LOCUS       NM_134389               2689 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus acyl-CoA synthetase bubblegum family member 1
            (Acsbg1), mRNA.
ACCESSION   NM_134389
VERSION     NM_134389.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2689)
  AUTHORS   Oishi,T., Iino,K., Okawa,Y., Kakizawa,K., Matsunari,S.,
            Yamashita,M., Taniguchi,T., Maekawa,M., Suda,T. and Oki,Y.
  TITLE     DNA methylation analysis in malignant pheochromocytoma and
            paraganglioma
  JOURNAL   J Clin Transl Endocrinol 7, 12-20 (2016)
   PUBMED   29067245
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2689)
  AUTHORS   Ohkuni,A., Ohno,Y. and Kihara,A.
  TITLE     Identification of acyl-CoA synthetases involved in the mammalian
            sphingosine 1-phosphate metabolic pathway
  JOURNAL   Biochem Biophys Res Commun 442 (3-4), 195-201 (2013)
   PUBMED   24269233
REFERENCE   3  (bases 1 to 2689)
  AUTHORS   Sheng,Y., Tsai-Morris,C.H., Li,J. and Dufau,M.L.
  TITLE     Lessons from the gonadotropin-regulated long chain acyl-CoA
            synthetase (GR-LACS) null mouse model: a role in steroidogenesis,
            but not result in X-ALD phenotype
  JOURNAL   J Steroid Biochem Mol Biol 114 (1-2), 44-56 (2009)
   PUBMED   19167491
REFERENCE   4  (bases 1 to 2689)
  AUTHORS   Song,S.Y., Kato,C., Adachi,E., Moriya-Sato,A., Inagawa-Ogashiwa,M.,
            Umeda,R. and Hashimoto,N.
  TITLE     Expression of an acyl-CoA synthetase, lipidosin, in astrocytes of
            the murine brain and its up-regulation during remyelination
            following cuprizone-induced demyelination
  JOURNAL   J Neurosci Res 85 (16), 3586-3597 (2007)
   PUBMED   17722065
REFERENCE   5  (bases 1 to 2689)
  AUTHORS   Li,J., Sheng,Y., Tang,P.Z., Tsai-Morris,C.H. and Dufau,M.L.
  TITLE     Tissue-cell- and species-specific expression of
            gonadotropin-regulated long chain acyl-CoA synthetase (GR-LACS) in
            gonads, adrenal and brain. Identification of novel forms in the
            brain
  JOURNAL   J Steroid Biochem Mol Biol 98 (4-5), 207-217 (2006)
   PUBMED   16469493
REFERENCE   6  (bases 1 to 2689)
  AUTHORS   Asheuer,M., Bieche,I., Laurendeau,I., Moser,A., Hainque,B.,
            Vidaud,M. and Aubourg,P.
  TITLE     Decreased expression of ABCD4 and BG1 genes early in the
            pathogenesis of X-linked adrenoleukodystrophy
  JOURNAL   Hum Mol Genet 14 (10), 1293-1303 (2005)
   PUBMED   15800013
REFERENCE   7  (bases 1 to 2689)
  AUTHORS   Fraisl,P., Forss-Petter,S., Zigman,M. and Berger,J.
  TITLE     Murine bubblegum orthologue is a microsomal very long-chain
            acyl-CoA synthetase
  JOURNAL   Biochem J 377 (Pt 1), 85-93 (2004)
   PUBMED   14516277
REFERENCE   8  (bases 1 to 2689)
  AUTHORS   Tang,P.Z., Tsai-Morris,C.H. and Dufau,M.L.
  TITLE     Cloning and characterization of a hormonally regulated rat long
            chain acyl-CoA synthetase
  JOURNAL   Proc Natl Acad Sci U S A 98 (12), 6581-6586 (2001)
   PUBMED   11381125
REFERENCE   9  (bases 1 to 2689)
  AUTHORS   Steinberg,S.J., Morgenthaler,J., Heinzer,A.K., Smith,K.D. and
            Watkins,P.A.
