LOCUS       NM_012820               3661 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus acyl-CoA synthetase long-chain family member 1
            (Acsl1), mRNA.
ACCESSION   NM_012820
VERSION     NM_012820.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3661)
  AUTHORS   Li,B., Liu,J., Xin,X., Zhang,L., Zhou,J., Xia,C., Zhu,W. and Yu,H.
  TITLE     MiR-34c promotes hepatic stellate cell activation and Liver
            Fibrogenesis by suppressing ACSL1 expression
  JOURNAL   Int J Med Sci 18 (3), 615-625 (2021)
   PUBMED   33437196
  REMARK    GeneRIF: MiR-34c promotes hepatic stellate cell activation and
            Liver Fibrogenesis by suppressing ACSL1 expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3661)
  AUTHORS   Klett,E.L., Chen,S., Yechoor,A., Lih,F.B. and Coleman,R.A.
  TITLE     Long-chain acyl-CoA synthetase isoforms differ in preferences for
            eicosanoid species and long-chain fatty acids
  JOURNAL   J Lipid Res 58 (5), 884-894 (2017)
   PUBMED   28209804
  REMARK    Erratum:[J Lipid Res. 2017 Dec;58(12):2365. doi:
            10.1194/jlr.M072512ERR.. PMID: 29196521]
REFERENCE   3  (bases 1 to 3661)
  AUTHORS   Narita,T., Naganuma,T., Sase,Y. and Kihara,A.
  TITLE     Long-chain bases of sphingolipids are transported into cells via
            the acyl-CoA synthetases
  JOURNAL   Sci Rep 6, 25469 (2016)
   PUBMED   27136724
  REMARK    GeneRIF: here we revealed that ACSs (Faa1 and Faa4 in yeast and
            ACSL1, ACSL4, ACSL5, ACSL6, and ACSVL4 in mammals) are involved in
            LCB uptake. In addition, we provided important insight into the
            molecular mechanism of LCFA transport
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3661)
  AUTHORS   Grevengoed,T.J., Martin,S.A., Katunga,L., Cooper,D.E.,
            Anderson,E.J., Murphy,R.C. and Coleman,R.A.
  TITLE     Acyl-CoA synthetase 1 deficiency alters cardiolipin species and
            impairs mitochondrial function
  JOURNAL   J Lipid Res 56 (8), 1572-1582 (2015)
   PUBMED   26136511
  REMARK    GeneRIF: Acyl-CoA synthetase 1 deficiency alters cardiolipin
            species and impairs mitochondrial function
REFERENCE   5  (bases 1 to 3661)
  AUTHORS   Schneider,H., Staudacher,S., Poppelreuther,M., Stremmel,W.,
            Ehehalt,R. and Fullekrug,J.
  TITLE     Protein mediated fatty acid uptake: synergy between
            CD36/FAT-facilitated transport and acyl-CoA synthetase-driven
            metabolism
  JOURNAL   Arch Biochem Biophys 546, 8-18 (2014)
   PUBMED   24503477
REFERENCE   6  (bases 1 to 3661)
  AUTHORS   Iijima,H., Fujino,T., Minekura,H., Suzuki,H., Kang,M.J. and
            Yamamoto,T.
  TITLE     Biochemical studies of two rat acyl-CoA synthetases, ACS1 and ACS2
  JOURNAL   Eur J Biochem 242 (2), 186-190 (1996)
   PUBMED   8973631
REFERENCE   7  (bases 1 to 3661)
  AUTHORS   Tzavara,E.T., Pouille,Y., Defer,N. and Hanoune,J.
  TITLE     Diurnal variation of the adenylyl cyclase type 1 in the rat pineal
            gland
  JOURNAL   Proc Natl Acad Sci U S A 93 (20), 11208-11212 (1996)
   PUBMED   8855334
REFERENCE   8  (bases 1 to 3661)
  AUTHORS   Shimomura,I., Tokunaga,K., Jiao,S., Funahashi,T., Keno,Y.,
            Kobatake,T., Kotani,K., Suzuki,H., Yamamoto,T., Tarui,S. et al.
  TITLE     Marked enhancement of acyl-CoA synthetase activity and mRNA,
            paralleled to lipoprotein lipase mRNA, in adipose tissues of Zucker
            obese rats (fa/fa)
  JOURNAL   Biochim Biophys Acta 1124 (2), 112-118 (1992)
   PUBMED   1543733
REFERENCE   9  (bases 1 to 3661)
  AUTHORS   Suzuki,H., Kawarabayasi,Y., Kondo,J., Abe,T., Nishikawa,K.,
            Kimura,S., Hashimoto,T. and Yamamoto,T.
  TITLE     Structure and regulation of rat long-chain acyl-CoA synthetase
  JOURNAL   J Biol Chem 265 (15), 8681-8685 (1990)
   PUBMED   2341402
REFERENCE   10 (bases 1 to 3661)
  AUTHORS   Otsuka,K., Murota,S. and Mori,Y.
