LOCUS       NM_031005               3688 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus actinin, alpha 1 (Actn1), mRNA.
ACCESSION   NM_031005
VERSION     NM_031005.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3688)
  AUTHORS   Zhou,H., Yang,Z., Mu,L. and Shi,Y.
  TITLE     Integrated Analysis of Multiple Microarray Studies to Identify Core
            Gene-Expression Signatures Involved in Tubulointerstitial Injury in
            Diabetic Nephropathy
  JOURNAL   Biomed Res Int 2022, 9554658 (2022)
   PUBMED   35592524
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3688)
  AUTHORS   Zhang,C., Wang,F., Xie,Z., Chen,L., Sinkemani,A., Yu,H. and Wu,X.
  TITLE     AMOT130 linking F-actin to YAP is involved in intervertebral disc
            degeneration
  JOURNAL   Cell Prolif 51 (6), e12492 (2018)
   PUBMED   30039887
  REMARK    GeneRIF: that a mechanism by which Hippo pathway and F-actin
            synergize to modulate YAP activation and localization in the
            context of intervertebral disc degeneration and help to control
            nucleus pulposus cells proliferation
REFERENCE   3  (bases 1 to 3688)
  AUTHORS   Matt,L., Kim,K., Hergarden,A.C., Patriarchi,T., Malik,Z.A.,
            Park,D.K., Chowdhury,D., Buonarati,O.R., Henderson,P.B., Gokcek
            Sarac,C., Zhang,Y., Mohapatra,D., Horne,M.C., Ames,J.B. and
            Hell,J.W.
  TITLE     alpha-Actinin Anchors PSD-95 at Postsynaptic Sites
  JOURNAL   Neuron 97 (5), 1094-1109 (2018)
   PUBMED   29429936
REFERENCE   4  (bases 1 to 3688)
  AUTHORS   Ogneva,I.V., Biryukov,N.S., Leinsoo,T.A. and Larina,I.M.
  TITLE     Possible role of non-muscle alpha-actinins in muscle cell
            mechanosensitivity
  JOURNAL   PLoS One 9 (4), e96395 (2014)
   PUBMED   24780915
  REMARK    GeneRIF: After 6 hours of antiorthostatic suspension alpha-actinin
            1 and alpha-actinin 4 levels decreased in the membranous fraction
            of proteins of cardiomyocytes and soleus muscle fibers.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3688)
  AUTHORS   Hao,J., Galindo,C.L., Tran,T.L. and Sawyer,D.B.
  TITLE     Neuregulin-1beta induces embryonic stem cell cardiomyogenesis via
            ErbB3/ErbB2 receptors
  JOURNAL   Biochem J 458 (2), 335-341 (2014)
   PUBMED   24364879
REFERENCE   6  (bases 1 to 3688)
  AUTHORS   Edlund,M., Lotano,M.A. and Otey,C.A.
  TITLE     Dynamics of alpha-actinin in focal adhesions and stress fibers
            visualized with alpha-actinin-green fluorescent protein
  JOURNAL   Cell Motil Cytoskeleton 48 (3), 190-200 (2001)
   PUBMED   11223950
REFERENCE   7  (bases 1 to 3688)
  AUTHORS   Bunn,R.C., Jensen,M.A. and Reed,B.C.
  TITLE     Protein interactions with the glucose transporter binding protein
            GLUT1CBP that provide a link between GLUT1 and the cytoskeleton
  JOURNAL   Mol Biol Cell 10 (4), 819-832 (1999)
   PUBMED   10198040
REFERENCE   8  (bases 1 to 3688)
  AUTHORS   Dubernard,V., Faucher,D., Launay,J.M. and Legrand,C.
  TITLE     Identification of the cytoskeletal protein alpha-actinin as a
            platelet thrombospondin-binding protein
  JOURNAL   FEBS Lett 364 (2), 109-114 (1995)
   PUBMED   7750553
REFERENCE   9  (bases 1 to 3688)
  AUTHORS   Gluck,U. and Ben-Ze'ev,A.
  TITLE     Modulation of alpha-actinin levels affects cell motility and
            confers tumorigenicity on 3T3 cells
  JOURNAL   J Cell Sci 107 (Pt 7), 1773-1782 (1994)
   PUBMED   7983147
REFERENCE   10 (bases 1 to 3688)
  AUTHORS   Sherniakov,M.A.
