LOCUS       NM_057107               2989 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus acyl-CoA synthetase long-chain family member 3
            (Acsl3), mRNA.
ACCESSION   NM_057107
VERSION     NM_057107.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2989)
  AUTHORS   Jeong,H.M., Kim,R.N., Kwon,M.J., Oh,E., Han,J., Lee,S.K.,
            Choi,J.S., Park,S., Nam,S.J., Gong,G.Y., Nam,J.W., Choi,D.H.,
            Lee,H., Nam,B.H., Choi,Y.L. and Shin,Y.K.
  TITLE     Targeted exome sequencing of Korean triple-negative breast cancer
            reveals homozygous deletions associated with poor prognosis of
            adjuvant chemotherapy-treated patients
  JOURNAL   Oncotarget 8 (37), 61538-61550 (2017)
   PUBMED   28977883
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2989)
  AUTHORS   Klett,E.L., Chen,S., Yechoor,A., Lih,F.B. and Coleman,R.A.
  TITLE     Long-chain acyl-CoA synthetase isoforms differ in preferences for
            eicosanoid species and long-chain fatty acids
  JOURNAL   J Lipid Res 58 (5), 884-894 (2017)
   PUBMED   28209804
  REMARK    Erratum:[J Lipid Res. 2017 Dec;58(12):2365. doi:
            10.1194/jlr.M072512ERR.. PMID: 29196521]
REFERENCE   3  (bases 1 to 2989)
  AUTHORS   Obinata,D., Takayama,K., Fujiwara,K., Suzuki,T., Tsutsumi,S.,
            Fukuda,N., Nagase,H., Fujimura,T., Urano,T., Homma,Y.,
            Aburatani,H., Takahashi,S. and Inoue,S.
  TITLE     Targeting Oct1 genomic function inhibits androgen receptor
            signaling and castration-resistant prostate cancer growth
  JOURNAL   Oncogene 35 (49), 6350-6358 (2016)
   PUBMED   27270436
REFERENCE   4  (bases 1 to 2989)
  AUTHORS   Shang,Y., Das,S., Rabold,R., Sham,J.S., Mitzner,W. and Tang,W.Y.
  TITLE     Epigenetic alterations by DNA methylation in house dust
            mite-induced airway hyperresponsiveness
  JOURNAL   Am J Respir Cell Mol Biol 49 (2), 279-287 (2013)
   PUBMED   23526225
REFERENCE   5  (bases 1 to 2989)
  AUTHORS   Pei,Z., Fraisl,P., Shi,X., Gabrielson,E., Forss-Petter,S.,
            Berger,J. and Watkins,P.A.
  TITLE     Very long-chain acyl-CoA synthetase 3: overexpression and growth
            dependence in lung cancer
  JOURNAL   PLoS One 8 (7), e69392 (2013)
   PUBMED   23936004
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2989)
  AUTHORS   Fujimoto,Y., Itabe,H., Sakai,J., Makita,M., Noda,J., Mori,M.,
            Higashi,Y., Kojima,S. and Takano,T.
  TITLE     Identification of major proteins in the lipid droplet-enriched
            fraction isolated from the human hepatocyte cell line HuH7
  JOURNAL   Biochim Biophys Acta 1644 (1), 47-59 (2004)
   PUBMED   14741744
REFERENCE   7  (bases 1 to 2989)
  AUTHORS   Benani,A., Vol,C., Heurtaux,T., Asensio,C., Dauca,M., Lapicque,F.,
            Netter,P. and Minn,A.
  TITLE     Up-regulation of fatty acid metabolizing-enzymes mRNA in rat spinal
            cord during persistent peripheral local inflammation
  JOURNAL   Eur J Neurosci 18 (7), 1904-1914 (2003)
   PUBMED   14622223
REFERENCE   8  (bases 1 to 2989)
  AUTHORS   Fujino,T., Man-Jong,K., Minekura,H., Suzuki,H. and Yamamoto,T.T.
