LOCUS       NM_053339               3934 bp    mRNA    linear   ROD 07-APR-2024
DEFINITION  Rattus norvegicus acyl-CoA oxidase 3, pristanoyl (Acox3), mRNA.
ACCESSION   NM_053339
VERSION     NM_053339.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3934)
  AUTHORS   Ghosh,D. and Berg,J.M.
  TITLE     A proteome-wide perspective on peroxisome targeting signal
            1(PTS1)-Pex5p affinities
  JOURNAL   J Am Chem Soc 132 (11), 3973-3979 (2010)
   PUBMED   20178365
REFERENCE   2  (bases 1 to 3934)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 3934)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   4  (bases 1 to 3934)
  AUTHORS   Baumgart,E., Vanhooren,J.C., Fransen,M., Mannaerts,G.P. and Van
            Veldhoven,P.P.
  TITLE     Mammalian peroxisomal acyl-CoA oxidases. III. Molecular
            characterization of human branched chain fatty acyl-CoA oxidase
  JOURNAL   Ann N Y Acad Sci 804, 678-679 (1996)
   PUBMED   8993592
REFERENCE   5  (bases 1 to 3934)
  AUTHORS   Vanhooren,J.C., Fransen,M., de Bethune,B., Baumgart,E., Baes,M.,
            Torrekens,S., Van Leuven,F., Mannaerts,G.P. and Van Veldhoven,P.P.
  TITLE     Rat pristanoyl-CoA oxidase. cDNA cloning and recognition of its
            C-terminal (SQL) by the peroxisomal-targeting signal 1 receptor
  JOURNAL   Eur J Biochem 239 (2), 302-309 (1996)
   PUBMED   8706733
REFERENCE   6  (bases 1 to 3934)
  AUTHORS   Van Veldhoven,P.P., Croes,K., Asselberghs,S., Herdewijn,P. and
            Mannaerts,G.P.
  TITLE     Peroxisomal beta-oxidation of 2-methyl-branched acyl-CoA esters:
            stereospecific recognition of the 2S-methyl compounds by
            trihydroxycoprostanoyl-CoA oxidase and pristanoyl-CoA oxidase
  JOURNAL   FEBS Lett 388 (1), 80-84 (1996)
   PUBMED   8654595
REFERENCE   7  (bases 1 to 3934)
  AUTHORS   Van Veldhoven,P.P., Van Rompuy,P., Fransen,M., De Bethune,B. and
            Mannaerts,G.P.
  TITLE     Large-scale purification and further characterization of rat
            pristanoyl-CoA oxidase
  JOURNAL   Eur J Biochem 222 (3), 795-801 (1994)
   PUBMED   8026493
REFERENCE   8  (bases 1 to 3934)
  AUTHORS   Van Veldhoven,P.P., Vanhove,G., Assselberghs,S., Eyssen,H.J. and
            Mannaerts,G.P.
