LOCUS       NM_145770               2505 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus acyl-CoA oxidase 2 (Acox2), mRNA.
ACCESSION   NM_145770
VERSION     NM_145770.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2505)
  AUTHORS   Monte,M.J., Alonso-Pena,M., Briz,O., Herraez,E., Berasain,C.,
            Argemi,J., Prieto,J. and Marin,J.J.G.
  TITLE     ACOX2 deficiency: An inborn error of bile acid synthesis identified
            in an adolescent with persistent hypertransaminasemia
  JOURNAL   J Hepatol 66 (3), 581-588 (2017)
   PUBMED   27884763
REFERENCE   2  (bases 1 to 2505)
  AUTHORS   Ghosh,D. and Berg,J.M.
  TITLE     A proteome-wide perspective on peroxisome targeting signal
            1(PTS1)-Pex5p affinities
  JOURNAL   J Am Chem Soc 132 (11), 3973-3979 (2010)
   PUBMED   20178365
REFERENCE   3  (bases 1 to 2505)
  AUTHORS   Tokuoka,K., Nakajima,Y., Hirotsu,K., Miyahara,I., Nishina,Y.,
            Shiga,K., Tamaoki,H., Setoyama,C., Tojo,H. and Miura,R.
  TITLE     Three-dimensional structure of rat-liver acyl-CoA oxidase in
            complex with a fatty acid: insights into substrate-recognition and
            reactivity toward molecular oxygen
  JOURNAL   J Biochem 139 (4), 789-795 (2006)
   PUBMED   16672280
  REMARK    GeneRIF: The overall dimeric structure and the folding pattern of
            each subunit are essentially superimposable on those of uncomplexed
            acyl-CoA oxidase-II structure.
REFERENCE   4  (bases 1 to 2505)
  AUTHORS   Moser,K. and White,F.M.
  TITLE     Phosphoproteomic analysis of rat liver by high capacity IMAC and
            LC-MS/MS
  JOURNAL   J Proteome Res 5 (1), 98-104 (2006)
   PUBMED   16396499
REFERENCE   5  (bases 1 to 2505)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   6  (bases 1 to 2505)
  AUTHORS   Baumgart,E., Vanhooren,J.C., Fransen,M., Marynen,P., Puype,M.,
            Vandekerckhove,J., Leunissen,J.A., Fahimi,H.D., Mannaerts,G.P. and
            van Veldhoven,P.P.
  TITLE     Molecular characterization of the human peroxisomal branched-chain
            acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue
            distribution, and evidence for the absence of the protein in
            Zellweger syndrome
  JOURNAL   Proc Natl Acad Sci U S A 93 (24), 13748-13753 (1996)
   PUBMED   8943006
REFERENCE   7  (bases 1 to 2505)
  AUTHORS   Baumgart,E., Vanhooren,J.C., Fransen,M., Van Leuven,F.,
            Fahimi,H.D., Van Veldhoven,P.P. and Mannaerts,G.P.
  TITLE     Molecular cloning and further characterization of rat peroxisomal
            trihydroxycoprostanoyl-CoA oxidase
  JOURNAL   Biochem J 320 (Pt 1) (Pt 1), 115-121 (1996)
   PUBMED   8947475
REFERENCE   8  (bases 1 to 2505)
  AUTHORS   Van Veldhoven,P.P., Croes,K., Asselberghs,S., Herdewijn,P. and
            Mannaerts,G.P.
  TITLE     Peroxisomal beta-oxidation of 2-methyl-branched acyl-CoA esters:
            stereospecific recognition of the 2S-methyl compounds by
            trihydroxycoprostanoyl-CoA oxidase and pristanoyl-CoA oxidase
  JOURNAL   FEBS Lett 388 (1), 80-84 (1996)
   PUBMED   8654595
REFERENCE   9  (bases 1 to 2505)
  AUTHORS   Van Veldhoven,P.P., Vanhove,G., Assselberghs,S., Eyssen,H.J. and
            Mannaerts,G.P.
  TITLE     Substrate specificities of rat liver peroxisomal acyl-CoA oxidases:
            palmitoyl-CoA oxidase (inducible acyl-CoA oxidase), pristanoyl-CoA
            oxidase (non-inducible acyl-CoA oxidase), and
            trihydroxycoprostanoyl-CoA oxidase
  JOURNAL   J Biol Chem 267 (28), 20065-20074 (1992)
   PUBMED   1400324
REFERENCE   10 (bases 1 to 2505)
  AUTHORS   Casteels,M., Schepers,L., Van Veldhoven,P.P., Eyssen,H.J. and
            Mannaerts,G.P.
