LOCUS       NM_012893               1237 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus actin gamma 2, smooth muscle (Actg2), mRNA.
ACCESSION   NM_012893
VERSION     NM_012893.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1237)
  AUTHORS   Li,A., Liang,L., Liang,P., Hu,Y., Xu,C., Hu,X., Shen,Y., Hu,D.,
            Li,Z. and Kamel,I.R.
  TITLE     Assessment of renal fibrosis in a rat model of unilateral ureteral
            obstruction with diffusion kurtosis imaging: Comparison with
            alpha-SMA expression and 18F-FDG PET
  JOURNAL   Magn Reson Imaging 66, 176-184 (2020)
   PUBMED   31484043
  REMARK    GeneRIF: Assessment of renal fibrosis in a rat model of unilateral
            ureteral obstruction with diffusion kurtosis imaging: Comparison
            with alpha-SMA expression and (18)F-FDG PET.
REFERENCE   2  (bases 1 to 1237)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   3  (bases 1 to 1237)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   4  (bases 1 to 1237)
  AUTHORS   Wang,H.Y., Wang,Y.J., Cui,M.J., Gu,C.M., Yang,L.Z., Zhao,Y.,
            Chen,Y., Zhao,D., Li,T.S. and Chi,B.R.
  TITLE     Hepatocyte growth factor-induced amelioration in renal interstitial
            fibrosis is associated with reduced expression of alpha-smooth
            muscle actin and transforming growth factor-beta1
  JOURNAL   Indian J Biochem Biophys 48 (5), 308-315 (2011)
   PUBMED   22165288
  REMARK    GeneRIF: Hepatocyte growth factor-induced amelioration in renal
            interstitial fibrosis is associated with reduced expression of
            alpha-smooth muscle actin and transforming growth factor-beta1
REFERENCE   5  (bases 1 to 1237)
  AUTHORS   Sun,Q., Taurin,S., Sethakorn,N., Long,X., Imamura,M., Wang,D.Z.,
            Zimmer,W.E., Dulin,N.O. and Miano,J.M.
  TITLE     Myocardin-dependent activation of the CArG box-rich smooth muscle
            gamma-actin gene: preferential utilization of a single CArG element
            through functional association with the NKX3.1 homeodomain protein
  JOURNAL   J Biol Chem 284 (47), 32582-32590 (2009)
   PUBMED   19797053
  REMARK    GeneRIF: MYOCD can discriminate among several juxtaposed CArG
            elements, presumably through its novel partnership with NKX3.1, to
            optimally transactivate the human ACTG2 promoter
REFERENCE   6  (bases 1 to 1237)
  AUTHORS   Shillingford,J.M., Miyoshi,K., Flagella,M., Shull,G.E. and
            Hennighausen,L.
  TITLE     Mouse mammary epithelial cells express the Na-K-Cl cotransporter,
            NKCC1: characterization, localization, and involvement in ductal
            development and morphogenesis
  JOURNAL   Mol Endocrinol 16 (6), 1309-1321 (2002)
   PUBMED   12040017
REFERENCE   7  (bases 1 to 1237)
  AUTHORS   McHugh,K.M. and Lessard,J.L.
  TITLE     The development expression of the rat alpha-vascular and
            gamma-enteric smooth muscle isoactins: isolation and
            characterization of a rat gamma-enteric actin cDNA
  JOURNAL   Mol Cell Biol 8 (12), 5224-5231 (1988)
   PUBMED   3244353
REFERENCE   8  (bases 1 to 1237)
  AUTHORS   Hsu,C.Y. and Frankel,F.R.
  TITLE     Effect of estrogen on the expression of mRNAs of different actin
            isoforms in immature rat uterus. Cloning of alpha-smooth muscle
            actin message
  JOURNAL   J Biol Chem 262 (20), 9594-9600 (1987)
   PUBMED   3597426
REFERENCE   9  (bases 1 to 1237)
  AUTHORS   Poliakov,L.E., Malinskii,D.M. and Kubakin,V.I.
  TITLE     [Complex evaluation of the health status indicators of military
            personnel]
  JOURNAL   Voen Med Zh (11), 15-20 (1978)
   PUBMED   734924
REFERENCE   10 (bases 1 to 1237)
  AUTHORS   Woyton,A.
