LOCUS       NM_013214               1453 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus acyl-CoA thioesterase 7 (Acot7), transcript
            variant 2, mRNA.
ACCESSION   NM_013214 XM_346754
VERSION     NM_013214.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1453)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   2  (bases 1 to 1453)
  AUTHORS   Hiratsuka,K., Yin,S.A., Ohtomo,T., Fujita,M., Ohtsuki,K., Isaka,H.,
            Suga,T., Kurosawa,T. and Yamada,J.
  TITLE     Intratesticular localization of the organic solute carrier protein,
            OSCP1, in spermatogenic cells in mice
  JOURNAL   Mol Reprod Dev 75 (10), 1495-1504 (2008)
   PUBMED   18324622
REFERENCE   3  (bases 1 to 1453)
  AUTHORS   Forwood,J.K., Thakur,A.S., Guncar,G., Marfori,M., Mouradov,D.,
            Meng,W., Robinson,J., Huber,T., Kellie,S., Martin,J.L., Hume,D.A.
            and Kobe,B.
  TITLE     Structural basis for recruitment of tandem hotdog domains in
            acyl-CoA thioesterase 7 and its role in inflammation
  JOURNAL   Proc Natl Acad Sci U S A 104 (25), 10382-10387 (2007)
   PUBMED   17563367
REFERENCE   4  (bases 1 to 1453)
  AUTHORS   Hunt,M.C., Yamada,J., Maltais,L.J., Wright,M.W., Podesta,E.J. and
            Alexson,S.E.
  TITLE     A revised nomenclature for mammalian acyl-CoA
            thioesterases/hydrolases
  JOURNAL   J Lipid Res 46 (9), 2029-2032 (2005)
   PUBMED   16103133
REFERENCE   5  (bases 1 to 1453)
  AUTHORS   Yamada,J., Kuramochi,Y., Takagi,M., Watanabe,T. and Suga,T.
  TITLE     Human brain acyl-CoA hydrolase isoforms encoded by a single gene
  JOURNAL   Biochem Biophys Res Commun 299 (1), 49-56 (2002)
   PUBMED   12435388
REFERENCE   6  (bases 1 to 1453)
  AUTHORS   Yamada,J., Kurata,A., Hirata,M., Taniguchi,T., Takama,H.,
            Furihata,T., Shiratori,K., Iida,N., Takagi-Sakuma,M., Watanabe,T.,
            Kurosaki,K., Endo,T. and Suga,T.
  TITLE     Purification, molecular cloning, and genomic organization of human
            brain long-chain acyl-CoA hydrolase
  JOURNAL   J Biochem 126 (6), 1013-1019 (1999)
   PUBMED   10578051
REFERENCE   7  (bases 1 to 1453)
  AUTHORS   Engberg,S.T., Aoyama,T., Alexson,S.E., Hashimoto,T. and
            Svensson,L.T.
  TITLE     Peroxisome proliferator-induced acyl-CoA thioesterase from rat
            liver cytosol: molecular cloning and functional expression in
            Chinese hamster ovary cells
  JOURNAL   Biochem J 323 (Pt 2) (Pt 2), 525-531 (1997)
   PUBMED   9163348
REFERENCE   8  (bases 1 to 1453)
  AUTHORS   Yamada,J., Furihata,T., Iida,N., Watanabe,T., Hosokawa,M.,
            Satoh,T., Someya,A., Nagaoka,I. and Suga,T.
  TITLE     Molecular cloning and expression of cDNAs encoding rat brain and
            liver cytosolic long-chain acyl-CoA hydrolases
  JOURNAL   Biochem Biophys Res Commun 232 (1), 198-203 (1997)
   PUBMED   9125130
REFERENCE   9  (bases 1 to 1453)
  AUTHORS   Broustas,C.G., Larkins,L.K., Uhler,M.D. and Hajra,A.K.
  TITLE     Molecular cloning and expression of cDNA encoding rat brain
            cytosolic acyl-coenzyme A thioester hydrolase
  JOURNAL   J Biol Chem 271 (18), 10470-10476 (1996)
   PUBMED   8631842
REFERENCE   10 (bases 1 to 1453)
  AUTHORS   Yamada,J., Matsumoto,I., Furihata,T., Sakuma,M. and Suga,T.
  TITLE     Purification and properties of long-chain acyl-CoA hydrolases from
            the liver cytosol of rats treated with peroxisome proliferator
  JOURNAL   Arch Biochem Biophys 308 (1), 118-125 (1994)
   PUBMED   7906114
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DY317682.1 and BC087716.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_013214.5.
