LOCUS       NM_001170468            4636 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus apoptotic chromatin condensation inducer 1
            (Acin1), mRNA.
ACCESSION   NM_001170468 XM_001054451 XM_001065227 XM_240178
VERSION     NM_001170468.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4636)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 4636)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 4636)
  AUTHORS   Singh,K.K., Erkelenz,S., Rattay,S., Dehof,A.K., Hildebrandt,A.,
            Schulze-Osthoff,K., Schaal,H. and Schwerk,C.
  TITLE     Human SAP18 mediates assembly of a splicing regulatory multiprotein
            complex via its ubiquitin-like fold
  JOURNAL   RNA 16 (12), 2442-2454 (2010)
   PUBMED   20966198
REFERENCE   4  (bases 1 to 4636)
  AUTHORS   Henne,W.M., Oomman,S., Attridge,J., Finckbone,V., Coates,P.,
            Bliss,R., Strahlendorf,H. and Strahlendorf,J.
  TITLE     AMPA-induced excitotoxicity increases nuclear levels of CAD,
            endonuclease G, and acinus and induces chromatin condensation in
            rat hippocampal pyramidal neurons
  JOURNAL   Cell Mol Neurobiol 26 (3), 321-339 (2006)
   PUBMED   16767516
  REMARK    GeneRIF: Data indicate increases in the nuclear levels of
            caspase-activated acinus and DNase and Endonuclease G (a
            caspase-independent endonuclease) in CA1 and CA3 pyramidal cell
            nuclei with different temporal patterns following an AMPA-insult.
REFERENCE   5  (bases 1 to 4636)
  AUTHORS   Tange,T.O., Shibuya,T., Jurica,M.S. and Moore,M.J.
  TITLE     Biochemical analysis of the EJC reveals two new factors and a
            stable tetrameric protein core
  JOURNAL   RNA 11 (12), 1869-1883 (2005)
   PUBMED   16314458
REFERENCE   6  (bases 1 to 4636)
  AUTHORS   Schwerk,C., Prasad,J., Degenhardt,K., Erdjument-Bromage,H.,
            White,E., Tempst,P., Kidd,V.J., Manley,J.L., Lahti,J.M. and
            Reinberg,D.
  TITLE     ASAP, a novel protein complex involved in RNA processing and
            apoptosis
  JOURNAL   Mol Cell Biol 23 (8), 2981-2990 (2003)
   PUBMED   12665594
REFERENCE   7  (bases 1 to 4636)
  AUTHORS   Sordet,O., Rebe,C., Plenchette,S., Zermati,Y., Hermine,O.,
            Vainchenker,W., Garrido,C., Solary,E. and Dubrez-Daloz,L.
  TITLE     Specific involvement of caspases in the differentiation of
            monocytes into macrophages
  JOURNAL   Blood 100 (13), 4446-4453 (2002)
   PUBMED   12393560
REFERENCE   8  (bases 1 to 4636)
  AUTHORS   Zermati,Y., Garrido,C., Amsellem,S., Fishelson,S., Bouscary,D.,
            Valensi,F., Varet,B., Solary,E. and Hermine,O.
  TITLE     Caspase activation is required for terminal erythroid
            differentiation
  JOURNAL   J Exp Med 193 (2), 247-254 (2001)
   PUBMED   11208865
REFERENCE   9  (bases 1 to 4636)
  AUTHORS   Misawa,K., Nosaka,T., Morita,S., Kaneko,A., Nakahata,T., Asano,S.
            and Kitamura,T.
  TITLE     A method to identify cDNAs based on localization of green
            fluorescent protein fusion products
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3062-3066 (2000)
   PUBMED   10716735
REFERENCE   10 (bases 1 to 4636)
  AUTHORS   Sahara,S., Aoto,M., Eguchi,Y., Imamoto,N., Yoneda,Y. and
            Tsujimoto,Y.
  TITLE     Acinus is a caspase-3-activated protein required for apoptotic
            chromatin condensation
  JOURNAL   Nature 401 (6749), 168-173 (1999)
   PUBMED   10490026
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA925536.1, FM033220.1, FM031419.1, JAXUCZ010000015.1, CB744719.1,
            FM029308.1, CA512047.1, EV770592.1, CF110347.1 and AI575776.1.
