LOCUS       NM_144748               2426 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Rattus norvegicus acyl-CoA synthetase medium-chain family member 2
            (Acsm2), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_144748
VERSION     NM_144748.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2426)
  AUTHORS   Kochan,G., Pilka,E.S., von Delft,F., Oppermann,U. and Yue,W.W.
  TITLE     Structural snapshots for the conformation-dependent catalysis by
            human medium-chain acyl-coenzyme A synthetase ACSM2A
  JOURNAL   J Mol Biol 388 (5), 997-1008 (2009)
   PUBMED   19345228
REFERENCE   2  (bases 1 to 2426)
  AUTHORS   Watkins,P.A., Maiguel,D., Jia,Z. and Pevsner,J.
  TITLE     Evidence for 26 distinct acyl-coenzyme A synthetase genes in the
            human genome
  JOURNAL   J Lipid Res 48 (12), 2736-2750 (2007)
   PUBMED   17762044
REFERENCE   3  (bases 1 to 2426)
  AUTHORS   Hilgers,K.F., Nagaraj,S.K., Karginova,E.A., Kazakova,I.G.,
            Chevalier,R.L., Carey,R.M., Pentz,E.S. and Gomez,R.A.
  TITLE     Molecular cloning of KS, a novel rat gene expressed exclusively in
            the kidney
  JOURNAL   Kidney Int 54 (5), 1444-1454 (1998)
   PUBMED   9844120
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF062389.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF062389.1, BC078721.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2426
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q35"
     gene            1..2426
                     /gene="Acsm2"
                     /gene_synonym="Acsm2a; KS"
                     /note="acyl-CoA synthetase medium-chain family member 2"
                     /db_xref="GeneID:246263"
                     /db_xref="RGD:708383"
     exon            1..98
                     /gene="Acsm2"
                     /gene_synonym="Acsm2a; KS"
                     /inference="alignment:Splign:2.1.0"
     exon            99..283
                     /gene="Acsm2"
                     /gene_synonym="Acsm2a; KS"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1825
                     /gene="Acsm2"
                     /gene_synonym="Acsm2a; KS"
                     /EC_number="6.2.1.2"
                     /EC_number="6.2.1.25"
                     /note="xenobiotic/medium-chain fatty acid:CoA ligase;
                     acyl-CoA synthetase medium-chain family member 2A;
                     butyrate--CoA ligase 2; kidney-specific protein KS;
                     benzoate--CoA ligase; middle-chain acyl-CoA synthetase 2;
                     butyryl-coenzyme A synthetase 2"
                     /codon_start=1
                     /product="acyl-coenzyme A synthetase ACSM2, mitochondrial"
                     /protein_id="NP_653349.1"
                     /db_xref="GeneID:246263"
                     /db_xref="RGD:708383"
                     /translation="MHWLWKIPRLCTFWGTEMFHRSFHMNIKKLMPIQWGHQEVPAKF
                     NFASDVIDHWASLEKAGKRSPGPALWWMNGSGEELKWNFRELSEISKQTANVLTGACG
                     LQRGDRVAVVLPRVPEWWLVTLGCMRSGLVFMPGTTQMKSTDILYRLQSSKARAIVAG
                     DEVVQEVDAVAPDCSFLKIKLLVSEKNREGWLNFKALLKDASPIHQCVETVSQESAAI
                     YFTSGTSGPPKMAEHSHCSLGLKAKMDAGWTGLGPSDTMWTISDTGWILNILGSFLEP
                     WVLGTCIFVHLLPKFDPQTVLKVLSSYPINTLLGAPLIYRMLLQQDLSSYKFPHLHSC
                     FSGGETLLPETLESWKAKTGLEIREIYGQTETGITCRVSRTMKVKPGYLGTAIVPYDV
                     QVIDEQGNVLPPGKEGDMALRVKPIRPIGMFSGYVDNPKKTQANIRGDFWLLGDRGIK
                     DTEGYFHFMGRTDDIINSSGYRIGPSEVENALMEHPAVVETAVISSPDPIRREVVKAF
                     VVLAPEFLSHDQDQLTKVLQEHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAK
                     EWKTSG"
     exon            284..494
                     /gene="Acsm2"
                     /gene_synonym="Acsm2a; KS"
                     /inference="alignment:Splign:2.1.0"
     exon            495..702
                     /gene="Acsm2"
                     /gene_synonym="Acsm2a; KS"
                     /inference="alignment:Splign:2.1.0"
     exon            703..846
                     /gene="Acsm2"
                     /gene_synonym="Acsm2a; KS"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1000
                     /gene="Acsm2"