  TITLE     Alternative translation initiation generates acyl-CoA synthetase 3
            isoforms with heterogeneous amino termini
  JOURNAL   J Biochem 122 (1), 212-216 (1997)
   PUBMED   9276691
REFERENCE   9  (bases 1 to 2989)
  AUTHORS   Fujino,T., Kang,M.J., Suzuki,H., Iijima,H. and Yamamoto,T.
  TITLE     Molecular characterization and expression of rat acyl-CoA
            synthetase 3
  JOURNAL   J Biol Chem 271 (28), 16748-16752 (1996)
   PUBMED   8663269
REFERENCE   10 (bases 1 to 2989)
  AUTHORS   Papadia,F., Ovaleo-Pandolfo,E., Pampari,G.C., Marchesi,G.,
            Romano,A. and Pouche,A.
  TITLE     [Long-term results of prolonged dicoumarol anticoagulant therapy in
            327 peipheral arteriopathic subjects]
  JOURNAL   Chir Ital 28 (6), 817-830 (1976)
   PUBMED   70280
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Mar 2, 2021 this sequence version replaced NM_057107.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ221868.1, SRR26643292.38124.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               JAXUCZ010000009.1  87563601-87563821
            222-636             JAXUCZ010000009.1  87589433-87589847
            637-814             JAXUCZ010000009.1  87594422-87594599
            815-924             JAXUCZ010000009.1  87596435-87596544
            925-1063            JAXUCZ010000009.1  87598079-87598217
            1064-1214           JAXUCZ010000009.1  87600151-87600301
            1215-1338           JAXUCZ010000009.1  87602240-87602363
            1339-1410           JAXUCZ010000009.1  87602572-87602643
            1411-1550           JAXUCZ010000009.1  87602921-87603060
            1551-1723           JAXUCZ010000009.1  87604925-87605097
            1724-1798           JAXUCZ010000009.1  87605647-87605721
            1799-1990           JAXUCZ010000009.1  87607234-87607425
            1991-2105           JAXUCZ010000009.1  87609614-87609728
            2106-2263           JAXUCZ010000009.1  87611379-87611536
            2264-2989           JAXUCZ010000009.1  87612350-87613075
FEATURES             Location/Qualifiers
     source          1..2989
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q34"
     gene            1..2989
                     /gene="Acsl3"
                     /gene_synonym="Acs3; Facl3; LACS 3"
                     /note="acyl-CoA synthetase long-chain family member 3"
                     /db_xref="GeneID:114024"
                     /db_xref="RGD:70552"
     exon            1..221
                     /gene="Acsl3"
                     /gene_synonym="Acs3; Facl3; LACS 3"
                     /inference="alignment:Splign:2.1.0"
     exon            222..636
                     /gene="Acsl3"
                     /gene_synonym="Acs3; Facl3; LACS 3"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..2421
                     /gene="Acsl3"
                     /gene_synonym="Acs3; Facl3; LACS 3"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.2"
                     /EC_number="6.2.1.15"
                     /note="long-chain-fatty-acid--CoA ligase 3; brain acyl-CoA
                     synthetase II; long-chain acyl-CoA synthetase 3; fatty
                     acid Coenzyme A ligase, long chain 3; arachidonate--CoA
                     ligase; arachidonate--CoA ligase Acsl3; medium-chain
                     acyl-CoA ligase Acsl3"
                     /codon_start=1
                     /product="fatty acid CoA ligase Acsl3"
