LOCUS       NM_019183               1489 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus actin, alpha, cardiac muscle 1 (Actc1), mRNA.
ACCESSION   NM_019183 XM_215801
VERSION     NM_019183.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1489)
  AUTHORS   Biesemann,C., Gronborg,M., Luquet,E., Wichert,S.P., Bernard,V.,
            Bungers,S.R., Cooper,B., Varoqueaux,F., Li,L., Byrne,J.A.,
            Urlaub,H., Jahn,O., Brose,N. and Herzog,E.
  TITLE     Proteomic screening of glutamatergic mouse brain synaptosomes
            isolated by fluorescence activated sorting
  JOURNAL   EMBO J 33 (2), 157-170 (2014)
   PUBMED   24413018
REFERENCE   2  (bases 1 to 1489)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   3  (bases 1 to 1489)
  AUTHORS   Galic,M., Jeong,S., Tsai,F.C., Joubert,L.M., Wu,Y.I., Hahn,K.M.,
            Cui,Y. and Meyer,T.
  TITLE     External push and internal pull forces recruit curvature-sensing
            N-BAR domain proteins to the plasma membrane
  JOURNAL   Nat Cell Biol 14 (8), 874-881 (2012)
   PUBMED   22750946
REFERENCE   4  (bases 1 to 1489)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   5  (bases 1 to 1489)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   6  (bases 1 to 1489)
  AUTHORS   Olson,T.M., Michels,V.V., Thibodeau,S.N., Tai,Y.S. and Keating,M.T.
  TITLE     Actin mutations in dilated cardiomyopathy, a heritable form of
            heart failure
  JOURNAL   Science 280 (5364), 750-752 (1998)
   PUBMED   9563954
REFERENCE   7  (bases 1 to 1489)
  AUTHORS   Kumar,A., Crawford,K., Close,L., Madison,M., Lorenz,J.,
            Doetschman,T., Pawlowski,S., Duffy,J., Neumann,J., Robbins,J.,
            Boivin,G.P., O'Toole,B.A. and Lessard,J.L.
  TITLE     Rescue of cardiac alpha-actin-deficient mice by enteric smooth
            muscle gamma-actin
  JOURNAL   Proc Natl Acad Sci U S A 94 (9), 4406-4411 (1997)
   PUBMED   9114002
REFERENCE   8  (bases 1 to 1489)
  AUTHORS   Mayer,Y., Czosnek,H., Zeelon,P.E., Yaffe,D. and Nudel,U.
  TITLE     Expression of the genes coding for the skeletal muscle and cardiac
            actions in the heart
  JOURNAL   Nucleic Acids Res 12 (2), 1087-1100 (1984)
   PUBMED   6546444
REFERENCE   9  (bases 1 to 1489)
  AUTHORS   Howie,L.J. and Drury,T.F.
  TITLE     Current estimates from the Health Interview Survey: United
            States--1977
  JOURNAL   Vital Health Stat 10 (126), 1-98 (1978)
   PUBMED   734919
REFERENCE   10 (bases 1 to 1489)
  AUTHORS   Falicki,Z., Pilasiewicz,B. and Pawlowicz,B.
  TITLE     [Analysis of written enunciations of a patient as the basis for
            diagnosing schizophrenia]
  JOURNAL   Pol Tyg Lek 33 (32), 1259-1260 (1978)
   PUBMED   704424
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK356511.1, CF109672.1, AI706373.1 and AI603593.1.
            
            On Oct 23, 2005 this sequence version replaced XM_215801.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127451.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-711               CK356511.1         1-711
            712-1109            CF109672.1         566-963
            1110-1117           AI706373.1         392-399             c
            1118-1489           AI603593.1         19-390              c
FEATURES             Location/Qualifiers
     source          1..1489
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..1489
                     /gene="Actc1"
                     /note="actin, alpha, cardiac muscle 1"
                     /db_xref="GeneID:29275"
                     /db_xref="RGD:2026"
     exon            1..163
                     /gene="Actc1"
                     /inference="alignment:Splign:2.1.0"
     exon            164..321
                     /gene="Actc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1326
                     /gene="Actc1"
                     /note="alpha-actin cardiac; alpha-cardiac actin; actin,
                     alpha, cardiac 1"
                     /codon_start=1
                     /product="actin, alpha cardiac muscle 1"
                     /protein_id="NP_062056.1"
                     /db_xref="GeneID:29275"
                     /db_xref="RGD:2026"
                     /translation="MCDDEETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQG
                     VMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEE
                     HPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDG
                     VTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKL
                     CYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGI
                     HETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAP
                     PERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF"
     exon            322..646
                     /gene="Actc1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..808
                     /gene="Actc1"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1000
                     /gene="Actc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1182
                     /gene="Actc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1489
                     /gene="Actc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaccaaataa ggcaaggtgg cagctcaggg gccctccacc cctgcccccg gctgctccaa
       61 ctgaccccgt ccatcagcgc gctataaagc cgcgctccag gcgactgtca cctagtgcct
      121 gccaccagcg ccagcccagc tgaacccagc cgcccaaagc acgcctacag atcccacaga
      181 agctgtacca ggatgtgtga cgacgaggag accacagctt tggtgtgcga caatggctcc
      241 ggactggtga aggctggctt tgcgggtgat gatgctccca gagctgtctt cccatccatc
      301 gtgggtcgcc cacgccacca gggtgtcatg gtaggtatgg ggcagaaaga ctcctatgta
      361 ggtgacgagg ctcagagcaa gcgaggcatc ctgactctga agtaccccat agagcacggc
      421 attatcacca actgggacga catggagaag atctggcacc acaccttcta caatgagctc
      481 cgtgtggccc ctgaggagca cccgaccctg ctcactgagg ccccactgaa ccccaaggcc
      541 aaccgtgaga agatgacaca gatcatgttt gagaccttca atgtgcctgc catgtatgtg
      601 gccatccagg cggtgctgtc cctgtacgct tctgggagaa ccacaggcat tgttctggat
      661 tctggcgacg gtgtgactca taacgtcccc atctatgagg gttatgcctt accccatgcc
      721 atcatgcgtc tggatctagc tggtcgggac ctcactgact accttatgaa gatcctcact
      781 gagcgcgggt actcctttgt caccaccgct gaacgtgaaa ttgtccgaga catcaaagaa
      841 aaactgtgtt atgtcgccct ggattttgag aatgagatgg ccaccgctgc atcttcctcc
      901 tctctggaga agagctacga acttcccgat ggccaggtca tcaccattgg caacgagcgt
      961 ttccgctgtc ctgagactct cttccagccc tctttcattg gtatggagtc tgccggcatt
     1021 cacgaaacta cttataacag catcatgaag tgtgacatcg atatccgcaa agacctgtac
     1081 gccaacaatg tcctgtctgg aggcaccacc atgtaccctg ggattgctga tcgtatgcaa
     1141 aaggaaataa ctgcactggc tcccagcacc atgaagatta agattattgc tccccctgag
     1201 cgtaaatact ctgtctggat tgggggctcc atcctggcct ctctgtctac cttccaacaa
     1261 atgtggatca gcaagcaaga gtacgatgag gccgggccct ccattgtcca ccgcaagtgc
     1321 ttctgaggcg gctaccttac actcaggacg acagtattgt gcttggaatc ctctgaggcc
     1381 ctctcccatc tcccatcagt cattgtacag tttgtttaca cacgtgcagt ttgtttgtgc
     1441 ttcaaatatt tattgcttta taaataaacc agaccaggac ttgcaacct
//