                     /gene_synonym="Acsm2a; KS"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1080
                     /gene="Acsm2"
                     /gene_synonym="Acsm2a; KS"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1204
                     /gene="Acsm2"
                     /gene_synonym="Acsm2a; KS"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1285
                     /gene="Acsm2"
                     /gene_synonym="Acsm2a; KS"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1387
                     /gene="Acsm2"
                     /gene_synonym="Acsm2a; KS"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1515
                     /gene="Acsm2"
                     /gene_synonym="Acsm2a; KS"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1615
                     /gene="Acsm2"
                     /gene_synonym="Acsm2a; KS"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1735
                     /gene="Acsm2"
                     /gene_synonym="Acsm2a; KS"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..2426
                     /gene="Acsm2"
                     /gene_synonym="Acsm2a; KS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catcagtgct gttctctcta ctggtgcttc gggaactcta gaactccttc ctgagaggga
       61 agcaaaccaa gctattgcca gagagagttc cataagagct ctgaatatgc attggctgtg
      121 gaaaattcca agactttgca ccttctgggg cactgagatg ttccaccgtt ctttccatat
      181 gaatatcaag aaactaatgc ccatacagtg gggccaccaa gaagtccctg ccaagttcaa
      241 cttcgctagt gatgtgatag atcactgggc cagcctggag aaggctggca agagatctcc
      301 aggtccagcc ctatggtgga tgaatggcag tggggaagaa ctaaagtgga acttcagaga
      361 actgagtgaa atcagtaaac agacggccaa tgttctcacc ggggcctgtg gcctgcagcg
      421 tggggaccgt gtagcagtag tgcttcctcg agtcccagag tggtggctgg tgaccctcgg
      481 ctgcatgcgt tctggtcttg ttttcatgcc tggaaccacc cagatgaaat ccacagacat
      541 actctacagg ctgcaatcat ccaaggccag ggccattgtg gctggggatg aagtggttca
      601 ggaagtggat gctgtggccc ctgactgctc ttttctgaaa atcaagttgc tggtgtctga
      661 aaaaaatcga gaaggatggc taaacttcaa ggcactgcta aaggatgcat cccccattca
      721 tcagtgtgtg gagactgtaa gccaagaatc agctgccatc tatttcacta gcgggaccag
      781 tggccctccc aagatggcag agcactccca ctgcagcctg ggcctcaagg ccaagatgga
      841 tgctggctgg acaggactgg gaccttctga cacaatgtgg accatctcag acacaggctg
      901 gatattaaac attttagggt catttctgga accttgggta ttgggaacgt gcatatttgt
      961 ccatcttttg ccaaagtttg atccacaaac tgttctaaag gtgctttcca gctaccccat
     1021 caataccctg ctgggtgccc ccctcattta ccggatgttg ctacaacagg atctttccag
     1081 ttacaagttc ccacatctgc atagctgctt cagtggagga gagaccctcc tcccggagac
     1141 tctggagagt tggaaagcca agacaggact ggaaatccga gaaatctatg gccagacaga
     1201 aacgggaatt acctgcagag tttctaggac aatgaaagtc aaaccaggct acctgggaac
     1261 agccattgtc ccttatgatg tccaggtcat agatgagcag ggcaatgtcc tgccccctgg
     1321 caaggaagga gacatggctc tcagggtgaa gcccatcagg cctataggca tgttctctgg
     1381 atatgtggac aatcccaaga agacacaggc taatattcga ggagactttt ggcttctggg
     1441 agaccgggga attaaggata cagaagggta tttccacttc atgggacgga cagacgatat
     1501 cattaattcc agtgggtacc gaattggacc ttccgaggtg gagaatgcac tgatggaaca
     1561 tcctgccgtg gttgaaacag ctgtgatcag cagcccagac cctatcagaa gagaggtggt
     1621 gaaggcattt gtggttctag cccctgagtt cctgtcccat gaccaagacc agctcaccaa
     1681 ggttcttcag gaacacgtga agtcagtgac agcaccctac aagtacccca ggaaggtgga
     1741 gtttgtctta gacctgccca agaccatcac aggaaaaatt gagcgagcta aacttcgagc
     1801 caaggaatgg aaaacatcag gataagccca ggcccagtga gactcccaag gctcttgctc
     1861 tgtctttccc aatccttttc ttatgactcc ttagtcttcc tatagcaata tgaaattatt
     1921 catgtagagg catgtatgtg atttaggtct ttgcttggtt attgacacag aacaatgaca
     1981 cgtttcatgc taaaagaaga aagaaagagg gaataagagg tttgaagtca gaaaaggcta
     2041 aaacagcaag ggaaagaaat tgccaattca agtggtcagg aaggggtaga gagaagggga
     2101 aagcagaatg aggagagaga gagatgagaa ggaactggag agaaatagaa aaagggttgt
     2161 gtagaaggac actagtgtct tcgccaagtt gtgtcaatcc ttagggacat catgcccaaa
     2221 ggagaaggaa ataccactta cagagcatgc ccaaggcact gttatacact tgtcatgagt
     2281 cctatacagg tcatgagcca tcttacttca tctgggtgac atctgcaggc tcatcttctg
     2341 caccccaaaa tgtaccactt cctgtagctc acattttttg ttctagcttt atttccttga
     2401 attaataata aaatcacttc aaaatc
//