                     /protein_id="NP_476448.1"
                     /db_xref="GeneID:114024"
                     /db_xref="RGD:70552"
                     /translation="MNNHVSSTPSTMKLKQTIHPILLYFIHFIISLYTILTYIPFYFL
                     CESKQEKPNHIKAKPVSSKPDSAYRSVNSMDGLASVLYPGCDTLDKVFMYAKNKFKDK
                     RLLGTREILNEEDEIQPNGKVFKKVILGHYNWLSYEDVFIRALDFGNGLQMLGQKPKA
                     NIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHGLNETEVTNIITSKELLQ
                     TKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGVIVHTMAAVQALGVKADVDKKAHSKP
                     LPSDIAVIMYTSGSTGIPKGVMISHSNIIASITGMARRIPRLGEEDVYIGYLPLAHVL
                     ELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSVLKPTLMAAVPEIMDRIYK
                     NVMNKVNEMSAFQRNLFILAYNYKMEQISKGCSTPLCDRFVFRNVRRLLGGNIRVLLC
                     GGAPLSATTQRFMNICFCCPVGQGYGLTESTGAGTITEVWDYNTGRVGAPLVCCEIKL
                     KNWEEGGYFNTDKPHPRGEILIGGQNVTMGYYKNEAKTKADFFEDENGQRWLCTGDIG
                     EFDPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLIDNICAYANSYHSYVIGF
                     VVPNQKELTELARTKGFNGTWEELCNSSEMENEVLKVLSEAAISASLEKFEIPLKIRL
                     SPDPWTPETGLVTDAFKLKRKELKTHYQADIERMYGRK"
     exon            637..814
                     /gene="Acsl3"
                     /gene_synonym="Acs3; Facl3; LACS 3"
                     /inference="alignment:Splign:2.1.0"
     exon            815..924
                     /gene="Acsl3"
                     /gene_synonym="Acs3; Facl3; LACS 3"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1063
                     /gene="Acsl3"
                     /gene_synonym="Acs3; Facl3; LACS 3"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1214
                     /gene="Acsl3"
                     /gene_synonym="Acs3; Facl3; LACS 3"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1338
                     /gene="Acsl3"
                     /gene_synonym="Acs3; Facl3; LACS 3"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1410
                     /gene="Acsl3"
                     /gene_synonym="Acs3; Facl3; LACS 3"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1550
                     /gene="Acsl3"
                     /gene_synonym="Acs3; Facl3; LACS 3"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1723
                     /gene="Acsl3"
                     /gene_synonym="Acs3; Facl3; LACS 3"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1798
                     /gene="Acsl3"
                     /gene_synonym="Acs3; Facl3; LACS 3"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1990
                     /gene="Acsl3"
                     /gene_synonym="Acs3; Facl3; LACS 3"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2105
                     /gene="Acsl3"
                     /gene_synonym="Acs3; Facl3; LACS 3"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2263
                     /gene="Acsl3"
                     /gene_synonym="Acs3; Facl3; LACS 3"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2989
                     /gene="Acsl3"
                     /gene_synonym="Acs3; Facl3; LACS 3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacgctgct cagctggcgc ccggggatcg acgctgcggt tgtggccgcg gccgcggact
       61 ctgacgggga ggcggcggca gagcgggagg ctgagccggc ggcgggcggt cttccccgtc
      121 tcgcaggaca gccccggcag ctgcgtcagg gtcctgagga ggtggcgctg agcgggagcc
      181 gctccgggaa gcagccaggc ctgcgtgggt cggagcccgc gattcccgtt gagatctgtt