            
            On or before Dec 20, 2009 this sequence version replaced
            XM_240178.4, XM_001065227.1, XM_001054451.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data from multiple strains because no single
            transcript was available for the full length of the gene. The
            extent of this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1705759.1,
                                           SRR26643287.31419.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               AA925536.1         1-219
            220-505             FM033220.1         1-286
            506-802             FM031419.1         285-581
            803-1791            JAXUCZ010000015.1  32095000-32095988   c
            1792-2020           CB744719.1         61-289
            2021-2546           FM029308.1         1-526
            2547-3048           CA512047.1         132-633
            3049-3617           EV770592.1         104-672
            3618-4543           CF110347.1         33-958
            4544-4636           AI575776.1         1-93                c
FEATURES             Location/Qualifiers
     source          1..4636
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..4636
                     /gene="Acin1"
                     /note="apoptotic chromatin condensation inducer 1"
                     /db_xref="GeneID:305884"
                     /db_xref="RGD:1311945"
     exon            1..349
                     /gene="Acin1"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..4057
                     /gene="Acin1"
                     /note="acinus"
                     /codon_start=1
                     /product="apoptotic chromatin condensation inducer in the
                     nucleus"
                     /protein_id="NP_001163939.1"
                     /db_xref="GeneID:305884"
                     /db_xref="RGD:1311945"
                     /translation="MWRRKRPNSSGGTRGILSGNRGVDYGSGRGQFGTFEGRWRKLPK
                     MPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRL
                     KGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAA
                     ELEEASAESEDEMTHPEGVASLLPPDFQSSLDRPELELSTHSPRKSSSFSEEKGESDD
                     EKPRKGERRSSRVRQARAKLPEYSQAAEEEEDQETPSRNLRVRADRNLKVEEEEEEEE
                     EEDDEEEEEEVDEGQKSREAEAPILKQFEDEDGEEMTRAKPEKVVDEKPPIIRSQEKD
                     ELEKGGRVTRSQEEARRSHLARQQQEKETQIVSLPQEENEVKSSQGLEEKSQSPSLPP
                     LPEDLEKAPVVLQPEQIVSEEETPPPLLTKEASSPPTHMQLQDEEEVEPAEGPAPPVL
                     IQLSPPGTDAGTREPIVSPHTVQLLRGLSPLSSTADTKAESPAERVSEESVLPLAQRS
                     ILPEHSAQKGAESEREKSAPLLPLTREELAPAKGITEESVKKQSLEQEEGRRASHTLF
                     PDHSLKPSADSSSSRSSSPSSSSSRSRSRSPDSSASRSQSSPRSKQREVSQARVHANP
                     HDRAKMGSRSTSESRSRSRSRSRSASSGSRKSLSPGVSRDGNTTYTETKDPSCGQEAA
                     APSVPQLQVLEPKEKAPTCSASVRGRHMSQPEPEQKHVIQRLQPEQESPKKCEAEEAE
                     PPAATQPQTSEPQLSQLPEAERTPHTAEEKEDVTMDTSENRPENEVPEPPVPIADQVS
                     NDDRPEGSAEEEERKESSMPKSFKRKISVVSATKGVQAGNSDTEGGQPGRKRRWGAST
                     AATQKKPSISITTESLKSLIPDIKPLAGQEAVVDLHADDSRISEDETERNGDDGTHDK
                     GLKICRTVTQVVPAEGQENGQREEEEEKEPEAEPPAPPQASVEAALPPPVEHEVKKVT
                     LGDTLTRRSISQQKSGVSITIDDPVRTAQVPSPPRGKISNIVHISNLVRPFTLGQLKE
                     LLGRTGTLVEEAFWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPKFLCADYAE
                     QDELDYHRGLLVDRPSEAKTEEQGAPRPLHPPPPPPVQPPPHPRAEPREQERAVREQW
                     AEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQE
                     EPPAKLLDDLFRKTKAAPCIYWLPLTESQIVQKEAEQAERAKEREKRRKEREEEEQKE
                     REKEAERERNRQLEREKRREHSRERERDRERERDRGDRDRDRERDRDRGRERDRRDTK
                     RHSRSRSRSTPVRDRGGRR"
     exon            350..415
                     /gene="Acin1"
