LOCUS       NM_031004               1412 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus actin alpha 2, smooth muscle (Acta2), mRNA.
ACCESSION   NM_031004 XM_001079913
VERSION     NM_031004.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1412)
  AUTHORS   Ali,E.M.T., El-Sayed,S.M. and Elbastawisy,Y.M.
  TITLE     Ultrastructural aberrations, histological disruption and
            upregulation of the VEGF, CD34 and ASMA immunoexpression in the
            myocardium of anemic albino rats
  JOURNAL   Acta Histochem 123 (5), 151731 (2021)
   PUBMED   34052675
  REMARK    GeneRIF: Ultrastructural aberrations, histological disruption and
            upregulation of the VEGF, CD34 and ASMA immunoexpression in the
            myocardium of anemic albino rats.
REFERENCE   2  (bases 1 to 1412)
  AUTHORS   Ren,M., Wang,T., Wei,X., Wang,Y., Ouyang,C., Xie,Y., Ye,X. and
            Han,Z.
  TITLE     LncRNA H19 regulates smooth muscle cell functions and participates
            in the development of aortic dissection through sponging
            miR-193b-3p
  JOURNAL   Biosci Rep 41 (1) (2021)
   PUBMED   33403385
REFERENCE   3  (bases 1 to 1412)
  AUTHORS   Xian,S., Chen,A., Wu,X., Lu,C., Wu,Y., Huang,F. and Zeng,Z.
  TITLE     Activation of activin/Smad2 and 3 signaling pathway and
            the&nbsp;potential involvement of endothelial-mesenchymal
            transition in the valvular damage due to rheumatic heart disease
  JOURNAL   Mol Med Rep 23 (1) (2021)
   PUBMED   33179113
REFERENCE   4  (bases 1 to 1412)
  AUTHORS   Spade,D.J., Hall,S.J., Wortzel,J.D., Reyes,G. and Boekelheide,K.
  TITLE     All-trans Retinoic Acid Disrupts Development in Ex Vivo Cultured
            Fetal Rat Testes. II: Modulation of Mono-(2-ethylhexyl) Phthalate
            Toxicity
  JOURNAL   Toxicol Sci 168 (1), 149-159 (2019)
   PUBMED   30476341
REFERENCE   5  (bases 1 to 1412)
  AUTHORS   Minocha,E., Chaturvedi,C.P. and Nityanand,S.
  TITLE     Renogenic characterization and in vitro differentiation of rat
            amniotic fluid stem cells into renal proximal tubular- and
            juxtaglomerular-like cells
  JOURNAL   In Vitro Cell Dev Biol Anim 55 (2), 138-147 (2019)
   PUBMED   30645697
REFERENCE   6  (bases 1 to 1412)
  AUTHORS   Shah,N.M., Groves,A.K. and Anderson,D.J.
  TITLE     Alternative neural crest cell fates are instructively promoted by
            TGFbeta superfamily members
  JOURNAL   Cell 85 (3), 331-343 (1996)
   PUBMED   8616889
REFERENCE   7  (bases 1 to 1412)
  AUTHORS   Hsu,C.Y. and Frankel,F.R.
  TITLE     Conserved and unique sequences in the 3'-untranslated region of rat
            smooth-muscle alpha-actin mRNA
  JOURNAL   Gene 69 (2), 345-348 (1988)
   PUBMED   3234770
REFERENCE   8  (bases 1 to 1412)
  AUTHORS   McHugh,K.M. and Lessard,J.L.
  TITLE     The nucleotide sequence of a rat vascular smooth muscle alpha-actin
            cDNA
  JOURNAL   Nucleic Acids Res 16 (9), 4167 (1988)
   PUBMED   3375082
REFERENCE   9  (bases 1 to 1412)
  AUTHORS   Hsu,C.Y. and Frankel,F.R.
  TITLE     Effect of estrogen on the expression of mRNAs of different actin
            isoforms in immature rat uterus. Cloning of alpha-smooth muscle
            actin message
  JOURNAL   J Biol Chem 262 (20), 9594-9600 (1987)
   PUBMED   3597426
REFERENCE   10 (bases 1 to 1412)
  AUTHORS   Mayer,Y., Czosnek,H., Zeelon,P.E., Yaffe,D. and Nudel,U.
  TITLE     Expression of the genes coding for the skeletal muscle and cardiac
            actions in the heart
  JOURNAL   Nucleic Acids Res 12 (2), 1087-1100 (1984)
   PUBMED   6546444
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN934985.1, CB608976.1, BI287899.1 and BI282383.1.
