LOCUS       NM_001107282            2143 bp    mRNA    linear   ROD 21-JAN-2025
DEFINITION  Rattus norvegicus aconitate decarboxylase 1 (Acod1), mRNA.
ACCESSION   NM_001107282 XM_001076716 XM_224476
VERSION     NM_001107282.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2143)
  AUTHORS   Cui,B.C., Aksenova,M., Sikirzhytskaya,A., Odhiambo,D., Korunova,E.,
            Sikirzhytski,V., Ji,H., Altomare,D., Broude,E., Frizzell,N.,
            Booze,R., Wyatt,M.D. and Shtutman,M.
  TITLE     Suppression of HIV-TAT and cocaine-induced neurotoxicity and
            inflammation by cell penetrable itaconate esters
  JOURNAL   J Neurovirol 30 (4), 337-352 (2024)
   PUBMED   38884890
REFERENCE   2  (bases 1 to 2143)
  AUTHORS   Zhao,Y., Liu,Z., Liu,G., Zhang,Y., Liu,S., Gan,D., Chang,W.,
            Peng,X., Sung,E.S., Gilbert,K., Zhu,Y., Wang,X., Zeng,Z.,
            Baldwin,H., Ren,G., Weaver,J., Huron,A., Mayberry,T., Wang,Q.,
            Wang,Y., Diaz-Rubio,M.E., Su,X., Stack,M.S., Zhang,S., Lu,X.,
            Sheldon,R.D., Li,J., Zhang,C., Wan,J. and Lu,X.
  TITLE     Neutrophils resist ferroptosis and promote breast cancer metastasis
            through aconitate decarboxylase 1
  JOURNAL   Cell Metab 35 (10), 1688-1703 (2023)
   PUBMED   37793345
REFERENCE   3  (bases 1 to 2143)
  AUTHORS   Papathanassiu,A.E., Ko,J.H., Imprialou,M., Bagnati,M.,
            Srivastava,P.K., Vu,H.A., Cucchi,D., McAdoo,S.P., Ananieva,E.A.,
            Mauro,C. and Behmoaras,J.
  TITLE     BCAT1 controls metabolic reprogramming in activated human
            macrophages and is associated with inflammatory diseases
  JOURNAL   Nat Commun 8, 16040 (2017)
   PUBMED   28699638
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2143)
  AUTHORS   Li,Y., Zhang,P., Wang,C., Han,C., Meng,J., Liu,X., Xu,S., Li,N.,
            Wang,Q., Shi,X. and Cao,X.
  TITLE     Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by
            increasing A20 expression in macrophages through reactive oxygen
            species
  JOURNAL   J Biol Chem 288 (23), 16225-16234 (2013)
   PUBMED   23609450
REFERENCE   5  (bases 1 to 2143)
  AUTHORS   Michelucci,A., Cordes,T., Ghelfi,J., Pailot,A., Reiling,N.,
            Goldmann,O., Binz,T., Wegner,A., Tallam,A., Rausell,A., Buttini,M.,
            Linster,C.L., Medina,E., Balling,R. and Hiller,K.
  TITLE     Immune-responsive gene 1 protein links metabolism to immunity by
            catalyzing itaconic acid production
  JOURNAL   Proc Natl Acad Sci U S A 110 (19), 7820-7825 (2013)
   PUBMED   23610393
REFERENCE   6  (bases 1 to 2143)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   7  (bases 1 to 2143)
  AUTHORS   Degrandi,D., Hoffmann,R., Beuter-Gunia,C. and Pfeffer,K.
  TITLE     The proinflammatory cytokine-induced IRG1 protein associates with
            mitochondria
  JOURNAL   J Interferon Cytokine Res 29 (1), 55-67 (2009)
   PUBMED   19014335
  REMARK    Erratum:[J Interferon Cytokine Res. 2009 Sep;29(9):643]
REFERENCE   8  (bases 1 to 2143)
  AUTHORS   Cheon,Y.P., Xu,X., Bagchi,M.K. and Bagchi,I.C.
  TITLE     Immune-responsive gene 1 is a novel target of progesterone receptor
            and plays a critical role during implantation in the mouse
  JOURNAL   Endocrinology 144 (12), 5623-5630 (2003)
   PUBMED   14500577
REFERENCE   9  (bases 1 to 2143)
  AUTHORS   Lee,C.G., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and
            O'Brien,W.E.
