LOCUS       NM_001108502            2103 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus acyl-CoA synthetase medium-chain family member 1
            (Acsm1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001108502 XM_001079043 XM_341917
VERSION     NM_001108502.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2103)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   2  (bases 1 to 2103)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 2103)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 2103)
  AUTHORS   Oka,Y., Kobayakawa,K., Nishizumi,H., Miyamichi,K., Hirose,S.,
            Tsuboi,A. and Sakano,H.
  TITLE     O-MACS, a novel member of the medium-chain acyl-CoA synthetase
            family, specifically expressed in the olfactory epithelium in a
            zone-specific manner
  JOURNAL   Eur J Biochem 270 (9), 1995-2004 (2003)
   PUBMED   12709059
REFERENCE   5  (bases 1 to 2103)
  AUTHORS   Fujino,T., Takei,Y.A., Sone,H., Ioka,R.X., Kamataki,A., Magoori,K.,
            Takahashi,S., Sakai,J. and Yamamoto,T.T.
  TITLE     Molecular identification and characterization of two medium-chain
            acyl-CoA synthetases, MACS1 and the Sa gene product
  JOURNAL   J Biol Chem 276 (38), 35961-35966 (2001)
   PUBMED   11470804
REFERENCE   6  (bases 1 to 2103)
  AUTHORS   Vessey,D.A., Kelley,M. and Warren,R.S.
  TITLE     Characterization of the CoA ligases of human liver mitochondria
            catalyzing the activation of short- and medium-chain fatty acids
            and xenobiotic carboxylic acids
  JOURNAL   Biochim Biophys Acta 1428 (2-3), 455-462 (1999)
   PUBMED   10434065
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168985.1.
            
            On Nov 20, 2012 this sequence version replaced NM_001108502.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168985.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2103
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q35"
     gene            1..2103
                     /gene="Acsm1"
                     /gene_synonym="Bucs1"
                     /note="acyl-CoA synthetase medium-chain family member 1"
                     /db_xref="GeneID:361638"
                     /db_xref="RGD:1306813"
     exon            1..100
                     /gene="Acsm1"
                     /gene_synonym="Bucs1"
                     /inference="alignment:Splign:2.1.0"
     exon            101..306
                     /gene="Acsm1"
                     /gene_synonym="Bucs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1848
                     /gene="Acsm1"
                     /gene_synonym="Bucs1"
                     /EC_number="6.2.1.2"
                     /note="butyryl Coenzyme A synthetase 1"
                     /codon_start=1
                     /product="acyl-coenzyme A synthetase ACSM1, mitochondrial"
                     /protein_id="NP_001101972.2"
                     /db_xref="GeneID:361638"
                     /db_xref="RGD:1306813"
                     /translation="MQWLRRFLTPLGICKFLHRFSLHRPQLHRWLISGDGAQRWNDYD
                     SPEEFNFASHVLDYWAQMEGEGKRGPGPALWWVNDQGDEIKWSFRELRDLSRRAANVF
                     EQTCGLQHGDRLALILPRVPEWWLVTVGCIRTGVIFIPGTAQMKAKDILYRIQMSQAK
                     AIVTTDSLVPEVESVASECPGLKTKIVVSDHNHEGWLNFRTLLRSASPDHTCVKSKMK
                     DPMVIFFTSGTTGYPKMAKHNQGLAFRSSVPSCRKFLKLKTSDVIWCMSDPGWILATV
                     GCLLEPWTAGATVFVHNLPQFDPKVIVETLFKYPITQCLAAPAVYRMVLQKNISNLRF
                     PTLEHCATGGESLLPEEYEQWKQRTGLSIHEVYGQSETGITCAIFREMKVKRGSIGKA
                     ILPFDIQIIDEKGNILPPNTEGYIGIRIKPTRPLGLFVGYENSPEKTSEVECGDFYNS
                     GDRATIDEDGYIWFLGRSDDVINASGYRIGPTEVENALVEHPAVSESAVVSSPDKDRG
                     EVVKAFIVLNPEFLSHDQEQLIKELQEHVKSVTAPYKYPRKVEFVSELPKTITGKIKR
                     KELRNKEFGQI"
     exon            307..517
                     /gene="Acsm1"
                     /gene_synonym="Bucs1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..725
                     /gene="Acsm1"
                     /gene_synonym="Bucs1"