  TITLE     Substrate specificities of rat liver peroxisomal acyl-CoA oxidases:
            palmitoyl-CoA oxidase (inducible acyl-CoA oxidase), pristanoyl-CoA
            oxidase (non-inducible acyl-CoA oxidase), and
            trihydroxycoprostanoyl-CoA oxidase
  JOURNAL   J Biol Chem 267 (28), 20065-20074 (1992)
   PUBMED   1400324
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Dec 1, 2020 this sequence version replaced NM_053339.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.47031.1,
                                           SRR26643292.52120.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               JAXUCZ010000014.1  79400747-79400881   c
            136-290             JAXUCZ010000014.1  79388057-79388211   c
            291-524             JAXUCZ010000014.1  79387488-79387721   c
            525-599             JAXUCZ010000014.1  79387130-79387204   c
            600-689             JAXUCZ010000014.1  79386599-79386688   c
            690-833             JAXUCZ010000014.1  79383406-79383549   c
            834-922             JAXUCZ010000014.1  79381647-79381735   c
            923-1019            JAXUCZ010000014.1  79377597-79377693   c
            1020-1202           JAXUCZ010000014.1  79375717-79375899   c
            1203-1325           JAXUCZ010000014.1  79374170-79374292   c
            1326-1446           JAXUCZ010000014.1  79373045-79373165   c
            1447-1569           JAXUCZ010000014.1  79367563-79367685   c
            1570-1683           JAXUCZ010000014.1  79366972-79367085   c
            1684-1799           JAXUCZ010000014.1  79365169-79365284   c
            1800-1974           JAXUCZ010000014.1  79363956-79364130   c
            1975-2042           JAXUCZ010000014.1  79363320-79363387   c
            2043-2129           JAXUCZ010000014.1  79362584-79362670   c
            2130-3934           JAXUCZ010000014.1  79358604-79360408   c
FEATURES             Location/Qualifiers
     source          1..3934
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..3934
                     /gene="Acox3"
                     /note="acyl-CoA oxidase 3, pristanoyl"
                     /db_xref="GeneID:83522"
                     /db_xref="RGD:69245"
     exon            1..135
                     /gene="Acox3"
                     /inference="alignment:Splign:2.1.0"
     exon            136..290
                     /gene="Acox3"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..2249
                     /gene="Acox3"
                     /EC_number="1.3.3.6"
                     /note="BRCACox; pristanoyl-CoA oxidase; branched-chain
                     acyl-CoA oxidase; acyl-Coenzyme A oxidase 3, pristanoyl"
                     /codon_start=1
                     /product="peroxisomal acyl-coenzyme A oxidase 3"
                     /protein_id="NP_445791.2"
                     /db_xref="GeneID:83522"
                     /db_xref="RGD:69245"
                     /translation="MGSSSERRDSVLWSDIPKGPLSAYRARASFNSKELMLFWDGQDV
                     LDFKKTIFSTLENDPLFARPFGADLPLEKERELNFLRCKRVFEYGFFNAEDMLKNPLK
                     ILVLMNCLGMYDWSLANKCVLHMLVFGSTIIGSGSEHHFKYLEKIYNLEIFGCFALTE
                     LSHGSNTKAMRTTAHYDPATQEFILHSPDFEAAKFWVGNLGKTATHAVVFAQLYTPDG
                     QCRGLHSFLVQIRDPKTLLPMPGVMVGDMGKKLGQNGLDNGFAMFHKVRIPRQNLLDR
                     TGNVTSEGTYNTPFKDVRQRLGASLGSLSSGRISIISISVVNLKLAVIIAIRFSATRR
                     QFGPTDKEEIPVLEYPLQQWRLLPYLAAAYALDHFSKTIFLDLIELQRGRQSGDHSDR