  TITLE     [Organization of the activities of the medical-sanitary battalion]
  JOURNAL   Voen Med Zh (11), 20-22 (1978)
   PUBMED   734925
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 30, 2020 this sequence version replaced NM_031005.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF115386.1, SRR21887622.2912627.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-358               JAXUCZ010000006.1  104825815-104826172 c
            359-473             JAXUCZ010000006.1  104773600-104773714 c
            474-593             JAXUCZ010000006.1  104769403-104769522 c
            594-680             JAXUCZ010000006.1  104763174-104763260 c
            681-768             JAXUCZ010000006.1  104761214-104761301 c
            769-847             JAXUCZ010000006.1  104760686-104760764 c
            848-929             JAXUCZ010000006.1  104757912-104757993 c
            930-1015            JAXUCZ010000006.1  104756657-104756742 c
            1016-1108           JAXUCZ010000006.1  104749078-104749170 c
            1109-1339           JAXUCZ010000006.1  104747566-104747796 c
            1340-1487           JAXUCZ010000006.1  104745433-104745580 c
            1488-1638           JAXUCZ010000006.1  104742642-104742792 c
            1639-1747           JAXUCZ010000006.1  104741527-104741635 c
            1748-1888           JAXUCZ010000006.1  104740477-104740617 c
            1889-2071           JAXUCZ010000006.1  104739005-104739187 c
            2072-2206           JAXUCZ010000006.1  104738658-104738792 c
            2207-2386           JAXUCZ010000006.1  104737569-104737748 c
            2387-2533           JAXUCZ010000006.1  104736475-104736621 c
            2534-2614           JAXUCZ010000006.1  104735436-104735516 c
            2615-2773           JAXUCZ010000006.1  104733624-104733782 c
            2774-3688           JAXUCZ010000006.1  104731485-104732399 c
FEATURES             Location/Qualifiers
     source          1..3688
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..3688
                     /gene="Actn1"
                     /note="actinin, alpha 1"
                     /db_xref="GeneID:81634"
                     /db_xref="RGD:70907"
     exon            1..358
                     /gene="Actn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..2932
                     /gene="Actn1"
                     /note="cytoskeletal protein; F-actin cross-linking
                     protein; non-muscle alpha-actinin-1"
                     /codon_start=1
                     /product="alpha-actinin-1"
                     /protein_id="NP_112267.1"
                     /db_xref="GeneID:81634"
                     /db_xref="RGD:70907"
                     /translation="MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSH
                     LRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIAS
                     KGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAP
                     YKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAERYLDI
                     PKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLM
                     EDYEKLASDLLEWIRRTIPWLENRVPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQL
                     EINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERL
                     DHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDR
                     VEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETID
                     QLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERL
                     AILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHSR
                     QQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYK
                     PKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDA
                     KGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEAEFARIMSI
                     VDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITGDELRRELPPDQ
                     AEYCIARMAPYAGPDSVPGALDYMSFSTALYGESDL"
     exon            359..473
                     /gene="Actn1"
                     /inference="alignment:Splign:2.1.0"
     exon            474..593
                     /gene="Actn1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..680
                     /gene="Actn1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..768
                     /gene="Actn1"
                     /inference="alignment:Splign:2.1.0"
     exon            769..847
                     /gene="Actn1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..929
                     /gene="Actn1"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1015
                     /gene="Actn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1108
                     /gene="Actn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1339
                     /gene="Actn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1487
                     /gene="Actn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1638
                     /gene="Actn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1747
                     /gene="Actn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1888
                     /gene="Actn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2071
