LOCUS       NM_053607               2666 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus acyl-CoA synthetase long-chain family member 5
            (Acsl5), mRNA.
ACCESSION   NM_053607 XM_039093161
VERSION     NM_053607.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2666)
  AUTHORS   Klett,E.L., Chen,S., Yechoor,A., Lih,F.B. and Coleman,R.A.
  TITLE     Long-chain acyl-CoA synthetase isoforms differ in preferences for
            eicosanoid species and long-chain fatty acids
  JOURNAL   J Lipid Res 58 (5), 884-894 (2017)
   PUBMED   28209804
  REMARK    Erratum:[J Lipid Res. 2017 Dec;58(12):2365. doi:
            10.1194/jlr.M072512ERR.. PMID: 29196521]
REFERENCE   2  (bases 1 to 2666)
  AUTHORS   Ohkuni,A., Ohno,Y. and Kihara,A.
  TITLE     Identification of acyl-CoA synthetases involved in the mammalian
            sphingosine 1-phosphate metabolic pathway
  JOURNAL   Biochem Biophys Res Commun 442 (3-4), 195-201 (2013)
   PUBMED   24269233
REFERENCE   3  (bases 1 to 2666)
  AUTHORS   Nakahara,K., Ohkuni,A., Kitamura,T., Abe,K., Naganuma,T., Ohno,Y.,
            Zoeller,R.A. and Kihara,A.
  TITLE     The Sjogren-Larsson syndrome gene encodes a hexadecenal
            dehydrogenase of the sphingosine 1-phosphate degradation pathway
  JOURNAL   Mol Cell 46 (4), 461-471 (2012)
   PUBMED   22633490
REFERENCE   4  (bases 1 to 2666)
  AUTHORS   Kaemmerer,E., Peuscher,A., Reinartz,A., Liedtke,C., Weiskirchen,R.,
            Kopitz,J. and Gassler,N.
  TITLE     Human intestinal acyl-CoA synthetase 5 is sensitive to the
            inhibitor triacsin C
  JOURNAL   World J Gastroenterol 17 (44), 4883-4889 (2011)
   PUBMED   22171129
  REMARK    GeneRIF: The data strongly indicate that human but not rat acyl-CoA
            synthetase 5 is sensitive to triacsin C and does not compensate for
            other triacsin C-sensitive ACSL isoforms.
REFERENCE   5  (bases 1 to 2666)
  AUTHORS   Bu,S.Y. and Mashek,D.G.
  TITLE     Hepatic long-chain acyl-CoA synthetase 5 mediates fatty acid
            channeling between anabolic and catabolic pathways
  JOURNAL   J Lipid Res 51 (11), 3270-3280 (2010)
   PUBMED   20798351
  REMARK    GeneRIF: ACSL5 activates and channels fatty acids toward anabolic
            pathways
REFERENCE   6  (bases 1 to 2666)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   7  (bases 1 to 2666)
  AUTHORS   Lewin,T.M., Van Horn,C.G., Krisans,S.K. and Coleman,R.A.
  TITLE     Rat liver acyl-CoA synthetase 4 is a peripheral-membrane protein
            located in two distinct subcellular organelles, peroxisomes, and
            mitochondrial-associated membrane
  JOURNAL   Arch Biochem Biophys 404 (2), 263-270 (2002)
   PUBMED   12147264
REFERENCE   8  (bases 1 to 2666)
  AUTHORS   Lewin,T.M., Kim,J.H., Granger,D.A., Vance,J.E. and Coleman,R.A.
  TITLE     Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different
            subcellular membranes in rat liver and can be inhibited
            independently
  JOURNAL   J Biol Chem 276 (27), 24674-24679 (2001)
   PUBMED   11319232
REFERENCE   9  (bases 1 to 2666)
  AUTHORS   Kim,J.H., Lewin,T.M. and Coleman,R.A.
