LOCUS       NM_031315               1589 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus acyl-CoA thioesterase 1 (Acot1), mRNA.
ACCESSION   NM_031315
VERSION     NM_031315.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1589)
  AUTHORS   Yi,X., Pashaj,A., Xia,M. and Moreau,R.
  TITLE     Reversal of obesity-induced hypertriglyceridemia by
            (R)-alpha-lipoic acid in ZDF (fa/fa) rats
  JOURNAL   Biochem Biophys Res Commun 439 (3), 390-395 (2013)
   PUBMED   23994635
REFERENCE   2  (bases 1 to 1589)
  AUTHORS   Ohtomo,T., Hoshino,A., Yajima,M., Tsuchiya,A., Momose,A.,
            Tanonaka,K., Toyoda,H., Kato,T. and Yamada,J.
  TITLE     Expression and distribution of acyl-CoA thioesterases in the white
            adipose tissue of rats
  JOURNAL   Histochem Cell Biol 140 (2), 223-232 (2013)
   PUBMED   23385637
  REMARK    GeneRIF: The Acot1 expression is transiently upregulated at an
            early stage of adipocyte maturation, possibly to maintain cytosolic
            acyl-CoAs below a certain level until the cells acquire their full
            capability for fat storage.
REFERENCE   3  (bases 1 to 1589)
  AUTHORS   Yang,S., Chen,C., Wang,H., Rao,X., Wang,F., Duan,Q., Chen,F.,
            Long,G., Gong,W., Zou,M.H. and Wang,D.W.
  TITLE     Protective effects of Acyl-coA thioesterase 1 on diabetic heart via
            PPARalpha/PGC1alpha signaling
  JOURNAL   PLoS One 7 (11), e50376 (2012)
   PUBMED   23226270
  REMARK    GeneRIF: ACOT1 plays a crucial protective role in the diabetic
            heart via PPARalpha/PGC1alpha signaling.
REFERENCE   4  (bases 1 to 1589)
  AUTHORS   Momose,A., Fujita,M., Ohtomo,T., Umemoto,N., Tanonaka,K.,
            Toyoda,H., Morikawa,M. and Yamada,J.
  TITLE     Regulated expression of acyl-CoA thioesterases in the
            differentiation of cultured rat brown adipocytes
  JOURNAL   Biochem Biophys Res Commun 404 (1), 74-78 (2011)
   PUBMED   21094633
  REMARK    GeneRIF: ACOT isoform expression may be regulated during brown
            adipocyte differentiation to support the fat storage and combustion
            characteristics of this cell type.
REFERENCE   5  (bases 1 to 1589)
  AUTHORS   Hunt,M.C., Rautanen,A., Westin,M.A., Svensson,L.T. and Alexson,S.E.
  TITLE     Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene
            clusters shows that convergent, functional evolution results in a
            reduced number of human peroxisomal ACOTs
  JOURNAL   FASEB J 20 (11), 1855-1864 (2006)
   PUBMED   16940157
REFERENCE   6  (bases 1 to 1589)
  AUTHORS   Huhtinen,K., O'Byrne,J., Lindquist,P.J., Contreras,J.A. and
            Alexson,S.E.
  TITLE     The peroxisome proliferator-induced cytosolic type I acyl-CoA
            thioesterase (CTE-I) is a serine-histidine-aspartic acid alpha
            /beta hydrolase
  JOURNAL   J Biol Chem 277 (5), 3424-3432 (2002)
   PUBMED   11694534
REFERENCE   7  (bases 1 to 1589)
  AUTHORS   Yamada,J., Suga,K., Furihata,T., Kitahara,M., Watanabe,T.,
            Hosokawa,M., Satoh,T. and Suga,T.
  TITLE     cDNA cloning and genomic organization of peroxisome
            proliferator-inducible long-chain acyl-CoA hydrolase from rat liver
            cytosol
  JOURNAL   Biochem Biophys Res Commun 248 (3), 608-612 (1998)
   PUBMED   9703974
REFERENCE   8  (bases 1 to 1589)
  AUTHORS   Lindquist,P.J., Svensson,L.T. and Alexson,S.E.
  TITLE     Molecular cloning of the peroxisome proliferator-induced 46-kDa
            cytosolic acyl-CoA thioesterase from mouse and rat
            liver--recombinant expression in Escherichia coli, tissue
            expression, and nutritional regulation
  JOURNAL   Eur J Biochem 251 (3), 631-640 (1998)
   PUBMED   9490035
REFERENCE   9  (bases 1 to 1589)
  AUTHORS   Svensson,L.T., Engberg,S.T., Aoyama,T., Usuda,N., Alexson,S.E. and
            Hashimoto,T.
  TITLE     Molecular cloning and characterization of a mitochondrial
            peroxisome proliferator-induced acyl-CoA thioesterase from rat
            liver
  JOURNAL   Biochem J 329 (Pt 3) (Pt 3), 601-608 (1998)
   PUBMED   9445388
REFERENCE   10 (bases 1 to 1589)
  AUTHORS   Yamada,J., Matsumoto,I., Furihata,T., Sakuma,M. and Suga,T.
  TITLE     Purification and properties of long-chain acyl-CoA hydrolases from
            the liver cytosol of rats treated with peroxisome proliferator
  JOURNAL   Arch Biochem Biophys 308 (1), 118-125 (1994)
   PUBMED   7906114
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from Y09334.1.
            
            [WARNING] On Aug 13, 2024 this sequence was replaced by
            NM_031315.3.
