LOCUS       NM_053623               4862 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus acyl-CoA synthetase long-chain family member 4
            (Acsl4), mRNA.
ACCESSION   NM_053623
VERSION     NM_053623.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4862)
  AUTHORS   Zhou,J., Tang,J., Zhang,C., Li,G., Lin,X., Liao,S., Luo,J., Yu,G.,
            Zheng,F., Guo,Z., Shao,W., Hu,H., Xu,L., Wu,S. and Li,H.
  TITLE     ALKBH5 targets ACSL4 mRNA stability to modulate ferroptosis in
            hyperbilirubinemia-induced brain damage
  JOURNAL   Free Radic Biol Med 220, 271-287 (2024)
   PUBMED   38734267
  REMARK    GeneRIF: ALKBH5 targets ACSL4 mRNA stability to modulate
            ferroptosis in hyperbilirubinemia-induced brain damage.
REFERENCE   2  (bases 1 to 4862)
  AUTHORS   Wang,Y., Zhang,G., Gao,Y., Zhang,X. and Qi,H.
  TITLE     METTL3 promotes trophoblast ferroptosis in preeclampsia by
            stabilizing the ACSL4 m6A modification
  JOURNAL   Exp Cell Res 437 (1), 113990 (2024)
   PUBMED   38462207
  REMARK    GeneRIF: METTL3 promotes trophoblast ferroptosis in preeclampsia by
            stabilizing the ACSL4 m[6]A modification.
REFERENCE   3  (bases 1 to 4862)
  AUTHORS   Qiu,M., Yan,W. and Liu,M.
  TITLE     YAP Facilitates NEDD4L-Mediated Ubiquitination and Degradation of
            ACSL4 to Alleviate Ferroptosis in Myocardial Ischemia-Reperfusion
            Injury
  JOURNAL   Can J Cardiol 39 (11), 1712-1727 (2023)
   PUBMED   37541340
  REMARK    GeneRIF: YAP Facilitates NEDD4L-Mediated Ubiquitination and
            Degradation of ACSL4 to Alleviate Ferroptosis in Myocardial
            Ischemia-Reperfusion Injury.
REFERENCE   4  (bases 1 to 4862)
  AUTHORS   Qu,X.F., Liang,T.Y., Wu,D.G., Lai,N.S., Deng,R.M., Ma,C., Li,X.,
            Li,H.Y., Liu,Y.Z., Shen,H.T. and Chen,G.
  TITLE     Acyl-CoA synthetase long chain family member 4 plays detrimental
            role in early brain injury after subarachnoid hemorrhage in rats by
            inducing ferroptosis
  JOURNAL   CNS Neurosci Ther 27 (4), 449-463 (2021)
   PUBMED   33314758
  REMARK    GeneRIF: Acyl-CoA synthetase long chain family member 4 plays
            detrimental role in early brain injury after subarachnoid
            hemorrhage in rats by inducing ferroptosis.
REFERENCE   5  (bases 1 to 4862)
  AUTHORS   Dattilo,M.A., Benzo,Y., Herrera,L.M., Prada,J.G., Lopez,P.F.,
            Caruso,C.M., Lasaga,M., Garcia,C.I., Paz,C. and Maloberti,P.M.
  TITLE     Regulation and role of Acyl-CoA synthetase 4 in glial cells
  JOURNAL   J Steroid Biochem Mol Biol 208, 105792 (2021)
   PUBMED   33246155
  REMARK    GeneRIF: Regulation and role of Acyl-CoA synthetase 4 in glial
            cells.
REFERENCE   6  (bases 1 to 4862)
  AUTHORS   Lewin,T.M., Kim,J.H., Granger,D.A., Vance,J.E. and Coleman,R.A.
  TITLE     Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different
            subcellular membranes in rat liver and can be inhibited
            independently
  JOURNAL   J Biol Chem 276 (27), 24674-24679 (2001)
   PUBMED   11319232
REFERENCE   7  (bases 1 to 4862)
  AUTHORS   Kim,J.H., Lewin,T.M. and Coleman,R.A.
  TITLE     Expression and characterization of recombinant rat Acyl-CoA
            synthetases 1, 4, and 5. Selective inhibition by triacsin C and
            thiazolidinediones
  JOURNAL   J Biol Chem 276 (27), 24667-24673 (2001)
   PUBMED   11319222
REFERENCE   8  (bases 1 to 4862)
  AUTHORS   Li,Z., Jiang,H., Xie,W., Zhang,Z., Smrcka,A.V. and Wu,D.
