LOCUS       NM_138907               2389 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus acyl-CoA thioesterase 2 (Acot2), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_138907
VERSION     NM_138907.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2389)
  AUTHORS   Momose,A., Fujita,M., Ohtomo,T., Umemoto,N., Tanonaka,K.,
            Toyoda,H., Morikawa,M. and Yamada,J.
  TITLE     Regulated expression of acyl-CoA thioesterases in the
            differentiation of cultured rat brown adipocytes
  JOURNAL   Biochem Biophys Res Commun 404 (1), 74-78 (2011)
   PUBMED   21094633
  REMARK    GeneRIF: ACOT isoform expression may be regulated during brown
            adipocyte differentiation to support the fat storage and combustion
            characteristics of this cell type.
REFERENCE   2  (bases 1 to 2389)
  AUTHORS   Ghosh,D. and Berg,J.M.
  TITLE     A proteome-wide perspective on peroxisome targeting signal
            1(PTS1)-Pex5p affinities
  JOURNAL   J Am Chem Soc 132 (11), 3973-3979 (2010)
   PUBMED   20178365
REFERENCE   3  (bases 1 to 2389)
  AUTHORS   Castilla,R., Gadaleta,M., Castillo,A.F., Duarte,A., Neuman,I.,
            Paz,C., Cornejo Maciel,F. and Podesta,E.J.
  TITLE     New enzymes involved in the mechanism of action of epidermal growth
            factor in a clonal strain of Leydig tumor cells
  JOURNAL   Endocrinology 149 (7), 3743-3752 (2008)
   PUBMED   18388199
REFERENCE   4  (bases 1 to 2389)
  AUTHORS   King,K.L., Young,M.E., Kerner,J., Huang,H., O'Shea,K.M.,
            Alexson,S.E., Hoppel,C.L. and Stanley,W.C.
  TITLE     Diabetes or peroxisome proliferator-activated receptor alpha
            agonist increases mitochondrial thioesterase I activity in heart
  JOURNAL   J Lipid Res 48 (7), 1511-1517 (2007)
   PUBMED   17438340
REFERENCE   5  (bases 1 to 2389)
  AUTHORS   Liang,Y., She,P., Wang,X. and Demarest,K.
  TITLE     The messenger RNA profiles in liver, hypothalamus, white adipose
            tissue, and skeletal muscle of female Zucker diabetic fatty rats
            after topiramate treatment
  JOURNAL   Metabolism 55 (10), 1411-1419 (2006)
   PUBMED   16979414
REFERENCE   6  (bases 1 to 2389)
  AUTHORS   Moreno,M., Lombardi,A., De Lange,P., Silvestri,E., Ragni,M.,
            Lanni,A. and Goglia,F.
  TITLE     Fasting, lipid metabolism, and triiodothyronine in rat
            gastrocnemius muscle: interrelated roles of uncoupling protein 3,
            mitochondrial thioesterase, and coenzyme Q
  JOURNAL   FASEB J 17 (9), 1112-1114 (2003)
   PUBMED   12692085
REFERENCE   7  (bases 1 to 2389)
  AUTHORS   Jones,J.M. and Gould,S.J.
  TITLE     Identification of PTE2, a human peroxisomal long-chain acyl-CoA
            thioesterase
  JOURNAL   Biochem Biophys Res Commun 275 (1), 233-240 (2000)
   PUBMED   10944470
REFERENCE   8  (bases 1 to 2389)
  AUTHORS   Yamada,J., Suga,K., Furihata,T., Kitahara,M., Watanabe,T.,
            Hosokawa,M., Satoh,T. and Suga,T.
  TITLE     cDNA cloning and genomic organization of peroxisome
            proliferator-inducible long-chain acyl-CoA hydrolase from rat liver
            cytosol
  JOURNAL   Biochem Biophys Res Commun 248 (3), 608-612 (1998)
   PUBMED   9703974
REFERENCE   9  (bases 1 to 2389)
  AUTHORS   Svensson,L.T., Engberg,S.T., Aoyama,T., Usuda,N., Alexson,S.E. and
            Hashimoto,T.