  TITLE     Expression and characterization of recombinant rat Acyl-CoA
            synthetases 1, 4, and 5. Selective inhibition by triacsin C and
            thiazolidinediones
  JOURNAL   J Biol Chem 276 (27), 24667-24673 (2001)
   PUBMED   11319222
REFERENCE   10 (bases 1 to 2666)
  AUTHORS   Oikawa,E., Iijima,H., Suzuki,T., Sasano,H., Sato,H., Kamataki,A.,
            Nagura,H., Kang,M.J., Fujino,T., Suzuki,H. and Yamamoto,T.T.
  TITLE     A novel acyl-CoA synthetase, ACS5, expressed in intestinal
            epithelial cells and proliferating preadipocytes
  JOURNAL   J Biochem 124 (3), 679-685 (1998)
   PUBMED   9722683
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Mar 8, 2021 this sequence version replaced
            XM_039093161.1, NM_053607.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1136462.1,
                                           SRR26643293.9446.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000001.1  264294851-264294984
            135-307             JAXUCZ010000001.1  264297662-264297834
            308-492             JAXUCZ010000001.1  264315275-264315459
            493-601             JAXUCZ010000001.1  264319245-264319353
            602-666             JAXUCZ010000001.1  264324512-264324576
            667-768             JAXUCZ010000001.1  264324686-264324787
            769-868             JAXUCZ010000001.1  264326139-264326238
            869-1047            JAXUCZ010000001.1  264327136-264327314
            1048-1080           JAXUCZ010000001.1  264328065-264328097
            1081-1132           JAXUCZ010000001.1  264328180-264328231
            1133-1206           JAXUCZ010000001.1  264328970-264329043
            1207-1284           JAXUCZ010000001.1  264329766-264329843
            1285-1419           JAXUCZ010000001.1  264330884-264331018
            1420-1554           JAXUCZ010000001.1  264333253-264333387
            1555-1650           JAXUCZ010000001.1  264334362-264334457
            1651-1723           JAXUCZ010000001.1  264336617-264336689
            1724-1812           JAXUCZ010000001.1  264336889-264336977
            1813-1929           JAXUCZ010000001.1  264337229-264337345
            1930-2073           JAXUCZ010000001.1  264338929-264339072
            2074-2175           JAXUCZ010000001.1  264339552-264339653
            2176-2247           JAXUCZ010000001.1  264340116-264340187
            2248-2394           JAXUCZ010000001.1  264340661-264340807
            2395-2666           JAXUCZ010000001.1  264341672-264341943
FEATURES             Location/Qualifiers
     source          1..2666
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..2666
                     /gene="Acsl5"
                     /gene_synonym="Acs5; Facl5"
                     /note="acyl-CoA synthetase long-chain family member 5"
                     /db_xref="GeneID:94340"
                     /db_xref="RGD:69402"
     exon            1..134
                     /gene="Acsl5"
                     /gene_synonym="Acs5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            135..307
                     /gene="Acsl5"
                     /gene_synonym="Acs5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            308..492
                     /gene="Acsl5"
                     /gene_synonym="Acs5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     CDS             337..2388
                     /gene="Acsl5"
                     /gene_synonym="Acs5; Facl5"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.15"
                     /note="LACS 5; long-chain acyl-CoA synthetase 5; fatty
                     acid Coenzyme A ligase, long chain 5; long-chain fatty
