LOCUS       NM_001414015            3771 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus acyl-CoA oxidase 1 (Acox1), transcript variant 1,
            mRNA.
ACCESSION   NM_001414015 XM_039086660
VERSION     NM_001414015.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3771)
  AUTHORS   Nakamura,M., Eguchi,A., Inohana,M., Nagahara,R., Murayama,H.,
            Kawashima,M., Mizukami,S., Koyanagi,M., Hayashi,S.M.,
            Maronpot,R.R., Shibutani,M. and Yoshida,T.
  TITLE     Differential impacts of mineralocorticoid receptor antagonist
            potassium canrenoate on liver and renal changes in high fat
            diet-mediated early hepatocarcinogenesis model rats
  JOURNAL   J Toxicol Sci 43 (10), 611-621 (2018)
   PUBMED   30298849
REFERENCE   2  (bases 1 to 3771)
  AUTHORS   Zeng,J., Deng,S., Wang,Y., Li,P., Tang,L. and Pang,Y.
  TITLE     Specific Inhibition of Acyl-CoA Oxidase-1 by an Acetylenic Acid
            Improves Hepatic Lipid and Reactive Oxygen Species (ROS) Metabolism
            in Rats Fed a High Fat Diet
  JOURNAL   J Biol Chem 292 (9), 3800-3809 (2017)
   PUBMED   28077576
  REMARK    GeneRIF: Inhibition of ACOX1 is a novel and effective approach for
            the treatment of high fat diet- or obesity-induced metabolic
            diseases by improving mitochondrial lipid and ROS metabolism
REFERENCE   3  (bases 1 to 3771)
  AUTHORS   Sanguesa,G., Shaligram,S., Akther,F., Roglans,N., Laguna,J.C.,
            Rahimian,R. and Alegret,M.
  TITLE     Type of supplemented simple sugar, not merely calorie intake,
            determines adverse effects on metabolism and aortic function in
            female rats
  JOURNAL   Am J Physiol Heart Circ Physiol 312 (2), H289-H304 (2017)
   PUBMED   27923787
REFERENCE   4  (bases 1 to 3771)
  AUTHORS   Zhang,H., Li,Y., Hu,J., Shen,W.J., Singh,M., Hou,X., Bittner,A.,
            Bittner,S., Cortez,Y., Tabassum,J., Kraemer,F.B. and Azhar,S.
  TITLE     Effect of Creosote Bush-Derived NDGA on Expression of Genes
            Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats:
            Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic
            Steatosis
  JOURNAL   PLoS One 10 (9), e0138203 (2015)
   PUBMED   26394137
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3771)
  AUTHORS   Bonfleur,M.L., Borck,P.C., Ribeiro,R.A., Caetano,L.C., Soares,G.M.,
            Carneiro,E.M. and Balbo,S.L.
  TITLE     Improvement in the expression of hepatic genes involved in fatty
            acid metabolism in obese rats supplemented with taurine
  JOURNAL   Life Sci 135, 15-21 (2015)
   PUBMED   26092479
  REMARK    GeneRIF: Tau supplementation prevented obesity and hepatic TG
            deposition by upregulating MTP mRNA, ameliorating hepatic lipid
            efflux, and consequently enhancing PPAR-alpha which increases lipid
            oxidation through ACO and CPT-1a gene expressions.
REFERENCE   6  (bases 1 to 3771)
  AUTHORS   Chu,R., Varanasi,U., Chu,S., Lin,Y., Usuda,N., Rao,M.S. and
            Reddy,J.K.
  TITLE     Overexpression and characterization of the human peroxisomal
            acyl-CoA oxidase in insect cells
  JOURNAL   J Biol Chem 270 (9), 4908-4915 (1995)
   PUBMED   7876265
REFERENCE   7  (bases 1 to 3771)
  AUTHORS   Van Veldhoven,P.P., Vanhove,G., Assselberghs,S., Eyssen,H.J. and
            Mannaerts,G.P.
  TITLE     Substrate specificities of rat liver peroxisomal acyl-CoA oxidases:
            palmitoyl-CoA oxidase (inducible acyl-CoA oxidase), pristanoyl-CoA
            oxidase (non-inducible acyl-CoA oxidase), and
            trihydroxycoprostanoyl-CoA oxidase
  JOURNAL   J Biol Chem 267 (28), 20065-20074 (1992)
   PUBMED   1400324
REFERENCE   8  (bases 1 to 3771)
  AUTHORS   Osumi,T., Ishii,N., Miyazawa,S. and Hashimoto,T.