  TITLE     Separate peroxisomal oxidases for fatty acyl-CoAs and
            trihydroxycoprostanoyl-CoA in human liver
  JOURNAL   J Lipid Res 31 (10), 1865-1872 (1990)
   PUBMED   2079609
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000260.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_145770.4.
            
            On Feb 10, 2021 this sequence version replaced NM_145770.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X95189.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                JACYVU010000260.1  11878782-11878792
            12-141              JACYVU010000260.1  11880538-11880667
            142-358             JACYVU010000260.1  11880784-11881000
            359-521             JACYVU010000260.1  11881572-11881734
            522-673             JACYVU010000260.1  11881926-11882077
            674-781             JACYVU010000260.1  11882422-11882529
            782-901             JACYVU010000260.1  11884184-11884303
            902-1017            JACYVU010000260.1  11884598-11884713
            1018-1190           JACYVU010000260.1  11885261-11885433
            1191-1353           JACYVU010000260.1  11887196-11887358
            1354-1544           JACYVU010000260.1  11889075-11889265
            1545-1724           JACYVU010000260.1  11890761-11890940
            1725-1830           JACYVU010000260.1  11893716-11893821
            1831-2048           JACYVU010000260.1  11896188-11896405
            2049-2181           JACYVU010000260.1  11905393-11905525
            2182-2505           JACYVU010000260.1  11909901-11910224
FEATURES             Location/Qualifiers
     source          1..2505
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..2505
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /note="acyl-CoA oxidase 2"
                     /db_xref="GeneID:252898"
                     /db_xref="RGD:628684"
     exon            1..11
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            12..141
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            142..358
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..2244
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /EC_number="1.17.99.3"
                     /note="acyl-Coenzyme A oxidase 2, branched chain; THCA-CoA
                     oxidase; trihydroxycoprostanoyl-CoA oxidase;
                     3-alpha,7-alpha,
                     12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase;
                     acyl-CoA oxidase 2, branched chain;
                     3-alpha,7-alpha,
                     12-alpha-trihydroxy-5-beta-cholestanoyl-CoA
                     24-hydroxylase"
                     /codon_start=1
                     /product="peroxisomal acyl-coenzyme A oxidase 2"
                     /protein_id="NP_665713.2"
                     /db_xref="GeneID:252898"
                     /db_xref="RGD:628684"
                     /translation="MGSPMHRVSLGDTWSWQVHPDIDSERHSPSFSVERLTNILDGGL
                     PNTVLRRKVESIIQSDPVFNLKKLYFMTREELYEDAIQKRFHLEKLAWSLGWSEDGPE
                     RIYANRVLDGNVNLSLHGVAMNAIRSLGSDEQIAKWGQLCKNFQIITTYAQTELGHGT
                     YLQGLETEATYDEARQEFVIHSPTMTSTKWWPGDLGWSVTHAVVLAQLTCLGVRHGMH
                     AFIVPIRSLEDHTPLPGITVGDIGPKMGLEHIDNGFLQLNHVRVPRENMLSRFAEVLP
                     DGTYQRLGTPQSNYLGMLVTRVQLLCKGILPSLQKACIIATRYSVIRHQSRLRPSDPE
                     AKILEYQTQQQKLLPQLAVSYAFHFTATSLSEFFHSSYSAILKRDFSLLPELHALSTG
                     MKATFADFCAQGAEICRRACGGHGYSKLSGLPTLVARATASCTYEGENTVLYLQVARF
                     LMKSYLQAQASPGATPQKPLPQSVMYIATQRPARCSAQTAADFRCPDVYTTAWAYVST
                     RLIRDAAHRTQTLMKSGVDQHDAWNQTTVIHLQAAKAYCYFITVKNFKEAVEKLDKEP
                     EIQRVLQRLCDLYALHGVLTNSGDFLHDGFLSGAQVDMAREAFLDLLPLIRKDAILLT
                     DAFDFSDHCLNSALGCYDGHVYERLFEWAQKSPANTQENPAYKKYIRPLMLGWRHKM"
     exon            359..521
