LOCUS       NM_001401824            1933 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus acrosin binding protein (Acrbp), transcript
            variant 2, mRNA.
ACCESSION   NM_001401824 XM_006237379
VERSION     NM_001401824.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1933)
  AUTHORS   Kanemori,Y., Koga,Y., Sudo,M., Kang,W., Kashiwabara,S., Ikawa,M.,
            Hasuwa,H., Nagashima,K., Ishikawa,Y., Ogonuki,N., Ogura,A. and
            Baba,T.
  TITLE     Biogenesis of sperm acrosome is regulated by pre-mRNA alternative
            splicing of Acrbp in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 113 (26), E3696-E3705 (2016)
   PUBMED   27303034
REFERENCE   2  (bases 1 to 1933)
  AUTHORS   Kanemori,Y., Ryu,J.H., Sudo,M., Niida-Araida,Y., Kodaira,K.,
            Takenaka,M., Kohno,N., Sugiura,S., Kashiwabara,S. and Baba,T.
  TITLE     Two functional forms of ACRBP/sp32 are produced by pre-mRNA
            alternative splicing in the mouse
  JOURNAL   Biol Reprod 88 (4), 105 (2013)
   PUBMED   23426433
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1933)
  AUTHORS   Tardif,S., Guyonnet,B., Cormier,N. and Cornwall,G.A.
  TITLE     Alteration in the processing of the ACRBP/sp32 protein and sperm
            head/acrosome malformations in proprotein convertase 4 (PCSK4) null
            mice
  JOURNAL   Mol Hum Reprod 18 (6), 298-307 (2012)
   PUBMED   22357636
REFERENCE   4  (bases 1 to 1933)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 1933)
  AUTHORS   Dube,C., Leclerc,P., Baba,T., Reyes-Moreno,C. and Bailey,J.L.
  TITLE     The proacrosin binding protein, sp32, is tyrosine phosphorylated
            during capacitation of pig sperm
  JOURNAL   J Androl 26 (4), 519-528 (2005)
   PUBMED   15955892
REFERENCE   6  (bases 1 to 1933)
  AUTHORS   Baba,T., Niida,Y., Michikawa,Y., Kashiwabara,S., Kodaira,K.,
            Takenaka,M., Kohno,N., Gerton,G.L. and Arai,Y.
  TITLE     An acrosomal protein, sp32, in mammalian sperm is a binding protein
            specific for two proacrosins and an acrosin intermediate
  JOURNAL   J Biol Chem 269 (13), 10133-10140 (1994)
   PUBMED   8144514
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Feb 25, 2022 this sequence version replaced XM_006237379.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.916705.1,
                                           SRR26360190.219088.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000004.1  159537400-159537533
            135-350             JAXUCZ010000004.1  159537878-159538093
            351-445             JAXUCZ010000004.1  159538289-159538383
            446-563             JAXUCZ010000004.1  159538833-159538950
            564-1029            JAXUCZ010000004.1  159540738-159541203
            1030-1162           JAXUCZ010000004.1  159541986-159542118
            1163-1342           JAXUCZ010000004.1  159548049-159548228
            1343-1510           JAXUCZ010000004.1  159548336-159548503
            1511-1594           JAXUCZ010000004.1  159549607-159549690
            1595-1933           JAXUCZ010000004.1  159550116-159550454
FEATURES             Location/Qualifiers
     source          1..1933
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1933
                     /gene="Acrbp"
                     /note="acrosin binding protein"
                     /db_xref="GeneID:500316"
                     /db_xref="RGD:1564880"
     exon            1..134
                     /gene="Acrbp"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1717
                     /gene="Acrbp"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; proacrosin-binding protein sp32; proacrosin
                     binding protein; acrosin-binding protein, 60 kDa form"
                     /codon_start=1
                     /product="acrosin-binding protein isoform 2 precursor"
                     /protein_id="NP_001388753.1"
                     /db_xref="GeneID:500316"
                     /db_xref="RGD:1564880"
                     /translation="MKLAASFLLMLLEVLLLPETPLSAEEALASTPGSPLSSTEYERF
