LOCUS       NM_001271383            2052 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus acyl-CoA thioesterase 11 (Acot11), mRNA.
ACCESSION   NM_001271383 XM_002729507 XM_003749990 XM_003754071 XM_003754072
VERSION     NM_001271383.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2052)
  AUTHORS   Okada,K., LeClair,K.B., Zhang,Y., Li,Y., Ozdemir,C., Krisko,T.I.,
            Hagen,S.J., Betensky,R.A., Banks,A.S. and Cohen,D.E.
  TITLE     Thioesterase superfamily member 1 suppresses cold thermogenesis by
            limiting the oxidation of lipid droplet-derived fatty acids in
            brown adipose tissue
  JOURNAL   Mol Metab 5 (5), 340-351 (2016)
   PUBMED   27110486
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2052)
  AUTHORS   Chen,D., Latham,J., Zhao,H., Bisoffi,M., Farelli,J. and
            Dunaway-Mariano,D.
  TITLE     Human brown fat inducible thioesterase variant 2 cellular
            localization and catalytic function
  JOURNAL   Biochemistry 51 (35), 6990-6999 (2012)
   PUBMED   22897136
REFERENCE   3  (bases 1 to 2052)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 2052)
  AUTHORS   Adams,S.H., Chui,C., Schilbach,S.L., Yu,X.X., Goddard,A.D.,
            Grimaldi,J.C., Lee,J., Dowd,P., Colman,S. and Lewin,D.A.
  TITLE     BFIT, a unique acyl-CoA thioesterase induced in thermogenic brown
            adipose tissue: cloning, organization of the human gene and
            assessment of a potential link to obesity
  JOURNAL   Biochem J 360 (Pt 1), 135-142 (2001)
   PUBMED   11696000
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Sep 21, 2012 this sequence version replaced
            XM_003749990.1, XM_002729507.2, XM_003754071.1, XM_003754072.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1807032.1,
                                           SRR26643298.28160.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000005.1  126804364-126804507 c
            145-358             JAXUCZ010000005.1  126777420-126777633 c
            359-428             JAXUCZ010000005.1  126776779-126776848 c
            429-489             JAXUCZ010000005.1  126770650-126770710 c
            490-588             JAXUCZ010000005.1  126769737-126769835 c
            589-724             JAXUCZ010000005.1  126769268-126769403 c
            725-878             JAXUCZ010000005.1  126767350-126767503 c
            879-998             JAXUCZ010000005.1  126766059-126766178 c
            999-1143            JAXUCZ010000005.1  126763500-126763644 c
            1144-1199           JAXUCZ010000005.1  126762503-126762558 c
            1200-1266           JAXUCZ010000005.1  126761259-126761325 c
            1267-1350           JAXUCZ010000005.1  126760886-126760969 c
            1351-1481           JAXUCZ010000005.1  126760046-126760176 c
            1482-1613           JAXUCZ010000005.1  126757827-126757958 c
            1614-1740           JAXUCZ010000005.1  126757279-126757405 c
            1741-2052           JAXUCZ010000005.1  126756255-126756566 c
FEATURES             Location/Qualifiers
     source          1..2052
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34"
     gene            1..2052
                     /gene="Acot11"
                     /gene_synonym="Thea"
                     /note="acyl-CoA thioesterase 11"
                     /db_xref="GeneID:100363074"
                     /db_xref="RGD:2324815"
     exon            1..144
                     /gene="Acot11"
                     /gene_synonym="Thea"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1896
                     /gene="Acot11"
                     /gene_synonym="Thea"
                     /EC_number="3.1.2.2"
                     /note="thioesterase, adipose associated"
                     /codon_start=1
                     /product="acyl-coenzyme A thioesterase 11"
                     /protein_id="NP_001258312.1"
                     /db_xref="GeneID:100363074"
                     /db_xref="RGD:2324815"
                     /translation="MIQNVGNHLRRGFASMFSSRTSRKSVSHPESGDASAMAEGEGYR
                     NPTEVQMSQLVLPCHTNHRGELSIGQLLKWIDTTACLSAERHAGCPCVTASMDDIYFD
                     HTISVGQVVNIKAKVNRAFNSSMEVGIQVVSEDLCSEKQWSVCKALATFVAHRELSKV
                     KLKQVVPLTEEEKTEHGVAAERRRMRLVYTDTIKDLLAHYAIQDDLDKDCSNMVPAEK
                     TRVESVELVLPPHANHQGNTFGGQIMAWMENVATIAASRLCHAHPTLKAIEMFHFRGP
                     SQVGDRLVLKAIVNNAFKHSMEVGVCVEAYRQEAETQRRHINSAFMTFVVLDKDDQPQ
                     KLPWIRPQPGDGERRYREASARKKIRLDRKYLVSCKQAEMALSVPWDPSNQVYLSYYN
                     VSSLKTLMAKDNWVLSVEISEVRLYILEEEFLSFHLEMVVNVDAAQVFQLLSDLSRRP
                     EWDKHCRSVELVQQVDEDDAIYHVISPTLSGNTKPQDFVILASRRKPCDSGDPYVIAL
                     RSVTLPTHRETPEYQRGETLCSGFCLWREGDQSTKVSYYNQATPGFLNYVTTNVAGLS
                     SEFYNTFKACESFLLDNRNDLAPSLQTL"
