LOCUS       NM_130739               2564 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus acyl-CoA synthetase long-chain family member 6
            (Acsl6), mRNA.
ACCESSION   NM_130739
VERSION     NM_130739.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2564)
  AUTHORS   Xu,L., Liu,Q., Long,T., Peng,L., Li,F., Sun,Z. and Xie,Q.
  TITLE     Ectopic Acsl6 Overexpression Partially Improves
            Isoproterenol-Induced Cardiac Hypertrophy In Vivo and Cardiomyocyte
            Hypertrophy In Vitro
  JOURNAL   J Cardiovasc Pharmacol 80 (6), 792-803 (2022)
   PUBMED   35976155
  REMARK    GeneRIF: Ectopic Acsl6 Overexpression Partially Improves
            Isoproterenol-Induced Cardiac Hypertrophy In Vivo and Cardiomyocyte
            Hypertrophy In Vitro.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2564)
  AUTHORS   Klett,E.L., Chen,S., Yechoor,A., Lih,F.B. and Coleman,R.A.
  TITLE     Long-chain acyl-CoA synthetase isoforms differ in preferences for
            eicosanoid species and long-chain fatty acids
  JOURNAL   J Lipid Res 58 (5), 884-894 (2017)
   PUBMED   28209804
  REMARK    Erratum:[J Lipid Res. 2017 Dec;58(12):2365. doi:
            10.1194/jlr.M072512ERR.. PMID: 29196521]
REFERENCE   3  (bases 1 to 2564)
  AUTHORS   Teodoro,B.G., Sampaio,I.H., Bomfim,L.H., Queiroz,A.L.,
            Silveira,L.R., Souza,A.O., Fernandes,A.M., Eberlin,M.N.,
            Huang,T.Y., Zheng,D., Neufer,P.D., Cortright,R.N. and Alberici,L.C.
  TITLE     Long-chain acyl-CoA synthetase 6 regulates lipid synthesis and
            mitochondrial oxidative capacity in human and rat skeletal muscle
  JOURNAL   J Physiol 595 (3), 677-693 (2017)
   PUBMED   27647415
  REMARK    GeneRIF: ACSL6 drives acyl-CoA toward lipid synthesis and its
            downregulation improves mitochondrial biogenesis, respiratory
            capacity and lipid oxidation
REFERENCE   4  (bases 1 to 2564)
  AUTHORS   Ohkuni,A., Ohno,Y. and Kihara,A.
  TITLE     Identification of acyl-CoA synthetases involved in the mammalian
            sphingosine 1-phosphate metabolic pathway
  JOURNAL   Biochem Biophys Res Commun 442 (3-4), 195-201 (2013)
   PUBMED   24269233
REFERENCE   5  (bases 1 to 2564)
  AUTHORS   Nakahara,K., Ohkuni,A., Kitamura,T., Abe,K., Naganuma,T., Ohno,Y.,
            Zoeller,R.A. and Kihara,A.
  TITLE     The Sjogren-Larsson syndrome gene encodes a hexadecenal
            dehydrogenase of the sphingosine 1-phosphate degradation pathway
  JOURNAL   Mol Cell 46 (4), 461-471 (2012)
   PUBMED   22633490
REFERENCE   6  (bases 1 to 2564)
  AUTHORS   Benani,A., Vol,C., Heurtaux,T., Asensio,C., Dauca,M., Lapicque,F.,
            Netter,P. and Minn,A.
  TITLE     Up-regulation of fatty acid metabolizing-enzymes mRNA in rat spinal
            cord during persistent peripheral local inflammation
  JOURNAL   Eur J Neurosci 18 (7), 1904-1914 (2003)
   PUBMED   14622223
REFERENCE   7  (bases 1 to 2564)
  AUTHORS   Kee,H.J., Koh,J.T., Yang,S.Y., Lee,Z.H., Baik,Y.H. and Kim,K.K.
  TITLE     A novel murine long-chain acyl-CoA synthetase expressed in brain
            participates in neuronal cell proliferation
  JOURNAL   Biochem Biophys Res Commun 305 (4), 925-933 (2003)
   PUBMED   12767919
REFERENCE   8  (bases 1 to 2564)
  AUTHORS   Dillon,J.S., Yaney,G.C., Zhou,Y., Voilley,N., Bowen,S., Chipkin,S.,
            Bliss,C.R., Schultz,V., Schuit,F.C., Prentki,M., Waxman,D.J. and
            Corkey,B.E.
