LOCUS       NM_001134901            4030 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus acid phosphatase 3 (Acp3), transcript variant 1,
            mRNA.
ACCESSION   NM_001134901
VERSION     NM_001134901.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4030)
  AUTHORS   Nishida,K., Kubota,T., Matsumoto,S., Kato,J., Watanabe,Y.,
            Yamamoto,A., Furui,M., Ohishi,A. and Nagasawa,K.
  TITLE     Expression of Prostatic Acid Phosphatase in Rat Circumvallate
            Papillae
  JOURNAL   PLoS One 11 (6), e0158401 (2016)
   PUBMED   27348306
  REMARK    GeneRIF: PAP-immunoreactivity was present in type I and one of type
            III taste cells of taste buds. Thus, it is suggested that PAP might
            be a responsible ectoenzyme for metabolism of extracellular
            nucleotides, being involved in the regulation of taste signaling in
            taste buds.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4030)
  AUTHORS   Lim,W., Bae,H., Sohn,J.Y., Jeong,W., Kim,S.H. and Song,G.
  TITLE     Dietary cholesterol affects expression of prostatic acid
            phosphatase in reproductive organs of male rats
  JOURNAL   Biochem Biophys Res Commun 456 (1), 421-427 (2015)
   PUBMED   25482440
  REMARK    GeneRIF: Acpp plays an important role in growth and development of
            the penis of rats, and its expression is modulated at epigenomic
            levels via specific miRs
REFERENCE   3  (bases 1 to 4030)
  AUTHORS   Huang,B., Li,X., Zhu,X.C. and Lu,Y.S.
  TITLE     Deceased expression of prostatic acid phosphatase in primary
            sensory neurons after peripheral nerve injury
  JOURNAL   Int J Clin Exp Pathol 7 (12), 8602-8608 (2014)
   PUBMED   25674224
  REMARK    GeneRIF: Our findings suggest that the decrease of PAP in dorsal
            root ganglion neurons is involved in pathophysiological mechanisms
            of neuropathic pain
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4030)
  AUTHORS   Tan,S., Li,L., Lu,L., Pan,C., Lu,H., Oksov,Y., Tang,X., Jiang,S.
            and Liu,S.
  TITLE     Peptides derived from HIV-1 gp120 co-receptor binding domain form
            amyloid fibrils and enhance HIV-1 infection
  JOURNAL   FEBS Lett 588 (9), 1515-1522 (2014)
   PUBMED   24657436
REFERENCE   5  (bases 1 to 4030)
  AUTHORS   Hurt,J.K., Fitzpatrick,B.J., Norris-Drouin,J. and Zylka,M.J.
  TITLE     Secretion and N-linked glycosylation are required for prostatic
            acid phosphatase catalytic and antinociceptive activity
  JOURNAL   PLoS One 7 (2), e32741 (2012)
   PUBMED   22389722
REFERENCE   6  (bases 1 to 4030)
  AUTHORS   Virkkunen,P., Hedberg,P., Palvimo,J.J., Birr,E., Porvari,K.,
            Ruokonen,M., Taavitsainen,P., Janne,O.A. and Vihko,P.
  TITLE     Structural comparison of human and rat prostate-specific acid
            phosphatase genes and their promoters: identification of putative
            androgen response elements
  JOURNAL   Biochem Biophys Res Commun 202 (1), 49-57 (1994)
   PUBMED   8037752
REFERENCE   7  (bases 1 to 4030)
  AUTHORS   Roiko,K., Janne,O.A. and Vihko,P.
  TITLE     Primary structure of rat secretory acid phosphatase and comparison
            to other acid phosphatases
  JOURNAL   Gene 89 (2), 223-229 (1990)
   PUBMED   2373368
REFERENCE   8  (bases 1 to 4030)
  AUTHORS   Plakhotin,M.V., Loktionova,L.Ia., Luk'ianovskii,V.A.,
            Filippov,Iu.I. and Ochirov,N.I.
  TITLE     [Osteosynthesis of the tubular bones using a polymeric pin]
  JOURNAL   Veterinariia (12), 89-90 (1978)
   PUBMED   734913
REFERENCE   9  (bases 1 to 4030)
  AUTHORS   Modzelewski,B. and Wasiak,J.
  TITLE     [Acute Meckel's diverticulitis in a patient with a pseudomucinous
            cyst of the appendix]
  JOURNAL   Pol Tyg Lek 33 (32), 1257-1258 (1978)
   PUBMED   704423
REFERENCE   10 (bases 1 to 4030)
  AUTHORS   Serrano,J.A., Shannon,W.A. Jr., Sternberger,N.J., Wasserkrug,H.L.,
            Serrano,A.A. and Seligman,A.M.