  TITLE     Inhibitory effect of D-penicillamine on the fibrosis caused by
            bleomycin treatment in rat carrageein granuloma
  JOURNAL   Chem Pharm Bull (Tokyo) 25 (6), 1220-1224 (1977)
   PUBMED   70279
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 27, 2020 this sequence version replaced NM_012820.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D90109.1, SRR26643296.35517.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               JAXUCZ010000016.1  52532185-52532392   c
            209-326             JAXUCZ010000016.1  52520456-52520573   c
            327-391             JAXUCZ010000016.1  52516678-52516742   c
            392-493             JAXUCZ010000016.1  52513165-52513266   c
            494-593             JAXUCZ010000016.1  52510821-52510920   c
            594-772             JAXUCZ010000016.1  52510439-52510617   c
            773-805             JAXUCZ010000016.1  52505892-52505924   c
            806-857             JAXUCZ010000016.1  52505698-52505749   c
            858-931             JAXUCZ010000016.1  52505145-52505218   c
            932-1009            JAXUCZ010000016.1  52502831-52502908   c
            1010-1144           JAXUCZ010000016.1  52500275-52500409   c
            1145-1279           JAXUCZ010000016.1  52498953-52499087   c
            1280-1375           JAXUCZ010000016.1  52497597-52497692   c
            1376-1448           JAXUCZ010000016.1  52496741-52496813   c
            1449-1537           JAXUCZ010000016.1  52494306-52494394   c
            1538-1654           JAXUCZ010000016.1  52493635-52493751   c
            1655-1798           JAXUCZ010000016.1  52492813-52492956   c
            1799-1900           JAXUCZ010000016.1  52490435-52490536   c
            1901-1972           JAXUCZ010000016.1  52490271-52490342   c
            1973-3661           JAXUCZ010000016.1  52487870-52489558   c
FEATURES             Location/Qualifiers
     source          1..3661
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..3661
                     /gene="Acsl1"
                     /gene_synonym="Acas; ACS; COAA; Facl2"
                     /note="acyl-CoA synthetase long-chain family member 1"
                     /db_xref="GeneID:25288"
                     /db_xref="RGD:2015"
     exon            1..208
                     /gene="Acsl1"
                     /gene_synonym="Acas; ACS; COAA; Facl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..2113
                     /gene="Acsl1"
                     /gene_synonym="Acas; ACS; COAA; Facl2"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.15"
                     /EC_number="6.2.1.24"
                     /note="LACS 1; long-chain acyl-CoA synthetase 1;
                     long-chain-fatty-acid--CoA ligase, liver isozyme; fatty
                     acid Coenzyme A ligase, long chain 2; phytanate--CoA
                     ligase; arachidonate--CoA ligase; Acyl CoA synthetase,
                     long chain"
                     /codon_start=1
                     /product="long-chain-fatty-acid--CoA ligase 1"
                     /protein_id="NP_036952.1"
                     /db_xref="GeneID:25288"
                     /db_xref="RGD:2015"
                     /translation="MEVHELFRYFRMPELIDIRQYVRTLPTNTLMGFGAFAALTTFWY
                     ATRPKALKPPCDLSMQSVEVTGTTEGVRRSAVLEDDKLLLYYYDDVRTMYDGFQRGIQ
                     VSNDGPCLGSRKPNQPYEWISYKQVAEMAECIGSALIQKGFKPCSEQFIGIFSQNRPE
                     WVTIEQGCFTYSMVVVPLYDTLGTDAITYIVNKAELSVIFADKPEKAKLLLEGVENKL
                     TPCLKIIVIMDSYDNDLVERGQKCGVEIIGLKALEDLGRVNRTKPKPPEPEDLAIICF
                     TSGTTGNPKGAMVTHQNIMNDCSGFIKATESAFIASPEDVLISFLPLAHMFETVVECV
                     MLCHGAKIGFFQGDIRLLMDDLKVLQPTIFPVVPRLLNRMFDRIFGQANTSVKRWLLD
                     FASKRKEAELRSGIVRNNSLWDKLIFHKIQSSLGGKVRLMITGAAPVSATVLTFLRAA
                     LGCQFYEGYGQTECTAGCCLSLPGDWTAGHVGAPMPCNYIKLVDVEDMNYQAAKGEGE
                     VCVKGANVFKGYLKDPARTAEALDKDGWLHTGDIGKWLPNGTLKIIDRKKHIFKLAQG