  TITLE     Very long-chain acyl-CoA synthetases. Human 'bubblegum' represents
            a new family of proteins capable of activating very long-chain
            fatty acids
  JOURNAL   J Biol Chem 275 (45), 35162-35169 (2000)
   PUBMED   10954726
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF208125.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF208125.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2689
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2689
                     /gene="Acsbg1"
                     /gene_synonym="Grlacs; Lpd"
                     /note="acyl-CoA synthetase bubblegum family member 1"
                     /db_xref="GeneID:171410"
                     /db_xref="RGD:708557"
     exon            1..150
                     /gene="Acsbg1"
                     /gene_synonym="Grlacs; Lpd"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..2194
                     /gene="Acsbg1"
                     /gene_synonym="Grlacs; Lpd"
                     /EC_number="6.2.1.3"
                     /note="gonadotropin-regulated long chain acyl CoA
                     synthetase; lipidosin"
                     /codon_start=1
                     /product="long-chain-fatty-acid--CoA ligase ACSBG1"
                     /protein_id="NP_599216.1"
                     /db_xref="GeneID:171410"
                     /db_xref="RGD:708557"
                     /translation="MPRSSEAGYCCLSRDSNMPDSRDDQQQGASMGTSPDNSQTSSLI
                     DGRTLSKESPSHGLELSAPEKARAASLDASEEALWTTRADGRVRLRLEPFCTQLPYTV
                     HQMFYEALDKYGNLSALGFKRKDKWERISYYQYYLIARKVAKGFLKLGLERAHSVAIL
                     GFNSPEWFFSAVGTVFAGGIVTGIYTTSSPEACQYIAHDCRANVIVVDTQKQLEKILK
                     IWKDLPHLKAVVIYQEPPPKKMANVYTMEELIELGQEVPEEALDAIIDTQQPNQCCVL
                     VYTSGTTGNPKGVMLSQDNITWTARYGSQAGDIQPAEVQQEVVVSYLPLSHIAAQIYD
                     LWTGIQWGAQVCFADPDALKGTLVNTLREVEPTSHMGVPRVWEKIMERIQEVAAQSGF
                     IRRKMLLWAMSVTLEQNLTCPSNDLKPFTSRLADYLVLARVRQALGFAKCQKNFYGAA
                     PMTAETQRFFLGLNIRLYAGYGLSESTGPHFMSSPYNYRLYSSGRVVPGCRVKLVNQD
                     ADGIGEICLWGRTIFMGYLNMEDKTHEAIDSEGWLHTGDMGRLDDDGFLYITGRLKEL
                     IITAGGENVPPVPIEEAVKMELPIISSAMLIGDQRKFLSMLLTLKCTLNPETSEPTDN
                     LTEQAVEFCQRVGSKASTVSEIVGQKDEAVYQAIHEGIQRVNANAAARPYHIQKWAIL
                     ERDFSISGGELGPTMKLKRLTVLEKYKDIIDSFYQEQKQ"
     exon            151..251
                     /gene="Acsbg1"
                     /gene_synonym="Grlacs; Lpd"
                     /inference="alignment:Splign:2.1.0"
     exon            252..472
                     /gene="Acsbg1"
                     /gene_synonym="Grlacs; Lpd"
                     /inference="alignment:Splign:2.1.0"
     exon            473..561
                     /gene="Acsbg1"
                     /gene_synonym="Grlacs; Lpd"
                     /inference="alignment:Splign:2.1.0"
     exon            562..682
                     /gene="Acsbg1"
                     /gene_synonym="Grlacs; Lpd"
                     /inference="alignment:Splign:2.1.0"
     exon            683..763
                     /gene="Acsbg1"
                     /gene_synonym="Grlacs; Lpd"
                     /inference="alignment:Splign:2.1.0"
     exon            764..913
                     /gene="Acsbg1"
                     /gene_synonym="Grlacs; Lpd"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1090
                     /gene="Acsbg1"
                     /gene_synonym="Grlacs; Lpd"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1272
                     /gene="Acsbg1"
                     /gene_synonym="Grlacs; Lpd"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1503
                     /gene="Acsbg1"
                     /gene_synonym="Grlacs; Lpd"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1721
                     /gene="Acsbg1"
