LOCUS       NM_130756               1503 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus acyl-CoA thioesterase 8 (Acot8), mRNA.
ACCESSION   NM_130756
VERSION     NM_130756.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1503)
  AUTHORS   Ghosh,D. and Berg,J.M.
  TITLE     A proteome-wide perspective on peroxisome targeting signal
            1(PTS1)-Pex5p affinities
  JOURNAL   J Am Chem Soc 132 (11), 3973-3979 (2010)
   PUBMED   20178365
REFERENCE   2  (bases 1 to 1503)
  AUTHORS   Westin,M.A., Hunt,M.C. and Alexson,S.E.
  TITLE     The identification of a succinyl-CoA thioesterase suggests a novel
            pathway for succinate production in peroxisomes
  JOURNAL   J Biol Chem 280 (46), 38125-38132 (2005)
   PUBMED   16141203
REFERENCE   3  (bases 1 to 1503)
  AUTHORS   Hunt,M.C., Yamada,J., Maltais,L.J., Wright,M.W., Podesta,E.J. and
            Alexson,S.E.
  TITLE     A revised nomenclature for mammalian acyl-CoA
            thioesterases/hydrolases
  JOURNAL   J Lipid Res 46 (9), 2029-2032 (2005)
   PUBMED   16103133
REFERENCE   4  (bases 1 to 1503)
  AUTHORS   Ishizuka,M., Toyama,Y., Watanabe,H., Fujiki,Y., Takeuchi,A.,
            Yamasaki,S., Yuasa,S., Miyazaki,M., Nakajima,N., Taki,S. and
            Saito,T.
  TITLE     Overexpression of human acyl-CoA thioesterase upregulates
            peroxisome biogenesis
  JOURNAL   Exp Cell Res 297 (1), 127-141 (2004)
   PUBMED   15194431
REFERENCE   5  (bases 1 to 1503)
  AUTHORS   Jones,J.M., Morrell,J.C. and Gould,S.J.
  TITLE     PEX19 is a predominantly cytosolic chaperone and import receptor
            for class 1 peroxisomal membrane proteins
  JOURNAL   J Cell Biol 164 (1), 57-67 (2004)
   PUBMED   14709540
REFERENCE   6  (bases 1 to 1503)
  AUTHORS   Ofman,R., el Mrabet,L., Dacremont,G., Spijer,D. and Wanders,R.J.
  TITLE     Demonstration of dimethylnonanoyl-CoA thioesterase activity in rat
            liver peroxisomes followed by purification and molecular cloning of
            the thioesterase involved
  JOURNAL   Biochem Biophys Res Commun 290 (2), 629-634 (2002)
   PUBMED   11785945
REFERENCE   7  (bases 1 to 1503)
  AUTHORS   Hunt,M.C., Solaas,K., Kase,B.F. and Alexson,S.E.
  TITLE     Characterization of an acyl-coA thioesterase that functions as a
            major regulator of peroxisomal lipid metabolism
  JOURNAL   J Biol Chem 277 (2), 1128-1138 (2002)
   PUBMED   11673457
REFERENCE   8  (bases 1 to 1503)
  AUTHORS   Jones,J.M., Nau,K., Geraghty,M.T., Erdmann,R. and Gould,S.J.
  TITLE     Identification of peroxisomal acyl-CoA thioesterases in yeast and
            humans
  JOURNAL   J Biol Chem 274 (14), 9216-9223 (1999)
   PUBMED   10092594
REFERENCE   9  (bases 1 to 1503)
  AUTHORS   Watanabe,H., Shiratori,T., Shoji,H., Miyatake,S., Okazaki,Y.,
            Ikuta,K., Sato,T. and Saito,T.
  TITLE     A novel acyl-CoA thioesterase enhances its enzymatic activity by
            direct binding with HIV Nef
  JOURNAL   Biochem Biophys Res Commun 238 (1), 234-239 (1997)
   PUBMED   9299485
REFERENCE   10 (bases 1 to 1503)
  AUTHORS   Liu,L.X., Margottin,F., Le Gall,S., Schwartz,O., Selig,L.,
            Benarous,R. and Benichou,S.
  TITLE     Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with
            Nef-mediated CD4 down-regulation
  JOURNAL   J Biol Chem 272 (21), 13779-13785 (1997)
   PUBMED   9153233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CV115391.1 and BC078751.1.
