LOCUS       NM_019212               1452 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus actin, alpha 1, skeletal muscle (Acta1), mRNA.
ACCESSION   NM_019212
VERSION     NM_019212.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1452)
  AUTHORS   Li,B., Wang,Z., Hu,Z., Zhang,M., Ren,Z., Zhou,Z., Huang,J. and
            Hu,X.
  TITLE     P38 MAPK Signaling Pathway Mediates Angiotensin II-Induced
            miR143/145 Gene Cluster Downregulation during Aortic Dissection
            Formation
  JOURNAL   Ann Vasc Surg 40, 262-273 (2017)
   PUBMED   28167124
REFERENCE   2  (bases 1 to 1452)
  AUTHORS   Lai,C.F., Lin,S.L., Chiang,W.C., Chen,Y.M., Wu,V.C., Young,G.H.,
            Ko,W.J., Kuo,M.L., Tsai,T.J. and Wu,K.D.
  TITLE     Blockade of cysteine-rich protein 61 attenuates renal inflammation
            and fibrosis after ischemic kidney injury
  JOURNAL   Am J Physiol Renal Physiol 307 (5), F581-F592 (2014)
   PUBMED   24920753
REFERENCE   3  (bases 1 to 1452)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   4  (bases 1 to 1452)
  AUTHORS   Barua,B., Fagnant,P.M., Winkelmann,D.A., Trybus,K.M. and
            Hitchcock-DeGregori,S.E.
  TITLE     A periodic pattern of evolutionarily conserved basic and acidic
            residues constitutes the binding interface of actin-tropomyosin
  JOURNAL   J Biol Chem 288 (14), 9602-9609 (2013)
   PUBMED   23420843
  REMARK    GeneRIF: analysis of the pattern of of evolutionarily conserved
            basic and acidic residues that constitutes the binding interface of
            actin-tropomyosin
REFERENCE   5  (bases 1 to 1452)
  AUTHORS   Costell,M.H., Ancellin,N., Bernard,R.E., Zhao,S., Upson,J.J.,
            Morgan,L.A., Maniscalco,K., Olzinski,A.R., Ballard,V.L., Herry,K.,
            Grondin,P., Dodic,N., Mirguet,O., Bouillot,A., Gellibert,F.,
            Coatney,R.W., Lepore,J.J., Jucker,B.M., Jolivette,L.J.,
            Willette,R.N., Schnackenberg,C.G. and Behm,D.J.
  TITLE     Comparison of soluble guanylate cyclase stimulators and activators
            in models of cardiovascular disease associated with oxidative
            stress
  JOURNAL   Front Pharmacol 3, 128 (2012)
   PUBMED   22783192
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1452)
  AUTHORS   van der Ven,P.F., Schaart,G., Jap,P.H., Sengers,R.C.,
            Stadhouders,A.M. and Ramaekers,F.C.
  TITLE     Differentiation of human skeletal muscle cells in culture:
            maturation as indicated by titin and desmin striation
  JOURNAL   Cell Tissue Res 270 (1), 189-198 (1992)
   PUBMED   1423520
REFERENCE   7  (bases 1 to 1452)
  AUTHORS   Garner,I., Sassoon,D., Vandekerckhove,J., Alonso,S. and
            Buckingham,M.E.
  TITLE     A developmental study of the abnormal expression of alpha-cardiac
            and alpha-skeletal actins in the striated muscle of a mutant mouse
  JOURNAL   Dev Biol 134 (1), 236-245 (1989)
   PUBMED   2731651
REFERENCE   8  (bases 1 to 1452)
  AUTHORS   Zakut,R., Shani,M., Givol,D., Neuman,S., Yaffe,D. and Nudel,U.
  TITLE     Nucleotide sequence of the rat skeletal muscle actin gene
  JOURNAL   Nature 298 (5877), 857-859 (1982)
   PUBMED   6287276
REFERENCE   9  (bases 1 to 1452)
  AUTHORS   Bonham,G.S.
  TITLE     Prevalence of chronic skin and musculoskeletal conditions. United
            States-1976
  JOURNAL   Vital Health Stat 10 (124), i-iv,1-57 (1978)
   PUBMED   734918
REFERENCE   10 (bases 1 to 1452)
  AUTHORS   Bielecki,M., Czechlowski,B., Kunicki,R., Tobolska,E. and
            Zelechowski,Z.