  TITLE     Molecular cloning and characterization of a mitochondrial
            peroxisome proliferator-induced acyl-CoA thioesterase from rat
            liver
  JOURNAL   Biochem J 329 (Pt 3) (Pt 3), 601-608 (1998)
   PUBMED   9445388
REFERENCE   10 (bases 1 to 2389)
  AUTHORS   Svensson,L.T., Alexson,S.E. and Hiltunen,J.K.
  TITLE     Very long chain and long chain acyl-CoA thioesterases in rat liver
            mitochondria. Identification, purification, characterization, and
            induction by peroxisome proliferators
  JOURNAL   J Biol Chem 270 (20), 12177-12183 (1995)
   PUBMED   7744868
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Mar 29, 2021 this sequence version replaced NM_138907.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072540.1, Y09333.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-749               JAXUCZ010000006.1  109342840-109343588
            750-952             JAXUCZ010000006.1  109345742-109345944
            953-2389            JAXUCZ010000006.1  109348237-109349673
FEATURES             Location/Qualifiers
     source          1..2389
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..2389
                     /gene="Acot2"
                     /gene_synonym="Mte1"
                     /note="acyl-CoA thioesterase 2"
                     /db_xref="GeneID:192272"
                     /db_xref="RGD:621055"
     exon            1..749
                     /gene="Acot2"
                     /gene_synonym="Mte1"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1531
                     /gene="Acot2"
                     /gene_synonym="Mte1"
                     /EC_number="3.1.2.2"
                     /note="MTE-I; ARTISt/p43; acyl coenzyme A thioester
                     hydrolase; very-long-chain acyl-CoA thioesterase;
                     mitochondrial acyl-CoA thioesterase 1"
                     /codon_start=1
                     /product="acyl-coenzyme A thioesterase 2, mitochondrial"
                     /protein_id="NP_620262.2"
                     /db_xref="GeneID:192272"
                     /db_xref="RGD:621055"
                     /translation="MVASSFAVLRASRLCQWGWKSWTQLSGPPPLSTGGRTTFARTNA
                     TLSLEPGSRSCWDEPLSITVRGLAPEQPVTLRAALRDEKGALFRAHARYRADAGGELD
                     LARAPALGGSFTGLEPMGLIWAMEPERPLWRLVKRDVQKPYVVELEVLDGHEPDGGQR
                     LAQAVHERHFMAPGVRRVPVRDGRVRATLFLPPEPGPFPGIIDLFGVGGGLLEYRASL
                     LAGKGFAVMALAYYNYDDLPKTMETMRIEYFEEAVNYLRGHPEVKGPGIGLLGISKGG
                     ELGLAMASFLKGITAAVVINGSVAAVGNTVCYKDETIPPVSLLRDKVKMTKDGLLDVV
                     EALQSPLVDKKSFIPVERSDTTFLFLVGQDDHNWKSEFYAREASKRLQAHGKEKPQII
                     CYPEAGHYIEPPYFPLCSAGMHLLVGANITFGGEPKPHSVAQLDAWQQLQTFFHKQLS
                     GKS"
     exon            750..952
                     /gene="Acot2"
                     /gene_synonym="Mte1"
                     /inference="alignment:Splign:2.1.0"
     exon            953..2389
                     /gene="Acot2"
