LOCUS       NP_599216                721 aa            linear   ROD 01-JUN-2024
DEFINITION  long-chain-fatty-acid--CoA ligase ACSBG1 [Rattus norvegicus].
ACCESSION   NP_599216
VERSION     NP_599216.1
DBSOURCE    REFSEQ: accession NM_134389.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 721)
  AUTHORS   Oishi,T., Iino,K., Okawa,Y., Kakizawa,K., Matsunari,S.,
            Yamashita,M., Taniguchi,T., Maekawa,M., Suda,T. and Oki,Y.
  TITLE     DNA methylation analysis in malignant pheochromocytoma and
            paraganglioma
  JOURNAL   J Clin Transl Endocrinol 7, 12-20 (2016)
   PUBMED   29067245
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 721)
  AUTHORS   Ohkuni,A., Ohno,Y. and Kihara,A.
  TITLE     Identification of acyl-CoA synthetases involved in the mammalian
            sphingosine 1-phosphate metabolic pathway
  JOURNAL   Biochem Biophys Res Commun 442 (3-4), 195-201 (2013)
   PUBMED   24269233
REFERENCE   3  (residues 1 to 721)
  AUTHORS   Sheng,Y., Tsai-Morris,C.H., Li,J. and Dufau,M.L.
  TITLE     Lessons from the gonadotropin-regulated long chain acyl-CoA
            synthetase (GR-LACS) null mouse model: a role in steroidogenesis,
            but not result in X-ALD phenotype
  JOURNAL   J Steroid Biochem Mol Biol 114 (1-2), 44-56 (2009)
   PUBMED   19167491
REFERENCE   4  (residues 1 to 721)
  AUTHORS   Song,S.Y., Kato,C., Adachi,E., Moriya-Sato,A., Inagawa-Ogashiwa,M.,
            Umeda,R. and Hashimoto,N.
  TITLE     Expression of an acyl-CoA synthetase, lipidosin, in astrocytes of
            the murine brain and its up-regulation during remyelination
            following cuprizone-induced demyelination
  JOURNAL   J Neurosci Res 85 (16), 3586-3597 (2007)
   PUBMED   17722065
REFERENCE   5  (residues 1 to 721)
  AUTHORS   Li,J., Sheng,Y., Tang,P.Z., Tsai-Morris,C.H. and Dufau,M.L.
  TITLE     Tissue-cell- and species-specific expression of
            gonadotropin-regulated long chain acyl-CoA synthetase (GR-LACS) in
            gonads, adrenal and brain. Identification of novel forms in the
            brain
  JOURNAL   J Steroid Biochem Mol Biol 98 (4-5), 207-217 (2006)
   PUBMED   16469493
REFERENCE   6  (residues 1 to 721)
  AUTHORS   Asheuer,M., Bieche,I., Laurendeau,I., Moser,A., Hainque,B.,
            Vidaud,M. and Aubourg,P.
  TITLE     Decreased expression of ABCD4 and BG1 genes early in the
            pathogenesis of X-linked adrenoleukodystrophy
  JOURNAL   Hum Mol Genet 14 (10), 1293-1303 (2005)
   PUBMED   15800013
REFERENCE   7  (residues 1 to 721)
  AUTHORS   Fraisl,P., Forss-Petter,S., Zigman,M. and Berger,J.
  TITLE     Murine bubblegum orthologue is a microsomal very long-chain
            acyl-CoA synthetase
  JOURNAL   Biochem J 377 (Pt 1), 85-93 (2004)
   PUBMED   14516277
REFERENCE   8  (residues 1 to 721)
  AUTHORS   Tang,P.Z., Tsai-Morris,C.H. and Dufau,M.L.
  TITLE     Cloning and characterization of a hormonally regulated rat long
            chain acyl-CoA synthetase
  JOURNAL   Proc Natl Acad Sci U S A 98 (12), 6581-6586 (2001)
   PUBMED   11381125
REFERENCE   9  (residues 1 to 721)
  AUTHORS   Steinberg,S.J., Morgenthaler,J., Heinzer,A.K., Smith,K.D. and
            Watkins,P.A.
  TITLE     Very long-chain acyl-CoA synthetases. Human 'bubblegum' represents
            a new family of proteins capable of activating very long-chain
            fatty acids
  JOURNAL   J Biol Chem 275 (45), 35162-35169 (2000)
   PUBMED   10954726
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF208125.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF208125.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     Protein         1..721
                     /product="long-chain-fatty-acid--CoA ligase ACSBG1"
                     /EC_number="6.2.1.3"
                     /note="gonadotropin-regulated long chain acyl CoA
                     synthetase; lipidosin"
                     /calculated_mol_wt=80388
     Region          1..64
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q924N5.1)"
     Site            34
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q924N5.1)"
     Site            50
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q924N5.1)"
     Site            53
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q924N5.1)"
     Site            70
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q924N5.1)"
     Region          122..716
                     /region_name="ACSBG_like"
                     /note="Bubblegum-like very long-chain fatty acid CoA
                     synthetase (VL-FACS); cd05933"
                     /db_xref="CDD:341256"
     Site            order(276,279..284,286..287)
                     /site_type="other"
                     /note="acyl-activating enzyme (AAE) consensus motif"
                     /db_xref="CDD:341256"
     Site            order(279,401..402,469..474,547,559,562,574,696)
                     /site_type="other"
                     /note="putative AMP binding site [chemical binding]"
                     /db_xref="CDD:341256"
     Site            order(279,323..324,372,374..375,378,401..402,469..474,547,
                     559,562,571..574,673)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:341256"
     Site            order(323,374..375,378,401,571..573,667,673)
                     /site_type="other"
                     /note="putative CoA binding site [chemical binding]"
                     /db_xref="CDD:341256"
     Site            655
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q99PU5; propagated from
                     UniProtKB/Swiss-Prot (Q924N5.1)"
     CDS             1..721
                     /gene="Acsbg1"
                     /gene_synonym="Grlacs; Lpd"
                     /coded_by="NM_134389.1:29..2194"
                     /db_xref="GeneID:171410"
                     /db_xref="RGD:708557"
ORIGIN      
        1 mprsseagyc clsrdsnmpd srddqqqgas mgtspdnsqt sslidgrtls kespshglel
       61 sapekaraas ldaseealwt tradgrvrlr lepfctqlpy tvhqmfyeal dkygnlsalg
      121 fkrkdkweri syyqyyliar kvakgflklg lerahsvail gfnspewffs avgtvfaggi
      181 vtgiyttssp eacqyiahdc ranvivvdtq kqlekilkiw kdlphlkavv iyqepppkkm
      241 anvytmeeli elgqevpeea ldaiidtqqp nqccvlvyts gttgnpkgvm lsqdnitwta
      301 rygsqagdiq paevqqevvv sylplshiaa qiydlwtgiq wgaqvcfadp dalkgtlvnt
      361 lreveptshm gvprvwekim eriqevaaqs gfirrkmllw amsvtleqnl tcpsndlkpf
      421 tsrladylvl arvrqalgfa kcqknfygaa pmtaetqrff lglnirlyag yglsestgph
      481 fmsspynyrl yssgrvvpgc rvklvnqdad gigeiclwgr tifmgylnme dktheaidse
      541 gwlhtgdmgr ldddgflyit grlkeliita ggenvppvpi eeavkmelpi issamligdq
      601 rkflsmlltl kctlnpetse ptdnlteqav efcqrvgska stvseivgqk deavyqaihe
      661 giqrvnanaa arpyhiqkwa ilerdfsisg gelgptmklk rltvlekykd iidsfyqeqk
      721 q
//
