LOCUS       NM_001170325            2943 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Rattus norvegicus actinin alpha 2 (Actn2), mRNA.
ACCESSION   NM_001170325 XM_001061664 XM_214499
VERSION     NM_001170325.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2943)
  AUTHORS   Wang,K., Wang,Y., Wan,H., Wang,J., Hu,L., Huang,S., Sheng,M.,
            Wu,J., Han,X., Yu,Y., Chen,P. and Chen,F.
  TITLE     Actn2 defects accelerates H9c2 hypertrophy via ERK phosphorylation
            under chronic stress
  JOURNAL   Genes Genomics 46 (9), 1013-1022 (2024)
   PUBMED   38990270
  REMARK    GeneRIF: Actn2 defects accelerates H9c2 hypertrophy via ERK
            phosphorylation under chronic stress.
REFERENCE   2  (bases 1 to 2943)
  AUTHORS   Sbai,O., Soussi,R., Bole,A., Khrestchatisky,M., Esclapez,M. and
            Ferhat,L.
  TITLE     The actin binding protein alpha-actinin-2 expression is associated
            with dendritic spine plasticity and migrating granule cells in the
            rat dentate gyrus following pilocarpine-induced seizures
  JOURNAL   Exp Neurol 335, 113512 (2021)
   PUBMED   33098872
  REMARK    GeneRIF: The actin binding protein alpha-actinin-2 expression is
            associated with dendritic spine plasticity and migrating granule
            cells in the rat dentate gyrus following pilocarpine-induced
            seizures.
REFERENCE   3  (bases 1 to 2943)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2943)
  AUTHORS   van Eldik,W., den Adel,B., Monshouwer-Kloots,J., Salvatori,D.,
            Maas,S., van der Made,I., Creemers,E.E., Frank,D., Frey,N.,
            Boontje,N., van der Velden,J., Steendijk,P., Mummery,C., Passier,R.
            and Beqqali,A.
  TITLE     Z-disc protein CHAPb induces cardiomyopathy and contractile
            dysfunction in the postnatal heart
  JOURNAL   PLoS One 12 (12), e0189139 (2017)
   PUBMED   29206857
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2943)
  AUTHORS   Qi,L., Yu,Y., Chi,X., Xu,W., Lu,D., Song,Y., Zhang,Y. and Zhang,H.
  TITLE     Kindlin-2 interacts with alpha-actinin-2 and beta1 integrin to
            maintain the integrity of the Z-disc in cardiac muscles
  JOURNAL   FEBS Lett 589 (16), 2155-2162 (2015)
   PUBMED   26143257
  REMARK    GeneRIF: Data suggest that kindlin-2 (Kind2/Fermt2) interacts with
            actin alpha 2 (Actn2) and integrin beta 1 (Itgb1) and co-localizes
            to cardiac sarcomere at Z-disc; knockdown of Kind2 leads to
            dissociation of Actn2 and Itgb1.
REFERENCE   6  (bases 1 to 2943)
  AUTHORS   Zhou,Q., Ruiz-Lozano,P., Martone,M.E. and Chen,J.
  TITLE     Cypher, a striated muscle-restricted PDZ and LIM domain-containing
            protein, binds to alpha-actinin-2 and protein kinase C
  JOURNAL   J Biol Chem 274 (28), 19807-19813 (1999)
   PUBMED   10391924
REFERENCE   7  (bases 1 to 2943)
  AUTHORS   Young,P., Ferguson,C., Banuelos,S. and Gautel,M.
  TITLE     Molecular structure of the sarcomeric Z-disk: two types of titin
            interactions lead to an asymmetrical sorting of alpha-actinin
  JOURNAL   EMBO J 17 (6), 1614-1624 (1998)
   PUBMED   9501083
REFERENCE   8  (bases 1 to 2943)
  AUTHORS   Wyszynski,M., Kharazia,V., Shanghvi,R., Rao,A., Beggs,A.H.,
            Craig,A.M., Weinberg,R. and Sheng,M.
  TITLE     Differential regional expression and ultrastructural localization
            of alpha-actinin-2, a putative NMDA receptor-anchoring protein, in
            rat brain
  JOURNAL   J Neurosci 18 (4), 1383-1392 (1998)
   PUBMED   9454847
REFERENCE   9  (bases 1 to 2943)
  AUTHORS   Kato,M., Sasaki,T., Ohya,T., Nakanishi,H., Nishioka,H., Imamura,M.
            and Takai,Y.
