LOCUS       NM_172009               3401 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Rattus norvegicus acetylcholinesterase (Ache), mRNA.
ACCESSION   NM_172009 XM_039089839
VERSION     NM_172009.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3401)
  AUTHORS   Crews,F.T., Fisher,R.P., Qin,L. and Vetreno,R.P.
  TITLE     HMGB1 neuroimmune signaling and REST-G9a gene repression contribute
            to ethanol-induced reversible suppression of the cholinergic neuron
            phenotype
  JOURNAL   Mol Psychiatry 28 (12), 5159-5172 (2023)
   PUBMED   37402853
REFERENCE   2  (bases 1 to 3401)
  AUTHORS   Javed,T., Habib,R., Ghafoor,S., Rumman,B., Awan,S., Ntepe,L.J.M.,
            Batool,S. and Nurulain,S.M.
  TITLE     Association of status of acetylcholinesterase and ACHE gene 3' UTR
            variants (rs17228602, rs17228616) with drug addiction vulnerability
            in pakistani population
  JOURNAL   Chem Biol Interact 308, 130-136 (2019)
   PUBMED   31129131
REFERENCE   3  (bases 1 to 3401)
  AUTHORS   Wu,J., Jin,T., Wang,H. and Li,S.T.
  TITLE     Sepsis decreases the activity of acetylcholinesterase by reducing
            its expression at the neuromuscular junction
  JOURNAL   Mol Med Rep 16 (4), 5263-5268 (2017)
   PUBMED   28849127
  REMARK    GeneRIF: sepsis decreased AChE activity by reducing its expression
            at the neuromuscular junction.
REFERENCE   4  (bases 1 to 3401)
  AUTHORS   Del Pino,J., Moyano,P., Diaz,G.G., Anadon,M.J., Diaz,M.J.,
            Garcia,J.M., Lobo,M., Pelayo,A., Sola,E. and Frejo,M.T.
  TITLE     Primary hippocampal neuronal cell death induction after acute and
            repeated paraquat exposures mediated by AChE variants alteration
            and cholinergic and glutamatergic transmission disruption
  JOURNAL   Toxicology 390, 88-99 (2017)
   PUBMED   28916328
  REMARK    GeneRIF: Paraquat-induced death of hippocampal neurons was
            partially mediated by AChE variants inducing and cholinergic and
            gultamatergic transmission disruption.
REFERENCE   5  (bases 1 to 3401)
  AUTHORS   Tejero,R., Lopez-Manzaneda,M., Arumugam,S. and Tabares,L.
  TITLE     Synaptotagmin-2, and -1, linked to neurotransmission impairment and
            vulnerability in Spinal Muscular Atrophy
  JOURNAL   Hum Mol Genet 25 (21), 4703-4716 (2016)
   PUBMED   28173138
REFERENCE   6  (bases 1 to 3401)
  AUTHORS   Dolgov,V.S.
  TITLE     [Sanitary and hygienic evaluation of a technological line for
            removing manure]
  JOURNAL   Veterinariia (12), 61-63 (1978)
   PUBMED   734904
REFERENCE   7  (bases 1 to 3401)
  AUTHORS   Dabrowski,Z., Gregorczyk,J., Samochowiec,L., Wojcicki,J.,
            Lawczynski,L., Antoszczyk,M., Chrzanowska-Ansilewska,K., Jurek,D.
            and Sych,Z.
  TITLE     [Effect of truncal vagotomy on the exocrine function of the
            pancreas in the dog]
  JOURNAL   Pol Tyg Lek 33 (28), 1093-1095 (1978)
   PUBMED   704405
REFERENCE   8  (bases 1 to 3401)
  AUTHORS   Packman,P.M., Godfrey,D.A., Williams,A.D. and Matschinsky,F.M.
  TITLE     Quantitative histochemical studies of the hypothalamus enzymes of
            acetylcholine metabolism
  JOURNAL   J Histochem Cytochem 25 (11), 1237-1246 (1977)
   PUBMED   334962
REFERENCE   9  (bases 1 to 3401)
  AUTHORS   Godfrey,D.A. and Matschinsky,F.M.
  TITLE     Enzymes of the cholinergic system in islets of Langerhans
  JOURNAL   J Histochem Cytochem 23 (9), 645-651 (1975)
   PUBMED   126256
REFERENCE   10 (bases 1 to 3401)
  AUTHORS   Flumerfelt,B.A. and Lewis,P.R.