                     EYIAPEKIENIYLRSEAVAQVFVHGESLQAFLIAIVVPDVEILPSWAQKRGFQGSFEE
                     LCRNKDINKAILEDMVKLGKNAGLKPFEQVKGIAVHPELFSIDNGLLTPTLKAKRPEL
                     RNYFRSQIDELYSTIKI"
     exon            209..326
                     /gene="Acsl1"
                     /gene_synonym="Acas; ACS; COAA; Facl2"
                     /inference="alignment:Splign:2.1.0"
     exon            327..391
                     /gene="Acsl1"
                     /gene_synonym="Acas; ACS; COAA; Facl2"
                     /inference="alignment:Splign:2.1.0"
     exon            392..493
                     /gene="Acsl1"
                     /gene_synonym="Acas; ACS; COAA; Facl2"
                     /inference="alignment:Splign:2.1.0"
     exon            494..593
                     /gene="Acsl1"
                     /gene_synonym="Acas; ACS; COAA; Facl2"
                     /inference="alignment:Splign:2.1.0"
     exon            594..772
                     /gene="Acsl1"
                     /gene_synonym="Acas; ACS; COAA; Facl2"
                     /inference="alignment:Splign:2.1.0"
     exon            773..805
                     /gene="Acsl1"
                     /gene_synonym="Acas; ACS; COAA; Facl2"
                     /inference="alignment:Splign:2.1.0"
     exon            806..857
                     /gene="Acsl1"
                     /gene_synonym="Acas; ACS; COAA; Facl2"
                     /inference="alignment:Splign:2.1.0"
     exon            858..931
                     /gene="Acsl1"
                     /gene_synonym="Acas; ACS; COAA; Facl2"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1009
                     /gene="Acsl1"
                     /gene_synonym="Acas; ACS; COAA; Facl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1144
                     /gene="Acsl1"
                     /gene_synonym="Acas; ACS; COAA; Facl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1279
                     /gene="Acsl1"
                     /gene_synonym="Acas; ACS; COAA; Facl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1375
                     /gene="Acsl1"
                     /gene_synonym="Acas; ACS; COAA; Facl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1448
                     /gene="Acsl1"
                     /gene_synonym="Acas; ACS; COAA; Facl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1537
                     /gene="Acsl1"
                     /gene_synonym="Acas; ACS; COAA; Facl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1654
                     /gene="Acsl1"
                     /gene_synonym="Acas; ACS; COAA; Facl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1798
                     /gene="Acsl1"
                     /gene_synonym="Acas; ACS; COAA; Facl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1900
                     /gene="Acsl1"
                     /gene_synonym="Acas; ACS; COAA; Facl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..1972
                     /gene="Acsl1"
                     /gene_synonym="Acas; ACS; COAA; Facl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..3661
                     /gene="Acsl1"
                     /gene_synonym="Acas; ACS; COAA; Facl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaacacaga actatggaag tccacgaatt gttccggtat tttcgaatgc cagagctgat
       61 tgacattcgg cagtacgtgc gtacccttcc aaccaacaca ctcatgggct tcggggcttt
      121 tgcagcgctc accaccttct ggtatgccac ccggccgaag gccctgaagc caccatgtga
      181 tctgtccatg cagtctgtgg aagtaacggg tactactgag ggtgtccgaa gatcagcagt
      241 ccttgaggac gacaagctct tgctgtacta ctacgacgat gtcagaacga tgtacgatgg
      301 cttccagagg gggattcagg tgtcaaatga tggcccttgt ttaggttcta gaaagccaaa
      361 ccagccatat gagtggattt cttacaaaca ggttgcagaa atggctgagt gcataggctc
      421 ggcgctgatc cagaagggtt tcaaaccttg ctcagagcag ttcatcggca tcttttctca
      481 gaacagacct gagtgggtga ccatcgagca ggggtgcttc acttactcca tggtggttgt