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            522..673
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            674..781
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            782..901
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1017
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1190
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1353
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1544
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1724
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1830
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..2048
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2181
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2505
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccatagcgaa gacttcatga agactgtccc aggcatgctg tgacacaaac tacagaaggt
       61 gggaaaagat ctttgtggtc aaaccatccg gaccttggct accgcagaca gaacaatact
      121 gaccgcattc actcatacac agttctcggc acctcccagt gctcagagca gaccctcaag
      181 gagacgagca gatccaggat ggggagccca atgcaccgag tgtccctggg ggacacctgg
      241 agctggcaag tgcacccgga catagacagt gaaaggcact caccgtcctt cagtgtggag
      301 cgactcacca acatccttga tggaggcctc ccaaacaccg tgctgcgaag aaaagtcgaa
      361 agcatcatac aaagtgaccc agtgtttaat ttgaagaagc tttacttcat gacccgagag
      421 gagctatatg aggatgcgat tcaaaagaga ttccatctcg agaagctagc ctggagcctg
      481 ggctggtcag aagatggtcc tgaacgcatt tatgctaaca gagtccttga tggaaacgtc
      541 aacttaagct tacatggtgt tgccatgaat gctatccgaa gcctgggctc agatgaacag
      601 attgctaaat ggggccaact ctgcaaaaac ttccaaatca tcacaacata cgcccagaca
      661 gagctgggac acgggacata cctacagggc ctggagactg aagccaccta tgatgaagcc
      721 aggcaggagt ttgtgataca cagccctacg atgacttcca ccaagtggtg gcctggggac
      781 ttgggatggt cggtcaccca tgctgtggtc ctagcccagt tgacctgctt aggagtccgg
      841 cacggcatgc acgccttcat tgtgcccatt cggagcctag aggatcacac cccactgcca
      901 ggaatcacag ttggggacat aggccccaag atgggtttgg aacacataga caatggcttc
      961 ctgcaactga accacgtgcg ggttcccaga gaaaacatgc tcagtcgctt tgcagaggtc
     1021 ttgccagatg gtacctacca gaggcttggg acgccacaga gcaattatct tggcatgttg
     1081 gtgacccggg tgcagctgct gtgtaaagga atcctaccct ccctccagaa ggcttgcatc
     1141 attgccacgc gctactcagt aatccgccat cagtctcgac ttcggcccag tgacccagag
     1201 gcaaaaatcc tggaatacca gacgcagcag cagaaactcc ttcctcagct tgctgtgagc
     1261 tatgccttcc acttcacggc caccagcctc tcagaattct tccacagctc ctacagtgct
     1321 attctgaaga gagacttcag cctcctgcct gagctccatg cattgagcac tggtatgaag
     1381 gccacgtttg cagacttctg tgcccagggg gccgagatct gtcgcagagc ttgtgggggc
     1441 catggctact caaagctgag cggcctgccg acactggttg ctcgagcaac agcctcttgc
     1501 acatatgagg gtgagaatac ggtgctctac ctgcaagtgg ccaggtttct gatgaagagc
     1561 tatctgcagg ctcaagcgtc cccaggcgcc acaccacaga agcctctccc tcagtccgtc
     1621 atgtatattg ccacacaaag gccagccagg tgctcagccc agactgcagc tgacttccgc
     1681 tgcccagatg tctataccac agcctgggca tatgtgtcta ccaggctcat aagagatgca
     1741 gcacaccgta cacagaccct catgaagtcc ggggttgacc agcatgatgc ctggaatcag
     1801 actactgtca tccaccttca ggctgctaag gcttactgct acttcatcac tgtgaagaat
     1861 ttcaaggaag ctgtggagaa actagacaag gaaccagaga ttcagcgtgt gctccaacgc
     1921 ctctgtgacc tctatgcctt acacggtgtt ctgactaact caggggactt tctgcatgat
     1981 ggcttcctgt ctggggccca ggtggacatg gccagagaag ccttcctaga cctgcttccc
     2041 ttgatccgga aggatgccat cttgttaacc gatgcttttg acttctcgga ccattgttta
     2101 aactcggcac ttggctgtta tgatggacac gtctacgaac gcctgtttga gtgggctcag
     2161 aagtccccag ccaatactca ggagaaccct gcctataaga agtatatccg accactgatg
     2221 ctcggctgga gacacaagat gtgaaaagtc aaaggatttg ggaccgagaa gcaccacggc
     2281 cttactatgg cacatataca tagagaattt aaagcacggg aggggggggg gggagcgctg
     2341 ctcggttaaa tcaggtagta aattggtaca tgaatggatg gtcatcctat tagtctacta
     2401 ttgagcgtgt ttgaaacttt cccttgtcca tctatagcat gtatttggct aaatgctaaa
     2461 atttttgttt tacatacagg aaaagctaat aaacttgtca gttac
//