  TITLE     [Mucosal relief of the cardia in cases of carcinoma (author's
            transl)]
  JOURNAL   Pol Przegl Radiol Med Nukl 42 (2), 91-97 (1978)
   PUBMED   704397
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On May 26, 2021 this sequence version replaced NM_019212.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ215790.1, FQ224323.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                JAXUCZ010000019.1  68784134-68784194   c
            62-202              JAXUCZ010000019.1  68783012-68783152   c
            203-527             JAXUCZ010000019.1  68782591-68782915   c
            528-689             JAXUCZ010000019.1  68782240-68782401   c
            690-881             JAXUCZ010000019.1  68781950-68782141   c
            882-1063            JAXUCZ010000019.1  68781633-68781814   c
            1064-1452           JAXUCZ010000019.1  68781168-68781556   c
FEATURES             Location/Qualifiers
     source          1..1452
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1452
                     /gene="Acta1"
                     /note="actin, alpha 1, skeletal muscle"
                     /db_xref="GeneID:29437"
                     /db_xref="RGD:2025"
     exon            1..61
                     /gene="Acta1"
                     /inference="alignment:Splign:2.1.0"
     exon            62..202
                     /gene="Acta1"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1207
                     /gene="Acta1"
                     /note="alpha-actin-1; actin alpha 1"
                     /codon_start=1
                     /product="actin, alpha skeletal muscle"
                     /protein_id="NP_062085.1"
                     /db_xref="GeneID:29437"
                     /db_xref="RGD:2025"
                     /translation="MCDEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQG
                     VMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEE
                     HPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDG
                     VTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKL
                     CYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGI
                     HETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAP
                     PERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF"
     exon            203..527
                     /gene="Acta1"
                     /inference="alignment:Splign:2.1.0"
     exon            528..689
                     /gene="Acta1"
                     /inference="alignment:Splign:2.1.0"
     exon            690..881
                     /gene="Acta1"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1063
                     /gene="Acta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1452
                     /gene="Acta1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacacggacg tgaagcctca cttcctaccc tcggcaccca gggccagagt cagagcagca
       61 gaaactagac accatgtgtg acgaggacga gaccaccgct cttgtgtgtg acaacggctc
      121 tggcctggtg aaagctggct ttgccgggga tgatgccccc agggctgtgt tcccatccat
      181 cgtgggtcgg ccccgtcacc agggtgtcat ggtcggtatg ggtcagaagg attcctacgt
      241 gggcgacgag gcccagagca agcgaggtat cctgaccctg aagtacccca ttgaacacgg
      301 cattatcacc aactgggacg acatggagaa gatctggcac cacaccttct acaatgagct
      361 gcgtgtggcc cccgaggagc acccgaccct gctcactgag gcccctttga accccaaagc
      421 taaccgggag aagatgactc aaatcatgtt tgagaccttc aacgtgcctg ctatgtatgt
      481 ggctattcag gcggtgctgt ctctctatgc ctccggccgt accaccggca tcgtgttgga
      541 ttctggggac ggtgtcaccc acaacgtgcc catctatgag ggttatgccc tgccacacgc
      601 catcatgcgt ctggacctgg ctggtcgcga ccttactgac tacctgatga aaatcctcac
      661 cgagcgtggc tattccttcg tgaccacagc tgaacgtgag attgtgcgcg acatcaaaga
      721 gaagctgtgc tacgtggccc tggacttcga gaatgagatg gccaccgctg cctcttcctc
      781 ctccctggaa aagagctatg agctgcctga cgggcaggtc atcaccatcg gcaatgagcg
      841 cttccgttgc ccggagacgc tcttccagcc ttcctttatc ggtatggagt ctgcggggat
      901 ccatgagacc acctacaaca gcatcatgaa gtgcgacatc gacatcagga aggacctgta
      961 cgccaacaac gtcatgtcag ggggcactac catgtacccc ggtatcgctg accgcatgca
     1021 gaaggagatc acagctctgg ctcccagcac catgaagatc aagatcatcg ccccccctga
     1081 gcgcaagtac tcagtgtgga tcggcggctc catcctggcc tcgctgtcca ccttccagca
     1141 gatgtggatc accaagcagg agtacgacga ggccggcccc tccattgtgc accgcaaatg
     1201 cttctaggcg cacccgcgtc tgtgtacgcg ctctctctcc tcaggacgac aatcgaccat
     1261 cgtgctatgg ttgcagggtg gccccatcct ccgccgtggc tccatcgccg ccactgcagc
     1321 cggcgcctgt ttttgacgtg tacatagatt cactcgtttt acctcatttt gttatttttc
     1381 aaacaaagcc ctgtggaagg aaatggaaaa cttgaagcat taaagccagc cattctgttt
     1441 tgctccaata aa
//