                     /inference="alignment:Splign:2.1.0"
     exon            416..527
                     /gene="Acin1"
                     /inference="alignment:Splign:2.1.0"
     exon            528..647
                     /gene="Acin1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..736
                     /gene="Acin1"
                     /inference="alignment:Splign:2.1.0"
     exon            737..2002
                     /gene="Acin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2221
                     /gene="Acin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2337
                     /gene="Acin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2479
                     /gene="Acin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2522
                     /gene="Acin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2656
                     /gene="Acin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2809
                     /gene="Acin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..2948
                     /gene="Acin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2949..3094
                     /gene="Acin1"
                     /inference="alignment:Splign:2.1.0"
     exon            3095..3202
                     /gene="Acin1"
                     /inference="alignment:Splign:2.1.0"
     exon            3203..3310
                     /gene="Acin1"
                     /inference="alignment:Splign:2.1.0"
     exon            3311..3635
                     /gene="Acin1"
                     /inference="alignment:Splign:2.1.0"
     exon            3636..3736
                     /gene="Acin1"
                     /inference="alignment:Splign:2.1.0"
     exon            3737..4621
                     /gene="Acin1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgctag gcagatggaa aaagccgatt ggtaccgatg tggagacgga aacgaccgaa
       61 cagttccgga ggaacccggg gaattctgag cggtaataga ggggtagact atggcagtgg
      121 gcggggccag ttcggtacgt tcgaagggcg ttggcggaaa ttaccgaaga tgcccgaagc
      181 cgtcgggacg gacccgagta cctcacgcaa gatggcggag ctggaggagg tgactctgga
      241 cgggaagcct cttcaggctc tgcgggtgac cgacctgaag gccgcactgg agcagcgagg
      301 cctagccaag agcgggcaga agagtgccct ggtcaagcgg ctcaaagggg ctctaatgct
      361 agaaaattta caaaaacact caacacccca tgctgcattc cagccaaatt ctcagattgg
      421 ggaggagatg agccagaaca gtttcataaa gcagtacctg gaaaagcagc aggagctact
      481 taggcagcgc ctagaacggg aagctcgaga ggctgcagaa cttgaagaag cttcagctga
      541 gtcggaggac gagatgaccc atcctgaggg agtggcttcc ctgctgcctc ctgactttca
      601 gagcagcctg gacagaccag agctggagct cagcacacat tcacctcgaa agagctcctc
      661 tttttctgaa gagaaaggtg aatccgatga tgagaaacca aggaaaggag aaagacgatc
      721 atcccgggtc agacaggcaa gagctaaact ccctgagtac agtcaggctg ctgaggagga
      781 agaggaccaa gagacgccat ctagaaacct gagggtcaga gcagatcgaa atttaaaagt
      841 agaggaggag gaggaagagg aggaagaaga agatgatgaa gaagaggaag aggaggtaga
      901 tgagggacag aaatctagag aagccgaggc accaatcctg aaacagtttg aggatgaaga
      961 cggggaggag atgaccagag caaaaccaga aaaggtagtg gatgagaaac ccccaatcat
     1021 aagatcccag gaaaaggatg agttagagaa aggagggcga gttacaagat cccaggaaga
     1081 agctagaaga agtcatctgg ccagacaaca acaagagaaa gagacacaaa ttgtttctct
     1141 ccctcaagaa gaaaatgagg taaaatcttc acaaggtttg gaagaaaaat cccagtctcc
     1201 ttccctgcct cccctccctg aagacctaga gaaggcccct gtcgtgctgc agccagagca
     1261 aatagtcagt gaagaggaaa cacccccacc tttacttacc aaggaagctt catctccacc
     1321 aactcatatg cagctccagg atgaagaaga agtggagcca gcggaaggcc cagcaccccc
     1381 tgtcctcatt cagttatctc ctcctggtac agatgctgga accagggagc ccatagtgtc
     1441 tccccacaca gtgcagctgc tcagaggcct gtctcctctg tcaagtactg cagacaccaa
     1501 agcagagtct ccagcagaga gagtgtcaga agagagtgtc ctgcccctgg cacagagaag
     1561 catactgccc gaacactcag cccagaaagg tgctgaaagt gagcgtgaaa agtctgctcc