  TITLE     Isolation and structural characterization of the rat acyl-CoA
            oxidase gene
  JOURNAL   J Biol Chem 262 (17), 8138-8143 (1987)
   PUBMED   3036801
REFERENCE   9  (bases 1 to 3771)
  AUTHORS   Miyazawa,S., Hayashi,H., Hijikata,M., Ishii,N., Furuta,S.,
            Kagamiyama,H., Osumi,T. and Hashimoto,T.
  TITLE     Complete nucleotide sequence of cDNA and predicted amino acid
            sequence of rat acyl-CoA oxidase
  JOURNAL   J Biol Chem 262 (17), 8131-8137 (1987)
   PUBMED   3036800
REFERENCE   10 (bases 1 to 3771)
  AUTHORS   Kawaguchi,A., Tsubotani,S., Seyama,Y., Yamakawa,T., Osumi,T.,
            Hashimoto,T., Kikuchi,T., Ando,M. and Okuda,S.
  TITLE     Stereochemistry of dehydrogenation catalyzed by Acyl-CoA oxidase
  JOURNAL   J Biochem 88 (5), 1481-1486 (1980)
   PUBMED   7462191
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 14, 2022 this sequence version replaced XM_039086660.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.14584.1,
                                           SRR26643295.41800.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               JAXUCZ010000010.1  101929928-101930136 c
            210-369             JAXUCZ010000010.1  101929536-101929695 c
            370-530             JAXUCZ010000010.1  101915064-101915224 c
            531-638             JAXUCZ010000010.1  101914193-101914300 c
            639-758             JAXUCZ010000010.1  101913733-101913852 c
            759-874             JAXUCZ010000010.1  101913256-101913371 c
            875-1044            JAXUCZ010000010.1  101912572-101912741 c
            1045-1207           JAXUCZ010000010.1  101911605-101911767 c
            1208-1398           JAXUCZ010000010.1  101911076-101911266 c
            1399-1578           JAXUCZ010000010.1  101908592-101908771 c
            1579-1684           JAXUCZ010000010.1  101908373-101908478 c
            1685-1828           JAXUCZ010000010.1  101907996-101908139 c
            1829-2035           JAXUCZ010000010.1  101907684-101907890 c
            2036-3771           JAXUCZ010000010.1  101905083-101906818 c
FEATURES             Location/Qualifiers
     source          1..3771
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..3771
                     /gene="Acox1"
                     /gene_synonym="ACO; aCoA; AOX; RATACOA1"
                     /note="acyl-CoA oxidase 1"
                     /db_xref="GeneID:50681"
                     /db_xref="RGD:619757"
     exon            1..209
                     /gene="Acox1"
                     /gene_synonym="ACO; aCoA; AOX; RATACOA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..2086
                     /gene="Acox1"
                     /gene_synonym="ACO; aCoA; AOX; RATACOA1"
                     /EC_number="1.3.3.6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peroxisomal acyl-coenzyme A oxidase 1; palmitoyl-CoA
                     oxidase; acyl-Coenzyme A oxidase 1, palmitoyl; acyl-CoA
                     oxidase 1, palmitoyl; peroxisomal acyl-coenzyme A oxidase
                     1-like; straight-chain acyl-CoA oxidase; peroxisomal fatty
                     acyl-CoA oxidase"
                     /codon_start=1
                     /product="peroxisomal acyl-coenzyme A oxidase 1 isoform 1"
                     /protein_id="NP_001400944.1"
                     /db_xref="GeneID:50681"
                     /db_xref="RGD:619757"
                     /translation="MNPDLRKERASATFNPELITHILDGSPENTRRRREIENLILNDP
                     DFQHEDYNFLTRSQRYEVAVKKSATMVKKMREYGISDPEEIMWFKNSVHRGHPEPLDL
                     HLGMFLPTLLHQATAEQQERFFMPAWNLEITGTYAQTEMGHGTHLRGLETTATYDPKT
                     QEFILNSPTVTSIKWWPGGLGKTSNHAIVLAQLITQGECYGLHAFVVPIREIGTHKPL
