LOCUS       NM_001414941            4774 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus acyl-CoA synthetase short-chain family member 3
            (Acss3), transcript variant 1, mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_001414941 XM_006241302
VERSION     NM_001414941.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4774)
  AUTHORS   Yoshimura,Y., Araki,A., Maruta,H., Takahashi,Y. and Yamashita,H.
  TITLE     Molecular cloning of rat acss3 and characterization of mammalian
            propionyl-CoA synthetase in the liver mitochondrial matrix
  JOURNAL   J Biochem 161 (3), 279-289 (2017)
   PUBMED   28003429
  REMARK    GeneRIF: The results suggested that ACSS3 is a liver mitochondrial
            matrix enzyme with high affinity to propionic acid, and its
            expression level is upregulated under ketogenic conditions.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Dec 15, 2022 this sequence version replaced XM_006241302.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2220921.1,
                                           SRR26360194.892762.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               JAXUCZ010000007.1  44336320-44336684   c
            366-510             JAXUCZ010000007.1  44309075-44309219   c
            511-699             JAXUCZ010000007.1  44273608-44273796   c
            700-834             JAXUCZ010000007.1  44269418-44269552   c
            835-975             JAXUCZ010000007.1  44265450-44265590   c
            976-1056            JAXUCZ010000007.1  44238472-44238552   c
            1057-1152           JAXUCZ010000007.1  44238294-44238389   c
            1153-1304           JAXUCZ010000007.1  44214898-44215049   c
            1305-1408           JAXUCZ010000007.1  44196530-44196633   c
            1409-1504           JAXUCZ010000007.1  44157116-44157211   c
            1505-1568           JAXUCZ010000007.1  44154815-44154878   c
            1569-1650           JAXUCZ010000007.1  44144496-44144577   c
            1651-1773           JAXUCZ010000007.1  44141116-44141238   c
            1774-1873           JAXUCZ010000007.1  44131652-44131751   c
            1874-2049           JAXUCZ010000007.1  44131392-44131567   c
            2050-4774           JAXUCZ010000007.1  44127725-44130449   c
FEATURES             Location/Qualifiers
     source          1..4774
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q21"
     gene            1..4774
                     /gene="Acss3"
                     /gene_synonym="RGD1307051"
                     /note="acyl-CoA synthetase short-chain family member 3"
                     /db_xref="GeneID:314800"
                     /db_xref="RGD:1307051"
     exon            1..365
                     /gene="Acss3"
                     /gene_synonym="RGD1307051"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..2118
                     /gene="Acss3"
                     /gene_synonym="RGD1307051"
                     /EC_number="6.2.1.1"
                     /EC_number="6.2.1.17"
                     /note="isoform 1 is encoded by transcript variant 1;
                     acyl-CoA synthetase short-chain family member 3,
                     mitochondrial; acetate--CoA ligase 3; propionate--CoA
                     ligase"
                     /codon_start=1
                     /product="acyl-CoA synthetase short-chain family member 3,
                     mitochondrial isoform 1"
                     /protein_id="NP_001401870.1"
                     /db_xref="GeneID:314800"
                     /db_xref="RGD:1307051"
                     /translation="MKPSWLQCRKVTGAGTLGAPLPGSPSVRGAGVARRALVAGFGGR
                     GCRALTTSSGGGEYKTHFAASVADPERFWGKAAEQISWYKPWTKTLENRYPPSTSWFV
                     EGMLNICYNAIDRHIENGQGDKIAIIYDSPVTDTKATISYKEVLEQVSKLAGVLVKQG
                     VKKGDTVVIYMPMIPQAIYAMLACARIGAIHSLIFGGFASKELSTRIDHVKPKVVVTA
                     SFGIEPGRKVEYMPLLEEALRIGQHKPDRLLIYNRPNMEKVPLMSGRDLDWEEEMAKA
                     QSHDCVPVLSEHPLYILYTSGTTGLPKGVVRPTGGYAVMLNWTMSSIYGLKPGEVWWA
                     ASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTA
                     IRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSKKVFRVPVLDHWWQTETG
