LOCUS       NP_001099994             682 aa            linear   ROD 20-SEP-2024
DEFINITION  acetyl-coenzyme A synthetase 2-like, mitochondrial [Rattus
            norvegicus].
ACCESSION   NP_001099994 XP_215897
VERSION     NP_001099994.1
DBSOURCE    REFSEQ: accession NM_001106524.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 682)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (residues 1 to 682)
  AUTHORS   Lakhter,A.J., Hamilton,J., Konger,R.L., Brustovetsky,N.,
            Broxmeyer,H.E. and Naidu,S.R.
  TITLE     Glucose-independent Acetate Metabolism Promotes Melanoma Cell
            Survival and Tumor Growth
  JOURNAL   J Biol Chem 291 (42), 21869-21879 (2016)
   PUBMED   27539851
REFERENCE   3  (residues 1 to 682)
  AUTHORS   Sakakibara,I., Fujino,T., Ishii,M., Tanaka,T., Shimosawa,T.,
            Miura,S., Zhang,W., Tokutake,Y., Yamamoto,J., Awano,M., Iwasaki,S.,
            Motoike,T., Okamura,M., Inagaki,T., Kita,K., Ezaki,O., Naito,M.,
            Kuwaki,T., Chohnan,S., Yamamoto,T.T., Hammer,R.E., Kodama,T.,
            Yanagisawa,M. and Sakai,J.
  TITLE     Fasting-induced hypothermia and reduced energy production in mice
            lacking acetyl-CoA synthetase 2
  JOURNAL   Cell Metab 9 (2), 191-202 (2009)
   PUBMED   19187775
REFERENCE   4  (residues 1 to 682)
  AUTHORS   Watkins,P.A., Maiguel,D., Jia,Z. and Pevsner,J.
  TITLE     Evidence for 26 distinct acyl-coenzyme A synthetase genes in the
            human genome
  JOURNAL   J Lipid Res 48 (12), 2736-2750 (2007)
   PUBMED   17762044
REFERENCE   5  (residues 1 to 682)
  AUTHORS   Hallows,W.C., Lee,S. and Denu,J.M.
  TITLE     Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
  JOURNAL   Proc Natl Acad Sci U S A 103 (27), 10230-10235 (2006)
   PUBMED   16790548
REFERENCE   6  (residues 1 to 682)
  AUTHORS   Schwer,B., Bunkenborg,J., Verdin,R.O., Andersen,J.S. and Verdin,E.
  TITLE     Reversible lysine acetylation controls the activity of the
            mitochondrial enzyme acetyl-CoA synthetase 2
  JOURNAL   Proc Natl Acad Sci U S A 103 (27), 10224-10229 (2006)
   PUBMED   16788062
REFERENCE   7  (residues 1 to 682)
  AUTHORS   Fujino,T., Kondo,J., Ishikawa,M., Morikawa,K. and Yamamoto,T.T.
  TITLE     Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in
            the oxidation of acetate
  JOURNAL   J Biol Chem 276 (14), 11420-11426 (2001)
   PUBMED   11150295
REFERENCE   8  (residues 1 to 682)
  AUTHORS   Barth,C., Sladek,M. and Decker,K.
  TITLE     The subcellular distribution of short-chain fatty acyl-CoA
            synthetase activity in rat tissues
  JOURNAL   Biochim Biophys Acta 248 (1), 24-33 (1971)
   PUBMED   4334748
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474050.2.
            
            On Oct 4, 2007 this sequence version replaced XP_215897.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5756307, SAMEA5760383
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..682
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     Protein         1..682
                     /product="acetyl-coenzyme A synthetase 2-like,
                     mitochondrial"
                     /EC_number="6.2.1.1"
                     /note="acetyl-Coenzyme A synthetase 2 (AMP forming)-like"
                     /calculated_mol_wt=74761
     Region          45..670
                     /region_name="Ac_CoA_lig_AcsA"
                     /note="acetate--CoA ligase; TIGR02188"
                     /db_xref="CDD:274022"
     Site            order(189..191,217,220,222,328,333..334,356..358,382..383,
                     386,409..412,434..439,526,538,541,549..552,610,615..616)
                     /site_type="active"
                     /db_xref="CDD:341270"
     Site            order(189..191,217,220,222,328,334,356..358,382..383,386,
                     549..551,610,615)
                     /site_type="other"
                     /note="CoA binding site [chemical binding]"
                     /db_xref="CDD:341270"
     Site            order(284,287..292,294..295)
                     /site_type="other"
                     /note="acyl-activating enzyme (AAE) consensus motif"
                     /db_xref="CDD:341270"
     Site            order(333..334,409..412,434..439,526,538,541,552)
                     /site_type="other"
                     /note="AMP binding site [chemical binding]"
                     /db_xref="CDD:341270"
     Site            order(333..334,409..410,437)
                     /site_type="other"
                     /note="acetate binding site [chemical binding]"
                     /db_xref="CDD:341270"
     CDS             1..682
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /coded_by="NM_001106524.1:33..2081"
                     /db_xref="GeneID:296259"
                     /db_xref="RGD:1306246"
ORIGIN      
        1 maarslgsgv grllrglhgh sgqsgwllsl srwtttrflg svpaaaqlgs ypalsaqaaq
       61 epaafwgpla rdtlvwdtpy htvwdcdfrt gkigwflggq lnvsvncldq hvqkspdtia
      121 liwerdepgt evrityrell ettcrlantl krhgvhrgdr vaiympvspl avaamlacar
      181 igaihtvvfa gfsaeslagr indakckvvi tfnqglrggr vvelkkivde avkncptvqh
      241 vlvahrtdtk vpmgnldipl eqemaneapv ctpesmnsed mlfmlytsgs tgtpkglvht
      301 qagyllyaam thklvfdyhp gdvfgcvadi gwitghsyvv ygplcngatt vlfestpvyp
      361 dagrywetvq rlkinqfyga ptavrlllkf gdawvkkydr sslrtlgsvg epinheawew
      421 lhkvvgdgrc tlvdtwwqte tggiciaprp sedgaeilpg mamrpffgiv palmdekgnv
      481 veggdvsgal cisqawpgma rtiygdhqrf vdayfrtypg yyftgdgahr teggyyqitg
      541 rmddvinisg hrlgtaeied amadhpavpe tavigyphdi kgeaafafiv lkddvrdanv
      601 vvnelklava tkiakyavpd qilvvkrlpk trsgkvmrrl lrkiitsrgq dlgdtttled
      661 psviteimsa freyeeqraa tn
//