  TITLE     Dehydroepiandrosterone sulfate and beta-cell function: enhanced
            glucose-induced insulin secretion and altered gene expression in
            rodent pancreatic beta-cells
  JOURNAL   Diabetes 49 (12), 2012-2020 (2000)
   PUBMED   11118002
REFERENCE   9  (bases 1 to 2564)
  AUTHORS   Yagasaki,F., Jinnai,I., Yoshida,S., Yokoyama,Y., Matsuda,A.,
            Kusumoto,S., Kobayashi,H., Terasaki,H., Ohyashiki,K., Asou,N.,
            Murohashi,I., Bessho,M. and Hirashima,K.
  TITLE     Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and
            acute myelogenous leukemia with t(5;12)(q31;p13)
  JOURNAL   Genes Chromosomes Cancer 26 (3), 192-202 (1999)
   PUBMED   10502316
REFERENCE   10 (bases 1 to 2564)
  AUTHORS   Fujino,T. and Yamamoto,T.
  TITLE     Cloning and functional expression of a novel long-chain acyl-CoA
            synthetase expressed in brain
  JOURNAL   J Biochem 111 (2), 197-203 (1992)
   PUBMED   1569043
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 26, 2020 this sequence version replaced NM_130739.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D10041.1, SRR26643298.60507.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               JAXUCZ010000010.1  38952161-38952274
            115-335             JAXUCZ010000010.1  38957353-38957573
            336-450             JAXUCZ010000010.1  38960504-38960618
            451-515             JAXUCZ010000010.1  38961221-38961285
            516-617             JAXUCZ010000010.1  38962234-38962335
            618-717             JAXUCZ010000010.1  38962718-38962817
            718-896             JAXUCZ010000010.1  38963522-38963700
            897-929             JAXUCZ010000010.1  38964810-38964842
            930-981             JAXUCZ010000010.1  38966832-38966883
            982-1055            JAXUCZ010000010.1  38972175-38972248
            1056-1133           JAXUCZ010000010.1  38974195-38974272
            1134-1268           JAXUCZ010000010.1  38975724-38975858
            1269-1403           JAXUCZ010000010.1  38976561-38976695
            1404-1499           JAXUCZ010000010.1  38978063-38978158
            1500-1572           JAXUCZ010000010.1  38979384-38979456
            1573-1661           JAXUCZ010000010.1  38982968-38983056
            1662-1778           JAXUCZ010000010.1  38983780-38983896
            1779-1922           JAXUCZ010000010.1  38988783-38988926
            1923-2024           JAXUCZ010000010.1  38990518-38990619
            2025-2096           JAXUCZ010000010.1  38991454-38991525
            2097-2564           JAXUCZ010000010.1  38999035-38999502
FEATURES             Location/Qualifiers
     source          1..2564
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..2564
                     /gene="Acsl6"
                     /gene_synonym="Facl6; Lacsl"
                     /note="acyl-CoA synthetase long-chain family member 6"
                     /db_xref="GeneID:117243"
                     /db_xref="RGD:69403"
     exon            1..114
                     /gene="Acsl6"
                     /gene_synonym="Facl6; Lacsl"
                     /inference="alignment:Splign:2.1.0"
     exon            115..335
                     /gene="Acsl6"
                     /gene_synonym="Facl6; Lacsl"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..2234
                     /gene="Acsl6"
                     /gene_synonym="Facl6; Lacsl"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.15"
                     /note="LACS 6; long-chain acyl-CoA synthetase 6;
                     long-chain-fatty-acid--CoA ligase, brain isozyme; fatty
                     acid Coenzyme A ligase, long chain 6; arachidonate--CoA