            
            On Dec 24, 2015 this sequence version replaced NM_031315.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y09334.1, AB010428.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132272, SAMD00132274
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1589              Y09334.1           3-1591
FEATURES             Location/Qualifiers
     source          1..1589
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..1589
                     /gene="Acot1"
                     /gene_synonym="Cte1"
                     /note="acyl-CoA thioesterase 1"
                     /db_xref="GeneID:50559"
                     /db_xref="RGD:70894"
     exon            1..464
                     /gene="Acot1"
                     /gene_synonym="Cte1"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..1267
                     /gene="Acot1"
                     /gene_synonym="Cte1"
                     /EC_number="3.1.2.2"
                     /note="acyl-CoA thioesterase 1, cytosolic; cytosolic
                     acyl-CoA thioesterase 1; ACH2; CTE-I; LACH2; long chain
                     acyl-CoA hydrolase; long chain acyl-CoA thioester
                     hydrolase; inducible cytosolic acyl-coenzyme A thioester
                     hydrolase; palmitoyl-coenzyme A thioesterase"
                     /codon_start=1
                     /product="acyl-coenzyme A thioesterase 1"
                     /protein_id="NP_112605.1"
                     /db_xref="GeneID:50559"
                     /db_xref="RGD:70894"
                     /translation="MEATLSLGPAGRSCWDEPLSITVRGLVPEQPVTLRAALRDEKGA
                     LFRARALYRADAHGELDLARAPALGGSFTGLEPMGLLWAMEPERPFWRLVKRDVQTPF
                     VVELEVLDGHKPDGGRLLARAVHERHFMAPGVRRVPVREGRVRATLFLPPEPGPFPGI
                     INLFGVGGGLLEYRASLLAGKGFAVMALAYYNYDDLPKTMETMRIEYFEEAVNYLRGH
                     PEVKGPGIGLLGISKGGELGLAMASFLKGITAAVVINGSVAAVGNTICYKDETIPPVT
                     ILRNQVKMTKDGLKDVVDALQSPLVEQKSFIPVERSDTTFLFLVGQDDHNWKSEFYAN
                     EISKRLQAHGKEKPQIICYPEAGHYIEPPYFPLCSAGMHLLVGANITFGGEPKPHSVA
                     QLDAWQQLQTFFHKQLGGKSHGVSPKI"
     exon            465..667
                     /gene="Acot1"
                     /gene_synonym="Cte1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..1579
                     /gene="Acot1"
                     /gene_synonym="Cte1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcgaaatg gaggcgactc tgagcctggg gcccgccggc cgcagctgct gggatgagcc
       61 gctgagcatc accgtgcgcg gcctggtccc cgagcagccc gtcacgctgc gcgcggccct
      121 gcgcgacgag aagggcgcgc tcttccgagc ccgcgcgctc taccgcgccg atgcccacgg
      181 agagctggac ctggcgcgcg cgcccgctct ggggggcagc ttcacggggc tcgagcccat
      241 ggggctgctc tgggccatgg agcccgaacg gcctttctgg cgcttggtca agcgcgacgt
      301 gcagacgccc ttcgtggtgg agctggaggt gctggacgga cacaaacccg acggcgggcg
      361 gctgctggcg cgggcggtgc acgagcgtca cttcatggct cccggggtgc ggcgggtgcc
      421 cgtgcgcgag ggcagggtgc gcgccacgct cttcctgccc ccagaacctg ggccctttcc
      481 tggaatcata aacctttttg gagttggagg cggccttctg gagtaccggg cgagtctgct
      541 ggctgggaag ggttttgccg tcatggctct ggcttattac aactacgacg acctccccaa
      601 gaccatggaa accatgcgca ttgagtactt tgaagaagcc gtgaactacc tgcgtggcca
      661 ccctgaggta aaaggaccag gaattgggct gcttgggatt tccaaagggg gtgaacttgg
      721 ccttgctatg gcctccttcc tgaagggcat cacggctgct gttgtcatca atggctccgt
      781 ggctgctgtt gggaacacca tatgctacaa ggatgagact ataccccctg tgactatcct
      841 gagaaaccag gtcaaaatga ccaaggatgg cctcaaggat gttgtagatg ctttgcaaag
      901 ccctctggta gaacagaaga gcttcatccc tgtggaaagg tctgacacga ccttcctgtt
      961 cctcgttggt caggatgacc acaactggaa gagcgagttc tatgccaatg agatctccaa
     1021 acgcttgcag gcccacggga aagagaagcc ccagatcatt tgctacccag aagcagggca
     1081 ctatatcgag cctccttact tcccactgtg cagcgctggc atgcacctcc tggtgggtgc
     1141 taacatcacc tttggagggg agcctaagcc tcactctgtg gcccagttgg atgcatggca
     1201 gcaactccag actttcttcc acaaacagtt gggtggtaag agtcatgggg tgtcccctaa
     1261 aatataacct gttatgtgat ggttttggca ggaaaagtac aaatactttg taggaatatc
     1321 agttcagatt acttcatctg aacatataac cgcttttggt ttacattttt aaaaattaat
     1381 tttagtatca aaatagtgct gattcaaagg ctggaaatat agttcagttg tagagtcctt
     1441 gactgactca tgcaagttcc tgggttcaat ctccgtgctg taagggaaaa gagcacattt
     1501 tatggaaact gtagctattc aagaaatagt gcctagaatt taaaggaacc atgagtaaac
     1561 actcttatgt aacttaaaaa aaaaaaaaa
//
