LOCUS       NM_001107793            2867 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus acyl-CoA synthetase short-chain family member 2
            (Acss2), mRNA.
ACCESSION   NM_001107793 XM_001064684 XM_230773
VERSION     NM_001107793.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2867)
  AUTHORS   Li Z, Sun T, He Z, Li Z, Zhang W, Wang J and Xiang H.
  TITLE     SCFAs Ameliorate Chronic Postsurgical Pain-Related Cognition
            Dysfunction via the ACSS2-HDAC2 Axis in Rats
  JOURNAL   Mol Neurobiol 59 (10), 6211-6227 (2022)
   PUBMED   35902549
  REMARK    GeneRIF: SCFAs Ameliorate Chronic Postsurgical Pain-Related
            Cognition Dysfunction via the ACSS2-HDAC2 Axis in Rats.
REFERENCE   2  (bases 1 to 2867)
  AUTHORS   Krencz I, Sebestyen A, Papay J, Jeney A, Hujber Z, Burger CD,
            Keller CA and Khoor A.
  TITLE     In situ analysis of mTORC1/2 and cellular metabolism-related
            proteins in human Lymphangioleiomyomatosis
  JOURNAL   Hum Pathol 79, 199-207 (2018)
   PUBMED   29885404
REFERENCE   3  (bases 1 to 2867)
  AUTHORS   Dodhia S, Celis K, Aylward A, Cai Y, Fontana ME, Trespalacios A,
            Hoffman DC, Alfonso HO, Eisig SB, Su GH, Chung WK and Haddad J Jr.
  TITLE     ACSS2 gene variant associated with cleft lip and palate in two
            independent Hispanic populations
  JOURNAL   Laryngoscope 127 (10), E336-E339 (2017)
   PUBMED   28543373
REFERENCE   4  (bases 1 to 2867)
  AUTHORS   Yoshimura Y, Araki A, Maruta H, Takahashi Y and Yamashita H.
  TITLE     Molecular cloning of rat acss3 and characterization of mammalian
            propionyl-CoA synthetase in the liver mitochondrial matrix
  JOURNAL   J Biochem 161 (3), 279-289 (2017)
   PUBMED   28003429
REFERENCE   5  (bases 1 to 2867)
  AUTHORS   Lakhter AJ, Hamilton J, Konger RL, Brustovetsky N, Broxmeyer HE and
            Naidu SR.
  TITLE     Glucose-independent Acetate Metabolism Promotes Melanoma Cell
            Survival and Tumor Growth
  JOURNAL   J Biol Chem 291 (42), 21869-21879 (2016)
   PUBMED   27539851
REFERENCE   6  (bases 1 to 2867)
  AUTHORS   Watkins PA, Maiguel D, Jia Z and Pevsner J.
  TITLE     Evidence for 26 distinct acyl-coenzyme A synthetase genes in the
            human genome
  JOURNAL   J Lipid Res 48 (12), 2736-2750 (2007)
   PUBMED   17762044
REFERENCE   7  (bases 1 to 2867)
  AUTHORS   Hallows WC, Lee S and Denu JM.
  TITLE     Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
  JOURNAL   Proc Natl Acad Sci U S A 103 (27), 10230-10235 (2006)
   PUBMED   16790548
REFERENCE   8  (bases 1 to 2867)
  AUTHORS   Fujino T, Kondo J, Ishikawa M, Morikawa K and Yamamoto TT.
  TITLE     Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in
            the oxidation of acetate
  JOURNAL   J Biol Chem 276 (14), 11420-11426 (2001)
   PUBMED   11150295
REFERENCE   9  (bases 1 to 2867)
  AUTHORS   Luong A, Hannah VC, Brown MS and Goldstein JL.
  TITLE     Molecular characterization of human acetyl-CoA synthetase, an
            enzyme regulated by sterol regulatory element-binding proteins
  JOURNAL   J Biol Chem 275 (34), 26458-26466 (2000)
   PUBMED   10843999
REFERENCE   10 (bases 1 to 2867)
  AUTHORS   Barth,C., Sladek,M. and Decker,K.