                     /gene_synonym="Grlacs; Lpd"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1861
                     /gene="Acsbg1"
                     /gene_synonym="Grlacs; Lpd"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..2108
                     /gene="Acsbg1"
                     /gene_synonym="Grlacs; Lpd"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2679
                     /gene="Acsbg1"
                     /gene_synonym="Grlacs; Lpd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cactgtcttc agtgaatgct cacagcagat gccacgcagt tctgaagctg gatactgctg
       61 tttgtccagg gactccaata tgcctgacag cagagacgat cagcagcagg gtgccagcat
      121 ggggacctcc ccagacaact cacaaaccag ctccttaatt gatgggcgga cactctccaa
      181 agagtctcca agtcatggtc tcgagctctc agctccagaa aaggcaagag ctgcctcttt
      241 ggatgcttca gaggaagcac tatggacaac tcgggccgat gggagagtgc gcctgcgcct
      301 ggaacccttc tgtacgcagc ttccctacac cgtgcaccag atgttctatg aggccctgga
      361 taagtacggg aacctcagtg ctctgggctt caagcgcaag gacaagtggg agcgcatctc
      421 ttactaccag tactacctga ttgcgcgcaa agtagccaaa ggcttcttga agctcggcct
      481 ggagcgtgct cacagcgtgg cgatcctcgg cttcaactct ccagaatggt ttttctctgc
      541 ggtgggcaca gtgtttgcag ggggcatcgt caccggcatt tacaccacca gctccccaga
      601 ggcctgccag tacattgccc atgactgccg agccaatgtc atcgtggttg acacacagaa
      661 gcagctggaa aagatcctga agatctggaa agacttgcca catctaaagg cagtggtgat
      721 ataccaagaa ccccctccca agaagatggc caatgtgtac acgatggagg aactcataga
      781 actggggcaa gaagtgcctg aggaggccct agatgccatc atcgataccc agcagcccaa
      841 ccagtgctgt gtgctcgtct acacatcagg caccacagga aaccccaagg gtgtgatgct
      901 gagtcaagac aatatcacat ggacagcacg gtatggcagt caggctgggg acatccagcc
      961 agcggaagtg cagcaagagg tagtggtcag ctacttgcct ctcagccaca ttgctgccca
     1021 gatctatgac ctgtggacgg gcatccagtg gggggcccag gtctgctttg cagatccaga
     1081 tgcccttaag gggaccctgg tgaacacact gcgggaggtg gagcccacat cccacatggg
     1141 agtgccccga gtatgggaga agatcatgga acggatccag gaggtggccg ctcaatctgg
     1201 cttcatccgc cgcaagatgc tgctgtgggc catgtctgtc accttggagc agaacctcac
     1261 ctgccctagc aacgacctga agcccttcac gagcagactg gcggattacc tagtattagc
     1321 cagggtccgt caggctctgg gctttgccaa gtgtcagaaa aacttctatg gagcagctcc
     1381 catgacggca gagacacaac gcttctttct gggcctcaac atccgcctgt acgcaggcta
     1441 tggcctcagt gagagcactg gccctcactt catgtccagc ccctacaact atcggcttta
     1501 cagctccggc agggtggtgc ccggctgtcg ggtgaagctg gtgaatcagg atgcagatgg
     1561 cattggtgag atctgtctgt ggggccgcac catcttcatg ggttatctga acatggagga
     1621 caaaacacat gaggccattg attctgaagg ctggctacac acaggtgaca tgggccgtct
     1681 ggatgatgac ggcttcctct acatcaccgg gcgcctcaaa gaattaatca tcactgcggg
     1741 cggggagaat gtgcccccgg tgcccatcga ggaggctgtg aagatggagt tgcccatcat
     1801 cagcagcgcc atgctgattg gggaccagag gaagttcctg tccatgctgc taacactgaa
     1861 gtgcacactg aacccagaaa cgtctgagcc aaccgacaat ctgacggagc aagctgtgga
     1921 gttctgccag agggtgggca gcaaggccag caccgtatcc gagatcgtgg ggcagaaaga
     1981 cgaggctgtg tatcaggcca tccacgaagg gatccagagg gtgaacgcga acgcggcagc
     2041 ccggccctac cacatccaga agtgggccat tctcgaacgt gacttctcca tttcaggtgg
     2101 agaactggga cccaccatga agttgaaacg gctcacggtt ctggagaagt acaaagatat
     2161 cattgattcc ttttatcaag agcaaaaaca gtagtcagga gccatgcttg tggcttctgc
     2221 tgaagaccag cctggcaagc atcctccaca ggaacctgac aaactgcttt tacccttagt
     2281 tcagggcaca gcactgacat ctccaatgcc ttcacctgca aattgattct aaccagtgct
     2341 cctattcagg tgtccaatga gaccattctc cttcccagag aaggactgct cactttggcc
     2401 tcgggtccag gcagatttac aaggttctag ttcataggtc tcctagggct ggctgttgga
     2461 gagggaaagg gattggcagt cccattacta atgtgtgctg cagagacagc agtcacagct
     2521 cgcctaatgg cctgacttta attctggctt cttggaaact agtatcactc tgccacctca
     2581 cacacgagag agaagcttga tgcttaataa tctgctgctg ccgctgtgac tgtatttagt
     2641 gtgtaatttt cagtattaaa ccttttaaca gatctgcaaa aaaaaaaaa
//