  TITLE     Roles of PLC-beta2 and -beta3 and PI3Kgamma in
            chemoattractant-mediated signal transduction
  JOURNAL   Science 287 (5455), 1046-1049 (2000)
   PUBMED   10669417
REFERENCE   9  (bases 1 to 4862)
  AUTHORS   Cao,Y., Traer,E., Zimmerman,G.A., McIntyre,T.M. and Prescott,S.M.
  TITLE     Cloning, expression, and chromosomal localization of human
            long-chain fatty acid-CoA ligase 4 (FACL4)
  JOURNAL   Genomics 49 (2), 327-330 (1998)
   PUBMED   9598324
REFERENCE   10 (bases 1 to 4862)
  AUTHORS   Kang,M.J., Fujino,T., Sasano,H., Minekura,H., Yabuki,N., Nagura,H.,
            Iijima,H. and Yamamoto,T.T.
  TITLE     A novel arachidonate-preferring acyl-CoA synthetase is present in
            steroidogenic cells of the rat adrenal, ovary, and testis
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 2880-2884 (1997)
   PUBMED   9096315
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D85189.1.
            
            [WARNING] On Jul 19, 2024 this sequence was replaced by
            NM_053623.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D85189.1, SRR8487227.331418.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4862
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq33"
     gene            1..4862
                     /gene="Acsl4"
                     /gene_synonym="Acs4; Facl4"
                     /note="acyl-CoA synthetase long-chain family member 4"
                     /db_xref="GeneID:113976"
                     /db_xref="RGD:69401"
     exon            1..129
                     /gene="Acsl4"
                     /gene_synonym="Acs4; Facl4"
                     /inference="alignment:Splign:2.1.0"
     exon            130..173
                     /gene="Acsl4"
                     /gene_synonym="Acs4; Facl4"
                     /inference="alignment:Splign:2.1.0"
     exon            174..413
                     /gene="Acsl4"
                     /gene_synonym="Acs4; Facl4"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..2198
                     /gene="Acsl4"
                     /gene_synonym="Acs4; Facl4"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.15"
                     /note="LACS 4; long-chain acyl-CoA synthetase 4; fatty
                     acid-Coenzyme A ligase, long chain 4; arachidonate--CoA
                     ligase"
                     /codon_start=1
                     /product="long-chain-fatty-acid--CoA ligase 4"
                     /protein_id="NP_446075.1"
                     /db_xref="GeneID:113976"
                     /db_xref="RGD:69401"
                     /translation="MAKRIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLFDH
                     AVAKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWINYLEVNCRVNNFGSGLT
                     ALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGKEAVVHGLNESEASYL
                     ITSVELLESKLKAALLDINCVKHIIYVDNKTINRAEYPEGLEIHSMQSVEELGSKPEN
                     SSIPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKDTYIG
                     YLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVP
                     EIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIKKGYDAPLCNLILFKKVKALLG
                     GNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVGAP
                     LICCEIKLKDWQEGGYTVHDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYSVDENGQR
                     WFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKS
                     DQSYVISFVVPNQKKLTLLAQQKGVEGSWVDICNNPAMEAEILKEIREAANAMKLERF
                     EIPIKVRLSPEPWTPETGLVTDAFKLKRKELKNHYLKDIERMYGGK"
     exon            414..591
                     /gene="Acsl4"
                     /gene_synonym="Acs4; Facl4"
                     /inference="alignment:Splign:2.1.0"
     exon            592..701
                     /gene="Acsl4"
                     /gene_synonym="Acs4; Facl4"
                     /inference="alignment:Splign:2.1.0"
     exon            702..840
                     /gene="Acsl4"