                     acid coenzyme A ligase 5; arachidonate--CoA ligase"
                     /codon_start=1
                     /product="long-chain-fatty-acid--CoA ligase 5"
                     /protein_id="NP_446059.2"
                     /db_xref="GeneID:94340"
                     /db_xref="RGD:69402"
                     /translation="MLFIFNFLFSPLPTPALICLLTFGTAIFLWLINRPQPVLPLIDL
                     DNQSVGIEGGARRGAFQKNNDLILYYFSDAKTLYEVFQRGLAVSDNGPCLGYRKPNQP
                     YKWISYKQVSDRAEYLGSCLLHKGYKPSQDQFIGIFAQNRPEWVISELACYTYSMVAV
                     PLYDTLGAEAIIYVINRADISVVICDTPQKATMLIENVEKDLTPGLKTVILMDPFDDD
                     LMKRGEKCGIEMLSLHDAENLGKENFKKPVPPNPEDLSVICFTSGTTGDPKGAMLTHQ
                     NIVSNMAAFLKFLEPIFQPTPEDVTISYLPLAHMFERLVQGVIFSCGGKIGFFQGDIR
                     LLPDDMKALKPTVFPTVPRLLNRVYDKVQNEAKTPLKKFLLNLAIISKFNEVRNGIIR
                     RNSLWDKLVFSKIQSSLGGKVRLMITGAAPISTPVLTFFRAAMGCWVFEAYGQTECTA
                     GCSITSPGDWTAGHVGTPVSCNFVKLEDVADMNYFSVNNEGEICIKGNNVFKGYLKDP
                     EKTQEVLDKDGWLHTGDIGRWLPNGTLKIIDRKKNIFKLAQGEYIAPEKIENVYSRSR
                     PILQVFVHGESLRSFLIGVVVPDPESLPSFAAKIGVKGSFEELCQNQCVKKAILEDLQ
                     KVGKEGGLKSFEQVKSIFVHPEPFSIENGLLTPTLKAKRVELAKFFQTQIKSLYESIE
                     E"
     exon            493..601
                     /gene="Acsl5"
                     /gene_synonym="Acs5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            602..666
                     /gene="Acsl5"
                     /gene_synonym="Acs5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            667..768
                     /gene="Acsl5"
                     /gene_synonym="Acs5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            769..868
                     /gene="Acsl5"
                     /gene_synonym="Acs5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1047
                     /gene="Acsl5"
                     /gene_synonym="Acs5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1080
                     /gene="Acsl5"
                     /gene_synonym="Acs5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1132
                     /gene="Acsl5"
                     /gene_synonym="Acs5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1206
                     /gene="Acsl5"
                     /gene_synonym="Acs5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1284
                     /gene="Acsl5"
                     /gene_synonym="Acs5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1419
                     /gene="Acsl5"
                     /gene_synonym="Acs5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1554
                     /gene="Acsl5"
                     /gene_synonym="Acs5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1650
                     /gene="Acsl5"
                     /gene_synonym="Acs5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1723
                     /gene="Acsl5"
                     /gene_synonym="Acs5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1812
                     /gene="Acsl5"
                     /gene_synonym="Acs5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1929
                     /gene="Acsl5"
                     /gene_synonym="Acs5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2073
                     /gene="Acsl5"
                     /gene_synonym="Acs5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2175
                     /gene="Acsl5"
                     /gene_synonym="Acs5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2247
                     /gene="Acsl5"
