LOCUS       NM_033231               2585 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus acyl-CoA synthetase medium-chain family member 3
            (Acsm3), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_033231
VERSION     NM_033231.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2585)
  AUTHORS   Junkova,K., Mirchi,L.F., Chylikova,B., Janku,M., Silhavy,J.,
            Huttl,M., Markova,I., Miklankova,D., Vcelak,J., Malinska,H.,
            Pravenec,M., Seda,O. and Liska,F.
  TITLE     Hepatic Transcriptome Profiling Reveals Lack of Acsm3 Expression in
            Polydactylous Rats with High-Fat Diet-Induced Hypertriglyceridemia
            and Visceral Fat Accumulation
  JOURNAL   Nutrients 13 (5), 1462 (2021)
   PUBMED   33923085
  REMARK    GeneRIF: Hepatic Transcriptome Profiling Reveals Lack of Acsm3
            Expression in Polydactylous Rats with High-Fat Diet-Induced
            Hypertriglyceridemia and Visceral Fat Accumulation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2585)
  AUTHORS   De Preter,V., Arijs,I., Windey,K., Vanhove,W., Vermeire,S.,
            Schuit,F., Rutgeerts,P. and Verbeke,K.
  TITLE     Impaired butyrate oxidation in ulcerative colitis is due to
            decreased butyrate uptake and a defect in the oxidation pathway
  JOURNAL   Inflamm Bowel Dis 18 (6), 1127-1136 (2012)
   PUBMED   21987487
REFERENCE   3  (bases 1 to 2585)
  AUTHORS   Watkins,P.A., Maiguel,D., Jia,Z. and Pevsner,J.
  TITLE     Evidence for 26 distinct acyl-coenzyme A synthetase genes in the
            human genome
  JOURNAL   J Lipid Res 48 (12), 2736-2750 (2007)
   PUBMED   17762044
REFERENCE   4  (bases 1 to 2585)
  AUTHORS   Naskar,R. and Thanos,S.
  TITLE     Retinal gene profiling in a hereditary rodent model of elevated
            intraocular pressure
  JOURNAL   Mol Vis 12, 1199-1210 (2006)
   PUBMED   17102796
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2585)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   6  (bases 1 to 2585)
  AUTHORS   Gu,L., Dene,H., Deng,A.Y., Hoebee,B., Bihoreau,M.T., James,M. and
            Rapp,J.P.
  TITLE     Genetic mapping of two blood pressure quantitative trait loci on
            rat chromosome 1
  JOURNAL   J Clin Invest 97 (3), 777-788 (1996)
   PUBMED   8609235
REFERENCE   7  (bases 1 to 2585)
  AUTHORS   Gu,L., Dene,H. and Rapp,J.P.
  TITLE     Possible alternative splicing of the rat SA gene
  JOURNAL   Mamm Genome 6 (9), 683-684 (1995)
   PUBMED   8535086
REFERENCE   8  (bases 1 to 2585)
  AUTHORS   Gu,L., Dene,H. and Rapp,J.P.
  TITLE     Three microsatellites defining four alleles for the rat SA gene
  JOURNAL   Mamm Genome 5 (12), 833 (1994)
   PUBMED   7894178
REFERENCE   9  (bases 1 to 2585)
  AUTHORS   Harris,E.L., Dene,H. and Rapp,J.P.
  TITLE     SA gene and blood pressure cosegregation using Dahl salt-sensitive
            rats
  JOURNAL   Am J Hypertens 6 (4), 330-334 (1993)
   PUBMED   8507454
REFERENCE   10 (bases 1 to 2585)
  AUTHORS   Lindpaintner,K., Hilbert,P., Ganten,D., Nadal-Ginard,B., Inagami,T.
            and Iwai,N.
  TITLE     Molecular genetics of the SA-gene: cosegregation with hypertension
            and mapping to rat chromosome 1
  JOURNAL   J Hypertens 11 (1), 19-23 (1993)
   PUBMED   8094726
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC090325.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090325.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2585
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q35"
     gene            1..2585
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /note="acyl-CoA synthetase medium-chain family member 3"
                     /db_xref="GeneID:24763"
                     /db_xref="RGD:62086"
     exon            1..68
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            69..216
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            217..490
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     CDS             290..2032
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /EC_number="6.2.1.2"
                     /EC_number="6.2.1.17"
                     /note="protein SA; butyrate--CoA ligase 3; middle-chain
                     acyl-CoA synthetase 3; SA rat hypertension-associated
                     protein; butyryl-coenzyme A synthetase 3; SA rat
                     hypertension-associated homolog; ssubA; SA
                     hypertension-associated homolog; propionate--CoA ligase"
                     /codon_start=1
                     /product="acyl-coenzyme A synthetase ACSM3, mitochondrial"
                     /protein_id="NP_150234.1"
                     /db_xref="GeneID:24763"
                     /db_xref="RGD:62086"
                     /translation="MAMLLRARCFHRLAIPDPRRILYKDYRTAIPQNFSNYESMKHDF
