LOCUS       NM_001398729            1176 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus atypical chemokine receptor 1 (Ackr1), mRNA.
ACCESSION   NM_001398729 XM_002728033
VERSION     NM_001398729.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1176)
  AUTHORS   Huang,W., Qin,W., Lv,L., Deng,H., Zhang,H., Zhang,J. and Zhang,L.
  TITLE     Duffy antigen / receptor for chemokines correlates with
            inflammatory reaction in rats with venous hypertension: implication
            for the pathogenesis of primary chronic venous disease
  JOURNAL   Vasa 43 (1), 47-54 (2014)
   PUBMED   24429330
  REMARK    GeneRIF: DARC plays a role in the inflammation of skin tissue under
            venous hypertension.
REFERENCE   2  (bases 1 to 1176)
  AUTHORS   Qi,W.W., Zhang,L., Zhang,J.W., Zhang,B.G., He,Y.F., Chen,C.M. and
            Yu,L.
  TITLE     [Experimental study of Duffy antigen receptor for chemokines in
            tissue and the inflammatory reaction of limb with venous
            hypertension]
  JOURNAL   Zhonghua Yi Xue Za Zhi 92 (9), 638-641 (2012)
   PUBMED   22800956
  REMARK    GeneRIF: The level of DARC in tissue and the degree of inflammatory
            reaction of venous hypertension have a positive correlation. DARC
            may promote the development of venous hypertension inflammation
            through augmenting the adhesion and migration of leukocytes.
REFERENCE   3  (bases 1 to 1176)
  AUTHORS   Mei,J., Liu,Y., Dai,N., Favara,M., Greene,T., Jeyaseelan,S.,
            Poncz,M., Lee,J.S. and Worthen,G.S.
  TITLE     CXCL5 regulates chemokine scavenging and pulmonary host defense to
            bacterial infection
  JOURNAL   Immunity 33 (1), 106-117 (2010)
   PUBMED   20643340
REFERENCE   4  (bases 1 to 1176)
  AUTHORS   Dawson,T.C., Lentsch,A.B., Wang,Z., Cowhig,J.E., Rot,A., Maeda,N.
            and Peiper,S.C.
  TITLE     Exaggerated response to endotoxin in mice lacking the Duffy
            antigen/receptor for chemokines (DARC)
  JOURNAL   Blood 96 (5), 1681-1684 (2000)
   PUBMED   10961863
REFERENCE   5  (bases 1 to 1176)
  AUTHORS   Neote,K., Mak,J.Y., Kolakowski,L.F. Jr. and Schall,T.J.
  TITLE     Functional and biochemical analysis of the cloned Duffy antigen:
            identity with the red blood cell chemokine receptor
  JOURNAL   Blood 84 (1), 44-52 (1994)
   PUBMED   7517217
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Dec 22, 2021 this sequence version replaced XM_002728033.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ231892.1, SRR26360176.376383.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               JAXUCZ010000013.1  88316224-88316354   c
            132-1176            JAXUCZ010000013.1  88314735-88315779   c
FEATURES             Location/Qualifiers
     source          1..1176
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..1176
                     /gene="Ackr1"
                     /gene_synonym="Darc"
                     /note="atypical chemokine receptor 1"
                     /db_xref="GeneID:689105"
                     /db_xref="RGD:1596198"
     exon            1..131
                     /gene="Ackr1"
                     /gene_synonym="Darc"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1079
                     /gene="Ackr1"
                     /gene_synonym="Darc"
                     /note="Duffy blood group, chemokine receptor; Duffy blood
                     group, atypical chemokine receptor"
                     /codon_start=1
                     /product="atypical chemokine receptor 1"
                     /protein_id="NP_001385658.1"
                     /db_xref="GeneID:689105"
                     /db_xref="RGD:1596198"
                     /translation="MGNCLHPVERFSVDNSRTQFTFENWNYSYEDNASYELTDDYNLT
                     GAAPCYSCNLLDSSSLPFFILTSVLGLLASGGILFTILRPFFHWQICPSWPILAQLAV
                     GSALFSISVTILAPGLYSAHSTALCNLGYWAWYTAAFAQALFIGCYVFLNPSLNIVQI
                     PGLTLGLTVGLWGAAALLGLPVALASDVYDGLCTLPSYRNLETLKYIHSAICFTIFTV
                     LPLTLLAAKGLKTALGKGPGPWVSVLWLWFIFWWPHGMVLMFDALVRSKAMLLQTCQS
                     QKMLDVMLDVAEALAMLHCVATPLLLALFCHQTTRRSLPSLSLPAR"
     exon            132..1176
                     /gene="Ackr1"
                     /gene_synonym="Darc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctagaacctg agagagttca ttagccctgg gcacttatct tggagccaca gctgctgaca
       61 gagtccagac cctgtactct gctgctctgc tgccctgagc ctgcagtgcc atggggaact
      121 gtctgcaccc ggtggaacgc ttttcagtag acaacagcag aactcagttt acgttcgaaa
      181 actggaatta ttcgtatgaa gataacgcct cctatgaact cacagatgac tacaacctga
      241 caggagcggc tccctgctac tcctgtaacc tgcttgacag ttcttccctg cccttcttca
      301 ttctcaccag tgtcctgggc ctgctggcaa gtggcggcat cctcttcaca attctccgac
      361 ctttcttcca ctggcagatt tgccccagct ggcccattct ggcacagtta gcagtgggca
      421 gtgccctgtt tagcatttcg gtgaccatcc tggcaccagg cttgtacagt gcccatagta
      481 cagccctgtg caacctgggc tactgggcct ggtatactgc tgcttttgct caggctctgt
      541 tcataggatg ctatgtcttc ctcaacccca gcctgaatat tgttcaaatc cctggcctca
      601 ccttgggact cactgtagga ctttggggag cagctgctct cttagggctg ccagtcgccc
      661 tggccagtga tgtttatgat ggcctctgca cccttccatc ctataggaat ctggaaactt
      721 tgaagtacat acattctgcc atctgtttta ccatcttcac ggtattgcca ctgactcttt
      781 tggcagccaa ggggctgaag acagcattgg gcaaggggcc aggcccctgg gttagtgtcc
      841 tgtggctctg gttcattttc tggtggcctc atgggatggt tctcatgttt gatgccttgg
      901 tgaggtcaaa agccatgctt ttgcaaacat gtcaatccca gaagatgctt gacgtgatgc
      961 tggacgtggc ggaagccctg gctatgctgc actgtgtggc tacaccactg cttctggcct
     1021 tgttctgcca ccagaccacc cgtagatcct tgccctctct gtccctccct gcaagatagg
     1081 cttctcaaat ggataccctt gcaggcaact cgtagtttgt tttttttttc ttccccacat
     1141 gtcaacttaa attaaagtct atactgcttt tgtgaa
//