  TITLE     [Toxic and sensitizing effects of epoxy resins and their hardeners
            on the human and animal body]
  JOURNAL   Pol Tyg Lek 33 (32), 1263-1264 (1978)
   PUBMED   704425
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M22323.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M22323.1, BC087689.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1237
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..1237
                     /gene="Actg2"
                     /gene_synonym="ACTGE; SMGA"
                     /note="actin gamma 2, smooth muscle"
                     /db_xref="GeneID:25365"
                     /db_xref="RGD:2027"
     exon            1..141
                     /gene="Actg2"
                     /gene_synonym="ACTGE; SMGA"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1146
                     /gene="Actg2"
                     /gene_synonym="ACTGE; SMGA"
                     /note="alpha-smooth muscle actin; alpha-actin-3; actin,
                     gamma 2, smooth muscle, enteric; gamma-2-actin; smooth
                     muscle gamma-actin; gamma-enteric smooth muscle actin"
                     /codon_start=1
                     /product="actin, gamma-enteric smooth muscle"
                     /protein_id="NP_037025.1"
                     /db_xref="GeneID:25365"
                     /db_xref="RGD:2027"
                     /translation="MCEEETTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGV
                     MVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEH
                     PTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGV
                     THNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLC
                     YVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIH
                     ETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPP
                     ERKYSVWIGGSILASLSTFQQMWISKPEYDEAGPSIVHRKCF"
     exon            142..270
                     /gene="Actg2"
                     /gene_synonym="ACTGE; SMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            271..381
                     /gene="Actg2"
                     /gene_synonym="ACTGE; SMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            382..466
                     /gene="Actg2"
                     /gene_synonym="ACTGE; SMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            467..628
                     /gene="Actg2"
                     /gene_synonym="ACTGE; SMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            629..820
                     /gene="Actg2"
                     /gene_synonym="ACTGE; SMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            821..1002
                     /gene="Actg2"
                     /gene_synonym="ACTGE; SMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1222
                     /gene="Actg2"
                     /gene_synonym="ACTGE; SMGA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccaccgcgc ccaccatgtg tgaagaagag accaccgccc ttgtgtgtga caatgggtct
       61 ggcctgtgca aggcaggctt tgcaggagac gacgctccca gggctgtctt tccctccatt
      121 gtgggccgcc ctcggcatca gggcgtgatg gtgggaatgg gccagaaaga cagctatgtg
      181 ggggacgaag cccagagcaa gcgtgggatc ctgaccctca aataccccat tgagcacggc
      241 atcatcacga actgggatga catggagaag atctggcacc actccttcta caacgagctg
      301 cgagtagcac cagaagagca cccgaccctg ctcacagagg cccccctaaa ccctaaagcc
      361 aacagggaga agatgaccca gatcatgttc gaaaccttca atgttcctgc catgtatgtt
      421 gccattcaag ctgtgctctc gctctatgca tctggccgca ccacaggcat cgtcctggat
      481 tcaggggatg gcgtcaccca caatgtcccc atctacgagg gctatgcact gccccatgcc
      541 atcatgcgtc ttgacctggc tggacgggat ctcacagact acctcatgaa aattctcaca
      601 gaaagaggct attcctttgt gaccacagct gagagagaaa ttgtgcgaga catcaaggag
      661 aagctgtgct acgtagccct ggattttgag aatgagatgg ccacggcggc ttcgtcttct
      721 tccctggaga agagctacga gttgcctgat gggcaggtca tcacgattgg caatgagcgc
      781 ttccgctgcc cggagaccct gttccagcct tccttcattg gcatggagtc agctggaatt
      841 catgagacaa catacaattc catcatgaag tgtgacattg acatccgcaa ggatttgtat
      901 gctaacaatg tcctctctgg gggcactacc atgtaccctg ggattgctga caggatgcag
      961 aaggagatca cagccttggc tcccagcacc atgaagatca agatcatcgc tcctccggag
     1021 cggaagtact cagtctggat tggaggctcc atcctggctt ctctctccac cttccagcaa
     1081 atgtggatca gcaagccaga gtatgatgaa gcggggccct ccattgtcca caggaaatgc
     1141 ttctaaagtc acagggcctt ctctggggat ccctgcaaga ctgctgtcac cagtcacaga
     1201 tcattaaaac cttcaagcct taaaaaaaaa aaaaaaa
//