                     /gene="Actn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2206
                     /gene="Actn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2386
                     /gene="Actn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2533
                     /gene="Actn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2614
                     /gene="Actn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2773
                     /gene="Actn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..3688
                     /gene="Actn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagattagg tcggagcgcg cgccccggga aggcagtccg cgagctccag ccgccgccgt
       61 cagcagcaac ctcctcgagc agagccgcgg cggaagcggg ctcaggggag cgagcccggc
      121 cccgccagcc cagcccagcc cagcccagcc cagcccaacc ctgccgactc cctccccacg
      181 cccgggtagc agccgccgtc gcctggagag aaggtggaga aagaaatcta gcccctagca
      241 cgcacgcacc atcatggacc attatgattc ccagcagacc aatgactata tgcagcctga
      301 agaggactgg gaccgggacc tgctcctgga tccggcctgg gagaagcagc agagaaagac
      361 cttcacggcc tggtgcaact cccacctgcg caaagcaggg acccagattg agaacattga
      421 agaggacttc cgagatggcc tgaagctcat gctgctcctg gaggtcatct caggtgagcg
      481 tttggccaag ccagagagag gcaagatgcg agtgcacaag atctccaacg tcaacaaggc
      541 cctggatttc atagccagca aaggggtcaa gctggtgtcc attggagctg aagaaattgt
      601 ggacgggaat gtgaagatga ccctgggcat gatctggacc atcatccttc gttttgccat
      661 ccaagacatc tctgtggaag agacatcagc taaagaaggg ttgctcctgt ggtgtcagag
      721 gaagacagcc ccatataaaa atgtcaacat ccaaaacttc cacatcagtt ggaaggatgg
      781 tcttggtttc tgtgccttga tccaccggca ccggcccgag ttgattgact atggaaagct
      841 tcgaaaggat gatccactca caaacctgaa cacagccttt gatgtggcag agagatacct
      901 ggacattcca aagatgctgg atgcagaaga catcgtcgga actgcccggc cagatgagaa
      961 agccattatg acctatgtgt ctagcttcta ccatgccttc tctggagccc agaaggcgga
     1021 aacagcagcc aatcgaatct gtaaagtgtt ggccgtcaat caagagaatg aacagcttat
     1081 ggaagactat gagaagctgg ccagtgatct gttagagtgg atccgccgca ccatcccatg
     1141 gctggagaat cgggtgcccg agaacaccat gcaggccatg cagcagaagc tggaggactt
     1201 ccgagactac cgacgcctgc acaagccgcc caaggtgcag gagaagtgcc agctggagat
     1261 caacttcaac acactgcaga ccaagctgcg gctaagcaac cggcctgcct tcatgccctc
     1321 cgagggcagg atggtctcgg atatcaacaa tgcctggggc tgcctggaac aggcagagaa
     1381 gggctacgag gagtggttgc tgaatgagat ccggaggcta gagaggttgg accacctggc
     1441 agagaagttc cggcagaagg cctccatcca tgaagcctgg acagacggca aagaagccat
     1501 gctgcggcag aaggattatg agacggccac cttgtccgag atcaaggccc tactcaagaa
     1561 gcacgaggcc tttgagagtg acctggctgc ccaccaggac cgcgtggagc agatcgcggc
     1621 cattgcccag gagcttaatg agctggacta ttatgactca ccaagtgtca acgctcgatg
     1681 ccaaaagatc tgtgaccagt gggacaatct aggggccctg actcagaagc ggagggaagc
     1741 tttagagcga acagagaagc tgctggagac catcgaccag ctatacttgg agtacgccaa
     1801 gagggctgca cccttcaaca actggatgga gggagccatg gaggaccttc aagacacctt
     1861 catcgtacat accattgagg agatccaggg actgaccaca gcccatgagc agttcaaggc
     1921 taccctcccg gatgcagaca aggagcgcct ggccatcctg ggcatccaca atgaagtgtc
     1981 caagattgtc cagacctatc atgtcaacat ggcaggcacc aacccctata caaccatcac
     2041 acctcaggag atcaatggca aatgggacca tgtacggcag ctggtgcccc ggagggacca
     2101 ggctctaaca gaggagcact cgaggcagca gcacaacgag aggttacgca agcagtttgg
     2161 ggcacaagcc aatgtcatcg gaccctggat ccagaccaag atggaggaga ttgggaggat
     2221 ctccattgag atgcacggta ccctggagga ccaactcagc cacctgcggc agtatgaaaa
     2281 gagcatcgtc aattataagc caaagattga ccagctggag ggcgaccacc agctcatcca
     2341 ggaagcactt atcttcgaca ataagcacac caactataca atggagcaca tccgtgtggg
     2401 ctgggagcag ctgctcacca ccattgccag gaccatcaat gaagtggaga accagatctt
     2461 gacccgggat gccaaaggca tcagccagga acagatgaac gaattccgag cctccttcaa
     2521 ccactttgac cgggatcact ccggcacgtt gggtcccgaa gagttcaaag cctgcctcat
     2581 cagcttgggt tatgatattg gcaacgaccc ccagggagag gcagaatttg cccggatcat
     2641 gagcattgta gacccaaacc gcttgggggt agtgacgttc caggccttca tcgacttcat
     2701 gtcccgagag acggctgaca cagatacagc ggatcaggtc atggcttcct tcaagatcct
     2761 ggctggagat aagaattaca tcaccgggga tgagctgcgc cgcgagctgc cacctgacca
     2821 agccgagtac tgcatcgcga gaatggcccc ctacgcgggc cctgactccg tgccgggtgc
     2881 tctagactac atgtccttct ccacggcgct gtacggcgag agtgacctct aacccacccc
     2941 tgcctccccc caccctggcc ttctgcgcgt gcgccccacc ctgctcctgc tccgcccagt
     3001 atggctgtct gcgtttggtt tcagctcagc caccaagggg acagagctcc gacccaggcg
     3061 gcaccgagcc tccctacccg caaagtgaca gtttacaaaa ttattttctg caaaaaagga
     3121 aaaaaaaagt tacatttaaa aaaaagttta aaaagaaaaa aaaaacaaaa aactacatat
     3181 tttattatag aaaaaaagta tttttttctc caccagtctt aaatggaaaa gaggaaaaat
     3241 taactatttg caccgaaatg tttttgttgt gacataggaa aataaccaag cacaaagtta
     3301 tattccattc tttttactga atttttttcc ttctacctgt tccatctgct gtgttcattt
     3361 ctctaatttc atgtccactt gggggtgggg taggtgggta ctcttgtcag aggcacactg
     3421 gtgcatgtgt gtttgctcgc tcacttgtcc atgagaatat tttatgatat taaagaaaac
     3481 cttttgaaat ggctgctttt caaagaagat aattcatggc ttctcatttt taagtctcct
     3541 caaaagtgtc gctggcctgt tttatgactg cagtgttgtt attgtttttt tttaaattct
     3601 gaatattgcc tattaaagat aggagaaact tggagattat gatgttgctt ggcacagact
     3661 gtattaaaac aacactccca cgagatta
//