                     SPITASCIGLGNSKTPPPGQAGKCVPGYNVMILDDNMQKLKARSLGNIVVKLPLPPGA
                     FSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGA
                     IEESVLSHGTVTDCAVVGKEDPLKGHVPLALCVLKKDVNATEEQVLEEIVKHVRQSIG
                     PVAAFRNAVFVKQLPKTRSGKIPRSTLSALVNGKPYKVTPTIEDPSIFGHIEEVLKQA
                     L"
     exon            366..510
                     /gene="Acss3"
                     /gene_synonym="RGD1307051"
                     /inference="alignment:Splign:2.1.0"
     exon            511..699
                     /gene="Acss3"
                     /gene_synonym="RGD1307051"
                     /inference="alignment:Splign:2.1.0"
     exon            700..834
                     /gene="Acss3"
                     /gene_synonym="RGD1307051"
                     /inference="alignment:Splign:2.1.0"
     exon            835..975
                     /gene="Acss3"
                     /gene_synonym="RGD1307051"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1056
                     /gene="Acss3"
                     /gene_synonym="RGD1307051"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1152
                     /gene="Acss3"
                     /gene_synonym="RGD1307051"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1304
                     /gene="Acss3"
                     /gene_synonym="RGD1307051"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1408
                     /gene="Acss3"
                     /gene_synonym="RGD1307051"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1504
                     /gene="Acss3"
                     /gene_synonym="RGD1307051"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1568
                     /gene="Acss3"
                     /gene_synonym="RGD1307051"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1650
                     /gene="Acss3"
                     /gene_synonym="RGD1307051"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1773
                     /gene="Acss3"
                     /gene_synonym="RGD1307051"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1873
                     /gene="Acss3"
                     /gene_synonym="RGD1307051"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2049
                     /gene="Acss3"
                     /gene_synonym="RGD1307051"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..4774
                     /gene="Acss3"
                     /gene_synonym="RGD1307051"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggggcagtg ccaccgctgt tgggatagca agctgctccg cctgcagcta gggacagaaa
       61 gaaagtatga agccctcctg gttgcaatgt cgcaaagtaa caggcgccgg gacgcttggg
      121 gcacctctgc caggatcccc ttcagtaaga ggagctggtg tggcccgaag ggctttggtg
      181 gccgggttcg ggggcagggg ctgcagggct ctgaccacaa gcagcggtgg tggcgagtac
      241 aagacccact ttgcagcctc tgtggctgac ccggagagat tctggggtaa agctgctgag
      301 cagatcagtt ggtacaagcc ctggaccaaa acactagaga acagataccc gccttccact
      361 agttggtttg tggaagggat gctcaacatt tgttacaatg ctattgatcg gcacatcgaa
      421 aatggccaag gggataagat cgctatcatc tatgacagtc ccgttacaga caccaaagca
      481 actatctcct ataaggaagt cttggagcag gtctctaagc tggctggtgt cttggtcaag
      541 caaggtgtca agaaaggtga tactgtggtc atctacatgc ccatgatccc acaagcaata
      601 tacgccatgt tggcatgtgc gaggataggc gcaattcaca gtctcatatt cggcgggttt
      661 gcatccaagg aattaagtac acgcattgat catgtgaagc ctaaggtggt tgttacagca
      721 tcattcggca ttgagcctgg gaggaaggta gagtacatgc cccttctaga agaagctctc
      781 agaataggac aacacaaacc agacagactc ctcatttaca accgtccaaa tatggagaaa
      841 gttcctttga tgtcaggtcg tgatcttgat tgggaagaag aaatggcaaa agcccagtca
      901 catgactgcg tgcctgttct ctcagagcat cccttgtaca ttctctacac atctggaaca
      961 actggcctgc ctaagggtgt agttagaccc actgggggat atgctgtaat gttgaactgg
     1021 acaatgtctt ccatatatgg acttaaacct ggagaggtat ggtgggcagc ttctgactta
     1081 ggctgggttg tcggacattc ctatatttgc tatggtcctc ttctacatgg aaacacaaca
     1141 gttttatatg aggggaaacc tgtgggaaca ccggatgctg gcgcttattt ccgtgtgctc
     1201 gcagagcatg gagtggctgc cttgtttaca gcaccaaccg caattagagc catccgtcaa
     1261 caggaccctg gggcagcctt ggggaagcag tactctctga caaggttcaa gacactgttt
     1321 gtggctgggg aaagatgtga tgtggagacc ctagagtggt ccaaaaaagt cttccgcgtt