                     /gene_synonym="Mte1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaagcgtca ctacttttgc ttttgttgct tgcttagcac tctgatccag cacagtaagc
       61 ccacacagct cagcctacgg ctcagtctaa ggactgcaaa taggcagctg gccactagag
      121 gatctctaac ttttcctacg aaactgaggg ctgaagtcaa agatacaaaa tggtggcctc
      181 gtctttcgct gtcctgagag caagcaggtt gtgccaatgg ggttggaaga gctggacgca
      241 gctgtcaggt cctccgccgc tcagcaccgg tggccggacc acttttgcgc ggacaaatgc
      301 tacgctgagc ctggagcccg ggagccgcag ctgctgggac gagccgttga gcatcaccgt
      361 gcgcggcctg gcccccgagc agcccgtcac gctgcgcgcg gccctgcgtg acgagaaggg
      421 cgcgctcttc cgagcccacg cgcgctaccg cgccgacgcc ggtggtgagc tggacctggc
      481 gcgcgctccc gcgctgggcg gcagcttcac ggggctcgag cccatggggc tgatctgggc
      541 catggagccc gaacggcctc tctggcgcct ggtcaagcgc gacgtgcaga agccttatgt
      601 ggtggagctg gaggtgctgg acggacacga gcccgacggc ggtcagcggc tggcacaggc
      661 agtgcacgag cgtcacttca tggctccagg ggtgcggcgc gtgcccgtgc gcgacggccg
      721 ggtgcgcgcc acgctcttcc tgcccccaga acctgggccc tttcctggaa tcatagacct
      781 ttttggagtt ggaggcggcc ttctggagta ccgggcgagt ctgctggctg ggaagggttt
      841 tgccgtcatg gctctggctt attacaacta cgacgacctc cccaagacca tggaaaccat
      901 gcgcattgag tactttgaag aagccgtgaa ctacctgcgt ggccaccctg aggtaaaagg
      961 accaggaatt gggctgcttg ggatttccaa agggggtgaa cttggccttg ctatggcctc
     1021 cttcctgaag ggcatcacgg ctgctgttgt catcaatggc tccgtggctg ctgttgggaa
     1081 caccgtatgc tacaaggatg agactatacc ccctgtgtcc cttctgagag acaaagtcaa
     1141 aatgaccaaa gatggtctct tggatgtcgt ggaagctctg caaagccctt tggtagacaa
     1201 gaagagcttc atccctgtgg aaaggtctga cacgaccttc ctgttcctcg ttggtcagga
     1261 tgaccacaac tggaagagcg agttctatgc cagagaggcc tccaaacgct tgcaggccca
     1321 cgggaaagag aagccccaga tcatctgcta cccagaagca gggcactata tcgagcctcc
     1381 ttacttccca ctgtgcagcg ctggcatgca cctcctggtg ggtgctaaca tcacctttgg
     1441 aggggagcct aagcctcact ctgtggccca gttggatgca tggcagcaac tccagacttt
     1501 cttccacaaa cagttgagtg gtaagagtta ggaggtgccc cctaaaatat aacctgttat
     1561 gtggtggttt ggggaaaaac ccaaatatca gaatgccact tcagtttagt tcatttgaac
     1621 acatactaat ttttttaagt ttctttcttc cttcctttct ttctttctgt tttttttttt
     1681 tttgttgttg ttgttgtttg tttgtttgtt tgagacaggg tttgtctgtt tacccctggc
     1741 tggcctggaa cttgctttgt agaccagagg ctaggcctga attctgaggt tggccggcct
     1801 ctgcctccca agtgctggca gtaaagccac acccagctta agtttttttt tttttttttt
     1861 cttttctttt tttttcggag ctggggaccg aacccagggc cttgcgcttg ctaggcaaac
     1921 gctctaccac tgagctaaat ccccaacccc cccttttttt tcttaatata atgaattaag
     1981 tgcctgtgag agactgagga tatagcttag tggcaatgca tttgactttc ttctatagtg
     2041 ccctgaattc attctccagt gctataagac aacaaagaaa ttaaaacttc cttataaaac
     2101 tgtgcctatt gacctggtga gatggctcag tgatagtggt gctttctgcc cagcctgaca
     2161 gcttgagatt gtctttcccc caggatctac atggtaggag agaaccaact ctgacaagtt
     2221 gtcctccaac acacgcacac acctgcacat gcacacacaa ataacatgta atttaaaaat
     2281 agtgcctatc caaaaataga gttcttttgt atcatgaatt aaaggggaac cttaagtata
     2341 aacattctta ttaagacaaa aaataaaaat tggatcatta tagacaaaa
//