            
            On Mar 26, 2009 this sequence version replaced NM_013214.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and 5'
            coding region, compared to variant 1, resulting in an isoform (2)
            with a distinct and shorter N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087716.1, U49694.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                DY317682.1         85-132
            49-1453             BC087716.1         1-1405
FEATURES             Location/Qualifiers
     source          1..1453
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1453
                     /gene="Acot7"
                     /gene_synonym="Bach"
                     /note="acyl-CoA thioesterase 7"
                     /db_xref="GeneID:26759"
                     /db_xref="RGD:628856"
     exon            1..159
                     /gene="Acot7"
                     /gene_synonym="Bach"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1129
                     /gene="Acot7"
                     /gene_synonym="Bach"
                     /EC_number="3.1.2.2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cytosolic acyl coenzyme A thioester hydrolase; ACT; ACH1;
                     LACH1; CTE-II; MTE-II; CTE-IIa; CTE-IIb; long chain
                     acyl-CoA thioester hydrolase; brain acyl-CoA hydrolase"
                     /codon_start=1
                     /product="cytosolic acyl coenzyme A thioester hydrolase
                     isoform 2"
                     /protein_id="NP_037346.2"
                     /db_xref="GeneID:26759"
                     /db_xref="RGD:628856"
                     /translation="MAPPRLIHSAPGLLDTCSQIPPPPSPPPPAVAAKMSGPTTDTPA
                     AIQICRIMRPDDANVAGNVHGGTILKMIEEAGVIISTRHCNSQNGERCVAALARVERT
                     DFLSPMCIGEVAHVSAEITYTSKHSVEVQVHVLSENILTGTKKLTNKATLWYVPLSLK
                     NVDKVLEVPPIVYLRQEQEEEGRKRYEAQKLERMETKWRNGDIVQPILNPEPNTVSYS
                     QSSLIHLVGPSDCTLHGFVHGGVTMKLMDEVAGIVAARHCKTNIVTASVDAINFHDKI
                     RKGCVITISGRMTFTSNKSMEIEVLVDADPVVDNSQKRYRAASAFFTYVSLNQEGKPL
                     PVPQLVPETEDEKKRFEEGKGRYLQMKAKRQGHTEPQP"
     exon            160..277
                     /gene="Acot7"
                     /gene_synonym="Bach"
                     /inference="alignment:Splign:2.1.0"
     exon            278..434
                     /gene="Acot7"
                     /gene_synonym="Bach"
                     /inference="alignment:Splign:2.1.0"
     exon            435..526
                     /gene="Acot7"
                     /gene_synonym="Bach"
                     /inference="alignment:Splign:2.1.0"
     exon            527..641
                     /gene="Acot7"
                     /gene_synonym="Bach"
                     /inference="alignment:Splign:2.1.0"
     exon            642..728
                     /gene="Acot7"
                     /gene_synonym="Bach"
                     /inference="alignment:Splign:2.1.0"
     exon            729..845
                     /gene="Acot7"
                     /gene_synonym="Bach"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1030
                     /gene="Acot7"
                     /gene_synonym="Bach"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1430
                     /gene="Acot7"
                     /gene_synonym="Bach"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcctctttt atggcgcctc ccaggctcat tcattcggcg ccgggcctgc tggacacctg
       61 ttctcagatc ccgccgccgc cgtcgccgcc gccgcccgcc gtcgcagcca agatgtccgg
      121 tcccaccacc gacacgccgg ccgccatcca gatctgccgg atcatgcgtc cggatgatgc
      181 caacgtggcc ggcaatgttc acggagggac cattctaaag atgatcgagg aggctggggt
      241 catcatcagc acccggcact gtaacagcca gaatggggag cgctgtgtgg ctgccctggc
      301 ccgggtggag cgcactgact tcctgtcgcc catgtgcatc ggtgaggtgg ctcacgtcag
      361 cgcagagatc acctatactt ccaagcactc tgtggaggtc caggtccacg tgttgtcgga
      421 gaacatcctc acaggtacca aaaagctgac caataaggcc accttgtggt atgtgcccct
      481 gtcattgaag aatgtggaca aggtccttga ggtgcctcct attgtgtatt tacggcagga
      541 acaggaggag gagggtcgga aacgctatga agcccagaag ctagaacgca tggagaccaa
      601 gtggaggaac ggagacattg tccagcccat cctgaaccca gagccgaaca cagtgagcta
      661 cagccagtcc agcctgatcc acctggtggg gccctcagac tgcactcttc atggcttcgt
      721 gcacggaggt gtcaccatga agctcatgga tgaggtggcc gggattgtgg ctgcgcgcca
      781 ctgcaagacc aatatagtga ctgcctctgt ggatgctatt aatttccatg acaagatccg
      841 gaaaggctgt gtcatcacca tctctggacg catgaccttc acaagcaata agtctatgga
      901 aattgaggtc ctggtggacg ctgaccctgt ggtggacaac tcacagaagc gctaccgggc
      961 tgccagtgcc ttcttcacct acgtgtccct gaatcaggag ggcaagccgc tgcctgtgcc
     1021 tcagcttgtg ccggagacgg aggacgagaa gaagcgtttt gaagaaggca aaggccgcta
     1081 tctgcagatg aaggcgaagc gacagggcca tacagagcct cagccctaga tgtcttcctc
     1141 cctcccatcc tgtcccgtcc tgggtcagca cagttgtggc agtagtcctg tgtgcagtca
     1201 cttagaagtc gcccccttgg ccaaaccccg atttcctttg agagctggtg ttgtgaagta
     1261 ccgtgtggca gtgttacctg tggcctgttc ccaaaacctg tgcaccaaag ctttatttat
     1321 atccctccag tccctgctcc catgttgtcc caaaggccat cgtggacacc agagcacact
     1381 gactggcctg gagaagccag caccactaat aaagctgctg tctggctgga aaaaaaaaaa
     1441 aaaaaaaaaa aaa
//