     1381 cctgtcctag accactggtg gcaaacagag actggatccc ccatcacagc atcatgtatc
     1441 ggactaggca actccaaaac acccccacca ggacaagcag gaaaatgtgt tccaggatac
     1501 aatgttatga ttttggatga caacatgcaa aaactgaagg ctagaagctt aggaaatatc
     1561 gtggtaaagt tgcctttacc acctggggct ttctcaggac tctggaagaa tcaggaagcg
     1621 ttcaagcatt tatactttga gaaatttcct ggatactatg acactatgga tgctggctac
     1681 atggatgagg aaggctatct ctatgttatg tcccgagtgg atgatgtaat aaacgttgca
     1741 ggccacagga tttctgcagg ggctattgag gagtcagtcc tttcacacgg cactgtgact
     1801 gactgcgctg tggttggcaa ggaagacccc ttgaaaggtc atgtcccatt agcactctgc
     1861 gtgttgaaga aagacgtaaa tgcaacagaa gaacaagttt tggaagagat tgtgaaacat
     1921 gttaggcaga gcattggccc ggtggctgct tttcgaaatg cagttttcgt caaacagtta
     1981 cccaaaacca ggtctggcaa aattccacgg tctaccctgt ctgccctggt caatggcaag
     2041 ccttataagg taacccctac aattgaggac cccagcattt ttggtcacat cgaagaagta
     2101 ctgaagcagg ctttgtgatg tttactcttt tgaatccctt cgtcttaact ttctagctgg
     2161 atctaggtct tctattttct acaagtaaat acttgaagaa aacatttctc atcaactgag
     2221 ctatgagctg tagtgtgtag ttagtctggt ggcccctgaa aggctgtaca ttgtgtttcg
     2281 cggaaacctg tttgccccct tacctctttt ctgtaacatg gatcattcta cactatcgcg
     2341 tgtgttaagg agcatgttaa ggagtatggc tttgctaact cgtgtgcttc ccaaacacat
     2401 tttagtggag aatatctgta ctacaaatgc actttctgga gataaaaatc agccacacgt
     2461 tgatcaaaat ctaaactgaa atctaagtca gaatataatt tacaatgcta tcgtagagac
     2521 tccaatgttg tttactgttc taaagatgac tgccatgctt ccaggtaatt agcaagacag
     2581 gataggctgc ctagcaacac aggacccagg gtcaagcacc actgcctggt tgcttgttac
     2641 ggggtaaggg gaggcatata tctggcagag aacctagcta tccttccacc aaatattttg
     2701 aggagataaa gacttctgca atcccctgtc atggttcact ctgtgtatct ggatgctttc
     2761 atctttctat ggaatcgagg gatgcccttc acctagaaag gagtaacaag aaagatctta
     2821 taagaaattg aaattttttc atcctctgct agatctcaat acattttcag aactttgcca
     2881 atatcaatga gccttctctc ttctctgtgt ctgtctctgt ctctctctgt ctctctgtct
     2941 ctctctctgt cttccctcac ctctgacaag gatgtgtttc ctaggttgtc ctcacaaatc
     3001 cttgtccccc tgcctcttat tcatagttgc tggggttagt tccaaagtag tactttttcc
     3061 tcctataagg gttgaaccca gagccttgtg cgtgatagga aagcatcttc cactgagctg
     3121 gatcactggt gctcaatgaa ttcatgttgg ttcttgaggt gcatatccca acaagtgatt
     3181 tttaagaaca atgcacagcc ttaaatacta gaaaaccatg cactccatca agagtgcagt
     3241 tctatcagat cccagagaaa tggctcagga gagaggctgt accaatactg caagagcctc
     3301 tggttttcaa gagaacccca aacatttact cttagtgcaa attttaattt gaatttgaat
     3361 aaatttcaaa tcatctaaaa tcatggtcta acatacattt cttctataaa acgatggagc
     3421 cttttaaaaa ctggaattaa gcctttaata aatttataga aattcaccca tttaatagag
     3481 cagaaagaaa ttgttgatta accagcttag agctctacac ttgttattat tgttagaatg
     3541 tatatttaaa ttacaaaaag tttactgtgt tcattgaatc tctgagagga cttggaataa
     3601 tttctcaatt cttcggattc ttttggaaac atgatgaaga gcacaatgtc ctcacagaat
     3661 agcccaaaaa tgaaatataa ataagcaaca acagataggc atttactggc cataaaagct
     3721 atgcgtatct tatatagagc tcttgtttta ggcctctttg gtctgtgttc taactgataa
     3781 gtccaaatac aagaaatata ggtgagaatt aacagattgc aatttatttg ttaaaagtta
     3841 tatatgtata aaggcccctt tatatttaaa ggctcttaga taaaggctcc attttaggca
     3901 actttggggg caaaaatgga taataaatgg cttctcaaaa ggaagtctta ttcattaaac
     3961 taccttcttt attggtaaca ttgaaaacaa tatcttatca tctttaatta ttttggtatt
     4021 ctgagttaaa ctaacatttt gtaacttgta gctgttgagt ttcttgaatt attcattgta
     4081 catgtacatt ttacccatta tcacaactgt tgggattaca aatcaatgat ttttaatatg
     4141 ttagcatcaa aatacagttc attactttct ccacatgaat caggtgcttt aactaaattt
     4201 ttcattttga tatttgcaag ttagaagaaa ctcaagcaga tctaagactt gagtaaagtt
     4261 ttcatctttg gaccatttgt agattttctt ctttctcaga cctgaacgga cacatcagca
     4321 agtaagcata gttattttcc agtagaaaga atcttaaaaa gtaagtaaac aaaatggaca
     4381 aaacaaacaa acagaaaaca gtttttcaca catggaaagg agctgttttt cttgtttcaa
     4441 tgaggaaatc catctcccct gcagactaga ggcagtgatc acgttgtggt cctaaaatga
     4501 agtcatcaga ctgcttagta acttgggagg aaattaaaga atgttctgtt ttaaaatctc
     4561 accataaggt ttttggcatt gcttgttttg tttgtcaaat tgcatctaaa atattttgaa
     4621 ttcaatgtgt ctctgatagc aatgacataa tccaagaaat gtgaccatac ttaaattgac
     4681 cttgatgact tctctgtgat ctttcatttt atgaaatttt taaatttgta agacacatgc
     4741 ggaatgaaaa taaaaagtac ctttaacgtt taaa
//