  TITLE     The cytochemical demonstration of prostatic acid phosphatase using
            a new substrate, phosphorylcholine
  JOURNAL   J Histochem Cytochem 24 (10), 1046-1056 (1976)
   PUBMED   977936
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000200.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001134901.3.
            
            On Sep 26, 2022 this sequence version replaced NM_001134901.1.
            
            Transcript Variant: This variant (1), also called TM-PAP, encodes
            the longer isoform. This isoform is a transmembrane protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ826426.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               JACYVU010000200.1  7912863-7913028     c
            167-262             JACYVU010000200.1  7903606-7903701     c
            263-349             JACYVU010000200.1  7901593-7901679     c
            350-502             JACYVU010000200.1  7901003-7901155     c
            503-601             JACYVU010000200.1  7897107-7897205     c
            602-694             JACYVU010000200.1  7893106-7893198     c
            695-827             JACYVU010000200.1  7891112-7891244     c
            828-910             JACYVU010000200.1  7886317-7886399     c
            911-1014            JACYVU010000200.1  7883790-7883893     c
            1015-1184           JACYVU010000200.1  7877290-7877459     c
            1185-4030           JACYVU010000200.1  7865027-7867872     c
FEATURES             Location/Qualifiers
     source          1..4030
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..4030
                     /gene="Acp3"
                     /gene_synonym="5'-NT; Acpp; Acpp11; FRAP; pap; Ppal;
                     RNACPP11"
                     /note="acid phosphatase 3"
                     /db_xref="GeneID:56780"
                     /db_xref="RGD:2023"
     exon            1..166
                     /gene="Acp3"
                     /gene_synonym="5'-NT; Acpp; Acpp11; FRAP; pap; Ppal;
                     RNACPP11"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1303
                     /gene="Acp3"
                     /gene_synonym="5'-NT; Acpp; Acpp11; FRAP; pap; Ppal;
                     RNACPP11"
                     /EC_number="3.1.3.2"
                     /EC_number="3.1.3.48"
                     /EC_number="3.1.3.5"
                     /note="long isoform precursor is encoded by transcript
                     variant 1; prostatic acid phosphatase (rPAP); TMPase;
                     5'-nucleotidase; ecto-5'-nucleotidase; thiamine
                     monophosphatase; fluoride-resistant acid phosphatase; acid
                     phosphatase, prostate; protein tyrosine phosphatase ACP3"
                     /codon_start=1
                     /product="prostatic acid phosphatase long isoform
                     precursor"
                     /protein_id="NP_001128373.1"
                     /db_xref="GeneID:56780"
                     /db_xref="RGD:2023"
                     /translation="MRAVPLHLVGTASLTLGFLLLLSLRLDPGQAKELKFVTLVFRHG
                     DRGPIETFPNDPIKESSWPQGFGQLTKWGMGQHYELGSYIRRRYGRFLNNSYKHDQVY
                     IRSTDVDRTLMSAMTNLAALFPPEGISIWNPRLLWQPIPVHTVSLSEDRLLYLPFRDC
                     PRFQELKSETLKSEEFLKRLQPYKSFIDTLPSLSGFEDQDLFEIWSRLYDPLYCESVH
                     NFTLPTWATEDAMTKLKELSELSLLSLYGIHKQKEKSRLQGGVLVNEILKNMKLATQP
                     QKARKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHIMELYQDNGGHFVEMYYRNET
                     QNEPYPLTLPGCTHSCPLEKFAELLDPVIPQDWATECMGTSNHQVLRVILATTFCLVT
                     GILVILLLVLIRHGPCWQRDVYRNI"
