LOCUS       NM_001106524            3595 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Rattus norvegicus acyl-CoA synthetase short-chain family member 1
            (Acss1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001106524 XM_215897
VERSION     NM_001106524.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3595)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3595)
  AUTHORS   Lakhter,A.J., Hamilton,J., Konger,R.L., Brustovetsky,N.,
            Broxmeyer,H.E. and Naidu,S.R.
  TITLE     Glucose-independent Acetate Metabolism Promotes Melanoma Cell
            Survival and Tumor Growth
  JOURNAL   J Biol Chem 291 (42), 21869-21879 (2016)
   PUBMED   27539851
REFERENCE   3  (bases 1 to 3595)
  AUTHORS   Sakakibara,I., Fujino,T., Ishii,M., Tanaka,T., Shimosawa,T.,
            Miura,S., Zhang,W., Tokutake,Y., Yamamoto,J., Awano,M., Iwasaki,S.,
            Motoike,T., Okamura,M., Inagaki,T., Kita,K., Ezaki,O., Naito,M.,
            Kuwaki,T., Chohnan,S., Yamamoto,T.T., Hammer,R.E., Kodama,T.,
            Yanagisawa,M. and Sakai,J.
  TITLE     Fasting-induced hypothermia and reduced energy production in mice
            lacking acetyl-CoA synthetase 2
  JOURNAL   Cell Metab 9 (2), 191-202 (2009)
   PUBMED   19187775
REFERENCE   4  (bases 1 to 3595)
  AUTHORS   Watkins,P.A., Maiguel,D., Jia,Z. and Pevsner,J.
  TITLE     Evidence for 26 distinct acyl-coenzyme A synthetase genes in the
            human genome
  JOURNAL   J Lipid Res 48 (12), 2736-2750 (2007)
   PUBMED   17762044
REFERENCE   5  (bases 1 to 3595)
  AUTHORS   Hallows,W.C., Lee,S. and Denu,J.M.
  TITLE     Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
  JOURNAL   Proc Natl Acad Sci U S A 103 (27), 10230-10235 (2006)
   PUBMED   16790548
REFERENCE   6  (bases 1 to 3595)
  AUTHORS   Schwer,B., Bunkenborg,J., Verdin,R.O., Andersen,J.S. and Verdin,E.
  TITLE     Reversible lysine acetylation controls the activity of the
            mitochondrial enzyme acetyl-CoA synthetase 2
  JOURNAL   Proc Natl Acad Sci U S A 103 (27), 10224-10229 (2006)
   PUBMED   16788062
REFERENCE   7  (bases 1 to 3595)
  AUTHORS   Fujino,T., Kondo,J., Ishikawa,M., Morikawa,K. and Yamamoto,T.T.
  TITLE     Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in
            the oxidation of acetate
  JOURNAL   J Biol Chem 276 (14), 11420-11426 (2001)
   PUBMED   11150295
REFERENCE   8  (bases 1 to 3595)
  AUTHORS   Barth,C., Sladek,M. and Decker,K.
  TITLE     The subcellular distribution of short-chain fatty acyl-CoA
            synthetase activity in rat tissues
  JOURNAL   Biochim Biophys Acta 248 (1), 24-33 (1971)
   PUBMED   4334748
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474050.2.