      541 tccgctctat gacacgcttg gaaccgacgc catcacctac atagtgaaca aagctgaact
      601 ctctgtgatt tttgctgaca agccagaaaa agccaaactc ttattagaag gtgtagaaaa
      661 taagttaaca ccatgcctta aaatcatagt catcatggac tcctacgaca atgatctggt
      721 ggaacgcggc cagaagtgtg gggtggaaat catcggccta aaagctctgg aggatcttgg
      781 aagagtgaac agaacgaaac ccaagcctcc agaacctgaa gatcttgcga taatctgttt
      841 cacaagtgga actacaggca accccaaagg agcaatggtc acccaccaaa acattatgaa
      901 cgattgctcc ggttttataa aagcgacgga gagtgcattc atcgcttccc cagaggatgt
      961 tctgatatct ttcttgcctc tcgcccatat gtttgagacc gttgtagagt gtgtaatgct
     1021 atgtcatgga gctaagatag gatttttcca aggagacatc aggctgctta tggatgacct
     1081 caaggtgctt cagcctacca tcttccctgt ggttccgaga ctgctaaacc ggatgtttga
     1141 cagaattttt ggacaagcaa acacgtcagt gaagcgatgg ctgttggatt ttgcctccaa
     1201 aaggaaagag gcggagcttc gcagtggcat cgtcagaaac aacagcctgt gggataaact
     1261 catctttcac aagatacagt cgagcctggg cgggaaagtc cggctgatga tcacaggagc
     1321 agccccagtg tctgccacag tgctgacgtt tctgagggcg gctctcggct gtcagttcta
     1381 tgaaggctac ggacagaccg agtgcaccgc tggttgctgc ctgagcttgc ctggagactg
     1441 gacagcaggc catgttggtg cccccatgcc ttgcaattat atcaagcttg tagatgtgga
     1501 agatatgaat taccaggctg ccaagggcga gggtgaggtg tgtgtgaaag gggcaaatgt
     1561 gttcaaaggc tacttgaaag acccagcaag aacagctgaa gccctagata aagatggttg
     1621 gttacacacg ggggacattg gaaaatggct gccaaatggc accttgaaga ttatcgacag
     1681 gaaaaagcac atatttaaac tagcccaagg agagtacata gctccagaaa agatcgaaaa
     1741 tatctacctg cggagcgaag ccgtggccca ggtgtttgtc catggagaaa gcttgcaggc
     1801 ctttctcata gccattgtag tacctgatgt ggagatccta ccttcctggg cacagaagag
     1861 aggatttcaa gggtcctttg aagaactgtg caggaacaag gatatcaata aagctatcct
     1921 ggaagacatg gtgaaacttg ggaagaatgc tggtttgaag ccatttgaac aggtcaaagg
     1981 cattgctgtg cacccggaat tattttctat tgacaatggc ctcctgactc caacactgaa
     2041 ggcaaaaagg ccagagctgc ggaactattt caggtcacag atagatgaac tgtactccac
     2101 catcaagatt taacatgagg aagaatcctt agaggaaatg gcgcacctcc acaatcctcc
     2161 tcgtaccaat ggcctttgag ttggtaactc tgcctgcagc gagtgtggga aaggaaatgc
     2221 catgctggac ttgtgcacag ggtcttacca tagggatagc agagggcacg gaacactgcc
     2281 ttacagtcac ctgtgttgta gcccatgatc ctggggatac acagtttcca aaacgagcct
     2341 taaacattgt aaaggggaac ccataaaagt gctaagttat ttaagacttc aaccaataag
     2401 gtgggtgtta aaacttctgt ctcctgtttt tctaaccaag gggttaggac ttactctttc
     2461 tgatacgtct gctgctggct gcacaccctg cagccgtctg ctgctctgaa gagtacagta
     2521 cactggaaga aagctacccc tttaagagca actgtccagg ctgaagaaag tcacagtgga
     2581 ccagagattt ctcttcttaa ccccttcccc ttgtcccttt ccctcaccac ctcacatgca
     2641 gtacatttat gtgacccttc tggtttgtaa gggttccaaa gggtccctgt tgtgcctgct
     2701 ggtaacctcg tgtttccagt acactaaaga acagatcctc ctcagaacaa tgcgggtacc
     2761 cagtctcaga aaaggaaaaa aaaaaaaagg tggctcctgc gttgagccag caacttgcag
     2821 gctcacacag atgtcctcag actccgctcc atctctgctc cctgcccctc ccattcttcc
     2881 caggggttat gagaaaccct gccttagact ctgcagtgaa gatggtgttc cgaagaatga
     2941 cctggatggg ccatgctcaa ctgtgattcc tcccccgctg tccactcgct cgctcgtcgt
     3001 ggaaccagcc cgtatctgca gcggcctctg tgctccaaat gtggttttcc tagcaaatgc
     3061 taatgtggtg atcaacttgc tttgttttct ttcccctccc agttaaactc aggcacagca
     3121 tgtcttcaga agtatctagg cagttggtat acgtgggtac ttattaaagt ggacagtaat
     3181 aagtaaatgt ccttattata aaactacctg atttatgtga aatgcatttg ataagccaaa
     3241 aatctggggt gtagaaatct gggggaaaaa aaatcatatc ctgggatcaa cttcccaagg
     3301 tatatttttt aagttaattt gggaaatgaa cagcatttca ctttgccgcg agtcttggcc
     3361 acatttgacc tatttgagct gtttatacat ttgaagccac tgttgttggc tgtgtgacag
     3421 tgtgtgtatt cttgaagcac aactgggttt gcactaaaga atcatcattg taataacact
     3481 atttggtagc ctaacttcat tttcgtattc ttaactgcac aggaagtcga taatttgtca
     3541 caacggggtt ttgaatgttt gctttcagtg ttggctattt ctatgtttta taaaccaaaa
     3601 cagaatttcc aaaaacaatg aaggaaacca aaataaatat ttctgcattt ggagtgagtg
     3661 g
//