                     /gene_synonym="Acs4; Facl4"
                     /inference="alignment:Splign:2.1.0"
     exon            841..991
                     /gene="Acsl4"
                     /gene_synonym="Acs4; Facl4"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1115
                     /gene="Acsl4"
                     /gene_synonym="Acs4; Facl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1187
                     /gene="Acsl4"
                     /gene_synonym="Acs4; Facl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1327
                     /gene="Acsl4"
                     /gene_synonym="Acs4; Facl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1500
                     /gene="Acsl4"
                     /gene_synonym="Acs4; Facl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1575
                     /gene="Acsl4"
                     /gene_synonym="Acs4; Facl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1767
                     /gene="Acsl4"
                     /gene_synonym="Acs4; Facl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1882
                     /gene="Acsl4"
                     /gene_synonym="Acs4; Facl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2040
                     /gene="Acsl4"
                     /gene_synonym="Acs4; Facl4"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..4862
                     /gene="Acsl4"
                     /gene_synonym="Acs4; Facl4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2345..2350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acsl4"
                     /gene_synonym="Acs4; Facl4"
     regulatory      2676..2681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acsl4"
                     /gene_synonym="Acs4; Facl4"
     regulatory      4855..4860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acsl4"
                     /gene_synonym="Acs4; Facl4"
ORIGIN      
        1 gccgaggctc gcccctcctt gcaaggctgc tccagagcta gcgggcacgc gagctcctct
       61 ccgggagctt ccttccccga aaggccggga cccagtggcg gactcgtggt gagcgaggca
      121 gcaccttcga tcccaggaga ttgacctgtt cttaaaagtg aaagaagaaa tctaagaaaa
      181 acgctatggc aaagagaata aaagctaagc ccacttcaga caaacccgga agtccatatc
      241 gctctgtcac gcacttcgac tcactagctg tcatagacat ccctggagca gatactctgg
      301 ataaattatt tgaccatgct gtagccaagt ttgggaagaa ggacagcctg gggacccggg
      361 agatcctgag cgaagaaaat gaaatgcagc caaatggaaa ggtttttaag aagttaattc
      421 ttgggaatta taaatggata aactatcttg aagtgaactg ccgagtgaat aactttggaa
      481 gtggcctcac tgcactggga ctgaaaccaa agaacaccat tgccattttc tgtgagacca
      541 gggcggagtg gatgattgca gcgcagacct gctttaagta caactttccg cttgtgactt
      601 tatatgctac ccttggcaaa gaagctgtcg ttcatggatt aaatgagtct gaggcttcct
      661 atctgattac tagtgttgaa cttctggaaa gcaaactgaa ggcggcatta ttagatatca
      721 attgtgttaa acatatcatt tatgtggata acaagactat caatagagcg gagtaccccg
      781 aggggcttga gattcacagc atgcagtcag tagaggagct gggatccaag ccagaaaact
      841 caagcattcc tccaagtaga ccaactcctt cggacatggc cattgtcatg tacaccagtg
      901 gctctactgg ccgccccaag ggagtgatga tgcaccatag caatctgata gctgggatga
      961 caggccagtg tgagcgcata cctggattag gaccaaagga cacatatatt ggctacttac
     1021 ctttggctca tgtgctggaa ctgacagcag agatctcctg ctttacctac ggctgtagga
     1081 ttggatattc gtcaccactc acactgtctg accagtccag caaaatcaag aagggaagca
     1141 agggtgattg tactgtactg aaacctacac ttatggcggc cgttccggaa atcatggata
     1201 gaatttacaa gaatgttatg agcaaggttc aagagatgaa ttatattcag aagactctat
     1261 ttaaaattgg gtatgattat aaattagagc aaatcaagaa aggatatgat gcccctcttt
     1321 gtaatctgat actgtttaag aaggtgaagg ctcttctagg aggaaatgtc cgcatgatgc
     1381 tgtccggcgg tgccccactg tccccccaga cacaccgatt catgaatgtc tgcttctgct
     1441 gccccattgg tcagggctat gggctgacag aatcatgcgg tgctggaaca gttactgaag
     1501 ttaccgacta cactactgga agagttggcg ctcctcttat ttgctgtgaa attaaactga
     1561 aggactggca ggaaggtggt tatacagttc atgataagcc aaaccccaga ggtgaaattg
     1621 tgattggagg ccagaatatc tccatgggat attttaaaaa tgaagagaaa acagcagaag