                     KIEIPEYFNFAKDVLDQWTNTEKTGKRLSNPAFWWVDGNGKEVRWSFEELGSLSRKFA
                     NILTEACSLQRGDRVMVILPKIPEWWLANVACLRTGTVLIPGTTQLTQKDILYRLQSS
                     KSKCIITDDTLAPAVDIVAAKCENLHSKLIVSQHSREGWGNLKEMMKYASDSHTCVDT
                     KHNELMAIYFTSGTTGPPKMIGHTHSSFGLGLSVNGRFWLDLIASDVMWNTSDTGWAK
                     SAWSSVFSPWTQGACVFAHYLPRFDSTSILQTLSKFPITVFCSAPTAYRMLIQNDITS
                     YKFNSLKHCVSAGEPINPEVMEQWKKKTGLDIYEGYGQTETVLICGNFKGMKIKPGSM
                     GKPSPAFNVEILDENGTILPPGQEGDIAVQVLPDRPFGLFTHYVDNPSKTASTLRGNF
                     YITGDRGYMDEDGYFWFVARSDDVILSSGYRIGPFEVESALIEHPSIAESAVVSSPDP
                     IRGEVVKAFIVLNPDYKLHDQEQLKKEIQEHVKKTTAPYKYPRKIEFIEELPKTVSGK
                     VKRNELRRKEWTTT"
     exon            491..701
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            702..909
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1053
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1210
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1290
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1414
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1495
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1597
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1725
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1825
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1945
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2564
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaaattgg ctttctctcc cattaagcag gtctactatc attccagctg tgggaagcag
       61 tatctttagt gaaaaacaag gaggctcaag tggaaaatct agaagagctc aagatcactg
      121 acttgtgagc ttctcacaca aggaggtgga caccaggagc gcctgggttt caaatgcatc
      181 cagttcatca acacgatgcc taaccaccaa atccatctgg agtagtctgc atggaaatct
      241 cacattccaa aacaattaat aatattgata ctagctatct cttgtcacca tggcaatgtt
      301 acttcgtgct aggtgttttc accgcctagc aatccctgat cccaggagaa tcttgtataa
      361 agattacaga acagcgattc ctcagaactt ttccaactat gagtccatga aacatgactt
      421 caaaatagag attccagagt atttcaattt tgcaaaagat gttttggacc aatggaccaa
      481 tacggaaaag actggaaaaa gactttccaa tccagccttc tggtgggtag atggaaatgg
      541 aaaggaggtg agatggagtt ttgaagaact tgggtcttta tccaggaaat ttgccaacat
      601 actcacagaa gcctgttccc tgcaaagagg agatagagta atggtgattc tgcccaagat
      661 cccagagtgg tggcttgcaa atgtagcctg tctgcgaaca gggacagttt taattccagg
      721 aaccactcag ctgacccaga aagacatcct ctacaggcta caatcttcaa aatcaaagtg
      781 cattattact gatgatactt tggccccagc agtagatatt gtagcagcta aatgtgaaaa
      841 tctccactcc aaattaattg tgtctcagca ctccagagaa ggctggggga acctcaagga
      901 gatgatgaaa tatgccagtg acagccacac ctgtgtggac acaaaacaca atgagttgat
      961 ggccatctac ttcaccagtg ggacgactgg gcctccgaag atgattggac acacccacag
     1021 cagttttggt ttaggactgt ctgtcaacgg aaggttctgg ctggatttga tagcctctga
     1081 cgtgatgtgg aatacgtcag atacaggctg ggcaaagtct gcatggagta gtgttttttc
     1141 tccgtggacc caaggagcat gtgtttttgc acactatttg ccccgttttg attcaacttc
     1201 catcttgcaa accctctcca agtttcccat cactgtcttc tgttctgcac caactgccta
     1261 ccggatgctt atacagaatg acataaccag ctataagttc aacagtttga agcactgtgt
     1321 gagtgccggg gaacccatca accctgaagt gatggaacaa tggaaaaaga agacaggact
     1381 agacatctac gaaggatatg gacagacaga aacggtgctg atctgtggaa atttcaaggg
     1441 gatgaaaatt aagcctggct caatggggaa gccctctcct gcttttaatg tggagatttt
     1501 agatgaaaat ggcactattc ttcctcctgg acaagaaggg gatattgctg ttcaagttct
     1561 tcctgatcga ccatttggcc tttttactca ttatgtagat aatccttcga aaacagcttc
     1621 aactctacga gggaatttct acatcactgg ggacagaggc tatatggatg aggatggcta
     1681 tttctggttt gttgcaagat cagacgatgt catattatcc tctggttacc gaattggacc
     1741 atttgaggta gagagtgctc tcatagagca tccttccatt gcagagtcag ctgttgtcag
     1801 cagccctgac cccatcagag gagaggtagt aaaggccttt attgtcctaa atcctgatta
     1861 caaactccat gatcaagaac aactgaaaaa agagattcag gagcatgtga aaaagactac
     1921 agcaccttac aaatacccca ggaagataga atttattgag gagctgccaa agactgtcag
     1981 tgggaaggtc aaaagaaatg aactgaggag aaaggaatgg acaacaactt aaacttggcc
     2041 cactaatcac ctgcatatct acaagtaaac acagtgtctc tgagtctaca ggaaccacag
     2101 atcacgtggg cagactgctt ttaaattgga tttaaactat tttgtagaat gaaaccatag
     2161 gctgaattat gaaatcatat aatcactgaa tccttctgcc ttcatgtcaa tgttcctgta
     2221 atttgcaaca taaaatgaat gttatcagat gccgtgatgc cttaaaattt attttaggag
     2281 ctgtttctaa accaaatctc tgccccatgg gttttcaaaa cttaactgaa caattctaat
     2341 atgccaatat acaaatcaga acaaatcttc aagctttgaa ggaaactgtc ataattctta
     2401 gaatacttac ctaaaagttg agtaggaatt ttactagtca taattttatt caagtaattt
     2461 aaaaatagtt tgaaatttgt ttcaatgtca aagtataaga gacagctgtc atattctatg
     2521 gttagttatt aaatttaacc taataaatat ggtttataaa aataaaaaaa aaaaaaaaaa
     2581 aaaaa
//