     1621 ccttctccct ctaacaagag aggagttagc acccgccaaa gggatcactg aggagtctgt
     1681 gaagaaacag tctttggaac aggaggaggg cagaagagct tcccacactc tcttcccaga
     1741 ccacagtttg aaaccgtcag ccgactcatc ctcgagccga tcatcctcac cttcatcctc
     1801 cagctctaga tccagatctc gatctcctga cagttcagct tcccgctcac agtcctctcc
     1861 aagatctaaa cagagagagg tgtctcaagc gcgagttcac gccaatcctc atgatagagc
     1921 caagatgggc tccaggtcaa catcagagtc taggtcacgt tctcgatctc gttcccgttc
     1981 cgcatcaagc ggcagcagaa aatctctgag ccctggagtc tccagagacg gcaacaccac
     2041 ctacactgaa accaaagatc cctcttgtgg tcaggaggct gcagctccat cagtgccaca
     2101 gctgcaggtc cttgaaccaa aggagaaggc tcccacgtgc tcagcctctg tccgggggag
     2161 gcatatgagc cagcctgagc cagagcaaaa gcacgtgatc cagaggttac agccggagca
     2221 ggagagccca aagaagtgtg aagctgaaga ggcagagcca ccagctgcca cccagcctca
     2281 gacctcagag cctcagctct ctcagctgcc agaggcggaa aggactcctc acaccgctga
     2341 agagaaggag gacgtgacca tggacacaag tgaaaacaga cctgaaaatg aggttcctga
     2401 gcctcctgtg cctattgcag accaagtcag caatgatgac cgcccagaag gcagtgctga
     2461 agaagaggag aggaaagaga gctcgatgcc caaatcattc aagaggaaaa tctccgttgt
     2521 ctcagctacc aagggggtgc aagctggaaa cagtgacaca gaggggggcc agcctggtcg
     2581 aaagcgtcgt tggggagcca gtactgctgc cacacagaag aaaccttcta tcagtatcac
     2641 cactgagtca ctcaagagcc tcatccccga catcaaaccc ctggcggggc aggaggctgt
     2701 tgtggatctt catgctgatg actcccgaat ctctgaggat gagacagagc gtaatggcga
     2761 cgatgggacc catgacaaag gactgaaaat atgccggaca gtcactcagg tagtacctgc
     2821 agagggccag gagaacgggc agagggaaga ggaagaagag aaagagcctg aagcagagcc
     2881 tcctgcgcct ccccaggcgt cggtggaggc tgccttgccc ccacctgtgg agcatgaagt
     2941 aaagaaagta acattaggag ataccttaac ccggaggtcc attagccaac agaagtctgg
     3001 agtttccatt acaattgatg acccagtccg aactgcccag gtgccctccc cacccagggg
     3061 caagatcagt aacattgtcc acatctccaa cttggttcgt cccttcactc taggccagct
     3121 aaaggagtta ttagggcgta cagggacttt ggtggaggag gccttctgga ttgacaagat
     3181 caaatctcat tgctttgtga cgtactcaac agtagaggaa gccgtggcca cccggacagc
     3241 tctgcacggg gtcaagtggc cccaatccaa ccccaaattc ctctgtgctg actatgctga
     3301 gcaagatgag ctggactatc accggggact cttggtagat cggccatctg aagctaagac
     3361 agaggaacag ggagcaccaa ggcccttgca tcccccaccc ccacccccag tccagccacc
     3421 acctcatccc agggctgagc cacgggagca ggaaagggct gtacgggagc agtgggcaga
     3481 acgggaacgg gaaatggagc ggcgggagag gactcggtct gagcgagaat gggatcggga
     3541 caaagttcga gaggggcccc gctcccgatc acggtcccgt gaccgccgcc gcaaagagcg
     3601 agcaaaatct aaagaaaaga agagtgagaa gaaagagaaa gctcaggagg agccgcctgc
     3661 caagttgctg gatgacctct tccgtaagac caaggcagct ccctgcatct attggctccc
     3721 actgactgag agccagattg ttcagaagga ggcagagcaa gcagaacggg ccaaggagcg
     3781 ggagaagcgg cgaaaggaac gagaagaaga agaacagaag gagcgggaga aggaagctga
     3841 gcgggaacgg aaccgacagc tagaacggga gaaacggagg gagcacagca gggagagaga
     3901 gagggacagg gaaagagaga gggacagggg cgaccgagat cgggacaggg aaagagaccg
     3961 agaccgaggc agggagaggg atcgcagaga caccaagcga cacagcagaa gccggagtcg
     4021 aagcacacct gtacgggacc ggggtgggcg ccgctagcta agaaaacact aggagagctg
     4081 caggtacctg ccactctgcc ctgggaggtt aaaggccaca gagggatagg tacagtcacc
     4141 accatcaccc tggaaccaag ggtctcacac cgttgctcag tgctgaacta taactgccac
     4201 acatccccac acaccaaatg gagtagtggc actctcccta ttccccaacc taactcttgg
     4261 aatttagccc tctcctttct tcctgttaag cctgagggaa gggccgggct atgaagggag
     4321 ggatgtggcc ggaagtggga ataaccattg tcccagactc ccattttctc tccatcctgc
     4381 tttccaactc cctcggtact cagccttttg ggaacagctg gggccaggac tgggtcacct
     4441 atgagctgaa tcagcctctc ctgagtccca ggcccctgca gttcccgggt tctctgtcct
     4501 gcagcctctt gccctctggt tccactttat atccaccttt tccttttgtt caatttttat
     4561 tttttttatt attaaatgat gtggtctatg gagaaaaaat aaaaatctga cttagtttta
     4621 aaaaaaaaaa aaaaaa
//