     1681 attattctgt ggatgaaaat ggacaaaggt ggttttgcac tggtgatatt ggagaattcc
     1741 accctgatgg atgcttacag attatcgatc gtaagaaaga tctggtgaag ctgcaagccg
     1801 gagagtacgt gtctcttggg aaagtcgaag ccgcactgaa gaattgtcca ctgatcgaca
     1861 acatctgtgc ttttgccaaa agtgaccagt cttatgtgat cagttttgtg gttcccaacc
     1921 agaaaaagtt gactcttttg gcacaacaga agggggtaga aggatcttgg gttgatattt
     1981 gcaataatcc tgccatggaa gctgaaatac tgaaagaaat tcgagaagct gcaaatgcca
     2041 tgaaattgga acgatttgaa attccaatca aagttcgatt gagcccagag ccatggaccc
     2101 ctgaaactgg tttggtaaca gatgccttca agctgaaaag gaaggaactg aagaaccatt
     2161 atcttaaaga cattgagcgg atgtatgggg gcaaataaaa ggcaactgtc tacttcacat
     2221 ttgcacagga ggtggcctga tggttttttt agttctagag tttaagcctt tgttgatctc
     2281 tctgttaaaa tgtaaggtga atcttctaaa gacatgaaac aaaaaaacaa ccaaaagtgg
     2341 ttacaataaa ttgcatagtc ctagagaagc tgaaattgaa gacatttccc tttagctgtg
     2401 ttattaagtt tagagcaaaa attctgtttt agaatattag ccttagctac acttgttttt
     2461 ctaaagatac tccatgctaa agtaaacaaa ttggacttgg actaggtgta gttgaagaaa
     2521 tctacagctt ccagtgtcta tgtcttccta gttcagaagt ttctatcgta atcattagga
     2581 caaaattacg tattaacact actcaaagcc gaagttccac caggctttga aatcctcttc
     2641 caaccatttc tcttgaaggg aaaaaaatca gttgtaataa atggattcag tatcttagaa
     2701 ggtattattt taagctcata attgccatgt aggtgagaca tagaatcatt ataatattgt
     2761 gaataattac agtgcctgaa gttaaaacta aaacaacaca cacataccaa aaatatctca
     2821 taatgtattt gaagggaggc tgaattgctc ctttggatgt ctaagaactt aaatcagcaa
     2881 ctgtaattat tgaaatgtct tcagaaaaat gtccactttg taaaagtgac ctttctgtgt
     2941 gtgatctagt caaaggctga gaccaagggg aacatgttag aaagtcaatc agaattcaat
     3001 aagatacatt gcttttctgt tagaaagttc atggcatcct aagcattcag aattaggatc
     3061 ctggcatagc actgagcctg ggaaagagat ttagcctctt taactttgat accagggctt
     3121 gattttaaaa tgtgcttgta ttaaattaca tttgtaattt atggtctgtt tgctgttgct
     3181 gattgattct tgatcagtag tgtgcatttc agagagcctt tcattttgct ttaatttcag
     3241 caaagcgggt tatgataaat gacttcctcg aatcttgttc aaacctacgg gtgattaagt
     3301 gtcttggatg agtctgagga agttaaaggg aagaaaacac tgttaacact tttcctgttt
     3361 gtgaagagtt tagaaactgg aaatgctaga tttgggagaa gggcagagtt acttgattaa
     3421 ggactgtctg tgcagtaact tgggagtgtg agtttctttt taaatcttca gctaaaatct
     3481 ggaattatat attcttgata gatattcgca cttgaaccat agttactgta tgtaaaaagc
     3541 aaaaattctt aatactgtta ttctttgcac ttttttcata gtcattttat acacacacac
     3601 acacacatgc atgtgtatgt gtgtgtgtat atataatata tatatgttgc ttacattgtg
     3661 ttgtacagat gtgggccacc actacaacaa aatgagttct ttgtgctcta aaatatttat
     3721 aaagaaatta tttaaatgtt atgtatatgg tggtaatatt gagaaaaaaa atcatctggt
     3781 attctgagca acagcgaagg tttttgtaaa agtttctttt cagtgttgtg caaactaaaa
     3841 tttgaggcaa gttttccctg aagttctatg tgagtattct catgcttccc atcttgcctt
     3901 tgaagtgtga aaagacatca agtagactac tagtcagctt ctacctactc ctagtgcact
     3961 gtttatccgt ttttttttaa aggcttttcc aatatatgta tcccatttgg aatggtgatt
     4021 ttaaaatgtg agtgcatgca gactatctta cttaagatac ttgcacccca cccacagcca
     4081 tctcccaaag ctggaacact gccaactagg tccttaagaa tcacgcattg aatacaaggt
     4141 cgggtgctgc taattcttca tgaaaatcct aacacacacg ttaagggacc agggagatgc
     4201 cactgccctc tgacttttca tcaaaaaaaa aatatatata tacatgttta tgtaaacaga
     4261 actattttcc atattcatag tgacttttta agtatttgag cctaaaggtt ttgatctcca
     4321 ttttatacct atttaaatcg ttcacaattt catgtcagcc atcaattaaa gctgtgctta
     4381 ctgttgattg tgtgtgcatt tctaaggtga acgctcctaa ttttttgctt taattacatg
     4441 aaagggtctt atttctttga tatttgtgct ctttttttta atgtagactg aaggtatgat
     4501 tgtgtgactt ttaagaaatg aaataccgat gaatgatcca tagagtccaa agtgagggag
     4561 aatgctgttt ctttgttcat agagactgac tagtaatctt tgcctatatt ttcctggtag
     4621 cagatgacaa atgtttctac agtgacaagc tgagaagagg ttaaaggtta aagattgtgt
     4681 ggcattcggg aactggagag atacgtttta attttgaatg tagttacaaa ttttatattc
     4741 atatttgtac tttctgttaa tgcacgattg tagaattgtt ctgtagattt tttgtgttta
     4801 ctcttgaaag gctttgtttg ttcttctttt taagtttgca cttgaatctt ataaaataaa
     4861 tc
//