     exon            167..262
                     /gene="Acp3"
                     /gene_synonym="5'-NT; Acpp; Acpp11; FRAP; pap; Ppal;
                     RNACPP11"
                     /inference="alignment:Splign:2.1.0"
     exon            263..349
                     /gene="Acp3"
                     /gene_synonym="5'-NT; Acpp; Acpp11; FRAP; pap; Ppal;
                     RNACPP11"
                     /inference="alignment:Splign:2.1.0"
     exon            350..502
                     /gene="Acp3"
                     /gene_synonym="5'-NT; Acpp; Acpp11; FRAP; pap; Ppal;
                     RNACPP11"
                     /inference="alignment:Splign:2.1.0"
     exon            503..601
                     /gene="Acp3"
                     /gene_synonym="5'-NT; Acpp; Acpp11; FRAP; pap; Ppal;
                     RNACPP11"
                     /inference="alignment:Splign:2.1.0"
     exon            602..694
                     /gene="Acp3"
                     /gene_synonym="5'-NT; Acpp; Acpp11; FRAP; pap; Ppal;
                     RNACPP11"
                     /inference="alignment:Splign:2.1.0"
     exon            695..827
                     /gene="Acp3"
                     /gene_synonym="5'-NT; Acpp; Acpp11; FRAP; pap; Ppal;
                     RNACPP11"
                     /inference="alignment:Splign:2.1.0"
     exon            828..910
                     /gene="Acp3"
                     /gene_synonym="5'-NT; Acpp; Acpp11; FRAP; pap; Ppal;
                     RNACPP11"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1014
                     /gene="Acp3"
                     /gene_synonym="5'-NT; Acpp; Acpp11; FRAP; pap; Ppal;
                     RNACPP11"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1184
                     /gene="Acp3"
                     /gene_synonym="5'-NT; Acpp; Acpp11; FRAP; pap; Ppal;
                     RNACPP11"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..4030
                     /gene="Acp3"
                     /gene_synonym="5'-NT; Acpp; Acpp11; FRAP; pap; Ppal;
                     RNACPP11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagtgcagc acctcctaca gctgccacaa gcagctctct tcccccacca tgagagctgt
       61 ccctctgcac ctcgtcggga cagcaagcct cacccttggc ttcttgctcc tgctatctct
      121 ccgcctggac ccaggccaag ccaaggagtt gaagtttgtg acattggtgt tccggcatgg
      181 agaccgaggt cccatcgaga cctttcctaa tgaccccatt aaggaatcct cgtggccaca
      241 aggatttggc caactcacca agtggggcat gggacagcac tacgaactcg gaagttatat
      301 aaggagaaga tacgggagat tcttgaacaa ctcctataaa catgaccagg tttatatccg
      361 aagcacagat gttgacagga ctctgatgag tgctatgaca aacctcgcag ccctgtttcc
      421 ccctgagggg atcagcatct ggaatcccag actgctctgg cagcccatcc cagtgcacac
      481 cgtgtctctc tctgaggatc ggttgctata cctgcctttc agggactgtc ctcgctttca
      541 agaactcaag agtgagactt taaaatctga ggagttcctg aagaggcttc aaccatataa
      601 aagcttcata gacaccttgc catcgctgtc gggattcgag gaccaggatc tttttgaaat
      661 ctggagtagg ctttacgacc ctttatattg cgagagtgtt cacaatttca ccttgcccac
      721 ctgggccaca gaggacgcca tgactaagtt gaaggagttg tcagaattat ctctgttatc
      781 tctttatgga attcacaagc agaaagagaa atctagactc caggggggcg tcctggtcaa
      841 tgaaattctc aagaacatga agcttgcaac tcaaccacag aaggccagga agctgatcat
      901 gtattctgca cacgacacta ctgtgagtgg cctgcagatg gcgctagacg tttataatgg
      961 acttctacct ccctacgctt cctgccacat aatggaattg taccaggata atggggggca
     1021 cttcgtggag atgtactacc ggaatgagac ccagaacgag ccctacccac tcacgctgcc
     1081 gggctgtacc cacagctgcc ctctggagaa gtttgcagag ctactggacc ccgtgatccc