            
            On Sep 28, 2011 this sequence version replaced NM_130756.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078751.1, FQ212945.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 CV115391.1         1-6
            7-1503              BC078751.1         1-1497
FEATURES             Location/Qualifiers
     source          1..1503
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1503
                     /gene="Acot8"
                     /gene_synonym="Pte1"
                     /note="acyl-CoA thioesterase 8"
                     /db_xref="GeneID:170588"
                     /db_xref="RGD:70368"
     exon            1..520
                     /gene="Acot8"
                     /gene_synonym="Pte1"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..1355
                     /gene="Acot8"
                     /gene_synonym="Pte1"
                     /EC_number="3.1.2.2"
                     /EC_number="3.1.2.1"
                     /EC_number="3.1.2.27"
                     /EC_number="3.1.2.3"
                     /EC_number="3.1.2.11"
                     /EC_number="3.1.2.5"
                     /note="PTE-1; PTE-2; choloyl-coenzyme A thioesterase;
                     peroxisomal acyl-CoA thioesterase 2; peroxisomal
                     long-chain acyl-CoA thioesterase 1; peroxisomal
                     acyl-coenzyme A thioester hydrolase 1;
                     4,8-dimethylnonanoyl-CoA thioesterase; peroxisomal
                     acyl-CoA thioesterase 1; 48-dimethylnonanoyl-CoA
                     thioesterase"
                     /codon_start=1
                     /product="acyl-coenzyme A thioesterase 8"
                     /protein_id="NP_570112.3"
                     /db_xref="GeneID:170588"
                     /db_xref="RGD:70368"
                     /translation="MATPTQKLTSTTTNQNLRLAHGNPRDFRPLERPAGSAGCLYKFP
                     RFSHLQQAVKMSKPEDLGDANGDADRGDLSGDLRSVLVTSVLNLEPLDEDLYRGRHYW
                     VPTSQRLFGGQIVGQALVAAAKSVSEDVHVHSLHCYFVRAGDPKVPVLYHVERTRTGA
                     SFSVRAVKAVQHGKAIFICQASFQQMQPSPLQHQFSMPTVPPPEELLDHEALIDQYLR
                     DPNLHEKYRVGLNRIAAREVPIEIKLVNPPALNQLQTLEPKQMFWVRARGYIGDGDIK
                     MHCCVAAYISDYAFLGTALLPHQSKYKVNFMVSLDHSMWFHAPFRADHWMLYECESPW
                     AGGSRGLVHGRLWRRDGVLAVTCAQEGVIRSKPRVSESKL"
     exon            521..657
                     /gene="Acot8"
                     /gene_synonym="Pte1"
                     /inference="alignment:Splign:2.1.0"
     exon            658..883
                     /gene="Acot8"
                     /gene_synonym="Pte1"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1041
                     /gene="Acot8"
                     /gene_synonym="Pte1"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1236
                     /gene="Acot8"
                     /gene_synonym="Pte1"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1479
                     /gene="Acot8"
                     /gene_synonym="Pte1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctggcaag ggcccaggtg tggcccggac tgagtggctt attgggagct tgggaggagc
       61 cggagaagag accggtaaca gcaacctggg ggcgactttg ctctgtgaca gaagggaaat
      121 gacactcatc ccttattatt catctccaat gctccgcccc ttcgctgatt cacccaatca
      181 cacgcggatc tcctaaactg gcacaaatag tctccaatct taaaatagat atggccacac
      241 ccactcagaa attgacaagc acaacgacca atcagaatct gcgtctcgca cacggaaacc
      301 ctagggattt ccggcccctg gagcgacctg ccggaagcgc tgggtgccta tataagtttc
      361 cgcgtttctc tcatctgcag caagcagtga aaatgtcaaa gccagaggac ctaggagatg
      421 ctaatggcga cgccgaccgc ggcgaccttt ccggggacct gcgtagtgtg ctggtcacca
      481 gcgtgctcaa cctcgagcct ctagatgaag atctctacag aggaaggcat tactgggtac
      541 ctacctccca gcggctcttt gggggtcaga ttgtgggcca ggctctggtg gctgcagcca
      601 agtccgtgag tgaagacgtc cacgtgcact ccctgcactg ctactttgtc cgggcagggg
      661 acccaaaggt gccagtgctg taccatgtgg agaggacacg aacaggagca agcttctcag
      721 tgcgtgcagt gaaggctgtg cagcatggca aggccatctt catctgccag gcctccttcc
      781 agcagatgca gcccagcccc ctgcagcacc agttctccat gcccactgtg ccccccccag
      841 aggagctgct ggaccatgag gccctcattg accagtactt aagggatcct aaccttcatg
      901 agaaatatcg agtggggctg aaccgaattg ctgcccgaga ggtgcctatt gagatcaagc
      961 tggtgaaccc acccgccctg aaccagctgc agacactgga gcccaaacag atgttctggg
     1021 tgcgagcccg gggctatatt ggggacggcg acatcaagat gcactgctgt gtggctgctt
     1081 acatctctga ctacgccttc ctggggacgg cactgctgcc tcaccagtcc aagtataaag
     1141 tgaacttcat ggtctcgctg gaccactcca tgtggttcca cgccccattc cgtgctgacc
     1201 actggatgct ctacgagtgt gagagcccct gggctggtgg ctctcgaggg ctggtacatg
     1261 ggcggctgtg gcgtcgggat ggggtccttg ctgtgacctg tgcccaggag ggtgtgatcc
     1321 gatcgaagcc tcgggtatcc gagagtaaac tatagttgga gattaactcg ctcgcctggg
     1381 gctctaagga ctctttctgc tgccattcct ttggcagagg tcacagttga gctgggcttc
     1441 ctgcctctta catccaataa agagattgct aacactggaa aaaaaaaaaa aaaaaaaaaa
     1501 aaa
//