                     ligase"
                     /codon_start=1
                     /product="long-chain-fatty-acid--CoA ligase 6"
                     /protein_id="NP_570095.2"
                     /db_xref="GeneID:117243"
                     /db_xref="RGD:69403"
                     /translation="MQTQEILRILRLPELSDLGQFFRSLSATTLVSMGALAAILAYWL
                     THRPKALQPPCNLLMQSEEVEDSGGARRSVIGDCTQLLTHYYDDARTMYQVFRRGLSI
                     SGNGPCLGFRKPEQPYQWLSYQEVAKRAEFLGSGLLQHDCKVGTEQFIGVFAQNRPEW
                     IIAELACYTYSMVVVPLYDTLGPGSIRYIINTADICTVIVDKPHKAILLLEHVERKET
                     PGLKLVILMEPFDDALRERGKKCGVDIKSMQAIEDSGQENHRVPVPPRPDDLSIVCFT
                     SGTTGNPKGAMLTHGNVVADFSGFLKVTESQWAPTCADVHFSYLPLAHMFERMVQSVV
                     YCHGGRVGFFQGDIRLLSDDMKALRPTIFPVVPRLLNRMYDKIFHQADTSLKRWLLEF
                     AAKRKQAEVRSGIIRNNSIWDELFFNKIQASLGGHVRMIVTGAAPASPTVLGFLRAAL
                     GCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDAEELNYWTSKGEGEI
                     CVKGPNVFKGYLKDEDRTKEALDSDGWLHTGDIGKWLPEGTLKIIDRKKHIFKLAQGE
                     YVAPEKIENIYIRSEPVAQIYVHGDSLKAFLVGIVVPDPEVMPCWAQKKGIEGNYQEL
                     CKSKELKKAILDDMVMLGKESGLHSFEQVKAIYIHCDMFSVQNGLLTPTLKAKRPELR
                     EYFKKQIEELYSISM"
     exon            336..450
                     /gene="Acsl6"
                     /gene_synonym="Facl6; Lacsl"
                     /inference="alignment:Splign:2.1.0"
     exon            451..515
                     /gene="Acsl6"
                     /gene_synonym="Facl6; Lacsl"
                     /inference="alignment:Splign:2.1.0"
     exon            516..617
                     /gene="Acsl6"
                     /gene_synonym="Facl6; Lacsl"
                     /inference="alignment:Splign:2.1.0"
     exon            618..717
                     /gene="Acsl6"
                     /gene_synonym="Facl6; Lacsl"
                     /inference="alignment:Splign:2.1.0"
     exon            718..896
                     /gene="Acsl6"
                     /gene_synonym="Facl6; Lacsl"
                     /inference="alignment:Splign:2.1.0"
     exon            897..929
                     /gene="Acsl6"
                     /gene_synonym="Facl6; Lacsl"
                     /inference="alignment:Splign:2.1.0"
     exon            930..981
                     /gene="Acsl6"
                     /gene_synonym="Facl6; Lacsl"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1055
                     /gene="Acsl6"
                     /gene_synonym="Facl6; Lacsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1133
                     /gene="Acsl6"
                     /gene_synonym="Facl6; Lacsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1268
                     /gene="Acsl6"
                     /gene_synonym="Facl6; Lacsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1403
                     /gene="Acsl6"
                     /gene_synonym="Facl6; Lacsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1499
                     /gene="Acsl6"
                     /gene_synonym="Facl6; Lacsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1572
                     /gene="Acsl6"
                     /gene_synonym="Facl6; Lacsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1661
                     /gene="Acsl6"
                     /gene_synonym="Facl6; Lacsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1778
                     /gene="Acsl6"
                     /gene_synonym="Facl6; Lacsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1922
                     /gene="Acsl6"
                     /gene_synonym="Facl6; Lacsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2024