     1141 ccaggactgg gccacagagt gtatgggcac aagcaaccac caagtgctga gggtcatcct
     1201 tgccactacg ttttgcctgg taaccgggat cctggtgata ttgctgcttg ttctcatccg
     1261 ccacggaccc tgctggcaga gagacgtgta tcggaacatc tgatcagaca gccgacttcc
     1321 ggtgatgtgt ctccgtgaag cagcaccggc aggaagctct tccgccacgc gggctctgtc
     1381 ctgcccatgc cctccgttta gaacttgtct agagatggtg tgagctcacc gcctcagggt
     1441 gagtgcagag ctggcacgtt agttctgtct ccttgccaca tagctgtggt gtgggctgct
     1501 cacagggcta gggtaggtct cttttgcaag ggacgcctcc gtcctctcac acagaggtcc
     1561 cgagagaaat aagaagccaa attctttccc acacaccttg tgactacgaa gagaaaaggg
     1621 agagaaagtg ggaccaagat gtcgattaga acataccaag taactcggaa tgttagtgta
     1681 gaagtggagg gtccgcagaa aaatgacttt agttattcaa tatgcctctc ttcctccctc
     1741 tctccctccc tccctctctc cctccctttc cctccctctc tctttccctc cctcctcccc
     1801 cctccctccc tcccccctct gtctctctct gtctctctct ctgaaaggca attcaaaccc
     1861 agagtttcat aactgacaaa cttctgtgtg tacatctaac acacatacac acacatccat
     1921 attcaaaatg tctttaggtg aactgtagca tcattcacct taagcaccgt tcaggtcatt
     1981 tcctctcagt ttccatacag agaaataact ggaaaaccag taagataagt tcaccccccc
     2041 cacccccacc cccctcactg ccttattttc atgcagctgc tatcacattc acttttaaat
     2101 tatatctctt catggtcgct atgaaatgat agtttttttt ttaacttatt taatttttac
     2161 tgtagtgctg gaatgcaaac cccctgggtc ccctgcaagc gcagagagta ctctatgtga
     2221 actacgccct tagtcctcta tgacttttgt aagtgtcaac acagaaagta aagatcccgt
     2281 gagaatgaca acctacgggc ttaaatccta tttcttcttc taaagtagaa aactccaaac
     2341 aagatgaatg cagaagtcgc gtctagattt cattctcggt gaacagcttt attctgcttc
     2401 caccaagtat gagtcatggt cccatcaaac gcttccatga cgagcaccac ccatgaagtc
     2461 agtaggaaaa agaccaaaat gtactttata ccgtgacaat ctgctccaga cacacaagca
     2521 ttcggctggt gataagtttg atcttgttcc tcagtaggtt gccctacttc cttggggttg
     2581 tccagatttc aaaatatgcc tggtgggcgg ggttagagaa ggacctctct cctctgaccg
     2641 tgcttctcca ctcacatgtg ctcttctgag gacagactga gaagttcaag ctcccaacac
     2701 catactcaga attcaccttg caggactgtc tagatgtggg gtgctgggac ctttgactcc
     2761 cagcacggaa ctctgctctc cacacagatc ctcaccccat ccctcgaggc ccacaggtta
     2821 aatacgactc gctcatgtct atagcctgta cttttaatat cattctcagt gagccagagt
     2881 cattgaaaac aaaactcaaa gagctcgctc tctctctctc tctctctctc tctctctctc
     2941 tctctctctc tctcatgcat gtatttatgt gagtatgcat gtgatatgag cacacatgtg
     3001 tgtgtgctgt cttctcacac gtgctcagag aacaaaggag gatgtcacac gccctgctct
     3061 attatttttc ttattacctt gaaacaagac ctctcactga acccagagct attctgacat
     3121 ccagcaagcc ccagtgatcc ttctggcttg tctccacaac actgaggtta cagggacaca
     3181 gggccacact caacttttga cataggtgct tgggacctga acttgggtcc tcatgcttgg
     3241 acagcaaggg ctcttaccca cctacccatt tgcccaatcc ccaggaccta ccatctcttt
     3301 gattactgta tagagagctc tcaagcttac catcactatg tcctttatct tcttccattg
     3361 gtaaatacca tagccagttt tcatacgccg tggcagaatc ccaagtgaca aatgctctat
     3421 agggattgtg caaagcacac aaatgaactg tagggtgtct cagaaaataa gcaacttcga
     3481 ggttggggat ttagctcatc ggtagagcgc ttgcctagca agtgcaaggc cctgggttca
     3541 atccccagct ccgaaaaaag gaaaaagaaa ataagcaact tcaacaagag gggatgtgaa
     3601 ctcctggtac tgataaccgc ttggtagatg ggaccaatgt gaccattctg gttgccatgg
     3661 tgatattgtt gcaagagcat cactagagct gcgatcacct ctgttgtgat gtgtgttcct
     3721 tatcatttga gaagcctttg catagcactg ccatgtagca atcactaact tgttgatagt
     3781 aattataaaa accaccagtg atgcatatac aggaaaacag agacagagag agagagagct
     3841 aggttatcct gtgctttgat ggcatagcac agagaattgg gaaacttgtg gaaaaaaaaa
     3901 tcctactgct taagaaatgg catacgtgag gctccgactg gcattcactg gacagctttt
     3961 atatggagac tgacatttct tcactcagca gctttttata catttcttcc ctggatttac
     4021 ttgtgtttcc
//
