LOCUS       NP_001026815             413 aa            linear   ROD 21-MAR-2023
DEFINITION  lysophosphatidic acid phosphatase type 6 [Rattus norvegicus].
ACCESSION   NP_001026815 XP_215655
VERSION     NP_001026815.1
DBSOURCE    REFSEQ: accession NM_001031645.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 413)
  AUTHORS   Nagamachi A, Matsui H, Asou H, Ozaki Y, Aki D, Kanai A, Takubo K,
            Suda T, Nakamura T, Wolff L, Honda H and Inaba T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   2  (residues 1 to 413)
  AUTHORS   Li J, Dong Y, Lu X, Wang L, Peng W, Zhang XC and Rao Z.
  TITLE     Crystal structures and biochemical studies of human
            lysophosphatidic acid phosphatase type 6
  JOURNAL   Protein Cell 4 (7), 548-561 (2013)
   PUBMED   23807634
REFERENCE   3  (residues 1 to 413)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (residues 1 to 413)
  AUTHORS   Takayama I, Daigo Y, Ward SM, Sanders KM, Walker RL, Horowitz B,
            Yamanaka T and Fujino MA.
  TITLE     Novel human and mouse genes encoding an acid phosphatase family
            member and its downregulation in W/W(V) mouse jejunum
  JOURNAL   Gut 50 (6), 790-796 (2002)
   PUBMED   12010880
REFERENCE   5  (residues 1 to 413)
  AUTHORS   Hiroyama M and Takenawa T.
  TITLE     Isolation of a cDNA encoding human lysophosphatidic acid
            phosphatase that is involved in the regulation of mitochondrial
            lipid biosynthesis
  JOURNAL   J Biol Chem 274 (41), 29172-29180 (1999)
   PUBMED   10506173
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099131.1.
            
            On Aug 12, 2005 this sequence version replaced XP_215655.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099131.1, SRR8487231.36823.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..413
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     Protein         1..413
                     /product="lysophosphatidic acid phosphatase type 6"
                     /EC_number="3.1.3.2"
                     /calculated_mol_wt=47150
     Region          37..366
                     /region_name="HP_HAP_like"
                     /note="Histidine phosphatase domain found in histidine
                     acid phosphatases and phytases; contains a His residue
                     which is phosphorylated during the reaction; cd07061"
                     /db_xref="CDD:132717"
     Site            order(46..47,50,156,321..322)
                     /site_type="active"
                     /note="catalytic core [active]"
                     /db_xref="CDD:132717"
     CDS             1..413
                     /gene="Acp6"
                     /coded_by="NM_001031645.1:19..1260"
                     /db_xref="GeneID:295305"
                     /db_xref="RGD:1306336"
ORIGIN      
        1 mrvwapvgvl aslaycfhqr rvalaeqrap vdrnllelkm vqvvfrhgar splkplpled
       61 qvewnpklle ippqtrfeyt vanlaggpkp hshydteyhr tvlrggmfag qltkvgmqqm
      121 falgerlrkn yvedipflsp iynpqevfvr stnmfrnles trcllaglfq rqkesviiht
      181 deaisevlyp nyqscwslre ktrgrkkaai sqpgiledle kvkagvgiad sdnvdffill
      241 dnmvaeeahs llsspalkrf aqlieqravd malymlqqed resiqmavgp flyilegnll
      301 kavdpstpps ktrkmylyat hdvtllpmll algifdnkwp pfavdltvel yqhqeskewf
      361 vrlsyngqeq vprgcpdklc pldkflntms aysvspekyr rlcsqtrime lge
//