                     /gene="Acsl6"
                     /gene_synonym="Facl6; Lacsl"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2096
                     /gene="Acsl6"
                     /gene_synonym="Facl6; Lacsl"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2564
                     /gene="Acsl6"
                     /gene_synonym="Facl6; Lacsl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccttccatc aagatgtggt aacctctttc cctgagcgcc acaggctcta gaaagagagg
       61 ctggttctag caggatcagc tccacctcct cagtgcccgg aggctgctgg aaagagattg
      121 ccctgtcact tctggagaag atgcagaccc aggagatcct gaggatcctg cggctgcccg
      181 agctatcgga cttgggccag tttttccgca gcctctcagc caccaccctt gtgagtatgg
      241 gtgcactggc tgccatcctt gcatactggc tcactcaccg gccaaaggcc ttgcaaccac
      301 catgcaacct cctgatgcag tcggaagaag tagaggacag tggtggagcc cggcgatctg
      361 tgattgggga ttgcactcag ttgcttaccc actactatga cgatgcccgg acgatgtacc
      421 aggtgttccg acgtgggctt agcatctcag ggaatggacc ctgtcttggc ttccggaagc
      481 cagagcaacc ttaccagtgg ctgtcctatc aagaggtggc caaaagggct gaattcctgg
      541 ggtcaggact tctccagcat gactgtaaag tgggcacaga gcagttcatt ggcgtttttg
      601 cacaaaatcg gccagagtgg atcattgctg agctggcctg ctacacatat tccatggtgg
      661 tggtaccgct ctatgacaca ctgggcccag ggtctatccg ctacatcatc aatacagcgg
      721 acatctgcac tgtaatcgtg gataagccgc ataaggctat actcctgcta gaacacgtgg
      781 agaggaagga gactccgggc ctcaagctgg tcatcctcat ggagccattt gacgatgccc
      841 tgagagagag gggaaagaag tgcggggtgg acatcaagtc catgcaggct atagaggact
      901 ccggccaaga gaatcatcgt gtccccgtgc ccccacggcc cgatgacctc tccattgtgt
      961 gtttcacgag cggtacaaca gggaacccca aaggtgcgat gctcacccac gggaacgtgg
     1021 tggccgattt ctcgggcttt ctgaaagtca cagagagtca gtgggccccc acttgtgcgg
     1081 atgtacactt ttcctatttg cctttagcac acatgtttga gcgaatggtg cagtctgttg
     1141 tctactgcca tggagggcgt gtgggcttct tccagggaga catccgcctc ctctcagacg
     1201 acatgaaagc tctccgcccc accatcttcc ctgtggtccc acggctgctg aatcggatgt
     1261 atgacaagat cttccaccag gcagacacct cactgaagcg ctggctcctg gagtttgcag
     1321 caaagcgcaa gcaggctgag gtccggagcg gaatcatcag aaacaatagt atctgggatg
     1381 aactcttctt taataagatt caggccagtc ttggagggca cgtgagaatg attgttaccg
     1441 gagcagcccc cgcatcacca acagtcctgg gattcctacg agcagctctg gggtgccagg
     1501 tctatgaagg ttatgggcaa actgaatgca cagctgggtg taccttcaca acgccagggg
     1561 actggacatc agggcacgtg ggagcccctc tgccctgcaa ccacatcaag ctggtcgacg
     1621 cagaggaact caactactgg accagcaaag gagaaggaga gatctgtgtg aaaggaccaa
     1681 atgtgttcaa aggctactta aaagacgagg acaggacaaa ggaggccctg gacagtgacg
     1741 gctggcttca cacgggagac attggaaaat ggctgccgga gggaacgctt aaaatcatcg
     1801 atcggaaaaa gcacatattt aaacttgctc agggggaata cgttgcgccc gagaagattg
     1861 agaacatcta catccgaagt gagcctgtgg cgcaaatcta cgtccatggg gacagcttaa
     1921 aggcctttct ggttggcatt gttgtgcctg accctgaagt catgccttgc tgggctcaga
     1981 agaaaggaat cgaagggaac taccaggaac tctgcaaaag taaggaattg aagaaagcca
     2041 ttctggatga catggtgatg ttggggaaag aaagtggact gcattctttt gaacaggtta
     2101 aagccattta catccattgt gacatgttct cagttcaaaa tggcttgctg acaccaacac
     2161 taaaggctaa gaggcccgag ctgagagagt acttcaaaaa gcaaatagaa gagctgtact
     2221 caatctccat gtgaagctca aggaggccct tctcagccca gcaaagtttg cagcaatatt
     2281 ctaattattc ttgagagaaa ggagtcagaa tgccacagct cagagtgaac gagcacctga
     2341 tttttttttt ttgcaactga gcctttcctg acctgagaag tctctaacaa tattttctct
     2401 accatcacca agtacacttt atttttatta aatgatattg tagcaagctg ctaaaaaaat
     2461 tattgcaaac ggtaatgtaa aaacaaatca agacactttc tcaagaactg tgtaccacta
     2521 aagtaatata ttcgcgatgt tcacagaatt ccattaaaca taaa
//
