgg gcatgatctg gaccatcatc ctccgctttg
      481 ccattcagga catctctgta gaagagacct cagccaaaga aggcttgctt ctctggtgtc
      541 agcggaaaac agcaccatac cgcaatgtca acgtacagaa cttccatacc agctggaagg
      601 atggcctggc cctctgtgct ctcatccacc gccaccggcc agatctcatt gactatgcca
      661 agcttcgcaa ggatgacccc attggaaacc tgaacactgc ctttgaggtg gcagagaaat
      721 acctggacat ccctaagatg ctggatgcag aagatattgt gaacaccccc aaaccagatg
      781 agaaagccat catgacctat gtttcctgct tctaccatgc atttgctggg gctgagcagg
      841 cagagactgc tgccaacagg atctgcaagg tcttagctgt gaaccaggaa aacgagaagc
      901 tgatggagga gtatgagaaa ctggctagtg agctgttgga gtggatccgc cgcactgtcc
      961 catggctaga gaaccgagtg ggtgaaccca gcatgagtgc catgcagcgc aagctggagg
     1021 acttccgcga ctacaggcgc ctgcacaagc ctccccgtgt gcaggagaag tgccagctgg
     1081 agatcaactt caacacgctg cagaccaagc tgcgcctgag ccaccgacct gctttcatgc
     1141 cctcagaggg caagctggtt tcggacatag ccaatgcgtg gcggggactg gagcaggtgg
     1201 agaagggcta tgaggactgg ctgctttcag agatcaggcg tctgcagagg cttcagcacc
     1261 tggctgagaa gttccagcag aaggcttccc tgcatgaagc ttggacccgg ggcaaagagg
     1321 aaatgttaaa ccagcatgac tacgagtcag cttcgctgca ggaggtgcgt gcgctcttgc
     1381 gacgtcatga ggcctttgag agcgacttgg ctgcacatca agaccgggtg gaacacattg
     1441 cagccctggc ccaggaactc aatgagctgg actaccatga ggcagcctcg gtgaatagcc
     1501 gctgccaagc catctgcgac cagtgggata acttgggtac actgacccag aagaggaggg
     1561 atgcactaga gagaatggag aagctcctgg aaaccattga ccagctgcag ctggagtttg
     1621 ctcggcgggc agcgcccttc aacaactggc tggatggggc tattgaggac ctgcaggatg
     1681 tgtggctagt gcactctgta gaagagacgc agagcctgct aacagcacat gaacagttca
     1741 aggcaacgtt gcctgaggcg gatcgagagc gaggtgccat cctgggcatt caaggagaga
     1801 ttcagaagat ctgtcagacg tatggactgc ggccaaagtc tggcaacccc tacatcaccc
     1861 tcagctcgca ggacatcaac aataagtggg acacggtcag aaagctggta cccagccgtg
     1921 accagacact gcaggaggag ctggcccggc agcaggtgaa tgagaggctc cggcgacagt
     1981 ttgcagccca ggccaatgcc ataggaccct ggatccaggg aaaggtggag gaagtagggc
     2041 ggctggcagc tgggctggct ggctctctgg aggagcagat ggcaggtctg cgacagcagg
     2101 agcagaacat catcaattac aagagcaaca tcgaccggct ggagggtgac caccagctgc
     2161 tgcaggaggg cctagtcttt gacaacaagc acacggtcta cagcatggag cacatccgtg
     2221 tgggctggga gcagctgctc acctccattg cccgcaccat caatgaggtg gagaaccagg
     2281 tactgacccg agatgccaag ggcctgagcc aggaacagct caacgagttc cgggcatctt
     2341 tcaaccactt tgaccggaag cggaatggga tgatggaacc tgatgatttc cgagcttgcc
     2401 tcatctccat gggctatgat ctgggagagg tggagtttgc tcggatcatg accatggtgg
     2461 accccaatgc agctggggtc gtgaccttcc aagccttcat tgacttcatg acccgagaga
     2521 ctgcagagac agacacagct gaacaagttg tagcctcctt caaaatccta gcaggagaca
     2581 agaactacat taccccagaa gagctgcgga gggagctccc agccgagcag gctgagtact
     2641 gcatccgtcg gatggcaccc tacaaaggat cgggggctcc gtccggggcc ctggactacg
     2701 tggctttctc tagtgccctc tacggagaga gtgacctctg acattcttag tggagaagag
     2761 gagagggcac ttcctgtggt ggattccact gtccctcaga gcaagggctt caaatcatcc
     2821 agcaccaacc acatttctga ataaagatcg ggttgtgggc ctctcccaaa aaaaaaaaaa
     2881 aaaaaaaaaa aaaaaaaaaa aaaa
//
