LOCUS       NM_130747               1725 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus acyl-CoA thioesterase 12 (Acot12), mRNA.
ACCESSION   NM_130747
VERSION     NM_130747.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1725)
  AUTHORS   Horibata,Y., Ando,H., Itoh,M. and Sugimoto,H.
  TITLE     Enzymatic and transcriptional regulation of the cytoplasmic
            acetyl-CoA hydrolase ACOT12
  JOURNAL   J Lipid Res 54 (8), 2049-2059 (2013)
   PUBMED   23709691
  REMARK    GeneRIF: The results suggest that cytosolic acetyl-CoA levels in
            the liver are controlled by lipid metabolites and hormones, which
            result in allosteric enzymatic and transcriptional regulation of
            ACOT12.
REFERENCE   2  (bases 1 to 1725)
  AUTHORS   Yamashita,H., Itsuki,A., Kimoto,M., Hiemori,M. and Tsuji,H.
  TITLE     Acetate generation in rat liver mitochondria; acetyl-CoA hydrolase
            activity is demonstrated by 3-ketoacyl-CoA thiolase
  JOURNAL   Biochim Biophys Acta 1761 (1), 17-23 (2006)
   PUBMED   16476568
  REMARK    GeneRIF: acetyl-CoA-hydrolyzing activity in isolated mitochondria
            was induced by the treatment of rats with di(2-ehtylhexyl)phthalate
            (DEHP).
REFERENCE   3  (bases 1 to 1725)
  AUTHORS   Hunt,M.C., Yamada,J., Maltais,L.J., Wright,M.W., Podesta,E.J. and
            Alexson,S.E.
  TITLE     A revised nomenclature for mammalian acyl-CoA
            thioesterases/hydrolases
  JOURNAL   J Lipid Res 46 (9), 2029-2032 (2005)
   PUBMED   16103133
REFERENCE   4  (bases 1 to 1725)
  AUTHORS   Suematsu,N., Okamoto,K. and Isohashi,F.
  TITLE     Mouse cytosolic acetyl-CoA hydrolase, a novel candidate for a key
            enzyme involved in fat metabolism: cDNA cloning, sequencing and
            functional expression
  JOURNAL   Acta Biochim Pol 49 (4), 937-945 (2002)
   PUBMED   12545200
REFERENCE   5  (bases 1 to 1725)
  AUTHORS   Suematsu,N., Okamoto,K., Shibata,K., Nakanishi,Y. and Isohashi,F.
  TITLE     Molecular cloning and functional expression of rat liver cytosolic
            acetyl-CoA hydrolase
  JOURNAL   Eur J Biochem 268 (9), 2700-2709 (2001)
   PUBMED   11322891
REFERENCE   6  (bases 1 to 1725)
  AUTHORS   Ebisuno,S., Isohashi,F., Nakanishi,Y., Higashi,T. and Sakamoto,Y.
  TITLE     The biphasic change of cytosolic acetyl-CoA hydrolase in rat liver
            during 3'-methyl-4-dimethylaminoazobenzene hepatocarcinogenesis
  JOURNAL   Jpn J Cancer Res 80 (2), 132-135 (1989)
   PUBMED   2566591
REFERENCE   7  (bases 1 to 1725)
  AUTHORS   Soling,H.D. and Rescher,C.
  TITLE     On the regulation of cold-labile cytosolic and of mitochondrial
            acetyl-CoA hydrolase in rat liver
  JOURNAL   Eur J Biochem 147 (1), 111-117 (1985)
   PUBMED   2857646
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB040609.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB040609.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1725
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="DONRYU"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..1725
                     /gene="Acot12"
                     /gene_synonym="Cach; rACH"
                     /note="acyl-CoA thioesterase 12"
                     /db_xref="GeneID:170570"
                     /db_xref="RGD:619752"
     exon            1..150
                     /gene="Acot12"
                     /gene_synonym="Cach; rACH"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1691
                     /gene="Acot12"
                     /gene_synonym="Cach; rACH"
                     /EC_number="3.1.2.1"
                     /note="acyl-coenzyme A thioesterase 12; CACH-1; rCACH-1;
                     acyl-CoA thioester hydrolase 12; cytoplasmic acetyl-CoA
                     hydrolase 1; cytosolic acetyl-CoA hydrolase"
                     /codon_start=1
                     /product="acetyl-coenzyme A thioesterase"
                     /protein_id="NP_570103.1"
                     /db_xref="GeneID:170570"
                     /db_xref="RGD:619752"
                     /translation="MEPTVAPGEVLMSQAIQPAHADSRGELSAGQLLKWMDTTACLAA
                     EKHAGISCVTASMDDILFEDTARIGQIVTIRAKVTRAFSTSMEISIKVRVQDKFTGIQ
                     KLLCVAFSTFVVKPLGKEKVHLKPVLLQTEQEQVEHRLASERRKVRLQHENTFSNIMK
                     ESNWLRDPVCNEEEGTATTMATSVQSIELVLPPHANHHGNTFGGQIMAWMETVATISA
                     SRLCHGHPFLKSVDMFKFRGPSTVGDRLVFNAIVNNTFQNSVEVGVRVEAFDCREWAE
                     GQGRHINSAFLIYNAVDDQEELITFPRIQPISKDDFRRYQGAIARRRIRLGRKYVISH
                     KKEVPLGTQWDISKKGSISNTNVEALKNLASKSGWEITTTLEKIKIYTLEEQDAISVK