  TITLE     Physical and functional interaction of rabphilin-3A with
            alpha-actinin
  JOURNAL   J Biol Chem 271 (50), 31775-31778 (1996)
   PUBMED   8943213
REFERENCE   10 (bases 1 to 2943)
  AUTHORS   Schiaffino,S. and Reggiani,C.
  TITLE     Molecular diversity of myofibrillar proteins: gene regulation and
            functional significance
  JOURNAL   Physiol Rev 76 (2), 371-423 (1996)
   PUBMED   8618961
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK355337.1, DY315226.1, CK358853.1, CK600096.1, FM118105.1,
            FM123616.1 and CR461659.1.
            
            On or before Dec 18, 2009 this sequence version replaced
            XM_214499.4, XM_001061664.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760384,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-731               CK355337.1         1-731
            732-1328            DY315226.1         62-658
            1329-1937           CK358853.1         124-732
            1938-2200           CK600096.1         398-660
            2201-2779           FM118105.1         116-694
            2780-2909           FM123616.1         494-623
            2910-2943           CR461659.1         2-35                c
FEATURES             Location/Qualifiers
     source          1..2943
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.1"
     gene            1..2943
                     /gene="Actn2"
                     /note="actinin alpha 2"
                     /db_xref="GeneID:291245"
                     /db_xref="RGD:1308097"
     exon            1..315
                     /gene="Actn2"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..2874
                     /gene="Actn2"
                     /codon_start=1
                     /product="alpha-actinin-2"
                     /protein_id="NP_001163796.1"
                     /db_xref="GeneID:291245"
                     /db_xref="RGD:1308097"
                     /translation="MNQIEPGVQYNYVYDEDEYMIQEEEWDRDLLLDPAWEKQQRKTF
                     TAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNK
                     ALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLW
                     CQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEI
                     AEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVN
                     QENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPK
                     VQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNE
                     IRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESD
                     LAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERTE
                     KLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLP
                     EADGERQSILAIQNEVEKVIQSYSIRISSSNPYSTVTMDELRNKWDKVKQLVPVRDQS
                     LQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYE
                     HNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVET
                     QILTRDAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRACLISMGYDLGEAEFARIM
                     TLVDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILASDKPYILAEELRRELPP
                     DQAQYCIKRMPPYSGPGSVPGALDYTAFSSALYGESDL"
     exon            316..430
                     /gene="Actn2"
                     /inference="alignment:Splign:2.1.0"
     exon            431..550
                     /gene="Actn2"
                     /inference="alignment:Splign:2.1.0"
     exon            551..637
                     /gene="Actn2"
                     /inference="alignment:Splign:2.1.0"
     exon            638..725
                     /gene="Actn2"
                     /inference="alignment:Splign:2.1.0"
     exon            726..804
                     /gene="Actn2"
                     /inference="alignment:Splign:2.1.0"
     exon            805..886
                     /gene="Actn2"
                     /inference="alignment:Splign:2.1.0"
     exon            887..972
                     /gene="Actn2"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1065
                     /gene="Actn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1296
                     /gene="Actn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1444
                     /gene="Actn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1595
                     /gene="Actn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1704
                     /gene="Actn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1845