                     /inference="alignment:Splign:2.1.0"
     exon            726..866
                     /gene="Acsm1"
                     /gene_synonym="Bucs1"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1026
                     /gene="Acsm1"
                     /gene_synonym="Bucs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1106
                     /gene="Acsm1"
                     /gene_synonym="Bucs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1230
                     /gene="Acsm1"
                     /gene_synonym="Bucs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1311
                     /gene="Acsm1"
                     /gene_synonym="Bucs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1413
                     /gene="Acsm1"
                     /gene_synonym="Bucs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1541
                     /gene="Acsm1"
                     /gene_synonym="Bucs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1641
                     /gene="Acsm1"
                     /gene_synonym="Bucs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1761
                     /gene="Acsm1"
                     /gene_synonym="Bucs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..2060
                     /gene="Acsm1"
                     /gene_synonym="Bucs1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagttccaca gctgtgttcc cagaactgaa aaggattgtg cacagaccct acaagcttcc
       61 tctcctagct atagtctacc tgtgtccttc acagtatcag tggactacct aaatatgcag
      121 tggctgagga ggttcctgac tccactgggc atctgcaaat tcttgcacag attctcccta
      181 caccgtccac agctgcacag atggttgatt tcaggagacg gagctcaaag atggaatgac
      241 tatgattcac ctgaggagtt taactttgca agtcatgtcc tggactactg ggctcaaatg
      301 gaaggggagg gcaagagagg accaggtcca gccttatggt gggtgaatga ccaaggagat
      361 gaaataaagt ggagcttcag ggagctgagg gacctcagcc gccgtgctgc caacgtcttt
      421 gagcagactt gtggcctgca gcatggagat cgcctggcct tgattctgcc tcgagtgccg
      481 gagtggtggc tggtgacagt gggctgcatt cgaacaggag tcatcttcat tcctgggact
      541 gcccaaatga aagccaagga tattctctac cgaatacaaa tgtctcaagc caaagccatt
      601 gtgaccacag acagccttgt tccagaggtg gaatctgtgg cttctgagtg tcctggtctg
      661 aaaaccaaga tagtggtgtc tgatcacaac catgaagggt ggcttaactt ccggacactg
      721 cttagatcag catccccaga ccatacctgt gttaagtcaa agatgaagga ccccatggtc
      781 atcttcttca ccagcgggac cacaggttac cccaagatgg caaagcacaa ccaaggactt
      841 gctttccggt cttctgtgcc ttcatgcaga aaatttttga agctgaagac atctgatgtc
      901 atttggtgca tgtcagaccc aggatggatt ctggctactg tgggatgcct gctcgaaccc
      961 tggacagcag gtgctacagt cttcgttcac aacctccctc agtttgaccc caaagtcatt
     1021 gtagagacac tgttcaaata ccctatcact caatgccttg ctgccccagc cgtgtatcga
     1081 atggttcttc agaagaatat ctccaatctc aggttcccca ccctggagca ttgcgcaact
     1141 ggtggagaga gcctgctgcc tgaggaatat gagcagtgga agcaaaggac aggcctttcc
     1201 attcatgagg tctatggaca gtcagaaacg gggatcacct gtgccatctt ccgggaaatg
     1261 aaggtcaagc gaggctccat agggaaggcc attttaccct ttgacataca gatcatcgat
     1321 gagaagggca acatcctccc gcccaacacg gaaggataca ttggcatcag gatcaagccc
     1381 accaggccgc taggcctctt cgtgggatat gagaatagcc cagagaagac atctgaagtg
     1441 gagtgtgggg acttttacaa tagtggggat agagcgacta ttgatgaaga tggctacatc
     1501 tggttcttgg ggaggagtga tgatgtcatc aatgcttccg ggtaccgcat cgggcctaca
     1561 gaggtggaga acgccttggt ggagcaccca gcggtgtcag agtctgcggt ggtgagcagc
     1621 cctgacaagg atcgaggaga ggtggtgaag gcttttattg tcctcaaccc agagttcctg
     1681 tcacatgatc aggaacagct tatcaaagag ctacaggagc atgtgaagtc agtgactgca
     1741 ccatacaagt accccaggaa ggtggagttt gtttcagaat tgcccaaaac catcacaggc
     1801 aaaatcaaaa gaaaggaact tcgaaataag gagttcggtc agatatgaac aacaatcaac
     1861 ccaaagcatc ctgtgacctg attcctttgc tttagggggt gggggtgggg tgagaatgga
     1921 atgcaggaag gggaagtgtg aaagagaaaa ccaagacccc aacatttttg gtgttttttt
     1981 tttaattcag ttgctaccct tcctgaaagg tcacagtgca ctctcatact gtaggcaata
     2041 aaaatacaga ttaaatatca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2101 aaa
//