                     FALLTPTWKAETTCRLRATHGCRNPTLVQLDQYENHGLVPDGAVCSDLPYASWFESFC
                     QFAQYRCSNHVYYAKRVRCSQPVSILSPNTLKEVESSAEVPLTSVTTPIVSRATATEH
                     QAFQPWPERLNNNVEELLQSSLSLGGKEQQSSRKLGLEQQHKQEQIQEHKLEEAQEQE
                     EQEEEEEEEEAKQEEGQGTEEGLDSVSRLQSDSEPKFQSKSLSSNPSFFTPRVREVES
                     APLMMENIQELIRSAQEMDEMNELYDDSWRSQSTGSLQQLPHTETLMVLCYSIMENTC
                     TMTPTAKAWSYMEEEILGFGDSVCDNLGRRHTAACPLCAFCSLKLEQCHSEASVLRQQ
                     CDASHKIPFISPLLSAQSISTGNQAKIPEKGRFAGLEMYGGLSSEFWCNRLALKGCED
                     DRVANWLKAEFLSFQDGDLPTKICDTNYVQYPNYCSFKSQQCLLKNQNRKMSRMKCML
                     NEKYHVLSPAKGEEVILRWSQEFNTLTLGQFG"
     exon            135..350
                     /gene="Acrbp"
                     /inference="alignment:Splign:2.1.0"
     exon            351..445
                     /gene="Acrbp"
                     /inference="alignment:Splign:2.1.0"
     exon            446..563
                     /gene="Acrbp"
                     /inference="alignment:Splign:2.1.0"
     exon            564..1029
                     /gene="Acrbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1162
                     /gene="Acrbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1342
                     /gene="Acrbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1510
                     /gene="Acrbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1594
                     /gene="Acrbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1933
                     /gene="Acrbp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcgcgctag caacccgaga cccacgatct ccgaggctta gcccgttgga ggtcgctttg
       61 ttgtgaaaac gcgggaggat cttaccaaga cgtgatgaaa ctagctgcta gcttccttct
      121 gatgcttctg gaagtgctgc tcctgcctga aacacctctt tcagctgagg aagctttagc
      181 ctccactcca ggcagccctc tctcatccac tgaatatgaa cgtttcttcg ccctgctgac
      241 cccaacctgg aaggcagaga ccacctgccg cctccgtgca acccacggct gccggaaccc
      301 cactctcgtt cagctggatc aatatgaaaa ccacggattg gtaccagatg gtgctgtctg
      361 ctctgaccta ccctatgctt cctggtttga gtctttctgc cagtttgctc agtatcgttg
      421 ctccaaccat gtctactatg ccaagagggt ccggtgctcc cagccagtct ccatcctttc
      481 ccccaacact ctaaaggagg tggagtcctc agcagaagtt cctctcactt ccgtgaccac
      541 ccccattgta tcccgtgcca cagccacgga acaccaggcc ttccagcctt ggcccgagcg
      601 gctcaacaac aatgtggagg agctgctcca gtcgtccttg tccctgggag gcaaggagca
      661 acagagtagt cggaagctag gcctggagca gcagcacaag caggagcaga tccaagaaca
      721 caagctagaa gaagcgcagg agcaggagga gcaagaggaa gaggaagagg aggaagaggc
      781 aaagcaggaa gaggggcagg ggacagagga gggtctggat tcagtgtcca gactgcagtc
      841 agactcggag cccaagtttc agtccaagtc actgtcttcc aacccttcct tcttcactcc
      901 ccgggtccga gaggtggagt ccgctccatt gatgatggag aacatccagg agctcatccg
      961 gtccgcccaa gaaatggacg aaatgaacga actgtacgat gactcctgga gaagccaaag
     1021 cactggcagc ctccagcagc tgccccacac ggagaccctg atggtgctat gctattccat
     1081 tatggagaat acctgcacca tgactcccac agccaaggcc tggagctaca tggaggagga
     1141 gatccttggc ttcggggatt cggtctgtga caatcttgga cggagacaca cagctgcctg
     1201 tcccctctgt gcattctgct ccctgaagct agagcagtgc cacagcgaag ccagcgtgct
     1261 gcgccagcaa tgcgacgcct cccacaagat cccgttcatc agccccctgc tctcagctca
     1321 gagcatatcc accggcaacc aggcgaagat accagaaaaa ggtcgctttg ctgggctaga
     1381 aatgtacgga gggctcagct ctgagttctg gtgtaaccgg ctcgccttga agggctgtga
     1441 agatgaccgg gtcgccaact ggctcaaggc agagttcctt agcttccaag atggggatct
     1501 ccccacgaag atttgtgaca caaactacgt ccagtaccca aactactgtt ccttcaaaag
     1561 ccaacagtgc ctgttgaaaa accagaacag aaagatgtcc cgcatgaagt gcatgctgaa
     1621 cgagaagtac cacgtgctga gcccggctaa aggcgaggag gttatactcc ggtggagcca
     1681 agagtttaac actttgactc taggccagtt tggatgagct gaggtctgtg ctgtccccac
     1741 cccagcccag cctttccaca ttctccatcg ctctcagact acatctgtca gttggcttcc
     1801 aggtgcctct caggggcctc ccacctggcc cctacgtgca ttttctttgg gttggaagaa
     1861 cagtcccaga gaggtgcatg atgggaactc cgcacgcctt gaagaatacc ttcaaataaa
     1921 atgtttgtct tca
//