  TITLE     The subcellular distribution of short-chain fatty acyl-CoA
            synthetase activity in rat tissues
  JOURNAL   Biochim Biophys Acta 248 (1), 24-33 (1971)
   PUBMED   4334748
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474050.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_230773.4, XM_001064684.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161963.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2867
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..2867
                     /gene="Acss2"
                     /gene_synonym="Acas2"
                     /note="acyl-CoA synthetase short-chain family member 2"
                     /db_xref="GeneID:311569"
                     /db_xref="RGD:1305489"
     exon            1..242
                     /gene="Acss2"
                     /gene_synonym="Acas2"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..2170
                     /gene="Acss2"
                     /gene_synonym="Acas2"
                     /EC_number="6.2.1.1"
                     /note="acetyl-Coenzyme A synthetase 2 (ADP forming)"
                     /codon_start=1
                     /product="acetyl-coenzyme A synthetase, cytoplasmic"
                     /protein_id="NP_001101263.1"
                     /db_xref="GeneID:311569"
                     /db_xref="RGD:1305489"
                     /translation="MGLPEERRKSGSGSRAREETGAEGRVRGWSPPPEVRRSAHVPSL
                     QRYRELHRRSVEEPREFWGNIAKEFYWKTPCPGPFLQYNFDVTKGKIFTEWMKGATTN
                     ICYNVLDRNVHEKKLGDKVAFYWEGNEPGETTKITYRELLVQVCQFSNVLRKQGVQKG
                     DRVAIYMPMILELVVAMLACARLGALHSIVFAGFSAESLCERILDSSCCLLITTDAFY
                     RGEKLVNLKELADESLEKCREKGFPVRCCIVVKHLGRAELGMNDSPSQSPPVKRPCPD
                     VQISWNEGVDLWWHELMQQAGDEFEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYM
                     LYVATTFKYVFDFHPEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDEG
                     RLWSIVDKYKVTKFYTAPTAIRMLMKFGDDPVTKHSRASLQVLGTVGEPINPEAWLWY
                     HRVVGSQRCPIVDTFWQTETGGHMLTPLPGATPMKPGSASFPFFGVAPAILNESGEEL
                     EGEAEGYLVFKQPWPGIMRTVYGNHTRFETTYFKKFPGYYVTGDGCRRDQDGYYWITG
                     RIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFS
                     PTLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLRKIAQNDHDLGDTST
                     VADPSVINHLFSHRCLTTQ"
     exon            243..438
                     /gene="Acss2"
                     /gene_synonym="Acas2"
                     /inference="alignment:Splign:2.1.0"
     exon            439..530
                     /gene="Acss2"
                     /gene_synonym="Acas2"
                     /inference="alignment:Splign:2.1.0"
     exon            531..634
                     /gene="Acss2"
                     /gene_synonym="Acas2"
                     /inference="alignment:Splign:2.1.0"
     exon            635..707
                     /gene="Acss2"
                     /gene_synonym="Acas2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..783
                     /gene="Acss2"
                     /gene_synonym="Acas2"
                     /inference="alignment:Splign:2.1.0"
     exon            784..898
                     /gene="Acss2"
                     /gene_synonym="Acas2"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1036
                     /gene="Acss2"
                     /gene_synonym="Acas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1207
                     /gene="Acss2"
                     /gene_synonym="Acas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1341
                     /gene="Acss2"
                     /gene_synonym="Acas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1474
                     /gene="Acss2"
                     /gene_synonym="Acas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1531
                     /gene="Acss2"
                     /gene_synonym="Acas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1612
                     /gene="Acss2"
                     /gene_synonym="Acas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1721
                     /gene="Acss2"