  TITLE     Cholinesterase activity in the hypoglossal nucleus of the rat and
            the changes produced by axotomy: a light and electron microscopic
            study
  JOURNAL   J Anat 119 (Pt 2), 309-331 (1975)
   PUBMED   1133098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Apr 7, 2023 this sequence version replaced
            XM_039089839.1, NM_172009.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094521.1, SRR26643292.47454.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                JAXUCZ010000012.1  25050327-25050410   c
            85-1177             JAXUCZ010000012.1  25047689-25048781   c
            1178-1662           JAXUCZ010000012.1  25046840-25047324   c
            1663-1832           JAXUCZ010000012.1  25045244-25045413   c
            1833-3401           JAXUCZ010000012.1  25042882-25044450   c
FEATURES             Location/Qualifiers
     source          1..3401
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..3401
                     /gene="Ache"
                     /note="acetylcholinesterase"
                     /db_xref="GeneID:83817"
                     /db_xref="RGD:69313"
     exon            1..84
                     /gene="Ache"
                     /inference="alignment:Splign:2.1.0"
     exon            85..1177
                     /gene="Ache"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1954
                     /gene="Ache"
                     /EC_number="3.1.1.7"
                     /note="glycolipid-anchored form of acetylcholinesterase"
                     /codon_start=1
                     /product="acetylcholinesterase precursor"
                     /protein_id="NP_742006.2"
                     /db_xref="GeneID:83817"
                     /db_xref="RGD:69313"
                     /translation="MRPPWYPLHTPSLASPLLFLLLSLLGGGARAEGREDPQLLVRVR
                     GGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGILDATTFQNVCYQ
                     YVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLIWIYGGGFYSGASS
                     LDVYDGRFLAQVEGTVLVSMNYRVGTFGFLALPGSRDAPGNVGLLDQRLALQWVQENI
                     AAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEAR
                     RRATLLARLVGCPPGGAGGNDTELISCLRTRPAQDLVDHEWHVLPQESIFRFSFVPVV
                     DGDFLSDTPEALINTGDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLA
                     GVRIGVPQASDLAAEAVVLHYTDWLHPEDPAHLRDAMSAVVGDHNVVCPVAQLAGRLA
                     AQGARVYAYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTVEERIFAQRLM
                     KYWTNFARTGDPNDPRDSKSPRWPPYTTAAQQYVSLNLKPLEVRRGLRAQTCAFWNRF
                     LPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQERCSDL"
     exon            1178..1662
                     /gene="Ache"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1832
                     /gene="Ache"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..3401
                     /gene="Ache"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgtcggct cagcctgcgc cggggaacat tggccgcctc cagctcccgg cgcggcccga
       61 cccggcccgg cttggccgcc tcagcagaca ccagccagtc ctggcagtca tgaggcctcc
      121 ctggtacccc ctgcatacac cctccctggc ttctccactc ctcttcctcc tcctctccct
      181 cctgggagga ggggcaaggg ctgagggccg ggaagaccct cagctgctgg tgagggttcg
      241 agggggccag ctgaggggca tccgcctgaa ggcccctgga ggcccagtct cagcttttct
      301 gggcatcccc tttgcagagc cacctgtggg ctcacgtaga tttatgccac cagagcccaa
      361 gcggccctgg tcaggaatat tggatgctac caccttccaa aatgtctgct accaatacgt
      421 ggacaccctg taccctgggt ttgagggtac cgagatgtgg aaccccaatc gagagctgag
      481 tgaagactgc ctttatctta atgtgtggac accatacccc aggcctactt ctcccacacc