            
            On Oct 4, 2007 this sequence version replaced XM_215897.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5756307, SAMEA5760383
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3595
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..3595
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /note="acyl-CoA synthetase short-chain family member 1"
                     /db_xref="GeneID:296259"
                     /db_xref="RGD:1306246"
     exon            1..345
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..2081
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /EC_number="6.2.1.1"
                     /note="acetyl-Coenzyme A synthetase 2 (AMP forming)-like"
                     /codon_start=1
                     /product="acetyl-coenzyme A synthetase 2-like,
                     mitochondrial"
                     /protein_id="NP_001099994.1"
                     /db_xref="GeneID:296259"
                     /db_xref="RGD:1306246"
                     /translation="MAARSLGSGVGRLLRGLHGHSGQSGWLLSLSRWTTTRFLGSVPA
                     AAQLGSYPALSAQAAQEPAAFWGPLARDTLVWDTPYHTVWDCDFRTGKIGWFLGGQLN
                     VSVNCLDQHVQKSPDTIALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDR
                     VAIYMPVSPLAVAAMLACARIGAIHTVVFAGFSAESLAGRINDAKCKVVITFNQGLRG
                     GRVVELKKIVDEAVKNCPTVQHVLVAHRTDTKVPMGNLDIPLEQEMANEAPVCTPESM
                     NSEDMLFMLYTSGSTGTPKGLVHTQAGYLLYAAMTHKLVFDYHPGDVFGCVADIGWIT
                     GHSYVVYGPLCNGATTVLFESTPVYPDAGRYWETVQRLKINQFYGAPTAVRLLLKFGD
                     AWVKKYDRSSLRTLGSVGEPINHEAWEWLHKVVGDGRCTLVDTWWQTETGGICIAPRP
                     SEDGAEILPGMAMRPFFGIVPALMDEKGNVVEGGDVSGALCISQAWPGMARTIYGDHQ
                     RFVDAYFRTYPGYYFTGDGAHRTEGGYYQITGRMDDVINISGHRLGTAEIEDAMADHP
                     AVPETAVIGYPHDIKGEAAFAFIVLKDDVRDANVVVNELKLAVATKIAKYAVPDQILV
                     VKRLPKTRSGKVMRRLLRKIITSRGQDLGDTTTLEDPSVITEIMSAFREYEEQRAATN
                     "
     exon            346..442
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     exon            443..642
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     exon            643..818
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     exon            819..971
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1119
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1257
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1350
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1463
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1590
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1718
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1782
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1901
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..3595
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctcctgca cccgcgtggg gcgtcgggcg agatggcggc gcgcagcctc ggcagcggtg
       61 tggggcgact gctgcgtggc ctgcacgggc actcgggaca atcggggtgg ttgctgagcc
      121 tgtcccgctg gaccaccacc cgattcctgg gcagtgttcc tgcagcagcg cagctaggct
      181 cgtaccccgc tttgagcgct caggcagccc aggagccggc cgccttctgg ggaccgctgg
      241 cccgtgacac actagtttgg gacactcctt accatactgt ctgggactgc gacttcagga
      301 cgggcaagat cggctggttc ctgggaggcc agttgaatgt gtctgtcaac tgcctggacc
      361 agcacgtgca gaagtctccc gacaccatag ctttgatttg ggagagagat gaacctggga
      421 cagaagtgag gatcacttac agggagcttc tggagaccac atgccgcctg gccaacacgc
      481 tgaagaggca tggtgtgcac cgaggggacc gtgtggccat ctacatgcct gtgtccccac
      541 tggctgtggc agcgatgctg gcctgtgcca ggattggagc tatccacaca gtggtttttg
      601 ctggctttag tgcagagtcc ttggccggga ggatcaatga tgccaagtgc aaggttgtta