                     /gene_synonym="Acas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1790
                     /gene="Acss2"
                     /gene_synonym="Acas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1967
                     /gene="Acss2"
                     /gene_synonym="Acas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2042
                     /gene="Acss2"
                     /gene_synonym="Acas2"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2867
                     /gene="Acss2"
                     /gene_synonym="Acas2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttttccccg ccccggcacc cgcagcgacc gcaacggcgg ccaaggtgct cagaacttga
       61 cgtgatgggg cttcccgagg agcggcgcaa gagcggcagc gggagccggg ctcgcgagga
      121 gaccggcgcc gagggccggg tgcggggttg gtccccgccg ccggaggtca gacgctcggc
      181 gcacgtcccc tctctgcagc gctaccgcga gctgcaccgg cgttctgtgg aggagccacg
      241 ggagttttgg ggaaacattg ccaaggaatt ttactggaaa accccatgcc ctggcccatt
      301 cctccagtac aactttgatg tgactaaagg gaaaatattc actgagtgga tgaaaggagc
      361 aaccacaaac atctgctaca atgtgctgga tagaaatgtc catgagaaaa aacttggcga
      421 caaagttgct ttttactggg agggcaatga gccaggggag accaccaaga tcacataccg
      481 tgaactcctg gtccaggtgt gtcagttcag caatgttctc cgtaaacagg gtgttcagaa
      541 gggtgaccga gtggccatct acatgcctat gatcttggag cttgtggtgg ctatgctggc
      601 atgtgctcgc cttggagctt tgcactccat tgtgtttgca ggcttctctg cagagtctct
      661 ctgtgaacgg atcttggatt ccagctgctg cctgctcatt actacagatg ccttctacag
      721 gggggaaaaa cttgtgaacc tgaaggagct ggctgatgag tccttggaga agtgccgaga
      781 gaagggtttc ccagtgagat gctgcattgt ggtcaaacat ctggggcggg cagagctggg
      841 catgaatgac tcccccagcc agtccccacc cgttaagagg ccatgtccag atgtccagat
      901 ctcctggaat gaaggggttg acttgtggtg gcatgaactc atgcagcagg caggagatga
      961 gtttgagcct gagtggtgtg atgccgagga ccctctcttc atcttgtata ccagtggctc
     1021 cacaggcaaa cccaagggtg tggtgcacac agttggaggc tacatgctct atgtggctac
     1081 aactttcaag tatgtgtttg atttccatcc ggaggatgta ttctggtgca cagcagacat
     1141 tggctggatc actggtcatt cctatgtcac ctatgggccg ctggcgaatg gtgccaccag
     1201 tgttttgttt gaggggatcc ccacataccc agatgaaggc cgcttgtgga gcattgtgga
     1261 caaatacaag gtgaccaagt tctacacggc accaacagca atccggatgc tcatgaagtt
     1321 tggagatgat cctgtcacca agcatagccg ggcatccttg caggtgctgg gcacagtagg
     1381 tgaacccatc aaccctgaag cctggctatg gtaccatcgg gtagtaggtt cccagcgttg
     1441 ccccattgta gacaccttct ggcaaacaga aacaggtggc catatgctga cccctctccc
     1501 tggtgccaca cccatgaaac caggttctgc ttctttcccg ttctttggtg ttgcgcctgc
     1561 aatcctgaac gagtcggggg aagaactgga aggggaagct gaaggttatc tggtgttcaa
     1621 gcagccctgg ccagggatca tgcgcacagt ttatgggaac cacacacgtt tcgagaccac
     1681 ctactttaag aagttccctg gctactacgt gactggagat ggctgccgac gggatcagga
     1741 cggctattac tggatcactg gcaggattga tgacatgctc aatgtgtctg gacatcttct
     1801 gagtacagca gaggtggaat cagcacttgt ggaacatgag gctgttgcag aggcagctgt
     1861 ggtgggccac cctcatcctg tgaagggtga atgcctctac tgctttgtta ccttgtgtga
     1921 cggccatacc ttcagcccca ccctcactga ggaactcaag aagcagatta gagaaaagat
     1981 tggccccatt gccacaccag actacatcca gaatgcaccc ggcttgccta aaacacgctc
     2041 aggaaaaatc atgaggagag tactccggaa gattgctcag aatgaccacg acctggggga
     2101 tacctctaca gtggctgacc catctgtcat caaccatctc ttcagtcacc gctgcctgac
     2161 cacacagtga acaagactct tatccaggat ttccctgtgc ttggctctcc aaatttctgc
     2221 ccatctatcc tgtccctcac ccaagagtac caagggccag tgctagttga catttaggtt
     2281 gaaactaggg agacagttac ttagactgcc aggtcgaagg gaacagggct caggtcaacc
     2341 atgcactgat actctcctag gctacagaga tctccaagcc cagaacagag acttgaacac
     2401 catgtcctta accagagtta gctatgcaga gtgtaagtga gggcctacct agaagcaggc
     2461 ggcacctcta atcctttttc agctttctca gaaagcacca gttcttacct tgggcctgca
     2521 ctagccttta taagtgacag ttagcaagtc tatgaataat tattttttaa aatactttgt
     2581 tgtctctgtt ctgagtctga attccttgtc aaatgatagc agtgtctgtt catttgctca
     2641 agagactagg caagtggctt cagtctccag aggacttcca tatcatctgc ttcgttgaaa
     2701 gattaagata tgctggtcct agaaccaagg gagttaacat tcctagtctg caccaggaac
     2761 agaaccctgc ccatgagagg cacttgtagg cgaaactctc ttttcttgta ctttttgtgc
     2821 taaagaccca ctgttgtagg aataaagttt atgaactcaa gaacata
//