      541 tgtcctcatc tggatctatg ggggtggttt ctacagtgga gcatcctcct tggacgtgta
      601 tgacggccgt ttcctggccc aggttgaggg aaccgtgttg gtatctatga actaccgagt
      661 gggaaccttt ggcttcttgg ctctaccagg aagcagagac gcccctggca atgtaggcct
      721 gctggatcaa cggcttgcct tgcaatgggt acaagaaaat atcgcagcct ttgggggaga
      781 cccaatgtca gtgactctgt ttggggagag tgcaggtgca gcctcagtgg gcatgcacat
      841 tctgtccctg cccagcagga gcctcttcca cagggctgtc ctgcagagtg gcacacccaa
      901 cgggccctgg gccactgtga gtgcgggaga ggccaggcgc agggccacac tgctggcccg
      961 ccttgtgggc tgtcccccag gtggcgctgg tggcaatgac accgagctga tatcctgctt
     1021 gaggacaagg cccgctcagg acctggtgga ccacgagtgg catgtgctgc ctcaagaaag
     1081 tatcttccgg ttttccttcg tgcctgtggt ggacggggat ttcctcagtg acacgccgga
     1141 ggccctcatc aatactggag attttcaaga cctgcaggtg ctggtgggtg tggtgaagga
     1201 cgagggctcc tactttctgg tttacggggt cccaggcttc agcaaagaca atgaatctct
     1261 catcagccgg gcccagttcc tggctggggt gcggatcggt gtaccccaag cgagtgacct
     1321 ggcggccgag gctgtggtcc tgcattatac agactggctg caccctgagg accctgccca
     1381 cctgagagat gccatgagtg cggtggtagg cgaccacaac gttgtgtgcc ctgtggccca
     1441 gctggctggg cgactggctg cccaaggggc tcgggtctat gcctacatct ttgaacaccg
     1501 tgcctccaca ttgacttggc ccctctggat gggggtgccc catggctatg aaatcgagtt
     1561 catctttggg ctccccctgg atccctcact gaactacacc gtggaggaga gaatctttgc
     1621 tcagcgactt atgaaatact ggaccaattt tgcccgcaca ggagacccca atgaccctcg
     1681 agactctaag tctccacggt ggccaccgta caccactgcc gcgcagcaat acgtgagcct
     1741 gaacctgaag cctttggagg tgcggcgggg actgcgcgcc cagacctgcg ccttctggaa
     1801 tcgttttctc cccaaattgc tcagcgccac agacacgctg gacgaggcgg agcgccagtg
     1861 gaaggccgag ttccaccgct ggagctccta catggtgcac tggaagaacc agttcgacca
     1921 ctatagcaag caggaacgct gctcagacct gtgacccctt gggggacccc aggtcctgcc
     1981 gtcctgcccg agcccctgat tgtatatact atttatttaa gggctgggat ataatacaac
     2041 cgagccccca ggccctgtcc accccgcccc gacttcctcc cactagggga tcctcatctt
     2101 ctgcatgttt tgggctgagc tcccctcccc gcggtgcctt cgcccctctg ggccgccaat
     2161 aaactgttac agctactaga gtctgtgcta ccggcgggaa cttggggcgg ggaccaggtc
     2221 acggagacgc taggaacaga agcctccgga ttggtgagca ctgatgtacc ctgcccgcag
     2281 catccggcgg aagtaagcac taggtccgcc ctaggggcgg agcttgcgac tgcgctgcaa
     2341 ggctggtttg ccggcgcctt ttagagagct cggaagtcgg tgtcaacttg tggaatgacc
     2401 tctcctgcta ctacgctgtt tggtatgagt tcccctgccc tagctaatcc cagaaaacac
     2461 caagaacccg gagtccgccc tgcctcggtg acagctgctc taccgagcac cctggagctg
     2521 ctaaaggacg tgcacctggg cctggctgta ccctgccagg atcccgcccg actggctctc
     2581 ctctcaggcc actaccttta ctatcactac ggttgcgatg gactggatga ccgcggctgg
     2641 ggatgcggct accgcaccct gcagactctg tgctcctggc cagagggcca gtcctccggc
     2701 gtgcctggac tggcagcctt gcagggagcc ctagaggaca tgggcgacaa gccccccggt
     2761 ttccggggct cccggaactg gatcggctgt gtagaggcca gtctctgtct agagcacttt
     2821 ggaggacctc agggacgcct gtaccacttg ccccgcggag cagagcttag gggagaactg
     2881 gagcggcttt attcacactt cacagcgggt gggggcccag taatggtggg aggagatgca
     2941 gatgctcagt ccaaggccct gctgggaatc tgtgaggggc cagatatgga agtctatgtc
     3001 ttgatactgg acccacacta ctggggcact ccaaaaaacc gttgtgaatt gcaagctgct
     3061 ggatgggtgg gctggcaaaa ggtaaaccat gtctttgatt ccaattcgtt ctacaacctg
     3121 tgcttgacca gacctatctg aaccaacacg ccctgtctgc actgtcggat agagcccaga
     3181 actgagactg atcagacatc tatttacttc tcacaggccc tccccccaac agcagacaag
     3241 tctctttcag catcaaaagt ttgggtcagg cacgatggcc gggcaggtga atctgagttc
     3301 agagtcaacc tggtataccc cacaagttct aggtcagccg gggtgaagac actgttctga
     3361 aaatggtaat aaattggcat aattcagctt cctatggcgc a
//