                     /gene_synonym="Acs5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2394
                     /gene="Acsl5"
                     /gene_synonym="Acs5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2666
                     /gene="Acsl5"
                     /gene_synonym="Acs5; Facl5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttgtcccta cgaaaaggga gagaaagtac acacagtcag agcatcccat ggaagactat
       61 gtcagaatcg gggctattgg tcagtccccc cacatcacaa taacctcacc tgtgaatggc
      121 ctaaaagaat gaaggtccaa aggttccaaa ggagctggca ggacactcag acaagatcca
      181 ctggcttcag gtgtgcctag tcctggagtt cagaaagacg gaggcagctg aatgtggtgc
      241 tgaaccaaca acatctagct acaaggggag ccactcctcc acccagcgac tgtgactgtt
      301 ctcacaggtc tgaatttcct gttggtattc acaaagatgc tttttatttt taacttcttg
      361 ttttccccac ttccgacccc ggccctgatc tgcctcctga catttggaac ggctatcttc
      421 ctgtggctga tcaacagacc tcagccagtc ttacctctca ttgacttgga caaccagtct
      481 gtagggattg agggaggagc acggagaggc gctttccaga agaacaatga cctaatcctt
      541 tattacttct cagacgccaa gacgttgtat gaagttttcc aaagaggact tgctgtgtct
      601 gacaatggac cttgcttggg atacagaaag ccgaaccagc cctacaagtg gatatcctac
      661 aagcaggtgt ctgatcgagc agagtacctg ggctcctgtc ttttgcataa aggatacaag
      721 ccatcgcagg accaatttat tggcatcttt gctcaaaata ggccagagtg ggtcatctcc
      781 gagttagcct gttacacata ttccatggta gctgtccccc tgtatgacac actgggagca
      841 gaagccatca tctatgtcat caacagagct gatatctccg tggtgatctg tgatacaccc
      901 caaaaagcaa caatgctgat agaaaatgtg gaaaaggacc ttaccccagg cctgaagaca
      961 gtcatcctca tggacccttt cgatgatgac ctgatgaaac gaggagagaa gtgtggcatt
     1021 gagatgttgt ctctgcatga tgctgagaat ctaggcaaag agaacttcaa aaaaccagtg
     1081 cctccgaacc cagaggatct aagtgttatc tgtttcacca gtggaactac aggtgacccc
     1141 aaaggagcta tgctgaccca tcaaaatatc gtttcaaaca tggctgcttt cctcaaattt
     1201 ctggagccta tcttccagcc cacccccgag gatgtgacca tatcctacct tcccttggcc
     1261 catatgtttg agaggcttgt ccagggtgtc atattttcct gtggaggcaa aattgggttc
     1321 ttccaaggag atatccggtt gctacctgat gacatgaagg ctttgaaacc cacagtgttt
     1381 cccacagtgc ctcgactcct taacagggtc tatgataagg tacaaaatga agccaagaca
     1441 cctttgaaaa agttcttatt gaacttggct atcatcagca aattcaacga agtgagaaat
     1501 ggcatcattc ggcggaacag tttgtgggac aagctcgtgt tttcaaagat ccaaagcagc
     1561 ctgggtggga aggttcgtct catgatcact ggagccgccc ctatctccac tccagtcttg
     1621 acgttcttca gggctgcaat gggatgctgg gtgtttgaag cttacggcca aacagaatgc
     1681 acagctgggt gttctattac atcacctggg gactggacag caggtcatgt tgggactccg
     1741 gtgtcctgca attttgtcaa gctggaagat gtggctgaca tgaactactt ttcagtaaac
     1801 aacgaaggcg agatctgcat caaaggcaac aatgtgttca aaggctacct aaaggaccca
     1861 gagaagacac aggaagtact ggacaaggat ggctggcttc acactgggga catcggtcgc
     1921 tggcttccaa atggaactct gaaaatcatt gaccggaaga agaatatttt caaattggca
     1981 caaggagaat acatcgctcc agagaagatt gaaaatgttt attccaggag cagaccaata
     2041 ttgcaagttt ttgtccatgg ggagagctta cggtcattcc tgataggagt ggtggttcct
     2101 gacccagagt cacttccctc atttgcagcc aagatcgggg taaagggatc ctttgaagaa
     2161 ctatgccaaa accagtgtgt aaagaaagcc attttagaag atttgcagaa agttgggaaa
     2221 gaaggtggcc ttaaatcctt tgagcaggtc aagagcatct ttgtgcatcc ggagccgttc
     2281 tcaattgaaa acgggcttct gacaccgaca ctgaaagcca aacgagtgga gcttgccaag
     2341 ttcttccaga cacaaatcaa gagcctctat gagagcatcg aagagtaact taagttgctg
     2401 agctggaagc ggtgggggac gaagcggaaa ctatgtccag cgaacttttc cagtaaatga
     2461 agcaatcact aaaggactgt cctgagttgg gagcaaagca acgtggacga gctcgatgtg
     2521 acgcctgcac tgcaggcgtc ttctgtgatg gaagctctgg atctttctcc ttggacttca
     2581 gtccctgcag tattttgctg ccagatagca tgtggtgcct ctacctgtaa atgtcagatc
     2641 tttgaaataa actattacag atatta
//