      241 gattgtattt ttgagcacat gaataaccac gtatcttcaa caccgtctac catgaagcta
      301 aaacaaacca tccaccccat acttttatat ttcatacatt ttataatatc actctatact
      361 attttaacat acatcccatt ttattttttg tgtgagtcaa aacaagagaa accaaaccac
      421 attaaagcaa agcctgtcag ttcaaaaccg gactctgcat acaggtctgt caacagtatg
      481 gatggcttag cttcagtatt gtatcctggc tgcgacacac ttgataaagt ttttatgtat
      541 gcaaaaaaca aatttaagga caaaagacta ttgggaacac gtgagatttt gaatgaggaa
      601 gatgaaatac aaccaaatgg aaaggttttt aaaaaggtta ttctggggca ctataattgg
      661 ctttcctatg aagatgtctt cattcgagcc ctcgattttg gaaatgggtt acaaatgttg
      721 ggccagaagc cgaaggccaa catcgccatc ttttgtgaga ccagggctga gtggatgatt
      781 gctgcgcagg cgtgtttcat gtacaacttc cagcttgtta cactgtatgc gactctggga
      841 ggtccagcca ttgtccatgg actgaatgag acagaggtga ccaacatcat tactagtaaa
      901 gaactcctgc aaacaaagct gaaggatatc gtctctttgg tcccacgtct gcggcatatc
      961 attactgttg atgggaagcc tccaacctgg tctgagttcc ccaagggcgt cattgtacac
     1021 accatggctg cagtgcaggc tctaggagta aaggctgacg tggacaagaa agctcacagc
     1081 aaaccactgc cctcagatat tgcagtaatc atgtacacaa gtggatccac aggaattcca
     1141 aagggagtca tgatctcaca cagcaacatc attgcctcta taacggggat ggcgagaagg
     1201 attccaagac tgggagagga agatgtatac attggatatt tgcccctggc acatgttcta
     1261 gaattaagcg ctgagcttgt gtgtctttct catggatgcc ggattggcta ctcttcacca
     1321 cagacattag cagatcagtc ttcaaaaata aagaaaggaa gcaaaggaga cacatccgtt
     1381 ctgaagccca cgctgatggc ggctgtgccg gaaatcatgg atcggatcta caaaaatgtc
     1441 atgaataaag tgaatgaaat gagtgctttt caacgaaact tgtttatttt ggcatataat
     1501 tataagatgg agcagatttc aaaagggtgt agtaccccac tgtgtgaccg ctttgttttc
     1561 cggaatgtcc gaaggctgct gggtggaaat attcgcgttt tattgtgcgg tggtgctcca
     1621 ctttctgcaa cgacacagcg attcatgaat atctgcttct gttgtcccgt tggccagggg
     1681 tatggactca cagaatctac tggggctgga acaattacag aagtgtggga ctacaatacc
     1741 ggcagagtgg gagcaccatt agtttgctgt gaaatcaaat taaagaactg ggaggaaggt
     1801 ggctatttta atactgacaa accacatccc agaggtgaaa ttctgattgg tggccaaaat
     1861 gtgacaatgg ggtactacaa aaatgaagca aaaacaaagg ccgatttctt tgaagatgaa
     1921 aacggacaga ggtggctgtg cactggcgat attggagagt ttgaccctga tggctgcctc
     1981 aagatcattg atcgtaaaaa ggaccttgtg aaactacagg caggagagta tgtttctcta
     2041 ggcaaagttg aggcagcttt gaagaacctc ccactgatag ataacatttg tgcatatgca
     2101 aacagttacc attcttacgt aattggattt gttgtgccaa atcaaaagga acttacggag
     2161 ctagctagaa cgaaaggatt taacggaact tgggaagagc tgtgtaacag cagtgaaatg
     2221 gaaaacgagg tccttaaagt gctttctgag gctgctattt cagcaagtct ggaaaagttt
     2281 gaaatcccac tgaaaattcg tttgagccct gacccatgga ctcccgaaac tggtctggtg
     2341 actgatgcct tcaagttgaa acgtaaagaa cttaaaacac actaccaggc agacattgag
     2401 cggatgtatg gaagaaaata attagtttgg gcattggttt gctacagtga gctcagatca
     2461 aatagggaaa tacttgaaat gtatgtctca ggccaaggca aactccattc ctcatattaa
     2521 accctggctg ttacttctca ctacgtcacc atttttaact gacaggatta gtaaactatt
     2581 aagacagcaa acatgtgtct gtctctgttt tttcccctcc tccagtttgc tttggcatct
     2641 atgactgtgt ttgtcaatag gagacttttt caaaatcata ctggggaagc agtgatttta
     2701 aaacctcaag tttttaaaca tgatttatat gttctgtaca attgttcagt ttgtaacttt
     2761 ttaaagtttg gatgtataga aggataaata ggaaatataa aaattggtta tttgggggct
     2821 tttttactta ttgtatttaa aaataaaagg gtatcaatgt gaaattatgt aaattttaaa
     2881 tgcttatgaa tcaaatcatt gttgaacaaa agatttgttg ctgtgtaatt attgtcttgt
     2941 atgcatttaa gagaaataaa tatactcaga cttatgtttt aagaaatgg
//