                     VEKQVGSPARVAYHLLSDFTKRPLWDPHYISCEVIDQVSEDDQIYYITCSVVNGDKPK
                     DFVVLVSQRKPLKDDNTYIVALMSVVLPSVPPSPQYIRSQVICAGFLIQPVDSSSCTV
                     AYLNQMSDSILPYFAGNIGGWSKSIEEAAASCIKFIENATHDGLKSVL"
     exon            151..220
                     /gene="Acot12"
                     /gene_synonym="Cach; rACH"
                     /inference="alignment:Splign:2.1.0"
     exon            221..281
                     /gene="Acot12"
                     /gene_synonym="Cach; rACH"
                     /inference="alignment:Splign:2.1.0"
     exon            282..383
                     /gene="Acot12"
                     /gene_synonym="Cach; rACH"
                     /inference="alignment:Splign:2.1.0"
     exon            384..519
                     /gene="Acot12"
                     /gene_synonym="Cach; rACH"
                     /inference="alignment:Splign:2.1.0"
     exon            520..676
                     /gene="Acot12"
                     /gene_synonym="Cach; rACH"
                     /inference="alignment:Splign:2.1.0"
     exon            677..796
                     /gene="Acot12"
                     /gene_synonym="Cach; rACH"
                     /inference="alignment:Splign:2.1.0"
     exon            797..947
                     /gene="Acot12"
                     /gene_synonym="Cach; rACH"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1003
                     /gene="Acot12"
                     /gene_synonym="Cach; rACH"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1067
                     /gene="Acot12"
                     /gene_synonym="Cach; rACH"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1151
                     /gene="Acot12"
                     /gene_synonym="Cach; rACH"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1285
                     /gene="Acot12"
                     /gene_synonym="Cach; rACH"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1414
                     /gene="Acot12"
                     /gene_synonym="Cach; rACH"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1541
                     /gene="Acot12"
                     /gene_synonym="Cach; rACH"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1706
                     /gene="Acot12"
                     /gene_synonym="Cach; rACH"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagctctctc agccgggacg atggaaccga cagtggctcc cggcgaggtg ctcatgagcc
       61 aggccatcca gcctgcgcac gccgactcgc gcggcgagct gagcgccggg caactactta
      121 agtggatgga caccactgcc tgcctggccg ctgaaaagca tgctgggatt tcctgtgtca
      181 cagcctcaat ggatgacatt ctgtttgagg acacggctag aattggacag attgttacca
      241 tcagagcaaa agtgactagg gcgttcagca caagcatgga gatcagtatc aaggtcagag
      301 tccaggacaa gttcactggc atccagaagc tcctctgtgt ggctttctcg acatttgtag
      361 ttaaaccgct cggcaaagaa aaggttcact tgaaacctgt tctgcttcaa acggagcaag
      421 agcaagtgga gcaccgtctg gcctccgaga ggaggaaagt ccggttacag catgagaaca
      481 ccttcagcaa cattatgaag gaaagcaact ggctcaggga tcccgtttgt aatgaagagg
      541 aaggaacggc caccaccatg gccacctctg tccagagcat tgagcttgtc ctcccacccc
      601 acgcaaacca ccacggaaac acatttggcg ggcagatcat ggcgtggatg gagacagtcg
      661 caaccatttc cgcaagccgc ctgtgtcatg ggcatccctt tctgaagtcc gtggatatgt
      721 ttaaattccg gggaccgtcc acagttgggg accgccttgt cttcaatgcc atcgtcaaca
      781 acacctttca gaacagtgtg gaagttggcg tacgtgttga ggcctttgac tgtcgggagt
      841 gggccgaggg ccaaggccgc cacatcaaca gcgcttttct catttacaat gctgttgatg
      901 accaggagga actcatcacc tttcccagaa tccagcccat ttcaaaggat gattttcgac
      961 ggtaccaggg agctattgca cggaggagaa ttcgcctggg caggaaatat gttatttccc
     1021 acaagaaaga agtcccactt ggcacacaat gggatataag caaaaaggga tccataagta
     1081 acaccaatgt ggaagctctc aaaaatctgg catccaaaag cggttgggag atcaccacca
     1141 ccttggagaa gataaaaata tatacactgg aagagcaaga tgccatatct gtaaaggtgg
     1201 aaaaacaggt tggaagtcca gcccgcgtgg cttatcatct cttgtccgac ttcacaaagc
     1261 gccctttatg ggacccccat tacatatctt gtgaagtcat agaccaggtg agtgaggacg
     1321 atcagatata ttacatcacc tgctcggtgg taaatggaga caaacccaag gacttcgtag
     1381 tacttgtgtc acaaagaaag cccctcaagg acgacaacac ctacatcgtg gcactaatgt
     1441 cagtggtact gccgtctgtc cctccatctc cacagtacat cagaagccag gtcatttgtg
     1501 ctgggttcct catccagcct gtcgacagca gttcgtgcac tgtagcatac ctgaaccaga
     1561 tgtcagacag catcctccct tactttgctg gcaatattgg tggctggtca aaatccattg
     1621 aggaagctgc agcctcttgt ataaaattca tagagaacgc cactcacgat ggacttaaaa
     1681 gtgtgttata aatggtcaac tctcagaaaa aaaaaaaaaa aaaaa
//