                     QAELGREIHALASAGKPLASWTAQRGIQECREACGGHGYLAMNRFGELRNDNDPNCTY
                     EGDNNVLLQQTSNYLLSLLEHPLQDGAHFTSPLKTVNFLEAYPGILGQKFMASSKADW
                     LDSEAPLAAYRWLVCYLLRESHQRYCQEKKSRGSDFEARNNSQVYGCRPLALAFMELT
                     VMQRFHEHTHSSSVPPSLRTVLGRLSMLYGLWCLSQHTALLYRGGYISGEQTGKAMED
                     AILMLCVQLKDDAVALVDAIAPSDFVLGSPIGRADGELYKNLWAAVLQQSGVLERAAW
                     WPEFTANKSVANRLKSQL"
     exon            291..524
                     /gene="Acox3"
                     /inference="alignment:Splign:2.1.0"
     exon            525..599
                     /gene="Acox3"
                     /inference="alignment:Splign:2.1.0"
     exon            600..689
                     /gene="Acox3"
                     /inference="alignment:Splign:2.1.0"
     exon            690..833
                     /gene="Acox3"
                     /inference="alignment:Splign:2.1.0"
     exon            834..922
                     /gene="Acox3"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1019
                     /gene="Acox3"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1202
                     /gene="Acox3"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1325
                     /gene="Acox3"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1446
                     /gene="Acox3"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1569
                     /gene="Acox3"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1683
                     /gene="Acox3"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1799
                     /gene="Acox3"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1974
                     /gene="Acox3"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2042
                     /gene="Acox3"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2129
                     /gene="Acox3"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..3934
                     /gene="Acox3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgttccggg atggggccgg ggcggcacca ccaacctgct ccaccctcag aggtctggac
       61 attcctgatc aacagtgttt gccggaccga cgccagtact aggaccacgg accgaccgca
      121 agctggatcc gggcggtgac agtaccatgg gatcctcatc ggaaagaaga gacagtgttt
      181 tatggtcaga catccccaag ggccccctta gtgcctaccg agcaagagcc tccttcaatt
      241 ccaaggagct gatgctcttc tgggacggcc aggatgtact cgacttcaag aaaaccatct
      301 tctcaacttt ggagaatgac cctctcttcg cccgcccatt cggggctgat ctgcctctgg
      361 agaaggaacg agaactgaac ttccttcgct gcaagagggt ctttgagtat ggcttcttca
      421 acgcagagga catgctaaag aaccccctga agattctagt attgatgaac tgcctgggca
      481 tgtacgactg gtccctggcc aacaaatgtg tcctccacat gttggttttt ggatctacaa
      541 ttatcggttc tggttctgag caccatttca agtaccttga gaagatatat aacctggaga
      601 tttttggctg ttttgctctc accgaactga gtcatgggag taataccaag gccatgagaa
      661 caacagctca ctatgatcct gctacccagg aattcatctt acattctcca gatttcgagg
      721 ctgccaaatt ttgggtgggc aacctgggca agaccgcaac tcatgcggtg gtgtttgccc
      781 agctgtacac gccagatggc cagtgccgag ggctgcattc cttcctggtg cagattcggg
      841 acccgaagac cctgcttccc atgccagggg tgatggtcgg tgacatgggg aagaagttgg
      901 gacagaatgg cctggataat ggattcgcca tgttccacaa agttcgaatt cctcgccaga
      961 acctgctgga ccggaccggg aatgtcacct ctgagggcac ttacaacacc ccctttaagg
     1021 atgtccggca gcgtttgggg gcatcattgg gcagcctgtc ctcgggacgc atctccatca
     1081 ttagcatttc tgtggtcaac ctgaagctgg ctgtgatcat agctatccga ttctcagcca