     exon            145..358
                     /gene="Acot11"
                     /gene_synonym="Thea"
                     /inference="alignment:Splign:2.1.0"
     exon            359..428
                     /gene="Acot11"
                     /gene_synonym="Thea"
                     /inference="alignment:Splign:2.1.0"
     exon            429..489
                     /gene="Acot11"
                     /gene_synonym="Thea"
                     /inference="alignment:Splign:2.1.0"
     exon            490..588
                     /gene="Acot11"
                     /gene_synonym="Thea"
                     /inference="alignment:Splign:2.1.0"
     exon            589..724
                     /gene="Acot11"
                     /gene_synonym="Thea"
                     /inference="alignment:Splign:2.1.0"
     exon            725..878
                     /gene="Acot11"
                     /gene_synonym="Thea"
                     /inference="alignment:Splign:2.1.0"
     exon            879..998
                     /gene="Acot11"
                     /gene_synonym="Thea"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1143
                     /gene="Acot11"
                     /gene_synonym="Thea"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1199
                     /gene="Acot11"
                     /gene_synonym="Thea"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1266
                     /gene="Acot11"
                     /gene_synonym="Thea"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1350
                     /gene="Acot11"
                     /gene_synonym="Thea"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1481
                     /gene="Acot11"
                     /gene_synonym="Thea"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1613
                     /gene="Acot11"
                     /gene_synonym="Thea"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1740
                     /gene="Acot11"
                     /gene_synonym="Thea"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..2052
                     /gene="Acot11"
                     /gene_synonym="Thea"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagccggct gcttttggag ctgctggacg cttgggactc aggtgaccag cggcccttta
       61 gaagcctaca gaccccctcc acagcgtggc aacccagcaa acggagcaga aatgatacag
      121 aatgtgggca accacttacg aaggggcttc gcctctatgt tctctagtcg gacatcccgg
      181 aagtcagtct ctcatccgga gtccggagac gcttccgcca tggcagaggg tgaaggctac
      241 cggaacccca cggaggtgca gatgagccag ctggtgctgc cctgccacac taaccaccgt
      301 ggggagctga gcattgggca gttgctcaaa tggatcgaca ccacagcctg cctatcagcg
      361 gagaggcatg ctggctgtcc ctgtgtcaca gcctccatgg atgacatcta cttcgaccat
      421 accattagtg tcggccaagt ggtgaatatc aaggccaagg tgaaccgggc cttcaactcc
      481 agcatggagg taggaatcca ggtggtctct gaagatctgt gctctgagaa acagtggagt
      541 gtctgcaagg ccttggccac cttcgtggcc caccgggagc tctccaaggt gaagctgaag
      601 caggttgtcc cattgacgga ggaggagaag accgagcatg gggtggcggc tgagcgccgg
      661 cgtatgcgac tggtctacac agacaccatc aaggatctcc tagctcacta tgccatccag
      721 gatgatctgg acaaggactg cagcaatatg gtgccagccg agaagacccg ggtggagagt
      781 gtggaactgg tgctgcctcc tcacgccaat catcagggca atacctttgg gggccagatc
      841 atggcctgga tggagaacgt ggccaccatt gcagccagcc ggctctgtca tgcccaccct
      901 acactcaagg ccatcgagat gttccatttc cgaggcccat ctcaggtggg ggaccgtctg
      961 gtgctcaagg ccatcgtgaa taatgccttc aagcatagca tggaggtggg tgtgtgtgta
     1021 gaggcttacc gccaggaggc tgagacccag cgccggcaca tcaacagcgc cttcatgact
     1081 ttcgtggtcc tggacaaaga tgaccagcct cagaagctgc cctggattcg tccccagcct
     1141 ggggatggtg aacggcgata ccgagaggcc agtgccagga agaagatccg cctggacagg
     1201 aagtaccttg tgtcctgtaa gcaggcggaa atggccctgt ctgttccctg ggatcctagc
     1261 aaccaggtat acctgagcta ttacaacgtg tcctctctga agacgcttat ggccaaggat
     1321 aactgggtgc tgtctgtgga gatcagtgag gttcgcctgt acatcctgga agaggagttc
     1381 ctgtcctttc acttggagat ggtggtaaat gtggatgccg cccaggtctt tcagctgctc
     1441 tcagacctga gcagaagacc agagtgggac aagcattgcc ggagtgtgga gctagtgcag
     1501 caagtggatg aggatgacgc catctaccat gtcatcagcc ctaccctgag tggtaacacc
     1561 aagccccaag actttgtgat cctggcctct aggaggaagc cttgtgacag tggggacccc
     1621 tacgtcattg ccctgaggtc tgtcacactg cccacgcacc gtgagacacc ggaatatcaa
     1681 cgtggggaga ctctctgttc aggcttctgt ttgtggcgtg agggggacca gtcgactaag
     1741 gtttcttact ataaccaggc tacccctggt tttctcaact atgtgaccac caatgtggct
     1801 ggcctgtcct cggagttcta caacactttc aaggcttgtg agagtttcct gttggacaac
     1861 cggaatgacc tggcccccag cctccagacc ctctagacac caccccatgc tgccccaggt
     1921 ctcacacagt gcgcggagca aagcagaggc atttattcac cttgactccc cagggaaacc
     1981 ttccacataa gatggtccag tcctactgga tggtcggtgt ctgtccacat gtgccagcaa
     2041 gtctttacgg ta
//