            
            On May 25, 2007 this sequence version replaced NM_031004.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158550.1, SRR8487226.75077.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-700               DN934985.1         30-729
            701-909             CB608976.1         296-504
            910-1374            BI287899.1         18-482              c
            1375-1412           BI282383.1         1-38                c
FEATURES             Location/Qualifiers
     source          1..1412
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..1412
                     /gene="Acta2"
                     /note="actin alpha 2, smooth muscle"
                     /db_xref="GeneID:81633"
                     /db_xref="RGD:621676"
     exon            1..34
                     /gene="Acta2"
                     /inference="alignment:Splign:2.1.0"
     exon            35..186
                     /gene="Acta2"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1191
                     /gene="Acta2"
                     /note="alpha-actin-2; smooth muscle alpha-actin; actin,
                     alpha 2, smooth muscle, aorta"
                     /codon_start=1
                     /product="actin, aortic smooth muscle"
                     /protein_id="NP_112266.1"
                     /db_xref="GeneID:81633"
                     /db_xref="RGD:621676"
                     /translation="MCEEEDSTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQG
                     VMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEE
                     HPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDG
                     VTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKL
                     CYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGI
                     HETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAP
                     PERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF"
     exon            187..315
                     /gene="Acta2"
                     /inference="alignment:Splign:2.1.0"
     exon            316..426
                     /gene="Acta2"
                     /inference="alignment:Splign:2.1.0"
     exon            427..511
                     /gene="Acta2"
                     /inference="alignment:Splign:2.1.0"
     exon            512..673
                     /gene="Acta2"
                     /inference="alignment:Splign:2.1.0"
     exon            674..865
                     /gene="Acta2"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1047
                     /gene="Acta2"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1395
                     /gene="Acta2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagagtgga gaagcccagc cagtcgccat caggaacctc gagaagctgc tccagctatg
       61 tgtgaagagg aagacagcac agctctggtg tgtgacaatg gctccgggct ctgtaaggcg
      121 ggctttgctg gtgatgatgc tcccagggct gttttcccat ccatcgtggg acgtcccaga
      181 caccagggag tgatggttgg aatgggccaa aaggacagct atgtggggga cgaagcgcag
      241 agcaagagag ggatcctgac cctgaagtat ccgatagaac acggcatcat caccaactgg
      301 gacgacatgg aaaagatctg gcaccactcc ttctataacg agcttcgcgt ggccccagag
      361 gagcatccga ccttgctaac ggaggcgccg ctgaacccta aggccaaccg ggagaaaatg
      421 acccagatta tgtttgagac cttcaatgtc cctgccatgt atgtggctat tcaggctgtg
      481 ctgtccctct atgcttctgg acgtacaact ggtattgtgc tggactctgg agatggcgtg
      541 actcacaacg tgcctatcta tgagggctat gctctgcctc atgccatcat gcgtctggac
      601 ttggctggcc gagatctcac cgactacctc atgaagatcc tgactgagcg tggctattcc
      661 ttcgtgacta ctgctgagcg tgagatcgtc cgtgacatca aggagaagct gtgctatgtc
      721 gctctggact ttgaaaatga gatggccact gctgcttcct cttcttccct ggagaagagc
      781 tacgaactgc ctgatgggca ggtgatcacc atcgggaatg aacgcttccg ctgcccggag
      841 accctcttcc agccatcttt cattggaatg gagtcggcgg gcatccacga aaccacctat
      901 aacagcatca tgaagtgtga tattgacatc aggaaggacc tctatgctaa caacgtcctc
      961 tcggggggca ctaccatgta cccaggcatt gctgacagga tgcagaagga gatcacagcc
     1021 ctcgctccca gcaccatgaa gatcaagatt attgctcctc cagaacgcaa atattctgtc
     1081 tggatcggcg gctccatcct ggcttctcta tctaccttcc agcagatgtg gatcagcaaa
     1141 caggagtatg acgaagctgg cccctccatt gtccaccgca aatgcttcta agtcacgccc
     1201 ccaccctccg ccccgccccc acccccgccc cgcccccgct ctgtctctag cacacaactg
     1261 tgaatgtttt gtggatcagc gccttcagtt cttttccaaa tcattcctac ctaaagcttt
     1321 gatttgttac tcgtgtgttt ttttttaata aatcagacat gtgctaccct tctagccctg
     1381 gcctgtcaac cctgaaaaaa aaaaaaaaaa aa
//