  TITLE     Cloning and analysis of gene regulation of a novel LPS-inducible
            cDNA
  JOURNAL   Immunogenetics 41 (5), 263-270 (1995)
   PUBMED   7721348
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473951.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_224476.4, XM_001076716.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680444,
                              SAMN09345330 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2143
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q21"
     gene            1..2143
                     /gene="Acod1"
                     /gene_synonym="Irg1; RGD1563454"
                     /note="aconitate decarboxylase 1"
                     /db_xref="GeneID:306127"
                     /db_xref="RGD:1563454"
     exon            1..108
                     /gene="Acod1"
                     /gene_synonym="Irg1; RGD1563454"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1563
                     /gene="Acod1"
                     /gene_synonym="Irg1; RGD1563454"
                     /EC_number="4.1.1.6"
                     /note="immunoresponsive 1 homolog; immunoresponsive gene
                     1"
                     /codon_start=1
                     /product="cis-aconitate decarboxylase"
                     /protein_id="NP_001100752.1"
                     /db_xref="GeneID:306127"
                     /db_xref="RGD:1563454"
                     /translation="MMLKSVTESFASMIHGLRVGHLTDGVIQRSKRMILDSLGVGFLG
                     TGTEVFHNVTQYSKIYSSNTSSTVWGRPDFRLPPTYAAFVNGVAIHSMDFDDTWHPAT
                     HPSGAVLPVLTALSEALPQTPKFSGLDLLLAFSVGIEVQGRLLHFSKEAKDIPKRFHP
                     PSVVGTLGSAAATSKFLGLSLTKCREALAIAVSHAGAPIANAATQTKPLHIGNAAKHG
                     MEATFLAMLGLQGNKQILDLGSGFGAFYANYSPKDLPSLDSHIWLLDQQDVAFKSFPA
                     HLATHWVADAAAAVRKHLVTSERALLPADHIERIVLRIPDVQYVNRPFPDSEHEARHS
                     FQYVACATLLDGSVTVPSFYSQKVNRPQVKELLKKVELEHPPDNLPSFNTLYCEISIT
                     LKDGTTFTERSDTFYGHWRKPLSQEDLHKKFRANASKILGEDTVESLITVVEKLEDLE
                     DCAMLTRLLKGPSVQEEASKLSSIFSFHHTSLPKFTNI"
     exon            109..270
                     /gene="Acod1"
                     /gene_synonym="Irg1; RGD1563454"
                     /inference="alignment:Splign:2.1.0"
     exon            271..360
                     /gene="Acod1"
                     /gene_synonym="Irg1; RGD1563454"
                     /inference="alignment:Splign:2.1.0"
     exon            361..566
                     /gene="Acod1"
                     /gene_synonym="Irg1; RGD1563454"
                     /inference="alignment:Splign:2.1.0"
     exon            567..2143
                     /gene="Acod1"
                     /gene_synonym="Irg1; RGD1563454"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatgactgtg tataaaggca cctggtcact caaggcacac agccagcaac tgctcctacc
       61 attcactcct gagccagagg taccttccaa agcatcatga tgctcaagtc tgtcacagag
      121 agctttgcca gtatgattca cggcttgaga gtgggccacc tgacagatgg cgtcattcag
      181 aggagcaaga ggatgatcct ggactctctg ggcgttggtt tcctgggaac aggcacggaa
      241 gtgttccata acgtcaccca atatagtaaa atctacagtt ccaacacctc cagcactgtt
      301 tggggtcgac cagacttcag gctccctccc acatatgctg cttttgttaa cggtgttgct
      361 attcactcca tggattttga tgacacgtgg caccctgcca cccacccttc cggggctgtc
      421 ctacctgtgc tcacagcttt atcggaagcc ctgccccaga cgccaaagtt ttctggcctc
      481 gacctgctgc tggcgttcag cgttggtatt gaagtacaag gacgattgtt gcacttctcc
      541 aaggaggcca aggacatacc aaagaggttc catcctccct ctgtggtggg gactctggga
      601 agtgctgctg ccacatccaa gtttttgggg ctcagcttaa caaagtgccg tgaggccttg
      661 gctattgctg tttcccatgc cggggcgccc atagcaaacg ctgccactca gactaagccc
      721 cttcatatcg gcaatgcagc caagcatggg atggaagcca catttctggc aatgctgggc
      781 ctccaaggaa acaaacagat cttggacctg gggtcagggt ttggcgcctt ctatgccaac
      841 tactccccca aagaccttcc aagcctggat tctcacatct ggctcctaga ccagcaggat
      901 gtggccttta agagcttccc ggcacatctg gctacccact gggtggcaga cgcagccgca
      961 gctgtgagaa agcacctcgt gacttcagaa agagccctgc ttcctgctga ccacatcgag
     1021 agaatcgtgc tcaggatccc tgatgtccag tacgtaaaca ggcccttccc ggactcagag
     1081 catgaagccc gtcattcctt ccagtatgtg gcctgtgcca cgctgctcga tggtagcgtc
     1141 actgtcccat ccttctatag ccagaaggtc aacaggcctc aggtgaaaga gttgctcaag
     1201 aaggtggagt tggaacatcc tcccgacaac ctgccaagct tcaacacgct ctactgtgaa
     1261 ataagcatca ctctaaagga tggaaccact ttcaccgagc gctctgacac cttctatggt
     1321 cactggagga aaccactgag ccaggaggat ctgcacaaga agttccgtgc caatgcctca
     1381 aagattctag gcgaggacac agtagaaagc cttataacgg tagtagaaaa actagaagac
     1441 ctagaagact gcgccatgct aaccagactt ctgaaaggac cctctgtcca agaggaggct
     1501 tccaaactat ccagcatatt ctcattccat cacacaagtt tgcccaagtt taccaatatc
     1561 taaacaatgt tgcaatggaa tagatacaac gttttagttt actgctccat atgctcagcc
     1621 atgaatacag caaggtggag agtccagaaa caagagataa gtgtatttag aaggagtctt
     1681 gtcctataag tttggtagaa ccagtcctac caccttcaaa caacgcagga tctgatgtgt
     1741 attcacaagg gtaaagtcta agtcacctgt tgcctgctta taatcttttc tgaggaatta
     1801 tttattagct ccgggaactt catagatgta gaggaatgtg catgtggctg gctgcagagg
     1861 gagcgatctt ggtctaccca ccacttatcc agagagggtg ggtactgccc aaccctcctc
     1921 tctgcaatgg ctggtttgag ggagtggcag gcaccttgtc ttcttccaca tatagccttg
     1981 aatccttctg cttccgcttc tctcctgcag atataagaca atctgagctg cagcagggaa
     2041 ggcttaagac ccatagtttc actctttcta tgagatagtc tgttaacctc aaaaattatt
     2101 ttgagaaaat ttgagaactt ggagacaata aaaaagaaag ggg
//