     1141 cgcggcgtca gtttggaccc acagataagg aagagatccc tgtcctcgag tatccactgc
     1201 agcaatggcg cctacttcca tacctggcag ctgcctatgc cttggaccac ttctccaaga
     1261 caatcttctt ggacctgata gagctacagc gtggccggca aagtggggac cacagtgaca
     1321 ggcaggcaga gctcggacgg gagatccacg cactagcatc agcgggcaag cccctagcct
     1381 catggacagc ccagcgggga attcaggagt gccgtgaggc gtgtggggga cacggctatc
     1441 tagccatgaa ccggtttggc gaactcagaa atgacaacga tccaaactgt acctatgaag
     1501 gtgacaacaa tgtcctgctg cagcagacca gcaactacct gctcagcctc ctggagcatc
     1561 ctctccaaga cggagctcac ttcacaagcc ctctcaagac agtgaacttc ctggaagcct
     1621 accctggaat cttgggccag aagttcatgg cctccagcaa ggctgactgg ttggactcag
     1681 aagcccccct ggcagcctac cgttggcttg tttgctacct gctccgagag agtcatcaga
     1741 gatactgtca agagaaaaag tccagaggca gtgactttga agcaaggaac aacagccagg
     1801 tgtatggctg ccggcccctg gccctggcct tcatggagct cactgtgatg cagcgcttcc
     1861 acgagcatac acacagctct agcgtgcctc catctctgcg gactgtgctt ggacggctca
     1921 gcatgctcta cggcctgtgg tgcctgagcc aacacacggc cctgctctac cgaggtggct
     1981 acatctctgg ggagcaaaca ggaaaagcga tggaggatgc catcctgatg ctgtgtgtgc
     2041 agctgaaaga cgatgcggtg gccttggtgg acgcgattgc cccttctgac tttgtcctgg
     2101 gctccccaat tggcagagct gatggcgagc tctataaaaa cctgtgggca gctgtcctgc
     2161 agcagagcgg tgtgctggag cgtgcggcct ggtggcctga gttcactgcc aacaaatctg
     2221 tggccaacag gctgaagtcc cagctgtaga cacagttgga ggggtgtctg agcaggagca
     2281 gccgatccag aggcctggac ccagacaatc agacacccac gctggaagac acactaaatc
     2341 ctctccttga ctctcgtcag cctgccgtac ccatccccaa tggggtattt gcaaggagtt
     2401 tgcacagtgt gtctccccga gggccttgga atttaacaaa ggattttgta atgctatctc
     2461 gggggcccag ataggaatgt aaagttctgc tcaggtaaac tttgggatcc gtggaagatt
     2521 ttcaagatgc tctcttctct ctgctgctat ctgcttcttt aaccctgctg tggggtaacc
     2581 atacgtctgt ttacctgcca cttgccactc tgtaccatgg actgtcagaa tgtaatttga
     2641 agatttttta tatgaaaaaa aatgttttat taagtccttc ggtggcacca gaagtttcca
     2701 ctgaggaaag tgctcccaca aaagacatgc accagtttgc tcaccacaga cacccccatt
     2761 gtgtcagtaa ctgcttagct gtggctttag tccttttgtt cctaaaacag gaggaatgcc
     2821 cagtgccatc tgttcccgtc aagtgtatct cagcaaattc acacacggca cgaccctgcc
     2881 acactggccg tagccagatc ttgtgatcct gaaaggcacg tgatgccatc ccttcctgcc
     2941 gtagggagga gcccatactg ttagcatttc tgacaaactg ttccgagccc caggtgcttg
     3001 cagagcctga gagcctctct cttcgacatc tgctctcggt cagccactac accctcccct
     3061 gggtcggccc cttcccagag tcccacccca gctgaatggg ggcctgccat cttgagtctc
     3121 tgtggaacct gagggtcatg tgttcacaga tgatgccctc caccggaatc tatggctttt
     3181 cccaacagtg accactaggt cctcccagct cttgggctcc ttgccctcca atcctgccag
     3241 gcaacaatca cctcagccac ctgttcgcct caccatactt ttgtgtggga gcttggttat
     3301 cgtcctgtct gattggaggc tgactagcat gtcacagaag tgcccatggt tagaagagtg
     3361 ctgcattaag ataagtcaca tgattcccag ggtcaggcag tctgactgca gagcgccccc
     3421 tggtggccga ggtgccaaca gataacaaat tattgaaaat ggctcattag ctagctatag
     3481 cttctgaggg gaaggagagt cagttttctc tcaggagtag ccactggcag gttgatcggg
     3541 ctccattgca tgcccacaca cccaagagca tatgtgcggc acagagtgga cttgatggct
     3601 tttgttgttg ttttgttatg tgtgcacatc tatgttttca tatctaccgg ttgggtatgc
     3661 ctttgtccct gggtagggac tggctctctg gacaagtaga tgtcctgtta gcctgcagac
     3721 atcacatgac tcccaagaac gaatcgtgta tcctggtccc tgctcctgtg catgcacatt
     3781 cccctcctct gtcccgaggc agaggcaagt ggtgtgtgag gcctatgggc agaggccaca
     3841 ttgtgaagac aaacttgtaa aggtcccata aaaatgaaac atttgtaaac agtgggaaag
     3901 acttgaataa ttgcaataaa gtgttaaaat tgaa
//