                     PGITVGDIGPKFGYEEMDNGYLKMDNYRIPRENMLMKYAQVKPDGTYVKPLSNKLTYG
                     TMVFVRSFLVGNAAQSLSKACTIAIRYSAVRRQSEIKQSEPEPQILDFQTQQYKLFPL
                     LATAYAFHFVGRYMKETYLRINESIGQGDLSELPELHALTAGLKAFTTWTANAGIEEC
                     RMACGGHGYSHSSGIPNIYVTFTPACTFEGENTVMMLQTARFLMKIYDQVRSGKLVGG
                     MVSYLNDLPSQRIQPQQVAVWPTMVDINSLEGLTEAYKLRAARLVEIAAKNLQTHVSH
                     RKSKEVAWNLTSVDLVRASEAHCHYVVVKVFSDKLPKIQDKAVQAVLRNLCLLYSLYG
                     ISQKGGDFLEGSIITGAQLSQVNARILELLTLIRPNAVALVDAFDFKDMTLGSVLGRY
                     DGNVYENLFEWAKKSPLNKTEVHESYHKHLKPLQSKL"
     exon            210..369
                     /gene="Acox1"
                     /gene_synonym="ACO; aCoA; AOX; RATACOA1"
                     /inference="alignment:Splign:2.1.0"
     exon            370..530
                     /gene="Acox1"
                     /gene_synonym="ACO; aCoA; AOX; RATACOA1"
                     /inference="alignment:Splign:2.1.0"
     exon            531..638
                     /gene="Acox1"
                     /gene_synonym="ACO; aCoA; AOX; RATACOA1"
                     /inference="alignment:Splign:2.1.0"
     exon            639..758
                     /gene="Acox1"
                     /gene_synonym="ACO; aCoA; AOX; RATACOA1"
                     /inference="alignment:Splign:2.1.0"
     exon            759..874
                     /gene="Acox1"
                     /gene_synonym="ACO; aCoA; AOX; RATACOA1"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1044
                     /gene="Acox1"
                     /gene_synonym="ACO; aCoA; AOX; RATACOA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1207
                     /gene="Acox1"
                     /gene_synonym="ACO; aCoA; AOX; RATACOA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1398
                     /gene="Acox1"
                     /gene_synonym="ACO; aCoA; AOX; RATACOA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1578
                     /gene="Acox1"
                     /gene_synonym="ACO; aCoA; AOX; RATACOA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1684
                     /gene="Acox1"
                     /gene_synonym="ACO; aCoA; AOX; RATACOA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1828
                     /gene="Acox1"
                     /gene_synonym="ACO; aCoA; AOX; RATACOA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..2035
                     /gene="Acox1"
                     /gene_synonym="ACO; aCoA; AOX; RATACOA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..3771
                     /gene="Acox1"
                     /gene_synonym="ACO; aCoA; AOX; RATACOA1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggccctgt cggcgcctgg gcagcggaca cgggtcgttg ctttggtgtc tgtcacttct
       61 gtcgccacct cctctgccaa caccaacact gacctccgtc atgaaccccg acctgcgcaa
      121 ggagcgggcc tccgccacct tcaatccgga gttgatcacg cacatcttgg atggcagtcc
      181 ggagaatacc cggcgccgtc gagaaattga gaacttgatt ctgaacgacc cagacttcca
      241 gcatgaggac tataacttcc tcactcgaag ccagcgttat gaggtggctg ttaagaagag
      301 tgccaccatg gtgaagaaga tgagggaata tggcatctcg gaccctgaag aaatcatgtg
      361 gtttaaaaac tctgtgcacc gagggcatcc tgagcctttg gaccttcact tgggcatgtt
      421 cctacccacc ttgcttcacc aggccaccgc agagcagcag gagcgcttct tcatgccggc
      481 ctggaatttg gagatcacgg gcacttatgc gcagacagag atgggtcatg gaactcatct
      541 tcgaggcttg gaaaccactg ccacatatga ccccaagacc caagagttca ttctcaacag
      601 ccctactgtg acttccatta agtggtggcc tgggggactt gggaaaactt ccaatcacgc
      661 aatagttctg gctcagctca tcactcaagg agagtgctac gggttacatg cctttgttgt
      721 ccctatccgt gaaattggga cccacaagcc cttgccaggc atcactgtcg gggatatcgg