                     /gene="Actn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..2028
                     /gene="Actn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2163
                     /gene="Actn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2343
                     /gene="Actn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2490
                     /gene="Actn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2556
                     /gene="Actn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2715
                     /gene="Actn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..2943
                     /gene="Actn2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgagactct gcgcccaggc gtgcagcccc aggaaccgcg agaaggtcac cacagcccgc
       61 cgcctatcca tccatccatc catccatcca tccatccatc catccatcca tccatccatc
      121 catttttcta tccgtctgtc catccctcgc gctgcgctcg ctccccagtc gccccagcca
      181 cccagcgcca tgaatcagat agagcccggc gtgcagtaca actatgtcta cgacgaagat
      241 gagtacatga tccaggagga ggagtgggac cgcgacctgc tcctcgaccc ggcctgggag
      301 aagcagcaga ggaagacttt cactgcctgg tgcaactcgc acctgcgcaa agccggcacc
      361 cagatcgaga acatagagga ggatttcagg aatggcctca agctcatgct gcttctggaa
      421 gtcatctcag gggaaaggct tcccaaacct gaccggggca aaatgcggtt ccacaagatt
      481 gcgaatgtca acaaggcttt ggattacata gccagcaagg gagtgaaatt ggtatctatt
      541 ggggctgaag aaatcgtcga tggcaatgtg aagatgaccc tgggtatgat ctggaccatc
      601 atcctccgct tcgccattca ggacatctca gtggaagaaa catctgccaa agagggcctg
      661 ctgctatggt gtcagaggaa gacagcacca taccgaaatg tgaacatcca gaacttccac
      721 accagctgga aagatggcct tggactctgt gccctcatcc acagacaccg gcctgacctc
      781 atcgactact caaagcttaa caaggatgac cccataggaa acattaacct ggccatggaa
      841 atagcagaga agcacttgga tatccctaaa atgttggatg ctgaagacat tgtcaacact
      901 cccaaacccg atgaaagagc catcatgact tacgtttcct gcttctacca tgctttcgcg
      961 ggagcggagc aggccgagac ggcagctaac aggatatgta aggttcttgc tgtgaatcaa
     1021 gagaatgaga ggctgatgga agaatatgag aggctagcga gtgagctctt ggaatggatt
     1081 cgacgcacaa tcccctggct ggagaacagg acaccggaga agaccatgca agccatgcag
     1141 aagaagctgg aggacttccg ggactatcgt cgtaagcaca agcccccaaa ggtgcaggag
     1201 aagtgccagc tggagatcaa cttcaacacc ctgcagacca agcttcggat cagcaaccgg
     1261 cctgccttca tgccctccga gggcaagatg gtgtcggaca ttgctggtgc ctggcagagg
     1321 ttggagcagg ccgagaaggg ctatgaggaa tggctattga atgagattcg aagactggag
     1381 cgcttggagc acttggctga gaagttcagg cagaaggcct ccacccatga gacatgggct
     1441 tacggcaaag aacagatctt gctgcagaag gactatgagt ctgcgtccct gacggaagtt
     1501 cgagccctac ttcggaagca cgaggccttt gagagtgacc tggcggcaca ccaggatcgt
     1561 gtggaacaga ttgcagccat tgctcaggag ctcaatgaac tggactacca cgatgctgtg
     1621 aacgtcaatg atcgttgcca gaaaatttgc gaccagtggg atagattggg gacgctcacc
     1681 cagaagagga gggaggcctt ggagagaacc gagaagttgc tagaaacaat tgaccagctg
     1741 cacctggagt ttgccaagag agctgcgccc ttcaacaact ggatggaggg cgccatggag
     1801 gacctgcagg acatgttcat cgtccacagc attgaggaga tccagagtct gatcaccgca
     1861 catgagcagt tcaaggccac gctgcccgag gccgatgggg agcggcagtc catcctagcc
     1921 atccagaatg aggtggagaa ggtgatccag agctacagta tccggatcag ctccagcaac
     1981 ccctacagca ctgtcaccat ggacgagctg cgcaacaagt gggacaaggt gaagcagctg
     2041 gtgccagtcc gggatcagtc cctgcaggag gagctggcac gccaacatgc taatgagcgc
     2101 ctacggcgcc agtttgctgc ccaggccaat gccatcggcc cctggatcca gaacaagatg
     2161 gaggagatcg ctcggagctc catccagatc acaggggccc tggaggacca gatgaaccag
     2221 ctgaagcagt acgagcacaa catcatcaac tacaagaaca acattgacaa gctggagggc
     2281 gaccaccagc tcatccagga agccctggtc ttcgacaaca agcacaccaa ctacaccatg
     2341 gagcatatcc gtgtcggatg ggagttgctg ctcacaacta tcgccagaac catcaatgag
     2401 gtggagaccc agatcctgac aagagatgcc aagggcatca cccaggagca gatgaatgag
     2461 ttcagagcct ccttcaacca ctttgacagg aggaagaatg gcctgatgga tcatgaggat
     2521 ttcagagcct gcctcatttc catgggctat gacttgggtg aagctgagtt tgcccgaatt
     2581 atgactctgg ttgaccccaa cggacaaggc acggtcacct tccagtcctt cattgacttc
     2641 atgactagag agaccgcaga cacggacact gcagaacagg tcatcgcctc cttccggatt
     2701 ctggcttctg ataagcctta catcttggca gaggaacttc gtcgagagct gcctccggat
     2761 caggcccagt actgcatcaa gagaatgccc ccatactcag gcccaggcag tgtccccggg
     2821 gccctggact acactgcctt ctcctctgcc ctctacgggg agagcgacct ctgatgctct
     2881 ttctgtaacc cctgacccta tcagaacgca ataaaggctc aagtgtaggt tgttacctgg
     2941 aaa
//