      661 tcaccttcaa ccaaggactc cggggagggc gtgtggtgga gctgaagaaa atagtggacg
      721 aagctgtgaa gaactgccca acagtgcagc atgtcctagt ggctcacagg acggacacca
      781 aggttcccat ggggaatctg gacatccccc ttgagcagga gatggccaat gaggcccctg
      841 tgtgtacccc tgaaagcatg aacagtgaag atatgctctt catgctctac acgtctggga
      901 gcactgggac acccaaggga ctcgttcata cacaggcagg ctatctgctg tatgccgcca
      961 tgacgcacaa gctcgtgttt gactaccatc caggtgatgt ctttggttgt gtggctgaca
     1021 tcggttggat cacaggacac agctatgtgg tgtatggacc cctctgcaat ggagctacca
     1081 cggtcctttt tgagagcacc ccagtttacc ctgatgctgg tcgttactgg gagacagtac
     1141 agaggctaaa gatcaaccag ttctatggtg ccccgacagc tgtccgactg ctgctgaagt
     1201 tcggggatgc ctgggtgaaa aagtatgacc gctcctccct gcgcacactg gggtcagtgg
     1261 gagagcccat caatcatgag gcctgggagt ggctccacaa agtggtgggt gatggcagat
     1321 gtaccctggt ggacacttgg tggcagacag aaactggagg catctgcatt gcaccacggc
     1381 cctcggaaga tggggcagag atcctcccag gcatggccat gaggccgttt tttggcattg
     1441 tccctgcact catggatgag aagggcaatg ttgtggaggg tggtgatgtc tctggggccc
     1501 tgtgtatttc ccaagcttgg ccaggcatgg caaggaccat ctacggtgac caccagaggt
     1561 tcgtagatgc ctacttcaga acgtacccag gttactactt cactggagat ggagctcacc
     1621 ggacggaggg tggctattac cagatcacag ggcgcatgga tgatgtcatc aacatcagtg
     1681 gtcatcgcct ggggactgca gagattgagg atgcaatggc tgaccatccc gctgtcccag
     1741 aaactgctgt cattgggtac cctcatgaca tcaaaggaga agctgcgttt gccttcattg
     1801 tactgaaaga tgacgtccgt gatgcaaacg tggtggtaaa tgagctcaag ttggcagtgg
     1861 ccaccaagat cgccaagtat gctgtgcctg accagatcct ggtggtgaag cgtctcccca
     1921 aaaccaggtc tgggaaggtg atgaggaggc tgctgaggaa gatcatcacc agcagggggc
     1981 aggatctagg ggacaccact accctggagg accccagtgt catcacggag atcatgagtg
     2041 cctttcggga gtacgaagag cagcgggctg ccaccaactg agaggtgcac ctctgtgttg
     2101 cccagacaaa gccgcacagg acccctggtc accctcaggg aaaggagctt caaagctggc
     2161 ttgtttcatc tgagcacatg acccatgtac tgccctattt gcagctgaag cccctctttc
     2221 tttctcctgg ggcctcgagc gctgcctctg gaaggggagg cctttgtcct acttctggtt
     2281 tccagaatta agtcataatt ggaactaaac cagcacgggg taaccagagg tcttagctcc
     2341 agaactgtca tgttttctcc agatgtgtgt agatacaaaa cacagaatat tttatttttt
     2401 tgtacttttt ctatttgggg agagtaacag aacatttggg tataatgtga acatttagtt
     2461 ttgcacgtgc gcgtgcgtat gcacacacac acacacacac acacacacac acacacacac
     2521 acacacacac acactgtggg aaaatattct tgcctcccca gggatgagga taacagaatg
     2581 tgctttttta aaaaaattat cattcagtgt gcttgaaatt caaaccatag atgtttgtgc
     2641 ctctgccaca taactgtccc catcctacta atccaagtcg ccatatccac ctcctgtgtc
     2701 tatttcatat ttggttcact tggtttattt tgtgatagaa cagactggac gattcttata
     2761 tttacgtttc gcaccttagg gattgcactc agggcctcct gaacactagg caagcactct
     2821 acctctgagc tgcacaccag cacctttaat ccccaagaga cggagtgaat gtcctctcct
     2881 ttacttgtga aatcatttgg gttcgcttct ctaagctgtg atctggaagg agcttctttc
     2941 cccagggaat atgacctcat aggaggtcat attgcttcaa acgtgtggtt gttcgtggca
     3001 accggtgaaa actcaggtgt cttactaagg ctctggtccc attggggctc ttgaagactc
     3061 tgcctgccct ttctcttgtg attggggcaa caagagccac tgtggtccaa tgacaacact
     3121 tggtgctctt gagcgagttc tctctcgatg tgccttaagt cctctggaca ctggtgagtg
     3181 tcacaaaccg tgaagtctgg aaaacgtatt ctgtagcttg gttgtggcta agcatgggag
     3241 ggcttgaagg ggtggcagct ctgtgagcag ggcccctggg ggcagaggaa gatggttctg
     3301 gctggtccac agaactcagc tctatgggtg tttcttagtt actgcacacc tactgtctgt
     3361 cctgacttct tgggtaatgg ggtaaatatt ctgatactcc cgggaggtgg agtggttgta
     3421 gtatgcacaa atattaatag tcctttgtta cagtcagcgg taaagagcca tgtgatggat
     3481 ttacttggct gactacagtt actttaggga atggcctagg tttccaggtt actgatagaa
     3541 cctatcagaa tgatttatag aaatattcaa ataaagcttt attttgttca gtgtc
//