      781 tcccaaattt ggttatgaag agatggataa cggctacctg aagatggaca attaccgtat
      841 tcccagagag aacatgctga tgaaatacgc ccaggtgaag cctgatggca catatgtaaa
      901 gcctttgagt aacaagctga cgtatgggac catggttttt gtgaggtcct tcctcgtggg
      961 aaatgcagct cagagtctgt ccaaggcttg cacaatcgcc atacgataca gcgctgtgag
     1021 gcgccagtct gaaatcaagc aaagcgaacc agaaccacag attttggatt ttcaaaccca
     1081 gcagtataaa ctcttcccgc tcctggccac tgcctatgcc ttccacttcg taggaaggta
     1141 catgaaggag acctaccttc gaattaatga gagcattggc caaggggacc tgagtgaact
     1201 gcctgagctt cacgccctca ctgctgggct gaaggctttt actacttgga cagccaatgc
     1261 tggcatcgaa gaatgtcgaa tggcctgcgg cgggcacggc tattctcaca gcagtgggat
     1321 tccaaatatt tacgtcactt ttaccccggc ctgcaccttc gagggagaga acactgttat
     1381 gatgctgcag acagccaggt tcttgatgaa aatctacgac caggtgcggt cggggaagtt
     1441 ggtgggtggt atggtgtcat acctgaatga cctgccgagt cagcggatcc agccacagca
     1501 ggtggcagtc tggccaacta tggtggacat caacagcctg gagggcctga cagaagccta
     1561 caagcttcgt gcagccagat tggtagaaat cgctgcaaaa aaccttcaga ctcacgtgag
     1621 tcacaggaag agcaaggaag tagcatggaa cctaacctct gtcgaccttg ttcgggcaag
     1681 tgaggcgcat tgccactacg tggtcgttaa ggtcttctca gacaaactcc ccaagattca
     1741 agacaaagcc gtccaagctg tgctgaggaa cctgtgtctc ttgtattctc tctatgggat
     1801 cagccagaaa ggaggggact ttcttgaggg gagcatcatc acaggggctc agctgtcaca
     1861 agtaaacgct cggatcctgg agctgctcac cctgatccgc cccaatgctg ttgctctggt
     1921 ggatgccttt gactttaagg acatgacact tggctctgtt cttggccgct atgatggaaa
     1981 tgtgtatgaa aacttgtttg agtgggccaa gaaatcccca ctgaacaaaa cagaggtcca
     2041 tgaatcttac cacaagcact tgaagcccct gcagtccaag ctttgaagtt tccctgggac
     2101 acgtctgagc tccacaagca gcagaaactc tctcctctac tcactaatcc ttgtgaaatc
     2161 gtcatcaaat ttgtgtagct acagagcaaa tgatgggttt cttttcctcc ctataagtaa
     2221 agagaaatga acagacttta gagattaaat gagaaattcg gtgttgtaag tgcagtaatg
     2281 cagacagaga cgtaggaact cagaaagctt cagagctgtg gtctgacttg catttgtact
     2341 gctgctaatc tcagtaggcc ttgactctgg agaattaaca gagttttaac tacaaatact
     2401 tacttatttt cacattttta ctgctaatca ctggatatat gttttttaaa caaaagtgtt
     2461 atatagagtg gaattttcca ggcattcgtg cctaccactt tctgatctac tgctaagagc
     2521 aggagtttgg gggccagaaa ctaatagaaa ccttgatgtg ggtgtgtggc tgtcacacag
     2581 gccgctgctg cctgccatgt gggtgtgtca cccctattaa ctgtcacatt aacatagtca
     2641 acaagaggac tccttcaaca cccacccacc aagaaaccag agttcccgat gggcacgagc
     2701 acccactcca ggctcagcct tcgtggtagt ggcactactg cgcctttgac cccacttttt
     2761 gacacagtta agttacttgt cttacctcca ggctttcagc cattgcctgg atttcagtca
     2821 tggtggctga ccttcccttt cttgcttgcc ttccttctcc tgaaagagat aaaagagata
     2881 gtagtcagcc tctcctcata gattaagtat atggagagcc ctcagctatg gtattactgt
     2941 attttggtga ctttgttaag taaatttcct gggacaatcc tgatttgaaa gattctgtat
     3001 tctgttgcac aagctattaa aatgctcagt ggtcaccaaa gtatttcaca cacacacact
     3061 cacaaatcac tcaggtcacc ttttacacta gaaataacag gaaagccctg gccacagcca
     3121 tctgctgaga gtgttagttg agatgtttcg ttgaagatgg ctgaagaaag tgcaggccct
     3181 ggggagtttc tccttgctga gagccggctc tgtggtgagc ccctagcagc cttacgaggc
     3241 ggtgaaacgg ccccttcaga tgaggagcag cctctacaat cattctgagc ttaaaggtga
     3301 aatatgcacc ttttgtccta taaatgtcct ataaatgctt ggggggaggg gtaatgtttt
     3361 gttttttttt tcttgaaaca gggcccagaa tggccttgaa ctctgatcct cacaacctgg
     3421 taaatgctgg gcctacaggt gtgcgccgac atgtctggct gatcggagct ctttattctt
     3481 aaaagcacag tagggagatg attgtaacat taagtctgtg tctgtggcat tcgcattgtg
     3541 agagcagttc cttagaacag ttctgagagc acagcatcaa tgtagtgaaa acgatgtcga
     3601 cgcctgacat gaaatcacaa ccctccgggt catcgacaca agccttaacc tttctcctgg
     3661 aatgactggt aatcccttaa gattgacagt acacagcatg tcaccttgtt ggggtttcta
     3721 ttgacagtaa ttcatattct ggaaaggaac taataaatat aaatgaccga g
//
