LOCUS       NM_031144               1293 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus actin, beta (Actb), mRNA.
ACCESSION   NM_031144
VERSION     NM_031144.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1293)
  AUTHORS   Yang,C., Zhang,X., Ge,X., He,C., Liu,S., Yang,S. and Huang,C.
  TITLE     N-Acetylcysteine protects against cobalt chloride-induced
            endothelial dysfunction by enhancing glucose-6-phosphate
            dehydrogenase activity
  JOURNAL   FEBS Open Bio 12 (8), 1475-1488 (2022)
   PUBMED   35666067
REFERENCE   2  (bases 1 to 1293)
  AUTHORS   Soliman,M.M., Aldhahrani,A., Gaber,A., Alsanie,W.F., Shukry,M.,
            Mohamed,W.A., Metwally,M.M.M. and Mohamed,A.A.
  TITLE     Impacts of n-acetyl cysteine on gibberellic acid-induced testicular
            dysfunction through regulation of inflammatory cytokines, steroid
            and antioxidant activity
  JOURNAL   Andrologia 53 (5), e14036 (2021)
   PUBMED   33724537
REFERENCE   3  (bases 1 to 1293)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1293)
  AUTHORS   Zhou,F., Chen,X., Chen,G., Yan,J. and Xiao,Y.
  TITLE     Identification of SAA and ACTB as potential biomarker of patients
            with severe HFMD using iTRAQ quantitative proteomics
  JOURNAL   Clin Biochem 67, 1-6 (2019)
   PUBMED   30817906
REFERENCE   5  (bases 1 to 1293)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   6  (bases 1 to 1293)
  AUTHORS   Park,F., Mattson,D.L., Roberts,L.A. and Cowley,A.W. Jr.
  TITLE     Evidence for the presence of smooth muscle alpha-actin within
            pericytes of the renal medulla
  JOURNAL   Am J Physiol 273 (5), R1742-R1748 (1997)
   PUBMED   9374818
REFERENCE   7  (bases 1 to 1293)
  AUTHORS   Shartava,A., Korn,W., Shah,A.K. and Goodman,S.R.
  TITLE     Irreversibly sickled cell beta-actin: defective filament formation
  JOURNAL   Am J Hematol 55 (2), 97-103 (1997)
   PUBMED   9209005
REFERENCE   8  (bases 1 to 1293)
  AUTHORS   Toyama,S. and Toyama,S.
  TITLE     A variant form of beta-actin in a mutant of KB cells resistant to
            cytochalasin B
  JOURNAL   Cell 37 (2), 609-614 (1984)
   PUBMED   6202424
REFERENCE   9  (bases 1 to 1293)
  AUTHORS   Nudel,U., Zakut,R., Shani,M., Neuman,S., Levy,Z. and Yaffe,D.
  TITLE     The nucleotide sequence of the rat cytoplasmic beta-actin gene
  JOURNAL   Nucleic Acids Res 11 (6), 1759-1771 (1983)
   PUBMED   6300777
REFERENCE   10 (bases 1 to 1293)
  AUTHORS   Bonham,G.S.
  TITLE     Prevalence of chronic skin and musculoskeletal conditions. United
            States-1976
  JOURNAL   Vital Health Stat 10 (124), i-iv,1-57 (1978)
   PUBMED   734918
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC063166.1.
            
            On Aug 31, 2012 this sequence version replaced NM_031144.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063166.1, FQ231503.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1293              BC063166.1         4-1296
FEATURES             Location/Qualifiers
     source          1..1293
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..1293
                     /gene="Actb"
                     /gene_synonym="Actx"
                     /note="actin, beta"
                     /db_xref="GeneID:81822"
                     /db_xref="RGD:628837"
     exon            1..72
                     /gene="Actb"
                     /gene_synonym="Actx"
                     /inference="alignment:Splign:2.1.0"
     exon            73..201
                     /gene="Actb"
                     /gene_synonym="Actx"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1206
                     /gene="Actb"
                     /gene_synonym="Actx"
                     /note="beta-actin; cytoplasmic beta-actin"
                     /codon_start=1
                     /product="actin, cytoplasmic 1"
                     /protein_id="NP_112406.1"
                     /db_xref="GeneID:81822"
                     /db_xref="RGD:628837"
                     /translation="MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVM
                     VGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHP
                     VLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVT
                     HTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCY
                     VALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHE
                     TTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPE
                     RKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF"
     exon            202..441
                     /gene="Actb"
                     /gene_synonym="Actx"
                     /inference="alignment:Splign:2.1.0"
     exon            442..880
                     /gene="Actb"
                     /gene_synonym="Actx"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1062
                     /gene="Actb"
                     /gene_synonym="Actx"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1264
                     /gene="Actb"
                     /gene_synonym="Actx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgagtccg cgtccacccg cgagtacaac cttcttgcag ctcctccgtc gccggtccac
       61 acccgccacc agttcgccat ggatgacgat atcgctgcgc tcgtcgtcga caacggctcc
      121 ggcatgtgca aggccggctt cgcgggcgac gatgctcccc gggccgtctt cccctccatc
      181 gtgggccgcc ctaggcacca gggtgtgatg gtgggtatgg gtcagaagga ctcctacgtg
      241 ggcgacgagg cccagagcaa gagaggcatc ctgaccctga agtaccccat tgaacacggc
      301 attgtcacca actgggacga tatggagaag atttggcacc acactttcta caatgagctg
      361 cgtgtggccc ctgaggagca ccctgtgctg ctcaccgagg cccctctgaa ccctaaggcc
      421 aaccgtgaaa agatgaccca gatcatgttt gagaccttca acaccccagc catgtacgta
      481 gccatccagg ctgtgttgtc cctgtatgcc tctggtcgta ccactggcat tgtgatggac
      541 tccggagacg gggtcaccca cactgtgccc atctatgagg gttacgcgct ccctcatgcc
      601 atcctgcgtc tggacctggc tggccgggac ctgacagact acctcatgaa gatcctgacc
      661 gagcgtggct acagcttcac caccacagct gagagggaaa tcgtgcgtga cattaaagag
      721 aagctgtgct atgttgccct agacttcgag caagagatgg ccactgccgc atcctcttcc
      781 tccctggaga agagctatga gctgcctgac ggtcaggtca tcactatcgg caatgagcgg
      841 ttccgatgcc ccgaggctct cttccagcct tccttcctgg gtatggaatc ctgtggcatc
      901 catgaaacta cattcaattc catcatgaag tgtgacgttg acatccgtaa agacctctat
      961 gccaacacag tgctgtctgg tggcaccacc atgtacccag gcattgctga caggatgcag
     1021 aaggagatta ctgccctggc tcctagcacc atgaagatca agatcattgc tcctcctgag
     1081 cgcaagtact ctgtgtggat tggtggctct atcctggcct cactgtccac cttccagcag
     1141 atgtggatca gcaagcagga gtacgatgag tccggcccct ccatcgtgca ccgcaaatgc
     1201 ttctaggcgg actgttactg agctgcgttt tacacccttt ctttgacaaa acctaacttg
     1261 cgcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
